Marine Metagenomics: New Tools for the Study and Exploitation of Marine Microbial Metabolism
Identifieur interne : 000131 ( Ncbi/Merge ); précédent : 000130; suivant : 000132Marine Metagenomics: New Tools for the Study and Exploitation of Marine Microbial Metabolism
Auteurs : Jonathan Kennedy ; Burkhardt Flemer ; Stephen A. Jackson ; David P. H. Lejon ; John P. Morrissey [Irlande (pays)] ; Fergal O Ara [Irlande (pays)] ; Alan D. W. Dobson [Irlande (pays)]Source :
- Marine Drugs [ 1660-3397 ] ; 2010.
Abstract
The marine environment is extremely diverse, with huge variations in pressure and temperature. Nevertheless, life, especially microbial life, thrives throughout the marine biosphere and microbes have adapted to all the divergent environments present. Large scale DNA sequence based approaches have recently been used to investigate the marine environment and these studies have revealed that the oceans harbor unprecedented microbial diversity. Novel gene families with representatives only within such metagenomic datasets represent a large proportion of the ocean metagenome. The presence of so many new gene families from these uncultured and highly diverse microbial populations represents a challenge for the understanding of and exploitation of the biology and biochemistry of the ocean environment. The application of new metagenomic and single cell genomics tools offers new ways to explore the complete metabolic diversity of the marine biome.
Url:
DOI: 10.3390/md8030608
PubMed: 20411118
PubMed Central: 2857354
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000711
- to stream Pmc, to step Curation: 000711
- to stream Pmc, to step Checkpoint: 000570
Links to Exploration step
PMC:2857354Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Marine Metagenomics: New Tools for the Study and Exploitation of Marine Microbial Metabolism</title>
<author><name sortKey="Kennedy, Jonathan" sort="Kennedy, Jonathan" uniqKey="Kennedy J" first="Jonathan" last="Kennedy">Jonathan Kennedy</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Flemer, Burkhardt" sort="Flemer, Burkhardt" uniqKey="Flemer B" first="Burkhardt" last="Flemer">Burkhardt Flemer</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jackson, Stephen A" sort="Jackson, Stephen A" uniqKey="Jackson S" first="Stephen A." last="Jackson">Stephen A. Jackson</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lejon, David P H" sort="Lejon, David P H" uniqKey="Lejon D" first="David P. H." last="Lejon">David P. H. Lejon</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morrissey, John P" sort="Morrissey, John P" uniqKey="Morrissey J" first="John P." last="Morrissey">John P. Morrissey</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-marinedrugs-08-00608"> Department of Microbiology, University College Cork, Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> Department of Microbiology, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Ara, Fergal" sort="O Ara, Fergal" uniqKey="O Ara F" first="Fergal" last="O Ara">Fergal O Ara</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-marinedrugs-08-00608"> Department of Microbiology, University College Cork, Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> Department of Microbiology, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-marinedrugs-08-00608"> BIOMERIT Research Centre, University College Cork, Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> BIOMERIT Research Centre, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dobson, Alan D W" sort="Dobson, Alan D W" uniqKey="Dobson A" first="Alan D. W." last="Dobson">Alan D. W. Dobson</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-marinedrugs-08-00608"> Department of Microbiology, University College Cork, Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> Department of Microbiology, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20411118</idno>
<idno type="pmc">2857354</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857354</idno>
<idno type="RBID">PMC:2857354</idno>
<idno type="doi">10.3390/md8030608</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000711</idno>
<idno type="wicri:Area/Pmc/Curation">000711</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000570</idno>
<idno type="wicri:Area/Ncbi/Merge">000131</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Marine Metagenomics: New Tools for the Study and Exploitation of Marine Microbial Metabolism</title>
<author><name sortKey="Kennedy, Jonathan" sort="Kennedy, Jonathan" uniqKey="Kennedy J" first="Jonathan" last="Kennedy">Jonathan Kennedy</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Flemer, Burkhardt" sort="Flemer, Burkhardt" uniqKey="Flemer B" first="Burkhardt" last="Flemer">Burkhardt Flemer</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jackson, Stephen A" sort="Jackson, Stephen A" uniqKey="Jackson S" first="Stephen A." last="Jackson">Stephen A. Jackson</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lejon, David P H" sort="Lejon, David P H" uniqKey="Lejon D" first="David P. H." last="Lejon">David P. H. Lejon</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morrissey, John P" sort="Morrissey, John P" uniqKey="Morrissey J" first="John P." last="Morrissey">John P. Morrissey</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-marinedrugs-08-00608"> Department of Microbiology, University College Cork, Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> Department of Microbiology, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Ara, Fergal" sort="O Ara, Fergal" uniqKey="O Ara F" first="Fergal" last="O Ara">Fergal O Ara</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-marinedrugs-08-00608"> Department of Microbiology, University College Cork, Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> Department of Microbiology, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-marinedrugs-08-00608"> BIOMERIT Research Centre, University College Cork, Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> BIOMERIT Research Centre, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dobson, Alan D W" sort="Dobson, Alan D W" uniqKey="Dobson A" first="Alan D. W." last="Dobson">Alan D. W. Dobson</name>
<affiliation><nlm:aff id="af1-marinedrugs-08-00608"> Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-marinedrugs-08-00608"> Department of Microbiology, University College Cork, Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> Department of Microbiology, University College Cork, Cork</wicri:regionArea>
<wicri:noRegion>Cork</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Marine Drugs</title>
<idno type="eISSN">1660-3397</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The marine environment is extremely diverse, with huge variations in pressure and temperature. Nevertheless, life, especially microbial life, thrives throughout the marine biosphere and microbes have adapted to all the divergent environments present. Large scale DNA sequence based approaches have recently been used to investigate the marine environment and these studies have revealed that the oceans harbor unprecedented microbial diversity. Novel gene families with representatives only within such metagenomic datasets represent a large proportion of the ocean metagenome. The presence of so many new gene families from these uncultured and highly diverse microbial populations represents a challenge for the understanding of and exploitation of the biology and biochemistry of the ocean environment. The application of new metagenomic and single cell genomics tools offers new ways to explore the complete metabolic diversity of the marine biome.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sogin, Ml" uniqKey="Sogin M">ML Sogin</name>
</author>
<author><name sortKey="Morrison, Hg" uniqKey="Morrison H">HG Morrison</name>
</author>
<author><name sortKey="Huber, Ja" uniqKey="Huber J">JA Huber</name>
</author>
<author><name sortKey="Mark Welch, D" uniqKey="Mark Welch D">D Mark Welch</name>
</author>
<author><name sortKey="Huse, Sm" uniqKey="Huse S">SM Huse</name>
</author>
<author><name sortKey="Neal, Pr" uniqKey="Neal P">PR Neal</name>
</author>
<author><name sortKey="Arrieta, Jm" uniqKey="Arrieta J">JM Arrieta</name>
</author>
<author><name sortKey="Herndl, Gj" uniqKey="Herndl G">GJ Herndl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dufresne, A" uniqKey="Dufresne A">A Dufresne</name>
</author>
<author><name sortKey="Garczarek, L" uniqKey="Garczarek L">L Garczarek</name>
</author>
<author><name sortKey="Partensky, F" uniqKey="Partensky F">F Partensky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giovannoni, Sj" uniqKey="Giovannoni S">SJ Giovannoni</name>
</author>
<author><name sortKey="Tripp, Hj" uniqKey="Tripp H">HJ Tripp</name>
</author>
<author><name sortKey="Givan, S" uniqKey="Givan S">S Givan</name>
</author>
<author><name sortKey="Podar, M" uniqKey="Podar M">M Podar</name>
</author>
<author><name sortKey="Vergin, Kl" uniqKey="Vergin K">KL Vergin</name>
</author>
<author><name sortKey="Baptista, D" uniqKey="Baptista D">D Baptista</name>
</author>
<author><name sortKey="Bibbs, L" uniqKey="Bibbs L">L Bibbs</name>
</author>
<author><name sortKey="Eads, J" uniqKey="Eads J">J Eads</name>
</author>
<author><name sortKey="Richardson, Th" uniqKey="Richardson T">TH Richardson</name>
</author>
<author><name sortKey="Noordewier, M" uniqKey="Noordewier M">M Noordewier</name>
</author>
<author><name sortKey="Rappe, Ms" uniqKey="Rappe M">MS Rappe</name>
</author>
<author><name sortKey="Short, Jm" uniqKey="Short J">JM Short</name>
</author>
<author><name sortKey="Carrington, Jc" uniqKey="Carrington J">JC Carrington</name>
</author>
<author><name sortKey="Mathur, Ej" uniqKey="Mathur E">EJ Mathur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beatty, Jt" uniqKey="Beatty J">JT Beatty</name>
</author>
<author><name sortKey="Overmann, J" uniqKey="Overmann J">J Overmann</name>
</author>
<author><name sortKey="Lince, Mt" uniqKey="Lince M">MT Lince</name>
</author>
<author><name sortKey="Manske, Ak" uniqKey="Manske A">AK Manske</name>
</author>
<author><name sortKey="Lang, As" uniqKey="Lang A">AS Lang</name>
</author>
<author><name sortKey="Blankenship, Re" uniqKey="Blankenship R">RE Blankenship</name>
</author>
<author><name sortKey="Van Dover, Cl" uniqKey="Van Dover C">CL Van Dover</name>
</author>
<author><name sortKey="Martinson, Ta" uniqKey="Martinson T">TA Martinson</name>
</author>
<author><name sortKey="Plumley, Fg" uniqKey="Plumley F">FG Plumley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jorgensen, Bb" uniqKey="Jorgensen B">BB Jorgensen</name>
</author>
<author><name sortKey="Boetius, A" uniqKey="Boetius A">A Boetius</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Handelsman, J" uniqKey="Handelsman J">J Handelsman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Edwards, Ra" uniqKey="Edwards R">RA Edwards</name>
</author>
<author><name sortKey="Rodriguez Brito, B" uniqKey="Rodriguez Brito B">B Rodriguez-Brito</name>
</author>
<author><name sortKey="Wegley, L" uniqKey="Wegley L">L Wegley</name>
</author>
<author><name sortKey="Haynes, M" uniqKey="Haynes M">M Haynes</name>
</author>
<author><name sortKey="Breitbart, M" uniqKey="Breitbart M">M Breitbart</name>
</author>
<author><name sortKey="Peterson, Dm" uniqKey="Peterson D">DM Peterson</name>
</author>
<author><name sortKey="Saar, Mo" uniqKey="Saar M">MO Saar</name>
</author>
<author><name sortKey="Alexander, S" uniqKey="Alexander S">S Alexander</name>
</author>
<author><name sortKey="Alexander, Ec" uniqKey="Alexander E">EC Alexander</name>
</author>
<author><name sortKey="Rohwer, F" uniqKey="Rohwer F">F Rohwer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wommack, Ke" uniqKey="Wommack K">KE Wommack</name>
</author>
<author><name sortKey="Bhavsar, J" uniqKey="Bhavsar J">J Bhavsar</name>
</author>
<author><name sortKey="Ravel, J" uniqKey="Ravel J">J Ravel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Horton, M" uniqKey="Horton M">M Horton</name>
</author>
<author><name sortKey="Bodenhausen, N" uniqKey="Bodenhausen N">N Bodenhausen</name>
</author>
<author><name sortKey="Bergelson, J" uniqKey="Bergelson J">J Bergelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name>
</author>
<author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
<author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name>
</author>
<author><name sortKey="Farmerie, W" uniqKey="Farmerie W">W Farmerie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finn, Rd" uniqKey="Finn R">RD Finn</name>
</author>
<author><name sortKey="Tate, J" uniqKey="Tate J">J Tate</name>
</author>
<author><name sortKey="Mistry, J" uniqKey="Mistry J">J Mistry</name>
</author>
<author><name sortKey="Coggill, Pc" uniqKey="Coggill P">PC Coggill</name>
</author>
<author><name sortKey="Sammut, Sj" uniqKey="Sammut S">SJ Sammut</name>
</author>
<author><name sortKey="Hotz, Hr" uniqKey="Hotz H">HR Hotz</name>
</author>
<author><name sortKey="Ceric, G" uniqKey="Ceric G">G Ceric</name>
</author>
<author><name sortKey="Forslund, K" uniqKey="Forslund K">K Forslund</name>
</author>
<author><name sortKey="Eddy, Sr" uniqKey="Eddy S">SR Eddy</name>
</author>
<author><name sortKey="Sonnhammer, El" uniqKey="Sonnhammer E">EL Sonnhammer</name>
</author>
<author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tatusov, Rl" uniqKey="Tatusov R">RL Tatusov</name>
</author>
<author><name sortKey="Koonin, Ev" uniqKey="Koonin E">EV Koonin</name>
</author>
<author><name sortKey="Lipman, Dj" uniqKey="Lipman D">DJ Lipman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Selengut, Jd" uniqKey="Selengut J">JD Selengut</name>
</author>
<author><name sortKey="Haft, Dh" uniqKey="Haft D">DH Haft</name>
</author>
<author><name sortKey="Davidsen, T" uniqKey="Davidsen T">T Davidsen</name>
</author>
<author><name sortKey="Ganapathy, A" uniqKey="Ganapathy A">A Ganapathy</name>
</author>
<author><name sortKey="Gwinn Giglio, M" uniqKey="Gwinn Giglio M">M Gwinn-Giglio</name>
</author>
<author><name sortKey="Nelson, Wc" uniqKey="Nelson W">WC Nelson</name>
</author>
<author><name sortKey="Richter, Ar" uniqKey="Richter A">AR Richter</name>
</author>
<author><name sortKey="White, O" uniqKey="White O">O White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Markowitz, Vm" uniqKey="Markowitz V">VM Markowitz</name>
</author>
<author><name sortKey="Ivanova, N" uniqKey="Ivanova N">N Ivanova</name>
</author>
<author><name sortKey="Palaniappan, K" uniqKey="Palaniappan K">K Palaniappan</name>
</author>
<author><name sortKey="Szeto, E" uniqKey="Szeto E">E Szeto</name>
</author>
<author><name sortKey="Korzeniewski, F" uniqKey="Korzeniewski F">F Korzeniewski</name>
</author>
<author><name sortKey="Lykidis, A" uniqKey="Lykidis A">A Lykidis</name>
</author>
<author><name sortKey="Anderson, I" uniqKey="Anderson I">I Anderson</name>
</author>
<author><name sortKey="Mavromatis, K" uniqKey="Mavromatis K">K Mavromatis</name>
</author>
<author><name sortKey="Kunin, V" uniqKey="Kunin V">V Kunin</name>
</author>
<author><name sortKey="Garcia Martin, H" uniqKey="Garcia Martin H">H Garcia Martin</name>
</author>
<author><name sortKey="Dubchak, I" uniqKey="Dubchak I">I Dubchak</name>
</author>
<author><name sortKey="Hugenholtz, P" uniqKey="Hugenholtz P">P Hugenholtz</name>
</author>
<author><name sortKey="Kyrpides, Nc" uniqKey="Kyrpides N">NC Kyrpides</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rusch, Db" uniqKey="Rusch D">DB Rusch</name>
</author>
<author><name sortKey="Halpern, Al" uniqKey="Halpern A">AL Halpern</name>
</author>
<author><name sortKey="Sutton, G" uniqKey="Sutton G">G Sutton</name>
</author>
<author><name sortKey="Heidelberg, Kb" uniqKey="Heidelberg K">KB Heidelberg</name>
</author>
<author><name sortKey="Williamson, S" uniqKey="Williamson S">S Williamson</name>
</author>
<author><name sortKey="Yooseph, S" uniqKey="Yooseph S">S Yooseph</name>
</author>
<author><name sortKey="Wu, D" uniqKey="Wu D">D Wu</name>
</author>
<author><name sortKey="Eisen, Ja" uniqKey="Eisen J">JA Eisen</name>
</author>
<author><name sortKey="Hoffman, Jm" uniqKey="Hoffman J">JM Hoffman</name>
</author>
<author><name sortKey="Remington, K" uniqKey="Remington K">K Remington</name>
</author>
<author><name sortKey="Beeson, K" uniqKey="Beeson K">K Beeson</name>
</author>
<author><name sortKey="Tran, B" uniqKey="Tran B">B Tran</name>
</author>
<author><name sortKey="Smith, H" uniqKey="Smith H">H Smith</name>
</author>
<author><name sortKey="Baden Tillson, H" uniqKey="Baden Tillson H">H Baden-Tillson</name>
</author>
<author><name sortKey="Stewart, C" uniqKey="Stewart C">C Stewart</name>
</author>
<author><name sortKey="Thorpe, J" uniqKey="Thorpe J">J Thorpe</name>
</author>
<author><name sortKey="Freeman, J" uniqKey="Freeman J">J Freeman</name>
</author>
<author><name sortKey="Andrews Pfannkoch, C" uniqKey="Andrews Pfannkoch C">C Andrews-Pfannkoch</name>
</author>
<author><name sortKey="Venter, Je" uniqKey="Venter J">JE Venter</name>
</author>
<author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Kravitz, S" uniqKey="Kravitz S">S Kravitz</name>
</author>
<author><name sortKey="Heidelberg, Jf" uniqKey="Heidelberg J">JF Heidelberg</name>
</author>
<author><name sortKey="Utterback, T" uniqKey="Utterback T">T Utterback</name>
</author>
<author><name sortKey="Rogers, Yh" uniqKey="Rogers Y">YH Rogers</name>
</author>
<author><name sortKey="Falcon, Li" uniqKey="Falcon L">LI Falcon</name>
</author>
<author><name sortKey="Souza, V" uniqKey="Souza V">V Souza</name>
</author>
<author><name sortKey="Bonilla Rosso, G" uniqKey="Bonilla Rosso G">G Bonilla-Rosso</name>
</author>
<author><name sortKey="Eguiarte, Le" uniqKey="Eguiarte L">LE Eguiarte</name>
</author>
<author><name sortKey="Karl, Dm" uniqKey="Karl D">DM Karl</name>
</author>
<author><name sortKey="Sathyendranath, S" uniqKey="Sathyendranath S">S Sathyendranath</name>
</author>
<author><name sortKey="Platt, T" uniqKey="Platt T">T Platt</name>
</author>
<author><name sortKey="Bermingham, E" uniqKey="Bermingham E">E Bermingham</name>
</author>
<author><name sortKey="Gallardo, V" uniqKey="Gallardo V">V Gallardo</name>
</author>
<author><name sortKey="Tamayo Castillo, G" uniqKey="Tamayo Castillo G">G Tamayo-Castillo</name>
</author>
<author><name sortKey="Ferrari, Mr" uniqKey="Ferrari M">MR Ferrari</name>
</author>
<author><name sortKey="Strausberg, Rl" uniqKey="Strausberg R">RL Strausberg</name>
</author>
<author><name sortKey="Nealson, K" uniqKey="Nealson K">K Nealson</name>
</author>
<author><name sortKey="Friedman, R" uniqKey="Friedman R">R Friedman</name>
</author>
<author><name sortKey="Frazier, M" uniqKey="Frazier M">M Frazier</name>
</author>
<author><name sortKey="Venter, Jc" uniqKey="Venter J">JC Venter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Venter, Jc" uniqKey="Venter J">JC Venter</name>
</author>
<author><name sortKey="Remington, K" uniqKey="Remington K">K Remington</name>
</author>
<author><name sortKey="Heidelberg, Jf" uniqKey="Heidelberg J">JF Heidelberg</name>
</author>
<author><name sortKey="Halpern, Al" uniqKey="Halpern A">AL Halpern</name>
</author>
<author><name sortKey="Rusch, D" uniqKey="Rusch D">D Rusch</name>
</author>
<author><name sortKey="Eisen, Ja" uniqKey="Eisen J">JA Eisen</name>
</author>
<author><name sortKey="Wu, D" uniqKey="Wu D">D Wu</name>
</author>
<author><name sortKey="Paulsen, I" uniqKey="Paulsen I">I Paulsen</name>
</author>
<author><name sortKey="Nelson, Ke" uniqKey="Nelson K">KE Nelson</name>
</author>
<author><name sortKey="Nelson, W" uniqKey="Nelson W">W Nelson</name>
</author>
<author><name sortKey="Fouts, De" uniqKey="Fouts D">DE Fouts</name>
</author>
<author><name sortKey="Levy, S" uniqKey="Levy S">S Levy</name>
</author>
<author><name sortKey="Knap, Ah" uniqKey="Knap A">AH Knap</name>
</author>
<author><name sortKey="Lomas, Mw" uniqKey="Lomas M">MW Lomas</name>
</author>
<author><name sortKey="Nealson, K" uniqKey="Nealson K">K Nealson</name>
</author>
<author><name sortKey="White, O" uniqKey="White O">O White</name>
</author>
<author><name sortKey="Peterson, J" uniqKey="Peterson J">J Peterson</name>
</author>
<author><name sortKey="Hoffman, J" uniqKey="Hoffman J">J Hoffman</name>
</author>
<author><name sortKey="Parsons, R" uniqKey="Parsons R">R Parsons</name>
</author>
<author><name sortKey="Baden Tillson, H" uniqKey="Baden Tillson H">H Baden-Tillson</name>
</author>
<author><name sortKey="Pfannkoch, C" uniqKey="Pfannkoch C">C Pfannkoch</name>
</author>
<author><name sortKey="Rogers, Yh" uniqKey="Rogers Y">YH Rogers</name>
</author>
<author><name sortKey="Smith, Ho" uniqKey="Smith H">HO Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giovannoni, Sj" uniqKey="Giovannoni S">SJ Giovannoni</name>
</author>
<author><name sortKey="Rappe, Ms" uniqKey="Rappe M">MS Rappe</name>
</author>
<author><name sortKey="Vergin, Kl" uniqKey="Vergin K">KL Vergin</name>
</author>
<author><name sortKey="Adair, Nl" uniqKey="Adair N">NL Adair</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin Cuadrado, Ab" uniqKey="Martin Cuadrado A">AB Martin-Cuadrado</name>
</author>
<author><name sortKey="Lopez Garcia, P" uniqKey="Lopez Garcia P">P Lopez-Garcia</name>
</author>
<author><name sortKey="Alba, Jc" uniqKey="Alba J">JC Alba</name>
</author>
<author><name sortKey="Moreira, D" uniqKey="Moreira D">D Moreira</name>
</author>
<author><name sortKey="Monticelli, L" uniqKey="Monticelli L">L Monticelli</name>
</author>
<author><name sortKey="Strittmatter, A" uniqKey="Strittmatter A">A Strittmatter</name>
</author>
<author><name sortKey="Gottschalk, G" uniqKey="Gottschalk G">G Gottschalk</name>
</author>
<author><name sortKey="Rodriguez Valera, F" uniqKey="Rodriguez Valera F">F Rodriguez-Valera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zaballos, M" uniqKey="Zaballos M">M Zaballos</name>
</author>
<author><name sortKey="Lopez Lopez, A" uniqKey="Lopez Lopez A">A Lopez-Lopez</name>
</author>
<author><name sortKey="Ovreas, L" uniqKey="Ovreas L">L Ovreas</name>
</author>
<author><name sortKey="Bartual, Sg" uniqKey="Bartual S">SG Bartual</name>
</author>
<author><name sortKey="D Uria, G" uniqKey="D Uria G">G D’Auria</name>
</author>
<author><name sortKey="Alba, Jc" uniqKey="Alba J">JC Alba</name>
</author>
<author><name sortKey="Legault, B" uniqKey="Legault B">B Legault</name>
</author>
<author><name sortKey="Pushker, R" uniqKey="Pushker R">R Pushker</name>
</author>
<author><name sortKey="Daae, Fl" uniqKey="Daae F">FL Daae</name>
</author>
<author><name sortKey="Rodriguez Valera, F" uniqKey="Rodriguez Valera F">F Rodriguez-Valera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delong, Ef" uniqKey="Delong E">EF DeLong</name>
</author>
<author><name sortKey="Preston, Cm" uniqKey="Preston C">CM Preston</name>
</author>
<author><name sortKey="Mincer, T" uniqKey="Mincer T">T Mincer</name>
</author>
<author><name sortKey="Rich, V" uniqKey="Rich V">V Rich</name>
</author>
<author><name sortKey="Hallam, Sj" uniqKey="Hallam S">SJ Hallam</name>
</author>
<author><name sortKey="Frigaard, Nu" uniqKey="Frigaard N">NU Frigaard</name>
</author>
<author><name sortKey="Martinez, A" uniqKey="Martinez A">A Martinez</name>
</author>
<author><name sortKey="Sullivan, Mb" uniqKey="Sullivan M">MB Sullivan</name>
</author>
<author><name sortKey="Edwards, R" uniqKey="Edwards R">R Edwards</name>
</author>
<author><name sortKey="Brito, Br" uniqKey="Brito B">BR Brito</name>
</author>
<author><name sortKey="Chisholm, Sw" uniqKey="Chisholm S">SW Chisholm</name>
</author>
<author><name sortKey="Karl, Dm" uniqKey="Karl D">DM Karl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Biddle, Jf" uniqKey="Biddle J">JF Biddle</name>
</author>
<author><name sortKey="Fitz Gibbon, S" uniqKey="Fitz Gibbon S">S Fitz-Gibbon</name>
</author>
<author><name sortKey="Schuster, Sc" uniqKey="Schuster S">SC Schuster</name>
</author>
<author><name sortKey="Brenchley, Je" uniqKey="Brenchley J">JE Brenchley</name>
</author>
<author><name sortKey="House, Ch" uniqKey="House C">CH House</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cooney, Rp" uniqKey="Cooney R">RP Cooney</name>
</author>
<author><name sortKey="Pantos, O" uniqKey="Pantos O">O Pantos</name>
</author>
<author><name sortKey="Le Tissier, Md" uniqKey="Le Tissier M">MD Le Tissier</name>
</author>
<author><name sortKey="Barer, Mr" uniqKey="Barer M">MR Barer</name>
</author>
<author><name sortKey="O Onnell, Ag" uniqKey="O Onnell A">AG O’Donnell</name>
</author>
<author><name sortKey="Bythell, Jc" uniqKey="Bythell J">JC Bythell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frias Lopez, J" uniqKey="Frias Lopez J">J Frias-Lopez</name>
</author>
<author><name sortKey="Klaus, Js" uniqKey="Klaus J">JS Klaus</name>
</author>
<author><name sortKey="Bonheyo, Gt" uniqKey="Bonheyo G">GT Bonheyo</name>
</author>
<author><name sortKey="Fouke, Bw" uniqKey="Fouke B">BW Fouke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kennedy, J" uniqKey="Kennedy J">J Kennedy</name>
</author>
<author><name sortKey="Codling, Ce" uniqKey="Codling C">CE Codling</name>
</author>
<author><name sortKey="Jones, Bv" uniqKey="Jones B">BV Jones</name>
</author>
<author><name sortKey="Dobson, Ad" uniqKey="Dobson A">AD Dobson</name>
</author>
<author><name sortKey="Marchesi, Jr" uniqKey="Marchesi J">JR Marchesi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lafi, Ff" uniqKey="Lafi F">FF Lafi</name>
</author>
<author><name sortKey="Fuerst, Ja" uniqKey="Fuerst J">JA Fuerst</name>
</author>
<author><name sortKey="Fieseler, L" uniqKey="Fieseler L">L Fieseler</name>
</author>
<author><name sortKey="Engels, C" uniqKey="Engels C">C Engels</name>
</author>
<author><name sortKey="Goh, Ww" uniqKey="Goh W">WW Goh</name>
</author>
<author><name sortKey="Hentschel, U" uniqKey="Hentschel U">U Hentschel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Webster, Ns" uniqKey="Webster N">NS Webster</name>
</author>
<author><name sortKey="Taylor, Mw" uniqKey="Taylor M">MW Taylor</name>
</author>
<author><name sortKey="Behnam, F" uniqKey="Behnam F">F Behnam</name>
</author>
<author><name sortKey="Lucker, S" uniqKey="Lucker S">S Lucker</name>
</author>
<author><name sortKey="Rattei, T" uniqKey="Rattei T">T Rattei</name>
</author>
<author><name sortKey="Whalan, S" uniqKey="Whalan S">S Whalan</name>
</author>
<author><name sortKey="Horn, M" uniqKey="Horn M">M Horn</name>
</author>
<author><name sortKey="Wagner, M" uniqKey="Wagner M">M Wagner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moreira, D" uniqKey="Moreira D">D Moreira</name>
</author>
<author><name sortKey="Rodriguez Valera, F" uniqKey="Rodriguez Valera F">F Rodriguez-Valera</name>
</author>
<author><name sortKey="Lopez Garcia, P" uniqKey="Lopez Garcia P">P Lopez-Garcia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fieseler, L" uniqKey="Fieseler L">L Fieseler</name>
</author>
<author><name sortKey="Horn, M" uniqKey="Horn M">M Horn</name>
</author>
<author><name sortKey="Wagner, M" uniqKey="Wagner M">M Wagner</name>
</author>
<author><name sortKey="Hentschel, U" uniqKey="Hentschel U">U Hentschel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmes, B" uniqKey="Holmes B">B Holmes</name>
</author>
<author><name sortKey="Blanch, H" uniqKey="Blanch H">H Blanch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mohamed, Nm" uniqKey="Mohamed N">NM Mohamed</name>
</author>
<author><name sortKey="Cicirelli, Em" uniqKey="Cicirelli E">EM Cicirelli</name>
</author>
<author><name sortKey="Kan, J" uniqKey="Kan J">J Kan</name>
</author>
<author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name>
</author>
<author><name sortKey="Fuqua, C" uniqKey="Fuqua C">C Fuqua</name>
</author>
<author><name sortKey="Hill, Rt" uniqKey="Hill R">RT Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pape, T" uniqKey="Pape T">T Pape</name>
</author>
<author><name sortKey="Hoffmann, F" uniqKey="Hoffmann F">F Hoffmann</name>
</author>
<author><name sortKey="Queric, N V" uniqKey="Queric N">N.-V Queric</name>
</author>
<author><name sortKey="Von Juterzenka, K" uniqKey="Von Juterzenka K">K von Juterzenka</name>
</author>
<author><name sortKey="Reitner, J" uniqKey="Reitner J">J Reitner</name>
</author>
<author><name sortKey="Michaelis, W" uniqKey="Michaelis W">W Michaelis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cragg, Gm" uniqKey="Cragg G">GM Cragg</name>
</author>
<author><name sortKey="Grothaus, Pg" uniqKey="Grothaus P">PG Grothaus</name>
</author>
<author><name sortKey="Newman, Dj" uniqKey="Newman D">DJ Newman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wegley, L" uniqKey="Wegley L">L Wegley</name>
</author>
<author><name sortKey="Edwards, R" uniqKey="Edwards R">R Edwards</name>
</author>
<author><name sortKey="Rodriguez Brito, B" uniqKey="Rodriguez Brito B">B Rodriguez-Brito</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
<author><name sortKey="Rohwer, F" uniqKey="Rohwer F">F Rohwer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seshardi, R" uniqKey="Seshardi R">R Seshardi</name>
</author>
<author><name sortKey="Kravitz, Sa" uniqKey="Kravitz S">SA Kravitz</name>
</author>
<author><name sortKey="Smarr, L" uniqKey="Smarr L">L Smarr</name>
</author>
<author><name sortKey="Gilna, P" uniqKey="Gilna P">P Gilna</name>
</author>
<author><name sortKey="Frazier, M" uniqKey="Frazier M">M Frazier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Markowitz, Vm" uniqKey="Markowitz V">VM Markowitz</name>
</author>
<author><name sortKey="Ivanova, Nn" uniqKey="Ivanova N">NN Ivanova</name>
</author>
<author><name sortKey="Szeto, E" uniqKey="Szeto E">E Szeto</name>
</author>
<author><name sortKey="Palaniappan, K" uniqKey="Palaniappan K">K Palaniappan</name>
</author>
<author><name sortKey="Chu, K" uniqKey="Chu K">K Chu</name>
</author>
<author><name sortKey="Dalevi, D" uniqKey="Dalevi D">D Dalevi</name>
</author>
<author><name sortKey="Chen, Im" uniqKey="Chen I">IM Chen</name>
</author>
<author><name sortKey="Grechkin, Y" uniqKey="Grechkin Y">Y Grechkin</name>
</author>
<author><name sortKey="Dubchak, I" uniqKey="Dubchak I">I Dubchak</name>
</author>
<author><name sortKey="Anderson, I" uniqKey="Anderson I">I Anderson</name>
</author>
<author><name sortKey="Lykidis, A" uniqKey="Lykidis A">A Lykidis</name>
</author>
<author><name sortKey="Mavromatis, K" uniqKey="Mavromatis K">K Mavromatis</name>
</author>
<author><name sortKey="Hugenholtz, P" uniqKey="Hugenholtz P">P Hugenholtz</name>
</author>
<author><name sortKey="Kyrpides, Nc" uniqKey="Kyrpides N">NC Kyrpides</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharma, Vk" uniqKey="Sharma V">VK Sharma</name>
</author>
<author><name sortKey="Kumar, N" uniqKey="Kumar N">N Kumar</name>
</author>
<author><name sortKey="Prakash, T" uniqKey="Prakash T">T Prakash</name>
</author>
<author><name sortKey="Taylor, Td" uniqKey="Taylor T">TD Taylor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoff, Kj" uniqKey="Hoff K">KJ Hoff</name>
</author>
<author><name sortKey="Lingner, T" uniqKey="Lingner T">T Lingner</name>
</author>
<author><name sortKey="Meinicke, P" uniqKey="Meinicke P">P Meinicke</name>
</author>
<author><name sortKey="Tech, M" uniqKey="Tech M">M Tech</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyer, F" uniqKey="Meyer F">F Meyer</name>
</author>
<author><name sortKey="Paarmann, D" uniqKey="Paarmann D">D Paarmann</name>
</author>
<author><name sortKey="D Ouza, M" uniqKey="D Ouza M">M D’Souza</name>
</author>
<author><name sortKey="Olson, R" uniqKey="Olson R">R Olson</name>
</author>
<author><name sortKey="Glass, Em" uniqKey="Glass E">EM Glass</name>
</author>
<author><name sortKey="Kubal, M" uniqKey="Kubal M">M Kubal</name>
</author>
<author><name sortKey="Paczian, T" uniqKey="Paczian T">T Paczian</name>
</author>
<author><name sortKey="Rodriguez, A" uniqKey="Rodriguez A">A Rodriguez</name>
</author>
<author><name sortKey="Stevens, R" uniqKey="Stevens R">R Stevens</name>
</author>
<author><name sortKey="Wilke, A" uniqKey="Wilke A">A Wilke</name>
</author>
<author><name sortKey="Wilkening, J" uniqKey="Wilkening J">J Wilkening</name>
</author>
<author><name sortKey="Edwards, Ra" uniqKey="Edwards R">RA Edwards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, C" uniqKey="Liang C">C Liang</name>
</author>
<author><name sortKey="Schmid, A" uniqKey="Schmid A">A Schmid</name>
</author>
<author><name sortKey="Lopez Sanchez, Mj" uniqKey="Lopez Sanchez M">MJ Lopez-Sanchez</name>
</author>
<author><name sortKey="Moya, A" uniqKey="Moya A">A Moya</name>
</author>
<author><name sortKey="Gross, R" uniqKey="Gross R">R Gross</name>
</author>
<author><name sortKey="Bernhardt, J" uniqKey="Bernhardt J">J Bernhardt</name>
</author>
<author><name sortKey="Dandekar, T" uniqKey="Dandekar T">T Dandekar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gerlach, W" uniqKey="Gerlach W">W Gerlach</name>
</author>
<author><name sortKey="Junemann, S" uniqKey="Junemann S">S Junemann</name>
</author>
<author><name sortKey="Tille, F" uniqKey="Tille F">F Tille</name>
</author>
<author><name sortKey="Goesmann, A" uniqKey="Goesmann A">A Goesmann</name>
</author>
<author><name sortKey="Stoye, J" uniqKey="Stoye J">J Stoye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huson, Dh" uniqKey="Huson D">DH Huson</name>
</author>
<author><name sortKey="Auch, Af" uniqKey="Auch A">AF Auch</name>
</author>
<author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name>
</author>
<author><name sortKey="Schuster, Sc" uniqKey="Schuster S">SC Schuster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitra, S" uniqKey="Mitra S">S Mitra</name>
</author>
<author><name sortKey="Klar, B" uniqKey="Klar B">B Klar</name>
</author>
<author><name sortKey="Huson, Dh" uniqKey="Huson D">DH Huson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kennedy, J" uniqKey="Kennedy J">J Kennedy</name>
</author>
<author><name sortKey="Marchesi, Jr" uniqKey="Marchesi J">JR Marchesi</name>
</author>
<author><name sortKey="Dobson, Ad" uniqKey="Dobson A">AD Dobson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Osta, Vm" uniqKey="D Osta V">VM D’Costa</name>
</author>
<author><name sortKey="Griffiths, E" uniqKey="Griffiths E">E Griffiths</name>
</author>
<author><name sortKey="Wright, Gd" uniqKey="Wright G">GD Wright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lammle, K" uniqKey="Lammle K">K Lammle</name>
</author>
<author><name sortKey="Zipper, H" uniqKey="Zipper H">H Zipper</name>
</author>
<author><name sortKey="Breuer, M" uniqKey="Breuer M">M Breuer</name>
</author>
<author><name sortKey="Hauer, B" uniqKey="Hauer B">B Hauer</name>
</author>
<author><name sortKey="Buta, C" uniqKey="Buta C">C Buta</name>
</author>
<author><name sortKey="Brunner, H" uniqKey="Brunner H">H Brunner</name>
</author>
<author><name sortKey="Rupp, S" uniqKey="Rupp S">S Rupp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suenaga, H" uniqKey="Suenaga H">H Suenaga</name>
</author>
<author><name sortKey="Ohnuki, T" uniqKey="Ohnuki T">T Ohnuki</name>
</author>
<author><name sortKey="Miyazaki, K" uniqKey="Miyazaki K">K Miyazaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azam, F" uniqKey="Azam F">F Azam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azam, F" uniqKey="Azam F">F Azam</name>
</author>
<author><name sortKey="Long, Ra" uniqKey="Long R">RA Long</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Whitman, Wb" uniqKey="Whitman W">WB Whitman</name>
</author>
<author><name sortKey="Coleman, Dc" uniqKey="Coleman D">DC Coleman</name>
</author>
<author><name sortKey="Wiebe, Wj" uniqKey="Wiebe W">WJ Wiebe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amann, Ri" uniqKey="Amann R">RI Amann</name>
</author>
<author><name sortKey="Ludwig, W" uniqKey="Ludwig W">W Ludwig</name>
</author>
<author><name sortKey="Schleifer, Kh" uniqKey="Schleifer K">KH Schleifer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yooseph, S" uniqKey="Yooseph S">S Yooseph</name>
</author>
<author><name sortKey="Sutton, G" uniqKey="Sutton G">G Sutton</name>
</author>
<author><name sortKey="Rusch, Db" uniqKey="Rusch D">DB Rusch</name>
</author>
<author><name sortKey="Halpern, Al" uniqKey="Halpern A">AL Halpern</name>
</author>
<author><name sortKey="Williamson, Sj" uniqKey="Williamson S">SJ Williamson</name>
</author>
<author><name sortKey="Remington, K" uniqKey="Remington K">K Remington</name>
</author>
<author><name sortKey="Eisen, Ja" uniqKey="Eisen J">JA Eisen</name>
</author>
<author><name sortKey="Heidelberg, Kb" uniqKey="Heidelberg K">KB Heidelberg</name>
</author>
<author><name sortKey="Manning, G" uniqKey="Manning G">G Manning</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Jaroszewski, L" uniqKey="Jaroszewski L">L Jaroszewski</name>
</author>
<author><name sortKey="Cieplak, P" uniqKey="Cieplak P">P Cieplak</name>
</author>
<author><name sortKey="Miller, Cs" uniqKey="Miller C">CS Miller</name>
</author>
<author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
<author><name sortKey="Mashiyama, St" uniqKey="Mashiyama S">ST Mashiyama</name>
</author>
<author><name sortKey="Joachimiak, Mp" uniqKey="Joachimiak M">MP Joachimiak</name>
</author>
<author><name sortKey="Van Belle, C" uniqKey="Van Belle C">C van Belle</name>
</author>
<author><name sortKey="Chandonia, Jm" uniqKey="Chandonia J">JM Chandonia</name>
</author>
<author><name sortKey="Soergel, Da" uniqKey="Soergel D">DA Soergel</name>
</author>
<author><name sortKey="Zhai, Y" uniqKey="Zhai Y">Y Zhai</name>
</author>
<author><name sortKey="Natarajan, K" uniqKey="Natarajan K">K Natarajan</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Raphael, Bj" uniqKey="Raphael B">BJ Raphael</name>
</author>
<author><name sortKey="Bafna, V" uniqKey="Bafna V">V Bafna</name>
</author>
<author><name sortKey="Friedman, R" uniqKey="Friedman R">R Friedman</name>
</author>
<author><name sortKey="Brenner, Se" uniqKey="Brenner S">SE Brenner</name>
</author>
<author><name sortKey="Godzik, A" uniqKey="Godzik A">A Godzik</name>
</author>
<author><name sortKey="Eisenberg, D" uniqKey="Eisenberg D">D Eisenberg</name>
</author>
<author><name sortKey="Dixon, Je" uniqKey="Dixon J">JE Dixon</name>
</author>
<author><name sortKey="Taylor, Ss" uniqKey="Taylor S">SS Taylor</name>
</author>
<author><name sortKey="Strausberg, Rl" uniqKey="Strausberg R">RL Strausberg</name>
</author>
<author><name sortKey="Frazier, M" uniqKey="Frazier M">M Frazier</name>
</author>
<author><name sortKey="Venter, Jc" uniqKey="Venter J">JC Venter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kennedy, J" uniqKey="Kennedy J">J Kennedy</name>
</author>
<author><name sortKey="Marchesi, Jr" uniqKey="Marchesi J">JR Marchesi</name>
</author>
<author><name sortKey="Dobson, Ad" uniqKey="Dobson A">AD Dobson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martinez, A" uniqKey="Martinez A">A Martinez</name>
</author>
<author><name sortKey="Kolvek, Sj" uniqKey="Kolvek S">SJ Kolvek</name>
</author>
<author><name sortKey="Yip, Cl" uniqKey="Yip C">CL Yip</name>
</author>
<author><name sortKey="Hopke, J" uniqKey="Hopke J">J Hopke</name>
</author>
<author><name sortKey="Brown, Ka" uniqKey="Brown K">KA Brown</name>
</author>
<author><name sortKey="Macneil, Ia" uniqKey="Macneil I">IA MacNeil</name>
</author>
<author><name sortKey="Osburne, Ms" uniqKey="Osburne M">MS Osburne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wexler, M" uniqKey="Wexler M">M Wexler</name>
</author>
<author><name sortKey="Bond, Pl" uniqKey="Bond P">PL Bond</name>
</author>
<author><name sortKey="Richardson, Dj" uniqKey="Richardson D">DJ Richardson</name>
</author>
<author><name sortKey="Johnston, Aw" uniqKey="Johnston A">AW Johnston</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Gy" uniqKey="Wang G">GY Wang</name>
</author>
<author><name sortKey="Graziani, E" uniqKey="Graziani E">E Graziani</name>
</author>
<author><name sortKey="Waters, B" uniqKey="Waters B">B Waters</name>
</author>
<author><name sortKey="Pan, W" uniqKey="Pan W">W Pan</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Mcdermott, J" uniqKey="Mcdermott J">J McDermott</name>
</author>
<author><name sortKey="Meurer, G" uniqKey="Meurer G">G Meurer</name>
</author>
<author><name sortKey="Saxena, G" uniqKey="Saxena G">G Saxena</name>
</author>
<author><name sortKey="Andersen, Rj" uniqKey="Andersen R">RJ Andersen</name>
</author>
<author><name sortKey="Davies, J" uniqKey="Davies J">J Davies</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Makrides, Sc" uniqKey="Makrides S">SC Makrides</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrer, M" uniqKey="Ferrer M">M Ferrer</name>
</author>
<author><name sortKey="Chernikova, Tn" uniqKey="Chernikova T">TN Chernikova</name>
</author>
<author><name sortKey="Yakimov, Mm" uniqKey="Yakimov M">MM Yakimov</name>
</author>
<author><name sortKey="Golyshin, Pn" uniqKey="Golyshin P">PN Golyshin</name>
</author>
<author><name sortKey="Timmis, Kn" uniqKey="Timmis K">KN Timmis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Uchiyama, T" uniqKey="Uchiyama T">T Uchiyama</name>
</author>
<author><name sortKey="Abe, T" uniqKey="Abe T">T Abe</name>
</author>
<author><name sortKey="Ikemura, T" uniqKey="Ikemura T">T Ikemura</name>
</author>
<author><name sortKey="Watanabe, K" uniqKey="Watanabe K">K Watanabe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yun, J" uniqKey="Yun J">J Yun</name>
</author>
<author><name sortKey="Ryu, S" uniqKey="Ryu S">S Ryu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Uchiyama, T" uniqKey="Uchiyama T">T Uchiyama</name>
</author>
<author><name sortKey="Watanabe, K" uniqKey="Watanabe K">K Watanabe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamada, K" uniqKey="Yamada K">K Yamada</name>
</author>
<author><name sortKey="Terahara, T" uniqKey="Terahara T">T Terahara</name>
</author>
<author><name sortKey="Kurata, S" uniqKey="Kurata S">S Kurata</name>
</author>
<author><name sortKey="Yokomaku, T" uniqKey="Yokomaku T">T Yokomaku</name>
</author>
<author><name sortKey="Tsuneda, S" uniqKey="Tsuneda S">S Tsuneda</name>
</author>
<author><name sortKey="Harayama, S" uniqKey="Harayama S">S Harayama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boubakri, H" uniqKey="Boubakri H">H Boubakri</name>
</author>
<author><name sortKey="Beuf, M" uniqKey="Beuf M">M Beuf</name>
</author>
<author><name sortKey="Simonet, P" uniqKey="Simonet P">P Simonet</name>
</author>
<author><name sortKey="Vogel, Tm" uniqKey="Vogel T">TM Vogel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chalfie, M" uniqKey="Chalfie M">M Chalfie</name>
</author>
<author><name sortKey="Tu, Y" uniqKey="Tu Y">Y Tu</name>
</author>
<author><name sortKey="Euskirchen, G" uniqKey="Euskirchen G">G Euskirchen</name>
</author>
<author><name sortKey="Ward, Ww" uniqKey="Ward W">WW Ward</name>
</author>
<author><name sortKey="Prasher, Dc" uniqKey="Prasher D">DC Prasher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shimomura, O" uniqKey="Shimomura O">O Shimomura</name>
</author>
<author><name sortKey="Johnson, Fh" uniqKey="Johnson F">FH Johnson</name>
</author>
<author><name sortKey="Saiga, Y" uniqKey="Saiga Y">Y Saiga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Engebrecht, J" uniqKey="Engebrecht J">J Engebrecht</name>
</author>
<author><name sortKey="Simon, M" uniqKey="Simon M">M Simon</name>
</author>
<author><name sortKey="Silverman, M" uniqKey="Silverman M">M Silverman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mathur, Ej" uniqKey="Mathur E">EJ Mathur</name>
</author>
<author><name sortKey="Toledo, G" uniqKey="Toledo G">G Toledo</name>
</author>
<author><name sortKey="Green, Bd" uniqKey="Green B">BD Green</name>
</author>
<author><name sortKey="Podar, M" uniqKey="Podar M">M Podar</name>
</author>
<author><name sortKey="Richardson, Th" uniqKey="Richardson T">TH Richardson</name>
</author>
<author><name sortKey="Kulwiec, M" uniqKey="Kulwiec M">M Kulwiec</name>
</author>
<author><name sortKey="Chang, Hw" uniqKey="Chang H">HW Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hardeman, F" uniqKey="Hardeman F">F Hardeman</name>
</author>
<author><name sortKey="Sjoling, S" uniqKey="Sjoling S">S Sjoling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name>
</author>
<author><name sortKey="Xiao, X" uniqKey="Xiao X">X Xiao</name>
</author>
<author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chu, X" uniqKey="Chu X">X Chu</name>
</author>
<author><name sortKey="He, H" uniqKey="He H">H He</name>
</author>
<author><name sortKey="Guo, C" uniqKey="Guo C">C Guo</name>
</author>
<author><name sortKey="Sun, B" uniqKey="Sun B">B Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Dg" uniqKey="Lee D">DG Lee</name>
</author>
<author><name sortKey="Jeon, Jh" uniqKey="Jeon J">JH Jeon</name>
</author>
<author><name sortKey="Jang, Mk" uniqKey="Jang M">MK Jang</name>
</author>
<author><name sortKey="Kim, Ny" uniqKey="Kim N">NY Kim</name>
</author>
<author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name>
</author>
<author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name>
</author>
<author><name sortKey="Kim, Sj" uniqKey="Kim S">SJ Kim</name>
</author>
<author><name sortKey="Kim, Gd" uniqKey="Kim G">GD Kim</name>
</author>
<author><name sortKey="Lee, Sh" uniqKey="Lee S">SH Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aurilia, V" uniqKey="Aurilia V">V Aurilia</name>
</author>
<author><name sortKey="Parracino, A" uniqKey="Parracino A">A Parracino</name>
</author>
<author><name sortKey="D Uria, S" uniqKey="D Uria S">S D’Auria</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrer, M" uniqKey="Ferrer M">M Ferrer</name>
</author>
<author><name sortKey="Golyshina, Ov" uniqKey="Golyshina O">OV Golyshina</name>
</author>
<author><name sortKey="Chernikova, Tn" uniqKey="Chernikova T">TN Chernikova</name>
</author>
<author><name sortKey="Khachane, An" uniqKey="Khachane A">AN Khachane</name>
</author>
<author><name sortKey="Martins Dos Santos, Va" uniqKey="Martins Dos Santos V">VA Martins Dos Santos</name>
</author>
<author><name sortKey="Yakimov, Mm" uniqKey="Yakimov M">MM Yakimov</name>
</author>
<author><name sortKey="Timmis, Kn" uniqKey="Timmis K">KN Timmis</name>
</author>
<author><name sortKey="Golyshin, Pn" uniqKey="Golyshin P">PN Golyshin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Pascale, D" uniqKey="De Pascale D">D de Pascale</name>
</author>
<author><name sortKey="Cusano, Am" uniqKey="Cusano A">AM Cusano</name>
</author>
<author><name sortKey="Autore, F" uniqKey="Autore F">F Autore</name>
</author>
<author><name sortKey="Parrilli, E" uniqKey="Parrilli E">E Parrilli</name>
</author>
<author><name sortKey="Di Prisco, G" uniqKey="Di Prisco G">G di Prisco</name>
</author>
<author><name sortKey="Marino, G" uniqKey="Marino G">G Marino</name>
</author>
<author><name sortKey="Tutino, Ml" uniqKey="Tutino M">ML Tutino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Mh" uniqKey="Lee M">MH Lee</name>
</author>
<author><name sortKey="Lee, Ch" uniqKey="Lee C">CH Lee</name>
</author>
<author><name sortKey="Oh, Tk" uniqKey="Oh T">TK Oh</name>
</author>
<author><name sortKey="Song, Jk" uniqKey="Song J">JK Song</name>
</author>
<author><name sortKey="Yoon, Jh" uniqKey="Yoon J">JH Yoon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jeon, Jh" uniqKey="Jeon J">JH Jeon</name>
</author>
<author><name sortKey="Kim, Jt" uniqKey="Kim J">JT Kim</name>
</author>
<author><name sortKey="Kim, Yj" uniqKey="Kim Y">YJ Kim</name>
</author>
<author><name sortKey="Kim, Hk" uniqKey="Kim H">HK Kim</name>
</author>
<author><name sortKey="Lee, Hs" uniqKey="Lee H">HS Lee</name>
</author>
<author><name sortKey="Kang, Sg" uniqKey="Kang S">SG Kang</name>
</author>
<author><name sortKey="Kim, Sj" uniqKey="Kim S">SJ Kim</name>
</author>
<author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shanmughapriya, S" uniqKey="Shanmughapriya S">S Shanmughapriya</name>
</author>
<author><name sortKey="Kiran, Gs" uniqKey="Kiran G">GS Kiran</name>
</author>
<author><name sortKey="Selvin, J" uniqKey="Selvin J">J Selvin</name>
</author>
<author><name sortKey="Thomas, Ta" uniqKey="Thomas T">TA Thomas</name>
</author>
<author><name sortKey="Rani, C" uniqKey="Rani C">C Rani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeng, R" uniqKey="Zeng R">R Zeng</name>
</author>
<author><name sortKey="Xiong, P" uniqKey="Xiong P">P Xiong</name>
</author>
<author><name sortKey="Wen, J" uniqKey="Wen J">J Wen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garsoux, G" uniqKey="Garsoux G">G Garsoux</name>
</author>
<author><name sortKey="Lamotte, J" uniqKey="Lamotte J">J Lamotte</name>
</author>
<author><name sortKey="Gerday, C" uniqKey="Gerday C">C Gerday</name>
</author>
<author><name sortKey="Feller, G" uniqKey="Feller G">G Feller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ekborg, Na" uniqKey="Ekborg N">NA Ekborg</name>
</author>
<author><name sortKey="Morrill, W" uniqKey="Morrill W">W Morrill</name>
</author>
<author><name sortKey="Burgoyne, Am" uniqKey="Burgoyne A">AM Burgoyne</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Distel, Dl" uniqKey="Distel D">DL Distel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cottrell, Mt" uniqKey="Cottrell M">MT Cottrell</name>
</author>
<author><name sortKey="Moore, Ja" uniqKey="Moore J">JA Moore</name>
</author>
<author><name sortKey="Kirchman, Dl" uniqKey="Kirchman D">DL Kirchman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hobel, Cf" uniqKey="Hobel C">CF Hobel</name>
</author>
<author><name sortKey="Hreggvidsson, Go" uniqKey="Hreggvidsson G">GO Hreggvidsson</name>
</author>
<author><name sortKey="Marteinsson, Vt" uniqKey="Marteinsson V">VT Marteinsson</name>
</author>
<author><name sortKey="Bahrani Mougeot, F" uniqKey="Bahrani Mougeot F">F Bahrani-Mougeot</name>
</author>
<author><name sortKey="Einarsson, Jm" uniqKey="Einarsson J">JM Einarsson</name>
</author>
<author><name sortKey="Kristjansson, Jk" uniqKey="Kristjansson J">JK Kristjansson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wasmund, K" uniqKey="Wasmund K">K Wasmund</name>
</author>
<author><name sortKey="Burns, Ka" uniqKey="Burns K">KA Burns</name>
</author>
<author><name sortKey="Kurtboke, Di" uniqKey="Kurtboke D">DI Kurtboke</name>
</author>
<author><name sortKey="Bourne, Dg" uniqKey="Bourne D">DG Bourne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrer, M" uniqKey="Ferrer M">M Ferrer</name>
</author>
<author><name sortKey="Beloqui, A" uniqKey="Beloqui A">A Beloqui</name>
</author>
<author><name sortKey="Timmis, Kn" uniqKey="Timmis K">KN Timmis</name>
</author>
<author><name sortKey="Golyshin, Pn" uniqKey="Golyshin P">PN Golyshin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jones, Bv" uniqKey="Jones B">BV Jones</name>
</author>
<author><name sortKey="Sun, F" uniqKey="Sun F">F Sun</name>
</author>
<author><name sortKey="Marchesi, Jr" uniqKey="Marchesi J">JR Marchesi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Sw" uniqKey="Lee S">SW Lee</name>
</author>
<author><name sortKey="Won, K" uniqKey="Won K">K Won</name>
</author>
<author><name sortKey="Lim, Hk" uniqKey="Lim H">HK Lim</name>
</author>
<author><name sortKey="Kim, Jc" uniqKey="Kim J">JC Kim</name>
</author>
<author><name sortKey="Choi, Gj" uniqKey="Choi G">GJ Choi</name>
</author>
<author><name sortKey="Cho, Ky" uniqKey="Cho K">KY Cho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guan, C" uniqKey="Guan C">C Guan</name>
</author>
<author><name sortKey="Ju, J" uniqKey="Ju J">J Ju</name>
</author>
<author><name sortKey="Borlee, Br" uniqKey="Borlee B">BR Borlee</name>
</author>
<author><name sortKey="Williamson, Ll" uniqKey="Williamson L">LL Williamson</name>
</author>
<author><name sortKey="Shen, B" uniqKey="Shen B">B Shen</name>
</author>
<author><name sortKey="Raffa, Kf" uniqKey="Raffa K">KF Raffa</name>
</author>
<author><name sortKey="Handelsman, J" uniqKey="Handelsman J">J Handelsman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stepanauskas, R" uniqKey="Stepanauskas R">R Stepanauskas</name>
</author>
<author><name sortKey="Sieracki, Me" uniqKey="Sieracki M">ME Sieracki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woyke, T" uniqKey="Woyke T">T Woyke</name>
</author>
<author><name sortKey="Xie, G" uniqKey="Xie G">G Xie</name>
</author>
<author><name sortKey="Copeland, A" uniqKey="Copeland A">A Copeland</name>
</author>
<author><name sortKey="Gonzalez, Jm" uniqKey="Gonzalez J">JM Gonzalez</name>
</author>
<author><name sortKey="Han, C" uniqKey="Han C">C Han</name>
</author>
<author><name sortKey="Kiss, H" uniqKey="Kiss H">H Kiss</name>
</author>
<author><name sortKey="Saw, Jh" uniqKey="Saw J">JH Saw</name>
</author>
<author><name sortKey="Senin, P" uniqKey="Senin P">P Senin</name>
</author>
<author><name sortKey="Yang, C" uniqKey="Yang C">C Yang</name>
</author>
<author><name sortKey="Chatterji, S" uniqKey="Chatterji S">S Chatterji</name>
</author>
<author><name sortKey="Cheng, Jf" uniqKey="Cheng J">JF Cheng</name>
</author>
<author><name sortKey="Eisen, Ja" uniqKey="Eisen J">JA Eisen</name>
</author>
<author><name sortKey="Sieracki, Me" uniqKey="Sieracki M">ME Sieracki</name>
</author>
<author><name sortKey="Stepanauskas, R" uniqKey="Stepanauskas R">R Stepanauskas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilbert, Ja" uniqKey="Gilbert J">JA Gilbert</name>
</author>
<author><name sortKey="Field, D" uniqKey="Field D">D Field</name>
</author>
<author><name sortKey="Swift, P" uniqKey="Swift P">P Swift</name>
</author>
<author><name sortKey="Newbold, L" uniqKey="Newbold L">L Newbold</name>
</author>
<author><name sortKey="Oliver, A" uniqKey="Oliver A">A Oliver</name>
</author>
<author><name sortKey="Smyth, T" uniqKey="Smyth T">T Smyth</name>
</author>
<author><name sortKey="Somerfield, Pj" uniqKey="Somerfield P">PJ Somerfield</name>
</author>
<author><name sortKey="Huse, S" uniqKey="Huse S">S Huse</name>
</author>
<author><name sortKey="Joint, I" uniqKey="Joint I">I Joint</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frias Lopez, J" uniqKey="Frias Lopez J">J Frias-Lopez</name>
</author>
<author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name>
</author>
<author><name sortKey="Tyson, Gw" uniqKey="Tyson G">GW Tyson</name>
</author>
<author><name sortKey="Coleman, Ml" uniqKey="Coleman M">ML Coleman</name>
</author>
<author><name sortKey="Schuster, Sc" uniqKey="Schuster S">SC Schuster</name>
</author>
<author><name sortKey="Chisholm, Sw" uniqKey="Chisholm S">SW Chisholm</name>
</author>
<author><name sortKey="Delong, Ef" uniqKey="Delong E">EF Delong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilbert, Ja" uniqKey="Gilbert J">JA Gilbert</name>
</author>
<author><name sortKey="Field, D" uniqKey="Field D">D Field</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Edwards, R" uniqKey="Edwards R">R Edwards</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Gilna, P" uniqKey="Gilna P">P Gilna</name>
</author>
<author><name sortKey="Joint, I" uniqKey="Joint I">I Joint</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilbert, Ja" uniqKey="Gilbert J">JA Gilbert</name>
</author>
<author><name sortKey="Thomas, S" uniqKey="Thomas S">S Thomas</name>
</author>
<author><name sortKey="Cooley, Na" uniqKey="Cooley N">NA Cooley</name>
</author>
<author><name sortKey="Kulakova, A" uniqKey="Kulakova A">A Kulakova</name>
</author>
<author><name sortKey="Field, D" uniqKey="Field D">D Field</name>
</author>
<author><name sortKey="Booth, T" uniqKey="Booth T">T Booth</name>
</author>
<author><name sortKey="Mcgrath, Jw" uniqKey="Mcgrath J">JW McGrath</name>
</author>
<author><name sortKey="Quinn, Jp" uniqKey="Quinn J">JP Quinn</name>
</author>
<author><name sortKey="Joint, I" uniqKey="Joint I">I Joint</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilmes, P" uniqKey="Wilmes P">P Wilmes</name>
</author>
<author><name sortKey="Bond, Pl" uniqKey="Bond P">PL Bond</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schweder, T" uniqKey="Schweder T">T Schweder</name>
</author>
<author><name sortKey="Markert, S" uniqKey="Markert S">S Markert</name>
</author>
<author><name sortKey="Hecker, M" uniqKey="Hecker M">M Hecker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toyoda, A" uniqKey="Toyoda A">A Toyoda</name>
</author>
<author><name sortKey="Iio, W" uniqKey="Iio W">W Iio</name>
</author>
<author><name sortKey="Mitsumori, M" uniqKey="Mitsumori M">M Mitsumori</name>
</author>
<author><name sortKey="Minato, H" uniqKey="Minato H">H Minato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beloqui, A" uniqKey="Beloqui A">A Beloqui</name>
</author>
<author><name sortKey="Guazzaroni, Me" uniqKey="Guazzaroni M">ME Guazzaroni</name>
</author>
<author><name sortKey="Pazos, F" uniqKey="Pazos F">F Pazos</name>
</author>
<author><name sortKey="Vieites, Jm" uniqKey="Vieites J">JM Vieites</name>
</author>
<author><name sortKey="Godoy, M" uniqKey="Godoy M">M Godoy</name>
</author>
<author><name sortKey="Golyshina, Ov" uniqKey="Golyshina O">OV Golyshina</name>
</author>
<author><name sortKey="Chernikova, Tn" uniqKey="Chernikova T">TN Chernikova</name>
</author>
<author><name sortKey="Waliczek, A" uniqKey="Waliczek A">A Waliczek</name>
</author>
<author><name sortKey="Silva Rocha, R" uniqKey="Silva Rocha R">R Silva-Rocha</name>
</author>
<author><name sortKey="Al Ramahi, Y" uniqKey="Al Ramahi Y">Y Al-Ramahi</name>
</author>
<author><name sortKey="La Cono, V" uniqKey="La Cono V">V La Cono</name>
</author>
<author><name sortKey="Mendez, C" uniqKey="Mendez C">C Mendez</name>
</author>
<author><name sortKey="Salas, Ja" uniqKey="Salas J">JA Salas</name>
</author>
<author><name sortKey="Solano, R" uniqKey="Solano R">R Solano</name>
</author>
<author><name sortKey="Yakimov, Mm" uniqKey="Yakimov M">MM Yakimov</name>
</author>
<author><name sortKey="Timmis, Kn" uniqKey="Timmis K">KN Timmis</name>
</author>
<author><name sortKey="Golyshin, Pn" uniqKey="Golyshin P">PN Golyshin</name>
</author>
<author><name sortKey="Ferrer, M" uniqKey="Ferrer M">M Ferrer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Hj" uniqKey="Park H">HJ Park</name>
</author>
<author><name sortKey="Jeon, Jh" uniqKey="Jeon J">JH Jeon</name>
</author>
<author><name sortKey="Kang, Sg" uniqKey="Kang S">SG Kang</name>
</author>
<author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name>
</author>
<author><name sortKey="Lee, Sa" uniqKey="Lee S">SA Lee</name>
</author>
<author><name sortKey="Kim, Hk" uniqKey="Kim H">HK Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jeon, Jh" uniqKey="Jeon J">JH Jeon</name>
</author>
<author><name sortKey="Kim, Jt" uniqKey="Kim J">JT Kim</name>
</author>
<author><name sortKey="Kang, Sg" uniqKey="Kang S">SG Kang</name>
</author>
<author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name>
</author>
<author><name sortKey="Kim, Sj" uniqKey="Kim S">SJ Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Sy" uniqKey="Park S">SY Park</name>
</author>
<author><name sortKey="Kim, Jt" uniqKey="Kim J">JT Kim</name>
</author>
<author><name sortKey="Kang, Sg" uniqKey="Kang S">SG Kang</name>
</author>
<author><name sortKey="Woo, Jh" uniqKey="Woo J">JH Woo</name>
</author>
<author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name>
</author>
<author><name sortKey="Choi, Ht" uniqKey="Choi H">HT Choi</name>
</author>
<author><name sortKey="Kim, Sj" uniqKey="Kim S">SJ Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Chi, Z" uniqKey="Chi Z">Z Chi</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lonhienne, T" uniqKey="Lonhienne T">T Lonhienne</name>
</author>
<author><name sortKey="Mavromatis, K" uniqKey="Mavromatis K">K Mavromatis</name>
</author>
<author><name sortKey="Vorgias, Ce" uniqKey="Vorgias C">CE Vorgias</name>
</author>
<author><name sortKey="Buchon, L" uniqKey="Buchon L">L Buchon</name>
</author>
<author><name sortKey="Gerday, C" uniqKey="Gerday C">C Gerday</name>
</author>
<author><name sortKey="Bouriotis, V" uniqKey="Bouriotis V">V Bouriotis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gabor, Em" uniqKey="Gabor E">EM Gabor</name>
</author>
<author><name sortKey="De Vries, Ej" uniqKey="De Vries E">EJ de Vries</name>
</author>
<author><name sortKey="Janssen, Db" uniqKey="Janssen D">DB Janssen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
<author><name sortKey="Chi, Z" uniqKey="Chi Z">Z Chi</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Duan, X" uniqKey="Duan X">X Duan</name>
</author>
<author><name sortKey="Ma, L" uniqKey="Ma L">L Ma</name>
</author>
<author><name sortKey="Gao, L" uniqKey="Gao L">L Gao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Chi, Z" uniqKey="Chi Z">Z Chi</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Hirimuthugoda, Ny" uniqKey="Hirimuthugoda N">NY Hirimuthugoda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeng, R" uniqKey="Zeng R">R Zeng</name>
</author>
<author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Lin, N" uniqKey="Lin N">N Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Acevedo, Jp" uniqKey="Acevedo J">JP Acevedo</name>
</author>
<author><name sortKey="Reyes, F" uniqKey="Reyes F">F Reyes</name>
</author>
<author><name sortKey="Parra, Lp" uniqKey="Parra L">LP Parra</name>
</author>
<author><name sortKey="Salazar, O" uniqKey="Salazar O">O Salazar</name>
</author>
<author><name sortKey="Andrews, Ba" uniqKey="Andrews B">BA Andrews</name>
</author>
<author><name sortKey="Asenjo, Ja" uniqKey="Asenjo J">JA Asenjo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chavez Croocker, P" uniqKey="Chavez Croocker P">P Chavez Croocker</name>
</author>
<author><name sortKey="Sako, Y" uniqKey="Sako Y">Y Sako</name>
</author>
<author><name sortKey="Uchida, A" uniqKey="Uchida A">A Uchida</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Collins, T" uniqKey="Collins T">T Collins</name>
</author>
<author><name sortKey="Meuwis, Ma" uniqKey="Meuwis M">MA Meuwis</name>
</author>
<author><name sortKey="Stals, I" uniqKey="Stals I">I Stals</name>
</author>
<author><name sortKey="Claeyssens, M" uniqKey="Claeyssens M">M Claeyssens</name>
</author>
<author><name sortKey="Feller, G" uniqKey="Feller G">G Feller</name>
</author>
<author><name sortKey="Gerday, C" uniqKey="Gerday C">C Gerday</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mar Drugs</journal-id>
<journal-id journal-id-type="publisher-id">MD</journal-id>
<journal-title-group><journal-title>Marine Drugs</journal-title>
</journal-title-group>
<issn pub-type="epub">1660-3397</issn>
<publisher><publisher-name>Molecular Diversity Preservation International</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20411118</article-id>
<article-id pub-id-type="pmc">2857354</article-id>
<article-id pub-id-type="doi">10.3390/md8030608</article-id>
<article-id pub-id-type="publisher-id">marinedrugs-08-00608</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Marine Metagenomics: New Tools for the Study and Exploitation of Marine Microbial Metabolism</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kennedy</surname>
<given-names>Jonathan</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-08-00608">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Flemer</surname>
<given-names>Burkhardt</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-08-00608">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jackson</surname>
<given-names>Stephen A.</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-08-00608">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lejon</surname>
<given-names>David P. H.</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-08-00608">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Morrissey</surname>
<given-names>John P.</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-08-00608">1</xref>
<xref ref-type="aff" rid="af2-marinedrugs-08-00608">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>O’Gara</surname>
<given-names>Fergal</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-08-00608">1</xref>
<xref ref-type="aff" rid="af2-marinedrugs-08-00608">2</xref>
<xref ref-type="aff" rid="af3-marinedrugs-08-00608">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dobson</surname>
<given-names>Alan D. W.</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-08-00608">1</xref>
<xref ref-type="aff" rid="af2-marinedrugs-08-00608">2</xref>
<xref ref-type="corresp" rid="c1-marinedrugs-08-00608">*</xref>
</contrib>
</contrib-group>
<aff id="af1-marinedrugs-08-00608"><label>1</label>
Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Cork, Ireland; E-Mails:<email>jonathan.kennedy@ucc.ie</email>
(J.K.);<email>bflemer@web.de</email>
(B.F.);<email>s.a.jackson@student.ucc.ie</email>
(S.A.J.);<email>d.lejon@ucc.ie</email>
(D.P.H.L.);<email>j.morrissey@ucc.ie</email>
(J.P.M.);<email>f.ogara@ucc.ie</email>
(F.O.)</aff>
<aff id="af2-marinedrugs-08-00608"><label>2</label>
Department of Microbiology, University College Cork, Cork, Ireland</aff>
<aff id="af3-marinedrugs-08-00608"><label>3</label>
BIOMERIT Research Centre, University College Cork, Cork, Ireland</aff>
<author-notes><corresp id="c1-marinedrugs-08-00608">* Author to whom correspondence should be addressed; E-Mail:
<email>a.dobson@ucc.ie</email>
; Tel.: +353-21-4901946; Fax: +353-21-4901932.</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>3</month>
<year>2010</year>
</pub-date>
<volume>8</volume>
<issue>3</issue>
<fpage>608</fpage>
<lpage>628</lpage>
<history><date date-type="received"><day>20</day>
<month>1</month>
<year>2010</year>
</date>
<date date-type="rev-recd"><day>4</day>
<month>2</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>12</day>
<month>3</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland</copyright-statement>
<copyright-year>2010</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>The marine environment is extremely diverse, with huge variations in pressure and temperature. Nevertheless, life, especially microbial life, thrives throughout the marine biosphere and microbes have adapted to all the divergent environments present. Large scale DNA sequence based approaches have recently been used to investigate the marine environment and these studies have revealed that the oceans harbor unprecedented microbial diversity. Novel gene families with representatives only within such metagenomic datasets represent a large proportion of the ocean metagenome. The presence of so many new gene families from these uncultured and highly diverse microbial populations represents a challenge for the understanding of and exploitation of the biology and biochemistry of the ocean environment. The application of new metagenomic and single cell genomics tools offers new ways to explore the complete metabolic diversity of the marine biome.</p>
</abstract>
<kwd-group><kwd>metagenome</kwd>
<kwd>marine</kwd>
<kwd>microorganism</kwd>
<kwd>enzyme</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="f1-marinedrugs-08-00608" position="float"><label>Figure 1</label>
<caption><p>Enzyme discovery from metagenomes: functional and sequence-based approaches.</p>
</caption>
<graphic xlink:href="marinedrugs-08-00608f1"></graphic>
</fig>
<fig id="f2-marinedrugs-08-00608" position="float"><label>Figure 2</label>
<caption><p>Examples of positive lipase (A) and protease activities (B) from a <italic>Haliclona simulans</italic>
metagenomic library.</p>
</caption>
<graphic xlink:href="marinedrugs-08-00608f2"></graphic>
</fig>
<table-wrap id="t1-marinedrugs-08-00608" position="float"><label>Table 1</label>
<caption><p>Marine enzymes discovered from Microbial and Metagenomic sources.</p>
</caption>
<table frame="box" rules="cols"><thead><tr><th align="left" rowspan="1" colspan="1">Activity</th>
<th align="left" rowspan="1" colspan="1">Source</th>
<th align="left" rowspan="1" colspan="1">Habitat</th>
<th align="center" rowspan="1" colspan="1">Reference</th>
</tr>
<tr><th colspan="4" align="left" rowspan="1"><hr></hr>
</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1">Esterase</td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Deep-sea sediment</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b97-marinedrugs-08-00608">97</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Deep-sea basin</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b72-marinedrugs-08-00608">72</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Surface seawater</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b69-marinedrugs-08-00608">69</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Arctic sediment</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b98-marinedrugs-08-00608">98</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><italic>Vibrio</italic>
sp.</td>
<td align="left" rowspan="1" colspan="1">Sea Hare Eggs</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b99-marinedrugs-08-00608">99</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><italic>Pseudoalteromonas haloplanktis</italic>
</td>
<td align="left" rowspan="1" colspan="1">Antarctic Seawater</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b71-marinedrugs-08-00608">71</xref>
]</td>
</tr>
<tr><td colspan="4" align="left" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Lipase</td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Tidal Flat</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b74-marinedrugs-08-00608">74</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Deep Sea sediment</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b75-marinedrugs-08-00608">75</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Baltic Sea sediment</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b67-marinedrugs-08-00608">67</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><italic>Pseudoalteromonas haloplanktis</italic>
TAC125</td>
<td align="left" rowspan="1" colspan="1">Antarctic Seawater</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b73-marinedrugs-08-00608">73</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><italic>Aureobasidium pullulans</italic>
HN2.3</td>
<td align="left" rowspan="1" colspan="1">Sea saltern</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b100-marinedrugs-08-00608">100</xref>
]</td>
</tr>
<tr><td colspan="4" align="left" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Cellulase</td>
<td align="left" rowspan="1" colspan="1"><italic>Pseudoalteromonas</italic>
sp. DY3</td>
<td align="left" rowspan="1" colspan="1">Deep-sea sediment</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b77-marinedrugs-08-00608">77</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><italic>Pseudoalteromonas haloplanktis</italic>
</td>
<td align="left" rowspan="1" colspan="1">Antarctic Seawater</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b78-marinedrugs-08-00608">78</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><italic>Teredinibacter turnerae</italic>
T7902T</td>
<td align="left" rowspan="1" colspan="1">Shipworm</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b79-marinedrugs-08-00608">79</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><underline><italic>Marinobacter</italic>
sp. MSI032.</underline>
</td>
<td align="left" rowspan="1" colspan="1">Marine sponge</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b76-marinedrugs-08-00608">76</xref>
]</td>
</tr>
<tr><td colspan="4" align="left" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Chitinase</td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Estuary</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b80-marinedrugs-08-00608">80</xref>
]<hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><italic>Arthrobacter</italic>
sp. TAD20</td>
<td align="left" rowspan="1" colspan="1">Antarctic ice</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b101-marinedrugs-08-00608">101</xref>
]<hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><italic>Rhodothermus marinus</italic>
</td>
<td align="left" rowspan="1" colspan="1">Marine hot spring</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b81-marinedrugs-08-00608">81</xref>
]</td>
</tr>
<tr><td colspan="4" align="left" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Amidase</td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Marine sediments/sludges</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b102-marinedrugs-08-00608">102</xref>
]</td>
</tr>
<tr><td colspan="4" align="left" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Amylase</td>
<td align="left" rowspan="1" colspan="1"><italic>Aureobasidium pullulans</italic>
N13d</td>
<td align="left" rowspan="1" colspan="1">Deep-sea sediment</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b103-marinedrugs-08-00608">103</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Deep sea hydrothermal vent</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b66-marinedrugs-08-00608">66</xref>
]</td>
</tr>
<tr><td colspan="4" align="left" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Phytase</td>
<td align="left" rowspan="1" colspan="1"><italic>Kodomaea ohmeri</italic>
BG3</td>
<td align="left" rowspan="1" colspan="1">Fish gut</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b104-marinedrugs-08-00608">104</xref>
]</td>
</tr>
<tr><td colspan="4" align="left" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Protease</td>
<td align="left" rowspan="1" colspan="1"><italic>Pseudomonas</italic>
strain DYA</td>
<td align="left" rowspan="1" colspan="1">Deep-sea sediment</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b105-marinedrugs-08-00608">105</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">Marine bacterium</td>
<td align="left" rowspan="1" colspan="1">Antarctic Seawater</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b106-marinedrugs-08-00608">106</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1"><italic>Aerpyrum pernix</italic>
K1</td>
<td align="left" rowspan="1" colspan="1">Coastal solfataric vent</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b107-marinedrugs-08-00608">107</xref>
]</td>
</tr>
<tr><td colspan="4" align="left" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Alkane hydroxylase</td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Hydrocarbon seep</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b82-marinedrugs-08-00608">82</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">Metagenome</td>
<td align="left" rowspan="1" colspan="1">Deep sea sediment</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b68-marinedrugs-08-00608">68</xref>
]</td>
</tr>
<tr><td colspan="4" align="left" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Xylanase</td>
<td align="left" rowspan="1" colspan="1"><italic>Pseudoalteromonas haloplanktis</italic>
</td>
<td align="left" rowspan="1" colspan="1">Antarctic Seawater</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="b108-marinedrugs-08-00608">108</xref>
]</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
<affiliations><list><country><li>Irlande (pays)</li>
</country>
</list>
<tree><noCountry><name sortKey="Flemer, Burkhardt" sort="Flemer, Burkhardt" uniqKey="Flemer B" first="Burkhardt" last="Flemer">Burkhardt Flemer</name>
<name sortKey="Jackson, Stephen A" sort="Jackson, Stephen A" uniqKey="Jackson S" first="Stephen A." last="Jackson">Stephen A. Jackson</name>
<name sortKey="Kennedy, Jonathan" sort="Kennedy, Jonathan" uniqKey="Kennedy J" first="Jonathan" last="Kennedy">Jonathan Kennedy</name>
<name sortKey="Lejon, David P H" sort="Lejon, David P H" uniqKey="Lejon D" first="David P. H." last="Lejon">David P. H. Lejon</name>
</noCountry>
<country name="Irlande (pays)"><noRegion><name sortKey="Morrissey, John P" sort="Morrissey, John P" uniqKey="Morrissey J" first="John P." last="Morrissey">John P. Morrissey</name>
</noRegion>
<name sortKey="Dobson, Alan D W" sort="Dobson, Alan D W" uniqKey="Dobson A" first="Alan D. W." last="Dobson">Alan D. W. Dobson</name>
<name sortKey="O Ara, Fergal" sort="O Ara, Fergal" uniqKey="O Ara F" first="Fergal" last="O Ara">Fergal O Ara</name>
<name sortKey="O Ara, Fergal" sort="O Ara, Fergal" uniqKey="O Ara F" first="Fergal" last="O Ara">Fergal O Ara</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/CyberinfraV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000131 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000131 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= CyberinfraV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:2857354 |texte= Marine Metagenomics: New Tools for the Study and Exploitation of Marine Microbial Metabolism }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:20411118" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a CyberinfraV1
![]() | This area was generated with Dilib version V0.6.25. | ![]() |