Study of the Viral and Microbial Communities Associated With Crohn's Disease: A Metagenomic Approach
Identifieur interne : 000413 ( Ncbi/Curation ); précédent : 000412; suivant : 000414Study of the Viral and Microbial Communities Associated With Crohn's Disease: A Metagenomic Approach
Auteurs : Vicente Pérez-Brocal [Espagne] ; Rodrigo García-L Pez [Espagne] ; Jorge F. Vázquez-Castellanos [Espagne] ; Pilar Nos [Espagne] ; Belén Beltrán [Espagne] ; Amparo Latorre [Espagne] ; Andrés Moya [Espagne]Source :
- Clinical and Translational Gastroenterology [ 2155-384X ] ; 2013.
Abstract
This study aimed to analyze and compare the diversity and structure of the viral and microbial communities in fecal samples from a control group of healthy volunteers and from patients affected by Crohn's disease (CD).
Healthy adult controls (
A lower diversity but more variability between the CD samples in both virome and microbiome was found, with a clear distinction between groups based on the microbiome. Only ≈5% of the differential viral biomarkers are more represented in the CD group (
Our use of an extensive database is critical to retrieve more viral hits than in previous approaches. Unrelated patterns of bacteria and bacteriophages may be due to uneven representation of certain viruses in databases, among other factors. Further characterization of
Url:
DOI: 10.1038/ctg.2013.9
PubMed: 23760301
PubMed Central: 3696940
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000023
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000023
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000264
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000413
Links to Exploration step
PMC:3696940Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Study of the Viral and Microbial Communities Associated With Crohn's Disease: A Metagenomic Approach</title>
<author><name sortKey="Perez Brocal, Vicente" sort="Perez Brocal, Vicente" uniqKey="Perez Brocal V" first="Vicente" last="Pérez-Brocal">Vicente Pérez-Brocal</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garcia L Pez, Rodrigo" sort="Garcia L Pez, Rodrigo" uniqKey="Garcia L Pez R" first="Rodrigo" last="García-L Pez">Rodrigo García-L Pez</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vazquez Castellanos, Jorge F" sort="Vazquez Castellanos, Jorge F" uniqKey="Vazquez Castellanos J" first="Jorge F" last="Vázquez-Castellanos">Jorge F. Vázquez-Castellanos</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nos, Pilar" sort="Nos, Pilar" uniqKey="Nos P" first="Pilar" last="Nos">Pilar Nos</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Unidad de Gastroenterología, Hospital Universitario La Fe, Valencia</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beltran, Belen" sort="Beltran, Belen" uniqKey="Beltran B" first="Belén" last="Beltrán">Belén Beltrán</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Unidad de Gastroenterología, Hospital Universitario La Fe, Valencia</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Latorre, Amparo" sort="Latorre, Amparo" uniqKey="Latorre A" first="Amparo" last="Latorre">Amparo Latorre</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moya, Andres" sort="Moya, Andres" uniqKey="Moya A" first="Andrés" last="Moya">Andrés Moya</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23760301</idno>
<idno type="pmc">3696940</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696940</idno>
<idno type="RBID">PMC:3696940</idno>
<idno type="doi">10.1038/ctg.2013.9</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000023</idno>
<idno type="wicri:Area/Pmc/Curation">000023</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000264</idno>
<idno type="wicri:Area/Ncbi/Merge">000413</idno>
<idno type="wicri:Area/Ncbi/Curation">000413</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Study of the Viral and Microbial Communities Associated With Crohn's Disease: A Metagenomic Approach</title>
<author><name sortKey="Perez Brocal, Vicente" sort="Perez Brocal, Vicente" uniqKey="Perez Brocal V" first="Vicente" last="Pérez-Brocal">Vicente Pérez-Brocal</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garcia L Pez, Rodrigo" sort="Garcia L Pez, Rodrigo" uniqKey="Garcia L Pez R" first="Rodrigo" last="García-L Pez">Rodrigo García-L Pez</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vazquez Castellanos, Jorge F" sort="Vazquez Castellanos, Jorge F" uniqKey="Vazquez Castellanos J" first="Jorge F" last="Vázquez-Castellanos">Jorge F. Vázquez-Castellanos</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nos, Pilar" sort="Nos, Pilar" uniqKey="Nos P" first="Pilar" last="Nos">Pilar Nos</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Unidad de Gastroenterología, Hospital Universitario La Fe, Valencia</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beltran, Belen" sort="Beltran, Belen" uniqKey="Beltran B" first="Belén" last="Beltrán">Belén Beltrán</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Unidad de Gastroenterología, Hospital Universitario La Fe, Valencia</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Latorre, Amparo" sort="Latorre, Amparo" uniqKey="Latorre A" first="Amparo" last="Latorre">Amparo Latorre</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Moya, Andres" sort="Moya, Andres" uniqKey="Moya A" first="Andrés" last="Moya">Andrés Moya</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Área de Genómica y Salud, Centro Superior de Investigación en Salud Pública—Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (CSISP-FISABIO)</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CIBER Epidemiología y Salud Pública (CIBERESP)</institution>
, Madrid,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Departamento de Genética, Cavanilles Institute on Biodiversity and Evolutionary Biology, University of València</institution>
, Valencia,<country>Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical and Translational Gastroenterology</title>
<idno type="eISSN">2155-384X</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>OBJECTIVES:</title>
<p>This study aimed to analyze and compare the diversity and structure of the viral and microbial communities in fecal samples from a control group of healthy volunteers and from patients affected by Crohn's disease (CD).</p>
</sec>
<sec><title>METHODS:</title>
<p>Healthy adult controls (<italic>n=</italic>
8) and patients affected by ileocolic CD (<italic>n=</italic>
11) were examined for the viral and microbial communities in their feces and, in one additional case, in the intestinal tissue. Using two different approaches, we compared the viral and microbial communities in several ways: by group (patients vs. controls), entity (viruses vs. bacteria), read assembly (unassembled vs. assembled reads), and methodology (our approach vs. an existing pipeline). Differences in the viral and microbial composition, and abundance between the two groups were analyzed to identify taxa that are under- or over-represented.</p>
</sec>
<sec><title>RESULTS:</title>
<p>A lower diversity but more variability between the CD samples in both virome and microbiome was found, with a clear distinction between groups based on the microbiome. Only ≈5% of the differential viral biomarkers are more represented in the CD group (<italic>Synechococcus phage</italic>
S CBS1 and <italic>Retroviridae</italic>
family viruses), compared with 95% in the control group. Unrelated patterns of bacteria and bacteriophages were observed.</p>
</sec>
<sec><title>CONCLUSIONS:</title>
<p>Our use of an extensive database is critical to retrieve more viral hits than in previous approaches. Unrelated patterns of bacteria and bacteriophages may be due to uneven representation of certain viruses in databases, among other factors. Further characterization of <italic>Retroviridae</italic>
viruses in the CD group could be of interest, given their links with immunodeficiency and the immune responses. To conclude, some methodological considerations underlying the analysis of the viral community composition and abundance are discussed.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Whitman, Wb" uniqKey="Whitman W">WB Whitman</name>
</author>
<author><name sortKey="Coleman, Dc" uniqKey="Coleman D">DC Coleman</name>
</author>
<author><name sortKey="Wiebe, Wj" uniqKey="Wiebe W">WJ Wiebe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sekirov, I" uniqKey="Sekirov I">I Sekirov</name>
</author>
<author><name sortKey="Russell, Sl" uniqKey="Russell S">SL Russell</name>
</author>
<author><name sortKey="Antunes, Lc" uniqKey="Antunes L">LC Antunes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wegrzyn, G" uniqKey="Wegrzyn G">G Wegrzyn</name>
</author>
<author><name sortKey="Thomas, Ms" uniqKey="Thomas M">MS Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kasman, Lm" uniqKey="Kasman L">LM Kasman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="G Rski, A" uniqKey="G Rski A">A Górski</name>
</author>
<author><name sortKey="Weber Dabrowska, B" uniqKey="Weber Dabrowska B">B Weber-Dabrowska</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ventura, M" uniqKey="Ventura M">M Ventura</name>
</author>
<author><name sortKey="Sozzi, T" uniqKey="Sozzi T">T Sozzi</name>
</author>
<author><name sortKey="Turroni, F" uniqKey="Turroni F">F Turroni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Davis, Bm" uniqKey="Davis B">BM Davis</name>
</author>
<author><name sortKey="Waldor, Mk" uniqKey="Waldor M">MK Waldor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breitbart, M" uniqKey="Breitbart M">M Breitbart</name>
</author>
<author><name sortKey="Salamon, P" uniqKey="Salamon P">P Salamon</name>
</author>
<author><name sortKey="Andresen, B" uniqKey="Andresen B">B Andresen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breitbart, M" uniqKey="Breitbart M">M Breitbart</name>
</author>
<author><name sortKey="Felts, B" uniqKey="Felts B">B Felts</name>
</author>
<author><name sortKey="Kelley, S" uniqKey="Kelley S">S Kelley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Venter, Jc" uniqKey="Venter J">JC Venter</name>
</author>
<author><name sortKey="Remington, K" uniqKey="Remington K">K Remington</name>
</author>
<author><name sortKey="Heidelberg, Jf" uniqKey="Heidelberg J">JF Heidelberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Angly, Fe" uniqKey="Angly F">FE Angly</name>
</author>
<author><name sortKey="Felts, B" uniqKey="Felts B">B Felts</name>
</author>
<author><name sortKey="Breitbart, M" uniqKey="Breitbart M">M Breitbart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bench, Sr" uniqKey="Bench S">SR Bench</name>
</author>
<author><name sortKey="Hanson, Te" uniqKey="Hanson T">TE Hanson</name>
</author>
<author><name sortKey="Williamson, Ke" uniqKey="Williamson K">KE Williamson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schoenfeld, T" uniqKey="Schoenfeld T">T Schoenfeld</name>
</author>
<author><name sortKey="Patterson, M" uniqKey="Patterson M">M Patterson</name>
</author>
<author><name sortKey="Richardson, Pm" uniqKey="Richardson P">PM Richardson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Williamson, Sj" uniqKey="Williamson S">SJ Williamson</name>
</author>
<author><name sortKey="Rusch, Db" uniqKey="Rusch D">DB Rusch</name>
</author>
<author><name sortKey="Yooseph, S" uniqKey="Yooseph S">S Yooseph</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="L Pez Bueno, A" uniqKey="L Pez Bueno A">A López-Bueno</name>
</author>
<author><name sortKey="Tamames, J" uniqKey="Tamames J">J Tamames</name>
</author>
<author><name sortKey="Velazquez, D" uniqKey="Velazquez D">D Velázquez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamaki, H" uniqKey="Tamaki H">H Tamaki</name>
</author>
<author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name>
</author>
<author><name sortKey="Angly, Fe" uniqKey="Angly F">FE Angly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cann, Aj" uniqKey="Cann A">AJ Cann</name>
</author>
<author><name sortKey="Fandrich, Se" uniqKey="Fandrich S">SE Fandrich</name>
</author>
<author><name sortKey="Heaphy, S" uniqKey="Heaphy S">S Heaphy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vega Thurber, Rl" uniqKey="Vega Thurber R">RL Vega Thurber</name>
</author>
<author><name sortKey="Barotta, Kl" uniqKey="Barotta K">KL Barotta</name>
</author>
<author><name sortKey="Halla, D" uniqKey="Halla D">D Halla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coetzee, B" uniqKey="Coetzee B">B Coetzee</name>
</author>
<author><name sortKey="Freeborough, Mj" uniqKey="Freeborough M">MJ Freeborough</name>
</author>
<author><name sortKey="Maree, Hj" uniqKey="Maree H">HJ Maree</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Victoria, Jg" uniqKey="Victoria J">JG Victoria</name>
</author>
<author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Shan, T" uniqKey="Shan T">T Shan</name>
</author>
<author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shan, T" uniqKey="Shan T">T Shan</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Simmonds, P" uniqKey="Simmonds P">P Simmonds</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breitbart, M" uniqKey="Breitbart M">M Breitbart</name>
</author>
<author><name sortKey="Rohwer, F" uniqKey="Rohwer F">F Rohwer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Allander, T" uniqKey="Allander T">T Allander</name>
</author>
<author><name sortKey="Tammi, Mt" uniqKey="Tammi M">MT Tammi</name>
</author>
<author><name sortKey="Eriksson, M" uniqKey="Eriksson M">M Eriksson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Willner, D" uniqKey="Willner D">D Willner</name>
</author>
<author><name sortKey="Furlan, M" uniqKey="Furlan M">M Furlan</name>
</author>
<author><name sortKey="Haynes, M" uniqKey="Haynes M">M Haynes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De La Cochetiere, Mf" uniqKey="De La Cochetiere M">MF De La Cochetiere</name>
</author>
<author><name sortKey="Durand, T" uniqKey="Durand T">T Durand</name>
</author>
<author><name sortKey="Lalande, V" uniqKey="Lalande V">V Lalande</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Othman, M" uniqKey="Othman M">M Othman</name>
</author>
<author><name sortKey="Aguero, R" uniqKey="Aguero R">R Aguero</name>
</author>
<author><name sortKey="Lin, Hc" uniqKey="Lin H">HC Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vaishnava, S" uniqKey="Vaishnava S">S Vaishnava</name>
</author>
<author><name sortKey="Behrendt, Cl" uniqKey="Behrendt C">CL Behrendt</name>
</author>
<author><name sortKey="Ismail, As" uniqKey="Ismail A">AS Ismail</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Foxman, Ef" uniqKey="Foxman E">EF Foxman</name>
</author>
<author><name sortKey="Iwasaki, A" uniqKey="Iwasaki A">A Iwasaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loftus, Ev" uniqKey="Loftus E">EV Loftus</name>
</author>
<author><name sortKey="Sandborn, Wj" uniqKey="Sandborn W">WJ Sandborn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xavier, Rj" uniqKey="Xavier R">RJ Xavier</name>
</author>
<author><name sortKey="Podolsky, Dk" uniqKey="Podolsky D">DK Podolsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Halme, L" uniqKey="Halme L">L Halme</name>
</author>
<author><name sortKey="Paavola Sakki, P" uniqKey="Paavola Sakki P">P Paavola-Sakki</name>
</author>
<author><name sortKey="Turunen, U" uniqKey="Turunen U">U Turunen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ekbom, A" uniqKey="Ekbom A">A Ekbom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Phillpotts, Rj" uniqKey="Phillpotts R">RJ Phillpotts</name>
</author>
<author><name sortKey="Hermon Taylor, J" uniqKey="Hermon Taylor J">J Hermon-Taylor</name>
</author>
<author><name sortKey="Brooke, Bn" uniqKey="Brooke B">BN Brooke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Phillpotts, Rj" uniqKey="Phillpotts R">RJ Phillpotts</name>
</author>
<author><name sortKey="Hermon Taylor, J" uniqKey="Hermon Taylor J">J Hermon-Taylor</name>
</author>
<author><name sortKey="Teich, Nm" uniqKey="Teich N">NM Teich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshimura, Hh" uniqKey="Yoshimura H">HH Yoshimura</name>
</author>
<author><name sortKey="Estes, Mk" uniqKey="Estes M">MK Estes</name>
</author>
<author><name sortKey="Graham, Dy" uniqKey="Graham D">DY Graham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Kruiningen, Hj" uniqKey="Van Kruiningen H">HJ Van Kruiningen</name>
</author>
<author><name sortKey="Poulin, M" uniqKey="Poulin M">M Poulin</name>
</author>
<author><name sortKey="Garmendia, Ae" uniqKey="Garmendia A">AE Garmendia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sura, R" uniqKey="Sura R">R Sura</name>
</author>
<author><name sortKey="Gavrilov, B" uniqKey="Gavrilov B">B Gavrilov</name>
</author>
<author><name sortKey="Flamand, L" uniqKey="Flamand L">L Flamand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lepage, P" uniqKey="Lepage P">P Lepage</name>
</author>
<author><name sortKey="Colombet, J" uniqKey="Colombet J">J Colombet</name>
</author>
<author><name sortKey="Marteau, P" uniqKey="Marteau P">P Marteau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cadwell, K" uniqKey="Cadwell K">K Cadwell</name>
</author>
<author><name sortKey="Patel, Kk" uniqKey="Patel K">KK Patel</name>
</author>
<author><name sortKey="Maloney, Ns" uniqKey="Maloney N">NS Maloney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hubbard, Vm" uniqKey="Hubbard V">VM Hubbard</name>
</author>
<author><name sortKey="Cadwell, K" uniqKey="Cadwell K">K Cadwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breitbart, M" uniqKey="Breitbart M">M Breitbart</name>
</author>
<author><name sortKey="Hewson, I" uniqKey="Hewson I">I Hewson</name>
</author>
<author><name sortKey="Felts, B" uniqKey="Felts B">B Felts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breitbart, M" uniqKey="Breitbart M">M Breitbart</name>
</author>
<author><name sortKey="Haynes, M" uniqKey="Haynes M">M Haynes</name>
</author>
<author><name sortKey="Kelley, S" uniqKey="Kelley S">S Kelley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name>
</author>
<author><name sortKey="Breitbart, M" uniqKey="Breitbart M">M Breitbart</name>
</author>
<author><name sortKey="Lee, Wh" uniqKey="Lee W">WH Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reyes, A" uniqKey="Reyes A">A Reyes</name>
</author>
<author><name sortKey="Haynes, M" uniqKey="Haynes M">M Haynes</name>
</author>
<author><name sortKey="Hanson, N" uniqKey="Hanson N">N Hanson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Ms" uniqKey="Kim M">MS Kim</name>
</author>
<author><name sortKey="Park, Ej" uniqKey="Park E">EJ Park</name>
</author>
<author><name sortKey="Roh, Sw" uniqKey="Roh S">SW Roh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Minot, S" uniqKey="Minot S">S Minot</name>
</author>
<author><name sortKey="Sinha, R" uniqKey="Sinha R">R Sinha</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Finkbeiner, Sr" uniqKey="Finkbeiner S">SR Finkbeiner</name>
</author>
<author><name sortKey="Allred, Af" uniqKey="Allred A">AF Allred</name>
</author>
<author><name sortKey="Tarr, Pi" uniqKey="Tarr P">PI Tarr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakamura, S" uniqKey="Nakamura S">S Nakamura</name>
</author>
<author><name sortKey="Yang, Cs" uniqKey="Yang C">CS Yang</name>
</author>
<author><name sortKey="Sakon, N" uniqKey="Sakon N">N Sakon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Victoria, Jg" uniqKey="Victoria J">JG Victoria</name>
</author>
<author><name sortKey="Kapoor, A" uniqKey="Kapoor A">A Kapoor</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schloss, Pd" uniqKey="Schloss P">PD Schloss</name>
</author>
<author><name sortKey="Westcott, Sl" uniqKey="Westcott S">SL Westcott</name>
</author>
<author><name sortKey="Ryabin, T" uniqKey="Ryabin T">T Ryabin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leplae, R" uniqKey="Leplae R">R Leplae</name>
</author>
<author><name sortKey="Lima Mendez, G" uniqKey="Lima Mendez G">G Lima-Mendez</name>
</author>
<author><name sortKey="Toussaint, A" uniqKey="Toussaint A">A Toussaint</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miller, Jr" uniqKey="Miller J">JR Miller</name>
</author>
<author><name sortKey="Koren, S" uniqKey="Koren S">S Koren</name>
</author>
<author><name sortKey="Sutton, G" uniqKey="Sutton G">G Sutton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roux, S" uniqKey="Roux S">S Roux</name>
</author>
<author><name sortKey="Faubladier, M" uniqKey="Faubladier M">M Faubladier</name>
</author>
<author><name sortKey="Paulhe, N" uniqKey="Paulhe N">N Paulhe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Angly, Fe" uniqKey="Angly F">FE Angly</name>
</author>
<author><name sortKey="Willner, D" uniqKey="Willner D">D Willner</name>
</author>
<author><name sortKey="Prieto Dav, A" uniqKey="Prieto Dav A">A Prieto-Davó</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goecks, J" uniqKey="Goecks J">J Goecks</name>
</author>
<author><name sortKey="Nekrutenko, A" uniqKey="Nekrutenko A">A Nekrutenko</name>
</author>
<author><name sortKey="Taylor, J" uniqKey="Taylor J">J Taylor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caporaso, Jg" uniqKey="Caporaso J">JG Caporaso</name>
</author>
<author><name sortKey="Kuczynski, J" uniqKey="Kuczynski J">J Kuczynski</name>
</author>
<author><name sortKey="Stombaugh, J" uniqKey="Stombaugh J">J Stombaugh</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Segata, N" uniqKey="Segata N">N Segata</name>
</author>
<author><name sortKey="Izard, J" uniqKey="Izard J">J Izard</name>
</author>
<author><name sortKey="Waldron, L" uniqKey="Waldron L">L Waldron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Garrity, Gm" uniqKey="Garrity G">GM Garrity</name>
</author>
<author><name sortKey="Tiedje, Jm" uniqKey="Tiedje J">JM Tiedje</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Comito, D" uniqKey="Comito D">D Comito</name>
</author>
<author><name sortKey="Romano, C" uniqKey="Romano C">C Romano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagalingam, Na" uniqKey="Nagalingam N">NA Nagalingam</name>
</author>
<author><name sortKey="Lynch, Sv" uniqKey="Lynch S">SV Lynch</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/CyberinfraV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000413 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000413 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= CyberinfraV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:3696940 |texte= Study of the Viral and Microbial Communities Associated With Crohn's Disease: A Metagenomic Approach }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:23760301" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a CyberinfraV1
![]() | This area was generated with Dilib version V0.6.25. | ![]() |