The PhenX Toolkit: Get the Most From Your Measures
Identifieur interne : 000246 ( Ncbi/Checkpoint ); précédent : 000245; suivant : 000247The PhenX Toolkit: Get the Most From Your Measures
Auteurs : Carol M. Hamilton ; Lisa C. Strader ; Joseph G. Pratt ; Deborah Maiese ; Tabitha Hendershot ; Richard K. Kwok ; Jane A. Hammond ; Wayne Huggins ; Dean Jackman ; Huaqin Pan ; Destiney S. Nettles ; Terri H. Beaty ; Lindsay A. Farrer ; Peter Kraft ; Mary L. Marazita ; Jose M. Ordovas ; Carlos N. Pato ; Margaret R. Spitz ; Diane Wagener ; Michelle Williams ; Heather A. Junkins ; William R. Harlan ; Erin M. Ramos ; Jonathan HainesSource :
- American Journal of Epidemiology [ 0002-9262 ] ; 2011.
Abstract
The potential for genome-wide association studies to relate phenotypes to specific genetic variation is greatly increased when data can be combined or compared across multiple studies. To facilitate replication and validation across studies, RTI International (Research Triangle Park, North Carolina) and the National Human Genome Research Institute (Bethesda, Maryland) are collaborating on the consensus measures for Phenotypes and eXposures (PhenX) project. The goal of PhenX is to identify 15 high-priority, well-established, and broadly applicable measures for each of 21 research domains. PhenX measures are selected by working groups of domain experts using a consensus process that includes input from the scientific community. The selected measures are then made freely available to the scientific community via the PhenX Toolkit. Thus, the PhenX Toolkit provides the research community with a core set of high-quality, well-established, low-burden measures intended for use in large-scale genomic studies. PhenX measures will have the most impact when included at the experimental design stage. The PhenX Toolkit also includes links to standards and resources in an effort to facilitate data harmonization to legacy data. Broad acceptance and use of PhenX measures will promote cross-study comparisons to increase statistical power for identifying and replicating variants associated with complex diseases and with gene-gene and gene-environment interactions.
Url:
DOI: 10.1093/aje/kwr193
PubMed: 21749974
PubMed Central: 3141081
Affiliations:
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Hamilton</name></author><author><name sortKey="Strader, Lisa C" sort="Strader, Lisa C" uniqKey="Strader L" first="Lisa C." last="Strader">Lisa C. Strader</name></author><author><name sortKey="Pratt, Joseph G" sort="Pratt, Joseph G" uniqKey="Pratt J" first="Joseph G." last="Pratt">Joseph G. Pratt</name></author><author><name sortKey="Maiese, Deborah" sort="Maiese, Deborah" uniqKey="Maiese D" first="Deborah" last="Maiese">Deborah Maiese</name></author><author><name sortKey="Hendershot, Tabitha" sort="Hendershot, Tabitha" uniqKey="Hendershot T" first="Tabitha" last="Hendershot">Tabitha Hendershot</name></author><author><name sortKey="Kwok, Richard K" sort="Kwok, Richard K" uniqKey="Kwok R" first="Richard K." last="Kwok">Richard K. Kwok</name></author><author><name sortKey="Hammond, Jane A" sort="Hammond, Jane A" uniqKey="Hammond J" first="Jane A." last="Hammond">Jane A. Hammond</name></author><author><name sortKey="Huggins, Wayne" sort="Huggins, Wayne" uniqKey="Huggins W" first="Wayne" last="Huggins">Wayne Huggins</name></author><author><name sortKey="Jackman, Dean" sort="Jackman, Dean" uniqKey="Jackman D" first="Dean" last="Jackman">Dean Jackman</name></author><author><name sortKey="Pan, Huaqin" sort="Pan, Huaqin" uniqKey="Pan H" first="Huaqin" last="Pan">Huaqin Pan</name></author><author><name sortKey="Nettles, Destiney S" sort="Nettles, Destiney S" uniqKey="Nettles D" first="Destiney S." last="Nettles">Destiney S. Nettles</name></author><author><name sortKey="Beaty, Terri H" sort="Beaty, Terri H" uniqKey="Beaty T" first="Terri H." last="Beaty">Terri H. Beaty</name></author><author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. 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Spitz</name></author><author><name sortKey="Wagener, Diane" sort="Wagener, Diane" uniqKey="Wagener D" first="Diane" last="Wagener">Diane Wagener</name></author><author><name sortKey="Williams, Michelle" sort="Williams, Michelle" uniqKey="Williams M" first="Michelle" last="Williams">Michelle Williams</name></author><author><name sortKey="Junkins, Heather A" sort="Junkins, Heather A" uniqKey="Junkins H" first="Heather A." last="Junkins">Heather A. Junkins</name></author><author><name sortKey="Harlan, William R" sort="Harlan, William R" uniqKey="Harlan W" first="William R." last="Harlan">William R. Harlan</name></author><author><name sortKey="Ramos, Erin M" sort="Ramos, Erin M" uniqKey="Ramos E" first="Erin M." last="Ramos">Erin M. Ramos</name></author><author><name sortKey="Haines, Jonathan" sort="Haines, Jonathan" uniqKey="Haines J" first="Jonathan" last="Haines">Jonathan Haines</name></author></analytic><series><title level="j">American Journal of Epidemiology</title><idno type="ISSN">0002-9262</idno><idno type="eISSN">1476-6256</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The potential for genome-wide association studies to relate phenotypes to specific genetic variation is greatly increased when data can be combined or compared across multiple studies. To facilitate replication and validation across studies, RTI International (Research Triangle Park, North Carolina) and the National Human Genome Research Institute (Bethesda, Maryland) are collaborating on the consensus measures for Phenotypes and eXposures (PhenX) project. The goal of PhenX is to identify 15 high-priority, well-established, and broadly applicable measures for each of 21 research domains. PhenX measures are selected by working groups of domain experts using a consensus process that includes input from the scientific community. The selected measures are then made freely available to the scientific community via the PhenX Toolkit. Thus, the PhenX Toolkit provides the research community with a core set of high-quality, well-established, low-burden measures intended for use in large-scale genomic studies. PhenX measures will have the most impact when included at the experimental design stage. The PhenX Toolkit also includes links to standards and resources in an effort to facilitate data harmonization to legacy data. Broad acceptance and use of PhenX measures will promote cross-study comparisons to increase statistical power for identifying and replicating variants associated with complex diseases and with gene-gene and gene-environment interactions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pennisi, E" uniqKey="Pennisi E">E Pennisi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Manolio, Ta" uniqKey="Manolio T">TA Manolio</name></author><author><name sortKey="Brooks, Ld" uniqKey="Brooks L">LD Brooks</name></author><author><name sortKey="Collins, Fs" uniqKey="Collins F">FS Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pearson, Ta" uniqKey="Pearson T">TA Pearson</name></author><author><name sortKey="Manolio, Ta" uniqKey="Manolio T">TA Manolio</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Beaty</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><name sortKey="Haines, Jonathan" sort="Haines, Jonathan" uniqKey="Haines J" first="Jonathan" last="Haines">Jonathan Haines</name><name sortKey="Hamilton, Carol M" sort="Hamilton, Carol M" uniqKey="Hamilton C" first="Carol M." last="Hamilton">Carol M. Hamilton</name><name sortKey="Hammond, Jane A" sort="Hammond, Jane A" uniqKey="Hammond J" first="Jane A." last="Hammond">Jane A. Hammond</name><name sortKey="Harlan, William R" sort="Harlan, William R" uniqKey="Harlan W" first="William R." last="Harlan">William R. Harlan</name><name sortKey="Hendershot, Tabitha" sort="Hendershot, Tabitha" uniqKey="Hendershot T" first="Tabitha" last="Hendershot">Tabitha Hendershot</name><name sortKey="Huggins, Wayne" sort="Huggins, Wayne" uniqKey="Huggins W" first="Wayne" last="Huggins">Wayne Huggins</name><name sortKey="Jackman, Dean" sort="Jackman, Dean" uniqKey="Jackman D" first="Dean" last="Jackman">Dean Jackman</name><name sortKey="Junkins, Heather A" sort="Junkins, Heather A" uniqKey="Junkins H" first="Heather A." last="Junkins">Heather A. Junkins</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Kwok, Richard K" sort="Kwok, Richard K" uniqKey="Kwok R" first="Richard K." last="Kwok">Richard K. Kwok</name><name sortKey="Maiese, Deborah" sort="Maiese, Deborah" uniqKey="Maiese D" first="Deborah" last="Maiese">Deborah Maiese</name><name sortKey="Marazita, Mary L" sort="Marazita, Mary L" uniqKey="Marazita M" first="Mary L." last="Marazita">Mary L. Marazita</name><name sortKey="Nettles, Destiney S" sort="Nettles, Destiney S" uniqKey="Nettles D" first="Destiney S." last="Nettles">Destiney S. Nettles</name><name sortKey="Ordovas, Jose M" sort="Ordovas, Jose M" uniqKey="Ordovas J" first="Jose M." last="Ordovas">Jose M. Ordovas</name><name sortKey="Pan, Huaqin" sort="Pan, Huaqin" uniqKey="Pan H" first="Huaqin" last="Pan">Huaqin Pan</name><name sortKey="Pato, Carlos N" sort="Pato, Carlos N" uniqKey="Pato C" first="Carlos N." last="Pato">Carlos N. Pato</name><name sortKey="Pratt, Joseph G" sort="Pratt, Joseph G" uniqKey="Pratt J" first="Joseph G." last="Pratt">Joseph G. Pratt</name><name sortKey="Ramos, Erin M" sort="Ramos, Erin M" uniqKey="Ramos E" first="Erin M." last="Ramos">Erin M. Ramos</name><name sortKey="Spitz, Margaret R" sort="Spitz, Margaret R" uniqKey="Spitz M" first="Margaret R." last="Spitz">Margaret R. Spitz</name><name sortKey="Strader, Lisa C" sort="Strader, Lisa C" uniqKey="Strader L" first="Lisa C." last="Strader">Lisa C. Strader</name><name sortKey="Wagener, Diane" sort="Wagener, Diane" uniqKey="Wagener D" first="Diane" last="Wagener">Diane Wagener</name><name sortKey="Williams, Michelle" sort="Williams, Michelle" uniqKey="Williams M" first="Michelle" last="Williams">Michelle Williams</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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