An Anomalous Type IV Secretion System in Rickettsia Is Evolutionarily Conserved
Identifieur interne : 000C22 ( Main/Merge ); précédent : 000C21; suivant : 000C23An Anomalous Type IV Secretion System in Rickettsia Is Evolutionarily Conserved
Auteurs : Joseph J. Gillespie [États-Unis] ; Nicole C. Ammerman [États-Unis] ; Sheila M. Dreher-Lesnick [États-Unis] ; M. Sayeedur Rahman [États-Unis] ; Micah J. Worley [États-Unis] ; Joao C. Setubal [États-Unis] ; Bruno S. Sobral [États-Unis] ; Abdu F. Azad [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Abstract
Bacterial type IV secretion systems (T4SSs) comprise a diverse transporter family functioning in conjugation, competence, and effector molecule (DNA and/or protein) translocation. Thirteen genome sequences from
Superimposition of T4SS structural/functional information over previously identified
We present the
Url:
DOI: 10.1371/journal.pone.0004833
PubMed: 19279686
PubMed Central: 2653234
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Checkpoint: 000078
Links to Exploration step
PMC:2653234Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Bacterial type IV secretion systems (T4SSs) comprise a diverse transporter family functioning in conjugation, competence, and effector molecule (DNA and/or protein) translocation. Thirteen genome sequences from <italic>Rickettsia</italic>
, obligate intracellular symbionts/pathogens of a wide range of eukaryotes, have revealed a reduced T4SS relative to the <italic>Agrobacterium tumefaciens</italic>
archetype (<italic>vir</italic>
). However, the <italic>Rickettsia</italic>
T4SS has not been functionally characterized for its role in symbiosis/virulence, and none of its substrates are known.</p>
</sec>
<sec><title>Results</title>
<p>Superimposition of T4SS structural/functional information over previously identified <italic>Rickettsia</italic>
components implicate a functional <italic>Rickettsia</italic>
T4SS. <italic>virB4</italic>
, <italic>virB8</italic>
and <italic>virB9</italic>
are duplicated, yet only one copy of each has the conserved features of similar genes in other T4SSs. An extraordinarily duplicated VirB6 gene encodes five hydrophobic proteins conserved only in a short region known to be involved in DNA transfer in <italic>A. tumefaciens</italic>
. <italic>virB1</italic>
, <italic>virB2</italic>
and <italic>virB7</italic>
are newly identified, revealing a <italic>Rickettsia</italic>
T4SS lacking only <italic>virB5</italic>
relative to the <italic>vir</italic>
archetype. Phylogeny estimation suggests vertical inheritance of all components, despite gene rearrangements into an archipelago of five islets. Similarities of <italic>Rickettsia</italic>
VirB7/VirB9 to ComB7/ComB9 proteins of ε-proteobacteria, as well as phylogenetic affinities to the <italic>Legionella lvh</italic>
T4SS, imply the Rickettsiales ancestor acquired a <italic>vir</italic>
-like locus from distantly related bacteria, perhaps while residing in a protozoan host. Modern modifications of these systems likely reflect diversification with various eukaryotic host cells.</p>
</sec>
<sec><title>Conclusion</title>
<p>We present the <italic>rvh</italic>
(Rickettsiales <italic>vir</italic>
homolog) T4SS, an evolutionary conserved transporter with an unknown role in rickettsial biology. This work lays the foundation for future laboratory characterization of this system, and also identifies the <italic>Legionella lvh</italic>
T4SS as a suitable genetic model.</p>
</sec>
</div>
</front>
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