Time course of myocardial sodium accumulation after burn trauma: a (31)P- and (23)Na-NMR study.
Identifieur interne : 000720 ( PubMed/Curation ); précédent : 000719; suivant : 000721Time course of myocardial sodium accumulation after burn trauma: a (31)P- and (23)Na-NMR study.
Auteurs : P J Sikes [États-Unis] ; P. Zhao ; D L Maass ; J W HortonSource :
- Journal of applied physiology (Bethesda, Md. : 1985) [ 8750-7587 ] ; 2001.
Descripteurs français
- KwdFr :
- Acidose (physiopathologie), Animaux, Brûlures (métabolisme), Brûlures (physiopathologie), Concentration en ions d'hydrogène, Contraction myocardique, Facteurs temps, Fonction ventriculaire gauche, Isotopes du sodium, Membranes intracellulaires (métabolisme), Myocarde (métabolisme), Mâle, Métabolisme énergétique, Phosphore, Rat Sprague-Dawley, Rats, Sodium (métabolisme), Spectrométrie de fluorescence, Spectroscopie par résonance magnétique.
- MESH :
- métabolisme : Brûlures, Membranes intracellulaires, Myocarde, Sodium.
- physiopathologie : Acidose, Brûlures.
- Animaux, Concentration en ions d'hydrogène, Contraction myocardique, Facteurs temps, Fonction ventriculaire gauche, Isotopes du sodium, Mâle, Métabolisme énergétique, Phosphore, Rat Sprague-Dawley, Rats, Spectrométrie de fluorescence, Spectroscopie par résonance magnétique.
English descriptors
- KwdEn :
- Acidosis (physiopathology), Animals, Burns (metabolism), Burns (physiopathology), Energy Metabolism, Hydrogen-Ion Concentration, Intracellular Membranes (metabolism), Magnetic Resonance Spectroscopy, Male, Myocardial Contraction, Myocardium (metabolism), Phosphorus, Rats, Rats, Sprague-Dawley, Sodium (metabolism), Sodium Isotopes, Spectrometry, Fluorescence, Time Factors, Ventricular Function, Left.
- MESH :
- chemical , metabolism : Sodium.
- chemical : Phosphorus, Sodium Isotopes.
- metabolism : Burns, Intracellular Membranes, Myocardium.
- physiopathology : Acidosis, Burns.
- Animals, Energy Metabolism, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Male, Myocardial Contraction, Rats, Rats, Sprague-Dawley, Spectrometry, Fluorescence, Time Factors, Ventricular Function, Left.
Abstract
In this study, (23)Na- and (31)P- nuclear magnetic resonance (NMR) spectra were examined in perfused rat hearts harvested 1, 2, 4, and 24 h after 40% total body surface area burn trauma and lactated Ringer resuscitation, 4 ml. kg(-1). %(-1) burn. (23)Na-NMR spectroscopy monitored myocardial intracellular Na+ using the paramagnetic shift reagent thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonic acid). Left ventricular function, cardiac high-energy phosphates (ATP/PCr), and myocyte intracellular pH were studied by using (31)P NMR spectroscopy to examine the hypothesis that burn-mediated acidification of cardiomyocytes contributes to subsequent Na+ accumulation by this cell population. Intracellular Na+ accumulation was confirmed by sodium-binding benzofuran isophthalate loading and fluorescence spectroscopy in cardiomyocytes isolated 1, 2, 4, 8, 12, 18, and 24 h postburn. This myocyte Na+ accumulation as early as 2 h postburn occurred despite no changes in cardiac ATP/PCr and intracellular pH. Left ventricular function progressively decreased after burn trauma. Cardiomyocyte Na+ accumulation paralleled cardiac contractile dysfunction, suggesting that myocardial Na+ overload contributes, in part, to the progressive postburn decrease in ventricular performance.
PubMed: 11717236
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Zhao</name></author><author><name sortKey="Maass, D L" sort="Maass, D L" uniqKey="Maass D" first="D L" last="Maass">D L Maass</name></author><author><name sortKey="Horton, J W" sort="Horton, J W" uniqKey="Horton J" first="J W" last="Horton">J W Horton</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11717236</idno><idno type="pmid">11717236</idno><idno type="wicri:Area/PubMed/Corpus">000720</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000720</idno><idno type="wicri:Area/PubMed/Curation">000720</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000720</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Time course of myocardial sodium accumulation after burn trauma: a (31)P- and (23)Na-NMR study.</title><author><name sortKey="Sikes, P J" sort="Sikes, P J" uniqKey="Sikes P" first="P J" last="Sikes">P J Sikes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9160, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9160</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, P" sort="Zhao, P" uniqKey="Zhao P" first="P" last="Zhao">P. Zhao</name></author><author><name sortKey="Maass, D L" sort="Maass, D L" uniqKey="Maass D" first="D L" last="Maass">D L Maass</name></author><author><name sortKey="Horton, J W" sort="Horton, J W" uniqKey="Horton J" first="J W" last="Horton">J W Horton</name></author></analytic><series><title level="j">Journal of applied physiology (Bethesda, Md. : 1985)</title><idno type="ISSN">8750-7587</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acidosis (physiopathology)</term><term>Animals</term><term>Burns (metabolism)</term><term>Burns (physiopathology)</term><term>Energy Metabolism</term><term>Hydrogen-Ion Concentration</term><term>Intracellular Membranes (metabolism)</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Myocardial Contraction</term><term>Myocardium (metabolism)</term><term>Phosphorus</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Sodium (metabolism)</term><term>Sodium Isotopes</term><term>Spectrometry, Fluorescence</term><term>Time Factors</term><term>Ventricular Function, Left</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acidose (physiopathologie)</term><term>Animaux</term><term>Brûlures (métabolisme)</term><term>Brûlures (physiopathologie)</term><term>Concentration en ions d'hydrogène</term><term>Contraction myocardique</term><term>Facteurs temps</term><term>Fonction ventriculaire gauche</term><term>Isotopes du sodium</term><term>Membranes intracellulaires (métabolisme)</term><term>Myocarde (métabolisme)</term><term>Mâle</term><term>Métabolisme énergétique</term><term>Phosphore</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Sodium (métabolisme)</term><term>Spectrométrie de fluorescence</term><term>Spectroscopie par résonance magnétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Sodium</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Phosphorus</term><term>Sodium Isotopes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Burns</term><term>Intracellular Membranes</term><term>Myocardium</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Brûlures</term><term>Membranes intracellulaires</term><term>Myocarde</term><term>Sodium</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Acidose</term><term>Brûlures</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Acidosis</term><term>Burns</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Energy Metabolism</term><term>Hydrogen-Ion Concentration</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Myocardial Contraction</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Spectrometry, Fluorescence</term><term>Time Factors</term><term>Ventricular Function, Left</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Concentration en ions d'hydrogène</term><term>Contraction myocardique</term><term>Facteurs temps</term><term>Fonction ventriculaire gauche</term><term>Isotopes du sodium</term><term>Mâle</term><term>Métabolisme énergétique</term><term>Phosphore</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Spectrométrie de fluorescence</term><term>Spectroscopie par résonance magnétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, (23)Na- and (31)P- nuclear magnetic resonance (NMR) spectra were examined in perfused rat hearts harvested 1, 2, 4, and 24 h after 40% total body surface area burn trauma and lactated Ringer resuscitation, 4 ml. kg(-1). %(-1) burn. (23)Na-NMR spectroscopy monitored myocardial intracellular Na+ using the paramagnetic shift reagent thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonic acid). Left ventricular function, cardiac high-energy phosphates (ATP/PCr), and myocyte intracellular pH were studied by using (31)P NMR spectroscopy to examine the hypothesis that burn-mediated acidification of cardiomyocytes contributes to subsequent Na+ accumulation by this cell population. Intracellular Na+ accumulation was confirmed by sodium-binding benzofuran isophthalate loading and fluorescence spectroscopy in cardiomyocytes isolated 1, 2, 4, 8, 12, 18, and 24 h postburn. This myocyte Na+ accumulation as early as 2 h postburn occurred despite no changes in cardiac ATP/PCr and intracellular pH. Left ventricular function progressively decreased after burn trauma. Cardiomyocyte Na+ accumulation paralleled cardiac contractile dysfunction, suggesting that myocardial Na+ overload contributes, in part, to the progressive postburn decrease in ventricular performance.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11717236</PMID><DateCreated><Year>2001</Year><Month>11</Month><Day>21</Day></DateCreated><DateCompleted><Year>2002</Year><Month>02</Month><Day>12</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">8750-7587</ISSN><JournalIssue CitedMedium="Print"><Volume>91</Volume><Issue>6</Issue><PubDate><Year>2001</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of applied physiology (Bethesda, Md. : 1985)</Title><ISOAbbreviation>J. Appl. Physiol.</ISOAbbreviation></Journal><ArticleTitle>Time course of myocardial sodium accumulation after burn trauma: a (31)P- and (23)Na-NMR study.</ArticleTitle><Pagination><MedlinePgn>2695-702</MedlinePgn></Pagination><Abstract><AbstractText>In this study, (23)Na- and (31)P- nuclear magnetic resonance (NMR) spectra were examined in perfused rat hearts harvested 1, 2, 4, and 24 h after 40% total body surface area burn trauma and lactated Ringer resuscitation, 4 ml. kg(-1). %(-1) burn. (23)Na-NMR spectroscopy monitored myocardial intracellular Na+ using the paramagnetic shift reagent thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonic acid). Left ventricular function, cardiac high-energy phosphates (ATP/PCr), and myocyte intracellular pH were studied by using (31)P NMR spectroscopy to examine the hypothesis that burn-mediated acidification of cardiomyocytes contributes to subsequent Na+ accumulation by this cell population. Intracellular Na+ accumulation was confirmed by sodium-binding benzofuran isophthalate loading and fluorescence spectroscopy in cardiomyocytes isolated 1, 2, 4, 8, 12, 18, and 24 h postburn. This myocyte Na+ accumulation as early as 2 h postburn occurred despite no changes in cardiac ATP/PCr and intracellular pH. Left ventricular function progressively decreased after burn trauma. Cardiomyocyte Na+ accumulation paralleled cardiac contractile dysfunction, suggesting that myocardial Na+ overload contributes, in part, to the progressive postburn decrease in ventricular performance.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sikes</LastName><ForeName>P J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9160, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Maass</LastName><ForeName>D L</ForeName><Initials>DL</Initials></Author><Author ValidYN="Y"><LastName>Horton</LastName><ForeName>J W</ForeName><Initials>JW</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>GM-57054-01A1</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Appl Physiol (1985)</MedlineTA><NlmUniqueID>8502536</NlmUniqueID><ISSNLinking>0161-7567</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012975">Sodium Isotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>27YLU75U4W</RegistryNumber><NameOfSubstance UI="D010758">Phosphorus</NameOfSubstance></Chemical><Chemical><RegistryNumber>9NEZ333N27</RegistryNumber><NameOfSubstance UI="D012964">Sodium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000138">Acidosis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002056">Burns</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004734">Energy Metabolism</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006863">Hydrogen-Ion Concentration</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007425">Intracellular Membranes</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009682">Magnetic Resonance Spectroscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009200">Myocardial Contraction</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009206">Myocardium</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010758">Phosphorus</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017207">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012964">Sodium</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012975">Sodium Isotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013050">Spectrometry, Fluorescence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016277">Ventricular Function, Left</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>11</Month><Day>22</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>2</Month><Day>13</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>11</Month><Day>22</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11717236</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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