A short term effect of homogeneous internal irradiation of the mouse lung with 170Tm2O3 particles.
Identifieur interne : 000853 ( PubMed/Corpus ); précédent : 000852; suivant : 000854A short term effect of homogeneous internal irradiation of the mouse lung with 170Tm2O3 particles.
Auteurs : B E Lambert ; L S Hansen ; A. Black ; M L PhippsSource :
- Radiation and environmental biophysics [ 0301-634X ] ; 1981.
English descriptors
- KwdEn :
- MESH :
- chemical : Aerosols, Radioisotopes, Thulium.
- radiation effects : Lung, Macrophages.
- Animals, Female, Mice, Radiation Dosage, Tissue Distribution.
Abstract
The short term effects on the free macrophage population in the mouse lung, following inhalation of thulium-170 oxide, have been studied, with a view to using the system as a model with which to compare the short term effects of inhomogeneous alpha irradiation. The clearance and distribution of thulium-170 was followed up to 44 days post inhalation. The mice had an initial lung burden (+/- SE) of 6.7 +/- 0.5 microCi 170Tm/g of lung and the pattern of removal of this could be described by a single exponential of half time 31 +/- 4 days. This exposure resulted in a uniform dose of about 24 Gy to the lung. The macrophage population was studied by counting cells lavaged from the lungs at intervals over the period of the experiment. The lung burden of 170Tm2O3 was found to decrease the free macrophage numbers by about a factor of 2 in 14 days with some slight recovery at 6 weeks post inhalation. It was found that nearly 50% of the activity in the lung lobes was removed by the lavages and that this fraction remained constant throughout.
PubMed: 7323265
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pubmed:7323265Le document en format XML
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Black</name></author><author><name sortKey="Phipps, M L" sort="Phipps, M L" uniqKey="Phipps M" first="M L" last="Phipps">M L Phipps</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1981">1981</date><idno type="RBID">pubmed:7323265</idno><idno type="pmid">7323265</idno><idno type="wicri:Area/PubMed/Corpus">000853</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000853</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A short term effect of homogeneous internal irradiation of the mouse lung with 170Tm2O3 particles.</title><author><name sortKey="Lambert, B E" sort="Lambert, B E" uniqKey="Lambert B" first="B E" last="Lambert">B E Lambert</name></author><author><name sortKey="Hansen, L S" sort="Hansen, L S" uniqKey="Hansen L" first="L S" last="Hansen">L S Hansen</name></author><author><name sortKey="Black, A" sort="Black, A" uniqKey="Black A" first="A" last="Black">A. Black</name></author><author><name sortKey="Phipps, M L" sort="Phipps, M L" uniqKey="Phipps M" first="M L" last="Phipps">M L Phipps</name></author></analytic><series><title level="j">Radiation and environmental biophysics</title><idno type="ISSN">0301-634X</idno><imprint><date when="1981" type="published">1981</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aerosols</term><term>Animals</term><term>Female</term><term>Lung (radiation effects)</term><term>Macrophages (radiation effects)</term><term>Mice</term><term>Radiation Dosage</term><term>Radioisotopes</term><term>Thulium</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Aerosols</term><term>Radioisotopes</term><term>Thulium</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Lung</term><term>Macrophages</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Mice</term><term>Radiation Dosage</term><term>Tissue Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The short term effects on the free macrophage population in the mouse lung, following inhalation of thulium-170 oxide, have been studied, with a view to using the system as a model with which to compare the short term effects of inhomogeneous alpha irradiation. The clearance and distribution of thulium-170 was followed up to 44 days post inhalation. The mice had an initial lung burden (+/- SE) of 6.7 +/- 0.5 microCi 170Tm/g of lung and the pattern of removal of this could be described by a single exponential of half time 31 +/- 4 days. This exposure resulted in a uniform dose of about 24 Gy to the lung. The macrophage population was studied by counting cells lavaged from the lungs at intervals over the period of the experiment. The lung burden of 170Tm2O3 was found to decrease the free macrophage numbers by about a factor of 2 in 14 days with some slight recovery at 6 weeks post inhalation. It was found that nearly 50% of the activity in the lung lobes was removed by the lavages and that this fraction remained constant throughout.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">7323265</PMID><DateCreated><Year>1982</Year><Month>03</Month><Day>13</Day></DateCreated><DateCompleted><Year>1982</Year><Month>03</Month><Day>13</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0301-634X</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>1981</Year></PubDate></JournalIssue><Title>Radiation and environmental biophysics</Title><ISOAbbreviation>Radiat Environ Biophys</ISOAbbreviation></Journal><ArticleTitle>A short term effect of homogeneous internal irradiation of the mouse lung with 170Tm2O3 particles.</ArticleTitle><Pagination><MedlinePgn>11-20</MedlinePgn></Pagination><Abstract><AbstractText>The short term effects on the free macrophage population in the mouse lung, following inhalation of thulium-170 oxide, have been studied, with a view to using the system as a model with which to compare the short term effects of inhomogeneous alpha irradiation. The clearance and distribution of thulium-170 was followed up to 44 days post inhalation. The mice had an initial lung burden (+/- SE) of 6.7 +/- 0.5 microCi 170Tm/g of lung and the pattern of removal of this could be described by a single exponential of half time 31 +/- 4 days. This exposure resulted in a uniform dose of about 24 Gy to the lung. The macrophage population was studied by counting cells lavaged from the lungs at intervals over the period of the experiment. The lung burden of 170Tm2O3 was found to decrease the free macrophage numbers by about a factor of 2 in 14 days with some slight recovery at 6 weeks post inhalation. It was found that nearly 50% of the activity in the lung lobes was removed by the lavages and that this fraction remained constant throughout.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lambert</LastName><ForeName>B E</ForeName><Initials>BE</Initials></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>L S</ForeName><Initials>LS</Initials></Author><Author ValidYN="Y"><LastName>Black</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Phipps</LastName><ForeName>M L</ForeName><Initials>ML</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>GERMANY, WEST</Country><MedlineTA>Radiat Environ Biophys</MedlineTA><NlmUniqueID>0415677</NlmUniqueID><ISSNLinking>0301-634X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000336">Aerosols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011868">Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>12036-44-1</RegistryNumber><NameOfSubstance UI="C033160">thulium oxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance UI="D013932">Thulium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000336">Aerosols</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008168">Lung</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000528">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008264">Macrophages</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000528">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011829">Radiation Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D011868">Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D013932">Thulium</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014018">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1981</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1981</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1981</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">7323265</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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