Dynamic sodium chemical shift imaging for the study of aqueous humor flow.
Identifieur interne : 000806 ( PubMed/Corpus ); précédent : 000805; suivant : 000807Dynamic sodium chemical shift imaging for the study of aqueous humor flow.
Auteurs : D V Weinberg ; N H Kolodny ; S J Kohler ; T A Burr ; A. Celi ; D J D'Amico ; E S GragoudasSource :
- Investigative ophthalmology & visual science [ 0146-0404 ] ; 1991.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Sodium.
- chemical , pharmacokinetics : Organometallic Compounds, Organophosphorus Compounds.
- drug effects : Anterior Chamber.
- metabolism : Aqueous Humor.
- methods : Magnetic Resonance Spectroscopy.
- Animals, Image Processing, Computer-Assisted, Rabbits.
Abstract
Ocular images were obtained using sodium chemical shift imaging (CSI) and 1,4,7,10-tetraazacyclododecane-N,N'N",N"'-tetramethylenephospho nate thulium (III) [Tm(DOTP)5-], a paramagnetic chemical shift reagent. After injecting the shift reagent into the anterior chamber of rabbits, serial imaging was done, monitoring the change in chemical shift with time. Sodium CSI produced images of the eye in three dimensions, quantitatively depicting the spatial and temporal changes in the concentration of a paramagnetic tracer substance. The Tm(DOTP)5- is eliminated from the anterior chamber by first-order kinetics with a half-life of 49 min. These data suggest that this substance is eliminated from the anterior chamber at the same rate as aqueous humor is replaced. Sodium CSI shows promise as a valuable technique for monitoring fluid dynamics in the living eye.
PubMed: 2071335
Links to Exploration step
pubmed:2071335Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dynamic sodium chemical shift imaging for the study of aqueous humor flow.</title>
<author><name sortKey="Weinberg, D V" sort="Weinberg, D V" uniqKey="Weinberg D" first="D V" last="Weinberg">D V Weinberg</name>
<affiliation><nlm:affiliation>Retina Service, Massachusetts Eye & Ear Infirmary, Boston 02114.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kolodny, N H" sort="Kolodny, N H" uniqKey="Kolodny N" first="N H" last="Kolodny">N H Kolodny</name>
</author>
<author><name sortKey="Kohler, S J" sort="Kohler, S J" uniqKey="Kohler S" first="S J" last="Kohler">S J Kohler</name>
</author>
<author><name sortKey="Burr, T A" sort="Burr, T A" uniqKey="Burr T" first="T A" last="Burr">T A Burr</name>
</author>
<author><name sortKey="Celi, A" sort="Celi, A" uniqKey="Celi A" first="A" last="Celi">A. Celi</name>
</author>
<author><name sortKey="D Amico, D J" sort="D Amico, D J" uniqKey="D Amico D" first="D J" last="D'Amico">D J D'Amico</name>
</author>
<author><name sortKey="Gragoudas, E S" sort="Gragoudas, E S" uniqKey="Gragoudas E" first="E S" last="Gragoudas">E S Gragoudas</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1991">1991</date>
<idno type="RBID">pubmed:2071335</idno>
<idno type="pmid">2071335</idno>
<idno type="wicri:Area/PubMed/Corpus">000806</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000806</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Dynamic sodium chemical shift imaging for the study of aqueous humor flow.</title>
<author><name sortKey="Weinberg, D V" sort="Weinberg, D V" uniqKey="Weinberg D" first="D V" last="Weinberg">D V Weinberg</name>
<affiliation><nlm:affiliation>Retina Service, Massachusetts Eye & Ear Infirmary, Boston 02114.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kolodny, N H" sort="Kolodny, N H" uniqKey="Kolodny N" first="N H" last="Kolodny">N H Kolodny</name>
</author>
<author><name sortKey="Kohler, S J" sort="Kohler, S J" uniqKey="Kohler S" first="S J" last="Kohler">S J Kohler</name>
</author>
<author><name sortKey="Burr, T A" sort="Burr, T A" uniqKey="Burr T" first="T A" last="Burr">T A Burr</name>
</author>
<author><name sortKey="Celi, A" sort="Celi, A" uniqKey="Celi A" first="A" last="Celi">A. Celi</name>
</author>
<author><name sortKey="D Amico, D J" sort="D Amico, D J" uniqKey="D Amico D" first="D J" last="D'Amico">D J D'Amico</name>
</author>
<author><name sortKey="Gragoudas, E S" sort="Gragoudas, E S" uniqKey="Gragoudas E" first="E S" last="Gragoudas">E S Gragoudas</name>
</author>
</analytic>
<series><title level="j">Investigative ophthalmology & visual science</title>
<idno type="ISSN">0146-0404</idno>
<imprint><date when="1991" type="published">1991</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Anterior Chamber (drug effects)</term>
<term>Aqueous Humor (metabolism)</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Spectroscopy (methods)</term>
<term>Organometallic Compounds (pharmacokinetics)</term>
<term>Organophosphorus Compounds (pharmacokinetics)</term>
<term>Rabbits</term>
<term>Sodium (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Sodium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Organometallic Compounds</term>
<term>Organophosphorus Compounds</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Anterior Chamber</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aqueous Humor</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Image Processing, Computer-Assisted</term>
<term>Rabbits</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Ocular images were obtained using sodium chemical shift imaging (CSI) and 1,4,7,10-tetraazacyclododecane-N,N'N",N"'-tetramethylenephospho nate thulium (III) [Tm(DOTP)5-], a paramagnetic chemical shift reagent. After injecting the shift reagent into the anterior chamber of rabbits, serial imaging was done, monitoring the change in chemical shift with time. Sodium CSI produced images of the eye in three dimensions, quantitatively depicting the spatial and temporal changes in the concentration of a paramagnetic tracer substance. The Tm(DOTP)5- is eliminated from the anterior chamber by first-order kinetics with a half-life of 49 min. These data suggest that this substance is eliminated from the anterior chamber at the same rate as aqueous humor is replaced. Sodium CSI shows promise as a valuable technique for monitoring fluid dynamics in the living eye.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">2071335</PMID>
<DateCreated><Year>1991</Year>
<Month>08</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>1991</Year>
<Month>08</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0146-0404</ISSN>
<JournalIssue CitedMedium="Print"><Volume>32</Volume>
<Issue>8</Issue>
<PubDate><Year>1991</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Investigative ophthalmology & visual science</Title>
<ISOAbbreviation>Invest. Ophthalmol. Vis. Sci.</ISOAbbreviation>
</Journal>
<ArticleTitle>Dynamic sodium chemical shift imaging for the study of aqueous humor flow.</ArticleTitle>
<Pagination><MedlinePgn>2212-8</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Ocular images were obtained using sodium chemical shift imaging (CSI) and 1,4,7,10-tetraazacyclododecane-N,N'N",N"'-tetramethylenephospho nate thulium (III) [Tm(DOTP)5-], a paramagnetic chemical shift reagent. After injecting the shift reagent into the anterior chamber of rabbits, serial imaging was done, monitoring the change in chemical shift with time. Sodium CSI produced images of the eye in three dimensions, quantitatively depicting the spatial and temporal changes in the concentration of a paramagnetic tracer substance. The Tm(DOTP)5- is eliminated from the anterior chamber by first-order kinetics with a half-life of 49 min. These data suggest that this substance is eliminated from the anterior chamber at the same rate as aqueous humor is replaced. Sodium CSI shows promise as a valuable technique for monitoring fluid dynamics in the living eye.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Weinberg</LastName>
<ForeName>D V</ForeName>
<Initials>DV</Initials>
<AffiliationInfo><Affiliation>Retina Service, Massachusetts Eye & Ear Infirmary, Boston 02114.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kolodny</LastName>
<ForeName>N H</ForeName>
<Initials>NH</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kohler</LastName>
<ForeName>S J</ForeName>
<Initials>SJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Burr</LastName>
<ForeName>T A</ForeName>
<Initials>TA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Celi</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>D'Amico</LastName>
<ForeName>D J</ForeName>
<Initials>DJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gragoudas</LastName>
<ForeName>E S</ForeName>
<Initials>ES</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>RR00995</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>UNITED STATES</Country>
<MedlineTA>Invest Ophthalmol Vis Sci</MedlineTA>
<NlmUniqueID>7703701</NlmUniqueID>
<ISSNLinking>0146-0404</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009942">Organometallic Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009943">Organophosphorus Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C069929">thulium(III) 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetramethylenephosphonate</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9NEZ333N27</RegistryNumber>
<NameOfSubstance UI="D012964">Sodium</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000867">Anterior Chamber</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001082">Aqueous Humor</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D007091">Image Processing, Computer-Assisted</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009682">Magnetic Resonance Spectroscopy</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009942">Organometallic Compounds</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009943">Organophosphorus Compounds</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011817">Rabbits</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012964">Sodium</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year>
<Month>7</Month>
<Day>1</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>1991</Year>
<Month>7</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1991</Year>
<Month>7</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">2071335</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000806 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000806 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Terre |area= ThuliumV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:2071335 |texte= Dynamic sodium chemical shift imaging for the study of aqueous humor flow. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:2071335" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a ThuliumV1
![]() | This area was generated with Dilib version V0.6.21. | ![]() |