ThuliumV1, PubMed, Corpus, bibRecord, 000806

Dynamic sodium chemical shift imaging for the study of aqueous humor flow.

Identifieur interne : 000806 ( PubMed/Corpus ); précédent : 000805; suivant : 000807

Dynamic sodium chemical shift imaging for the study of aqueous humor flow.

Auteurs : D V Weinberg ; N H Kolodny ; S J Kohler ; T A Burr ; A. Celi ; D J D'Amico ; E S Gragoudas

Source :

Investigative ophthalmology & visual science [ 0146-0404 ] ; 1991.

RBID : pubmed:2071335

English descriptors

KwdEn :
- Animals, Anterior Chamber (drug effects), Aqueous Humor (metabolism), Image Processing, Computer-Assisted, Magnetic Resonance Spectroscopy (methods), Organometallic Compounds (pharmacokinetics), Organophosphorus Compounds (pharmacokinetics), Rabbits, Sodium (metabolism).
MESH :
- chemical , metabolism : Sodium.
- chemical , pharmacokinetics : Organometallic Compounds, Organophosphorus Compounds.
- drug effects : Anterior Chamber.
- metabolism : Aqueous Humor.
- methods : Magnetic Resonance Spectroscopy.
- Animals, Image Processing, Computer-Assisted, Rabbits.

Abstract

Ocular images were obtained using sodium chemical shift imaging (CSI) and 1,4,7,10-tetraazacyclododecane-N,N'N",N"'-tetramethylenephospho nate thulium (III) [Tm(DOTP)5-], a paramagnetic chemical shift reagent. After injecting the shift reagent into the anterior chamber of rabbits, serial imaging was done, monitoring the change in chemical shift with time. Sodium CSI produced images of the eye in three dimensions, quantitatively depicting the spatial and temporal changes in the concentration of a paramagnetic tracer substance. The Tm(DOTP)5- is eliminated from the anterior chamber by first-order kinetics with a half-life of 49 min. These data suggest that this substance is eliminated from the anterior chamber at the same rate as aqueous humor is replaced. Sodium CSI shows promise as a valuable technique for monitoring fluid dynamics in the living eye.

PubMed: 2071335

Links to Exploration step

pubmed:2071335

Le document en format XML

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<author><name sortKey="Weinberg, D V" sort="Weinberg, D V" uniqKey="Weinberg D" first="D V" last="Weinberg">D V Weinberg</name>
<affiliation><nlm:affiliation>Retina Service, Massachusetts Eye & Ear Infirmary, Boston 02114.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kolodny, N H" sort="Kolodny, N H" uniqKey="Kolodny N" first="N H" last="Kolodny">N H Kolodny</name>
</author>
<author><name sortKey="Kohler, S J" sort="Kohler, S J" uniqKey="Kohler S" first="S J" last="Kohler">S J Kohler</name>
</author>
<author><name sortKey="Burr, T A" sort="Burr, T A" uniqKey="Burr T" first="T A" last="Burr">T A Burr</name>
</author>
<author><name sortKey="Celi, A" sort="Celi, A" uniqKey="Celi A" first="A" last="Celi">A. Celi</name>
</author>
<author><name sortKey="D Amico, D J" sort="D Amico, D J" uniqKey="D Amico D" first="D J" last="D'Amico">D J D'Amico</name>
</author>
<author><name sortKey="Gragoudas, E S" sort="Gragoudas, E S" uniqKey="Gragoudas E" first="E S" last="Gragoudas">E S Gragoudas</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Dynamic sodium chemical shift imaging for the study of aqueous humor flow.</title>
<author><name sortKey="Weinberg, D V" sort="Weinberg, D V" uniqKey="Weinberg D" first="D V" last="Weinberg">D V Weinberg</name>
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<author><name sortKey="Kolodny, N H" sort="Kolodny, N H" uniqKey="Kolodny N" first="N H" last="Kolodny">N H Kolodny</name>
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<author><name sortKey="Kohler, S J" sort="Kohler, S J" uniqKey="Kohler S" first="S J" last="Kohler">S J Kohler</name>
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<author><name sortKey="Burr, T A" sort="Burr, T A" uniqKey="Burr T" first="T A" last="Burr">T A Burr</name>
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<author><name sortKey="Celi, A" sort="Celi, A" uniqKey="Celi A" first="A" last="Celi">A. Celi</name>
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<author><name sortKey="D Amico, D J" sort="D Amico, D J" uniqKey="D Amico D" first="D J" last="D'Amico">D J D'Amico</name>
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<author><name sortKey="Gragoudas, E S" sort="Gragoudas, E S" uniqKey="Gragoudas E" first="E S" last="Gragoudas">E S Gragoudas</name>
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<series><title level="j">Investigative ophthalmology & visual science</title>
<idno type="ISSN">0146-0404</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Anterior Chamber (drug effects)</term>
<term>Aqueous Humor (metabolism)</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Spectroscopy (methods)</term>
<term>Organometallic Compounds (pharmacokinetics)</term>
<term>Organophosphorus Compounds (pharmacokinetics)</term>
<term>Rabbits</term>
<term>Sodium (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Sodium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Organometallic Compounds</term>
<term>Organophosphorus Compounds</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Anterior Chamber</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aqueous Humor</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Image Processing, Computer-Assisted</term>
<term>Rabbits</term>
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<front><div type="abstract" xml:lang="en">Ocular images were obtained using sodium chemical shift imaging (CSI) and 1,4,7,10-tetraazacyclododecane-N,N'N",N"'-tetramethylenephospho nate thulium (III) [Tm(DOTP)5-], a paramagnetic chemical shift reagent. After injecting the shift reagent into the anterior chamber of rabbits, serial imaging was done, monitoring the change in chemical shift with time. Sodium CSI produced images of the eye in three dimensions, quantitatively depicting the spatial and temporal changes in the concentration of a paramagnetic tracer substance. The Tm(DOTP)5- is eliminated from the anterior chamber by first-order kinetics with a half-life of 49 min. These data suggest that this substance is eliminated from the anterior chamber at the same rate as aqueous humor is replaced. Sodium CSI shows promise as a valuable technique for monitoring fluid dynamics in the living eye.</div>
</front>
</TEI>
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<DateCreated><Year>1991</Year>
<Month>08</Month>
<Day>21</Day>
</DateCreated>
<DateCompleted><Year>1991</Year>
<Month>08</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0146-0404</ISSN>
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<Issue>8</Issue>
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<Title>Investigative ophthalmology & visual science</Title>
<ISOAbbreviation>Invest. Ophthalmol. Vis. Sci.</ISOAbbreviation>
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<ArticleTitle>Dynamic sodium chemical shift imaging for the study of aqueous humor flow.</ArticleTitle>
<Pagination><MedlinePgn>2212-8</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Ocular images were obtained using sodium chemical shift imaging (CSI) and 1,4,7,10-tetraazacyclododecane-N,N'N",N"'-tetramethylenephospho nate thulium (III) [Tm(DOTP)5-], a paramagnetic chemical shift reagent. After injecting the shift reagent into the anterior chamber of rabbits, serial imaging was done, monitoring the change in chemical shift with time. Sodium CSI produced images of the eye in three dimensions, quantitatively depicting the spatial and temporal changes in the concentration of a paramagnetic tracer substance. The Tm(DOTP)5- is eliminated from the anterior chamber by first-order kinetics with a half-life of 49 min. These data suggest that this substance is eliminated from the anterior chamber at the same rate as aqueous humor is replaced. Sodium CSI shows promise as a valuable technique for monitoring fluid dynamics in the living eye.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Weinberg</LastName>
<ForeName>D V</ForeName>
<Initials>DV</Initials>
<AffiliationInfo><Affiliation>Retina Service, Massachusetts Eye & Ear Infirmary, Boston 02114.</Affiliation>
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<Author ValidYN="Y"><LastName>Kohler</LastName>
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<Author ValidYN="Y"><LastName>Burr</LastName>
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<Author ValidYN="Y"><LastName>Celi</LastName>
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<Author ValidYN="Y"><LastName>D'Amico</LastName>
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<Author ValidYN="Y"><LastName>Gragoudas</LastName>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>UNITED STATES</Country>
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<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000867">Anterior Chamber</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001082">Aqueous Humor</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D007091">Image Processing, Computer-Assisted</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009682">Magnetic Resonance Spectroscopy</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009942">Organometallic Compounds</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="Y" UI="D009943">Organophosphorus Compounds</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000493">pharmacokinetics</QualifierName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011817">Rabbits</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012964">Sodium</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName>
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Dynamic sodium chemical shift imaging for the study of aqueous humor flow.

Dynamic sodium chemical shift imaging for the study of aqueous humor flow.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki