The role of lysosomes in the selective concentration of mineral elements. A microanalytical study.
Identifieur interne : 000761 ( PubMed/Corpus ); précédent : 000760; suivant : 000762The role of lysosomes in the selective concentration of mineral elements. A microanalytical study.
Auteurs : J P BerrySource :
- Cellular and molecular biology (Noisy-le-Grand, France) [ 0145-5680 ] ; 1996.
English descriptors
- KwdEn :
- MESH :
- chemical , isolation & purification : Metals.
- metabolism : Lysosomes, Metals, Metals, Heavy.
- Cell Compartmentation, Electron Probe Microanalysis, Tissue Distribution.
Abstract
The role of the lysosome during the intracellular concentration of diverse mineral elements has been evidenced by the electron probe X-ray microanalysis (EPMA). This highly sensitive technique allows an in situ chemical analysis of any chemical element with an atomic number greater than 11, present in ultra-thin tissue sections. Therefore, it has been demonstrated by using this EPMA that 21 out of the 92 elements of the periodic table, once injected in a soluble form, were selectively concentrated within lysosomes of several types of mammalian cells. Amongst these 21 elements, 15 are concentrated and precipitated in an insoluble from in association with phosphorus whereas the other 6 are precipitated in association with sulphur. Amongst the 15 elements which precipitate with phosphorus in lysosomes, there are: 3 group IIIB elements of the periodic system, (aluminium, gallium and indium); the rare-earth elements (cerium, gadolinium, lanthanum, thulium and samarium); 2 group IVA elements (hafnium and zirconium), two actinides (uranium and thorium) and elements such as chromium and niobium. The 6 elements which precipitate with sulphur comprise the 3 group VIII elements of the classification (nickel, palladium, platinum) and the 3 group IB elements (copper, silver and gold). The mechanisms responsible for this selective concentration involve enzymatic processes and predominantly acid phosphatases for elements precipitating as phosphates and arylsulfatases for elements precipitating with sulphur.
PubMed: 8793193
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pubmed:8793193Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of lysosomes in the selective concentration of mineral elements. A microanalytical study.</title><author><name sortKey="Berry, J P" sort="Berry, J P" uniqKey="Berry J" first="J P" last="Berry">J P Berry</name><affiliation><nlm:affiliation>Laboratoire de Biophysique, S.C. 27 de 1'INSERM, Faculté de Médecine, Créteil, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:8793193</idno><idno type="pmid">8793193</idno><idno type="wicri:Area/PubMed/Corpus">000761</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000761</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The role of lysosomes in the selective concentration of mineral elements. A microanalytical study.</title><author><name sortKey="Berry, J P" sort="Berry, J P" uniqKey="Berry J" first="J P" last="Berry">J P Berry</name><affiliation><nlm:affiliation>Laboratoire de Biophysique, S.C. 27 de 1'INSERM, Faculté de Médecine, Créteil, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cellular and molecular biology (Noisy-le-Grand, France)</title><idno type="ISSN">0145-5680</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Compartmentation</term><term>Electron Probe Microanalysis</term><term>Lysosomes (metabolism)</term><term>Metals (isolation & purification)</term><term>Metals (metabolism)</term><term>Metals, Heavy (metabolism)</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Metals</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lysosomes</term><term>Metals</term><term>Metals, Heavy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Compartmentation</term><term>Electron Probe Microanalysis</term><term>Tissue Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of the lysosome during the intracellular concentration of diverse mineral elements has been evidenced by the electron probe X-ray microanalysis (EPMA). This highly sensitive technique allows an in situ chemical analysis of any chemical element with an atomic number greater than 11, present in ultra-thin tissue sections. Therefore, it has been demonstrated by using this EPMA that 21 out of the 92 elements of the periodic table, once injected in a soluble form, were selectively concentrated within lysosomes of several types of mammalian cells. Amongst these 21 elements, 15 are concentrated and precipitated in an insoluble from in association with phosphorus whereas the other 6 are precipitated in association with sulphur. Amongst the 15 elements which precipitate with phosphorus in lysosomes, there are: 3 group IIIB elements of the periodic system, (aluminium, gallium and indium); the rare-earth elements (cerium, gadolinium, lanthanum, thulium and samarium); 2 group IVA elements (hafnium and zirconium), two actinides (uranium and thorium) and elements such as chromium and niobium. The 6 elements which precipitate with sulphur comprise the 3 group VIII elements of the classification (nickel, palladium, platinum) and the 3 group IB elements (copper, silver and gold). The mechanisms responsible for this selective concentration involve enzymatic processes and predominantly acid phosphatases for elements precipitating as phosphates and arylsulfatases for elements precipitating with sulphur.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8793193</PMID><DateCreated><Year>1996</Year><Month>12</Month><Day>10</Day></DateCreated><DateCompleted><Year>1996</Year><Month>12</Month><Day>10</Day></DateCompleted><DateRevised><Year>2005</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0145-5680</ISSN><JournalIssue CitedMedium="Print"><Volume>42</Volume><Issue>3</Issue><PubDate><Year>1996</Year><Month>May</Month></PubDate></JournalIssue><Title>Cellular and molecular biology (Noisy-le-Grand, France)</Title><ISOAbbreviation>Cell. Mol. Biol. (Noisy-le-grand)</ISOAbbreviation></Journal><ArticleTitle>The role of lysosomes in the selective concentration of mineral elements. A microanalytical study.</ArticleTitle><Pagination><MedlinePgn>395-411</MedlinePgn></Pagination><Abstract><AbstractText>The role of the lysosome during the intracellular concentration of diverse mineral elements has been evidenced by the electron probe X-ray microanalysis (EPMA). This highly sensitive technique allows an in situ chemical analysis of any chemical element with an atomic number greater than 11, present in ultra-thin tissue sections. Therefore, it has been demonstrated by using this EPMA that 21 out of the 92 elements of the periodic table, once injected in a soluble form, were selectively concentrated within lysosomes of several types of mammalian cells. Amongst these 21 elements, 15 are concentrated and precipitated in an insoluble from in association with phosphorus whereas the other 6 are precipitated in association with sulphur. Amongst the 15 elements which precipitate with phosphorus in lysosomes, there are: 3 group IIIB elements of the periodic system, (aluminium, gallium and indium); the rare-earth elements (cerium, gadolinium, lanthanum, thulium and samarium); 2 group IVA elements (hafnium and zirconium), two actinides (uranium and thorium) and elements such as chromium and niobium. The 6 elements which precipitate with sulphur comprise the 3 group VIII elements of the classification (nickel, palladium, platinum) and the 3 group IB elements (copper, silver and gold). The mechanisms responsible for this selective concentration involve enzymatic processes and predominantly acid phosphatases for elements precipitating as phosphates and arylsulfatases for elements precipitating with sulphur.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Berry</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Laboratoire de Biophysique, S.C. 27 de 1'INSERM, Faculté de Médecine, Créteil, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>FRANCE</Country><MedlineTA>Cell Mol Biol (Noisy-le-grand)</MedlineTA><NlmUniqueID>9216789</NlmUniqueID><ISSNLinking>0145-5680</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008670">Metals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019216">Metals, Heavy</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D002451">Cell Compartmentation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D004577">Electron Probe Microanalysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008247">Lysosomes</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008670">Metals</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000302">isolation & purification</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019216">Metals, Heavy</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014018">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>26</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>5</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>5</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8793193</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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