Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study.
Identifieur interne : 000716 ( PubMed/Corpus ); précédent : 000715; suivant : 000717Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study.
Auteurs : Christian Büchel ; Karin Bornhovd ; Markus Quante ; Volkmar Glauche ; Burkhard Bromm ; Cornelius WeillerSource :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2002.
English descriptors
- KwdEn :
- Adult, Affect (physiology), Dose-Response Relationship, Radiation, Emotions (physiology), Female, Gyrus Cinguli (anatomy & histology), Gyrus Cinguli (physiology), Humans, Infrared Rays, Lasers, Magnetic Resonance Imaging, Male, Motor Activity (physiology), Motor Activity (radiation effects), Neurons (physiology), Pain, Pain Measurement (instrumentation), Pain Threshold (physiology), Physical Stimulation (instrumentation).
- MESH :
- anatomy & histology : Gyrus Cinguli.
- instrumentation : Pain Measurement, Physical Stimulation.
- physiology : Affect, Emotions, Gyrus Cinguli, Motor Activity, Neurons, Pain Threshold.
- radiation effects : Motor Activity.
- Adult, Dose-Response Relationship, Radiation, Female, Humans, Infrared Rays, Lasers, Magnetic Resonance Imaging, Male, Pain.
Abstract
Neuroimaging studies have demonstrated activations in the anterior cingulate cortex (ACC) related to the affective component of pain, but not to stimulus intensity. However, it is possible that the low spatial resolution of positron emission tomography, as used in the majority of these studies, obscured areas coding stimulus intensity. We revisited this issue, using a parametric single-trial functional magnetic resonance imaging design, and investigated pain, stimulus intensity, and stimulus awareness (i.e., pain unrelated) responses within the ACC in nine healthy volunteers. Four different stimulus intensities ranging from warm to painful (300-600 mJ) were applied with a thulium yttrium-aluminum granite infrared laser in a randomized order and rated by the subjects on a five point scale (P0-P4). Pain-related regions in the ventral posterior ACC showed a response that did not distinguish between innocuous trials (P0 and P1) but showed a positive linear relationship with the blood oxygenation level-dependent contrast signal for painful trials (P2-P4). Regions in the dorsal anterior ACC along the cingulate sulcus differentiated between P0 (not perceived) and P1 but exhibited no additional signal increase with P2; these regions are related to stimulus awareness and probably to cognitive processing. Most importantly, we identified a region in the dorsal posterior ACC showing a response that discriminated between nonpainful trials (P0 and P1); therefore, this region was simply related to basic sensory processing and not to pain intensity. Stimulus-related activations were all located adjacent to the cingulate motor area, highlighting the strategic link of stimulus processing and response generation in the posterior ACC.
PubMed: 11826125
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pubmed:11826125Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study.</title><author><name sortKey="Buchel, Christian" sort="Buchel, Christian" uniqKey="Buchel C" first="Christian" last="Büchel">Christian Büchel</name><affiliation><nlm:affiliation>Cognitive Neuroscience Laboratory, Department of Neurology, and Department of Physiology, Hamburg University Medical School, Hamburg, D-20246 Germany. buechel@uke.uni-hamburg.de</nlm:affiliation></affiliation></author><author><name sortKey="Bornhovd, Karin" sort="Bornhovd, Karin" uniqKey="Bornhovd K" first="Karin" last="Bornhovd">Karin Bornhovd</name></author><author><name sortKey="Quante, Markus" sort="Quante, Markus" uniqKey="Quante M" first="Markus" last="Quante">Markus Quante</name></author><author><name sortKey="Glauche, Volkmar" sort="Glauche, Volkmar" uniqKey="Glauche V" first="Volkmar" last="Glauche">Volkmar Glauche</name></author><author><name sortKey="Bromm, Burkhard" sort="Bromm, Burkhard" uniqKey="Bromm B" first="Burkhard" last="Bromm">Burkhard Bromm</name></author><author><name sortKey="Weiller, Cornelius" sort="Weiller, Cornelius" uniqKey="Weiller C" first="Cornelius" last="Weiller">Cornelius Weiller</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:11826125</idno><idno type="pmid">11826125</idno><idno type="wicri:Area/PubMed/Corpus">000716</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000716</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study.</title><author><name sortKey="Buchel, Christian" sort="Buchel, Christian" uniqKey="Buchel C" first="Christian" last="Büchel">Christian Büchel</name><affiliation><nlm:affiliation>Cognitive Neuroscience Laboratory, Department of Neurology, and Department of Physiology, Hamburg University Medical School, Hamburg, D-20246 Germany. buechel@uke.uni-hamburg.de</nlm:affiliation></affiliation></author><author><name sortKey="Bornhovd, Karin" sort="Bornhovd, Karin" uniqKey="Bornhovd K" first="Karin" last="Bornhovd">Karin Bornhovd</name></author><author><name sortKey="Quante, Markus" sort="Quante, Markus" uniqKey="Quante M" first="Markus" last="Quante">Markus Quante</name></author><author><name sortKey="Glauche, Volkmar" sort="Glauche, Volkmar" uniqKey="Glauche V" first="Volkmar" last="Glauche">Volkmar Glauche</name></author><author><name sortKey="Bromm, Burkhard" sort="Bromm, Burkhard" uniqKey="Bromm B" first="Burkhard" last="Bromm">Burkhard Bromm</name></author><author><name sortKey="Weiller, Cornelius" sort="Weiller, Cornelius" uniqKey="Weiller C" first="Cornelius" last="Weiller">Cornelius Weiller</name></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="eISSN">1529-2401</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Affect (physiology)</term><term>Dose-Response Relationship, Radiation</term><term>Emotions (physiology)</term><term>Female</term><term>Gyrus Cinguli (anatomy & histology)</term><term>Gyrus Cinguli (physiology)</term><term>Humans</term><term>Infrared Rays</term><term>Lasers</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Motor Activity (physiology)</term><term>Motor Activity (radiation effects)</term><term>Neurons (physiology)</term><term>Pain</term><term>Pain Measurement (instrumentation)</term><term>Pain Threshold (physiology)</term><term>Physical Stimulation (instrumentation)</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Gyrus Cinguli</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Pain Measurement</term><term>Physical Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Affect</term><term>Emotions</term><term>Gyrus Cinguli</term><term>Motor Activity</term><term>Neurons</term><term>Pain Threshold</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Dose-Response Relationship, Radiation</term><term>Female</term><term>Humans</term><term>Infrared Rays</term><term>Lasers</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Pain</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neuroimaging studies have demonstrated activations in the anterior cingulate cortex (ACC) related to the affective component of pain, but not to stimulus intensity. However, it is possible that the low spatial resolution of positron emission tomography, as used in the majority of these studies, obscured areas coding stimulus intensity. We revisited this issue, using a parametric single-trial functional magnetic resonance imaging design, and investigated pain, stimulus intensity, and stimulus awareness (i.e., pain unrelated) responses within the ACC in nine healthy volunteers. Four different stimulus intensities ranging from warm to painful (300-600 mJ) were applied with a thulium yttrium-aluminum granite infrared laser in a randomized order and rated by the subjects on a five point scale (P0-P4). Pain-related regions in the ventral posterior ACC showed a response that did not distinguish between innocuous trials (P0 and P1) but showed a positive linear relationship with the blood oxygenation level-dependent contrast signal for painful trials (P2-P4). Regions in the dorsal anterior ACC along the cingulate sulcus differentiated between P0 (not perceived) and P1 but exhibited no additional signal increase with P2; these regions are related to stimulus awareness and probably to cognitive processing. Most importantly, we identified a region in the dorsal posterior ACC showing a response that discriminated between nonpainful trials (P0 and P1); therefore, this region was simply related to basic sensory processing and not to pain intensity. Stimulus-related activations were all located adjacent to the cingulate motor area, highlighting the strategic link of stimulus processing and response generation in the posterior ACC.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11826125</PMID><DateCreated><Year>2002</Year><Month>02</Month><Day>04</Day></DateCreated><DateCompleted><Year>2002</Year><Month>02</Month><Day>27</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1529-2401</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>3</Issue><PubDate><Year>2002</Year><Month>Feb</Month><Day>1</Day></PubDate></JournalIssue><Title>The Journal of neuroscience : the official journal of the Society for Neuroscience</Title><ISOAbbreviation>J. Neurosci.</ISOAbbreviation></Journal><ArticleTitle>Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study.</ArticleTitle><Pagination><MedlinePgn>970-6</MedlinePgn></Pagination><Abstract><AbstractText>Neuroimaging studies have demonstrated activations in the anterior cingulate cortex (ACC) related to the affective component of pain, but not to stimulus intensity. However, it is possible that the low spatial resolution of positron emission tomography, as used in the majority of these studies, obscured areas coding stimulus intensity. We revisited this issue, using a parametric single-trial functional magnetic resonance imaging design, and investigated pain, stimulus intensity, and stimulus awareness (i.e., pain unrelated) responses within the ACC in nine healthy volunteers. Four different stimulus intensities ranging from warm to painful (300-600 mJ) were applied with a thulium yttrium-aluminum granite infrared laser in a randomized order and rated by the subjects on a five point scale (P0-P4). Pain-related regions in the ventral posterior ACC showed a response that did not distinguish between innocuous trials (P0 and P1) but showed a positive linear relationship with the blood oxygenation level-dependent contrast signal for painful trials (P2-P4). Regions in the dorsal anterior ACC along the cingulate sulcus differentiated between P0 (not perceived) and P1 but exhibited no additional signal increase with P2; these regions are related to stimulus awareness and probably to cognitive processing. Most importantly, we identified a region in the dorsal posterior ACC showing a response that discriminated between nonpainful trials (P0 and P1); therefore, this region was simply related to basic sensory processing and not to pain intensity. Stimulus-related activations were all located adjacent to the cingulate motor area, highlighting the strategic link of stimulus processing and response generation in the posterior ACC.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Büchel</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Cognitive Neuroscience Laboratory, Department of Neurology, and Department of Physiology, Hamburg University Medical School, Hamburg, D-20246 Germany. buechel@uke.uni-hamburg.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bornhovd</LastName><ForeName>Karin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Quante</LastName><ForeName>Markus</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Glauche</LastName><ForeName>Volkmar</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Bromm</LastName><ForeName>Burkhard</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Weiller</LastName><ForeName>Cornelius</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Neurosci</MedlineTA><NlmUniqueID>8102140</NlmUniqueID><ISSNLinking>0270-6474</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000339">Affect</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004307">Dose-Response Relationship, Radiation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004644">Emotions</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006179">Gyrus Cinguli</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000033">anatomy & histology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007259">Infrared Rays</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007834">Lasers</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009043">Motor Activity</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000528">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009474">Neurons</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D010146">Pain</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010147">Pain Measurement</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017288">Pain Threshold</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010812">Physical Stimulation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>2</Month><Day>5</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>2</Month><Day>28</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>2</Month><Day>5</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11826125</ArticleId><ArticleId IdType="pii">22/3/970</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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