Subcortical structures involved in pain processing: evidence from single-trial fMRI.
Identifieur interne : 000712 ( PubMed/Corpus ); précédent : 000711; suivant : 000713Subcortical structures involved in pain processing: evidence from single-trial fMRI.
Auteurs : U. Bingel ; M. Quante ; R. Knab ; B. Bromm ; C. Weiller ; C. BüchelSource :
- Pain [ 0304-3959 ] ; 2002.
English descriptors
- KwdEn :
- Adult, Amygdala (physiology), Brain (physiology), Brain Stem (physiology), Cerebellum (physiology), Female, Functional Laterality (physiology), Hippocampus (physiology), Humans, Lasers, Magnetic Resonance Imaging, Male, Nociceptors (physiology), Pain (physiopathology), Putamen (physiology), Red Nucleus (physiology).
- MESH :
- physiology : Amygdala, Brain, Brain Stem, Cerebellum, Functional Laterality, Hippocampus, Nociceptors, Putamen, Red Nucleus.
- physiopathology : Pain.
- Adult, Female, Humans, Lasers, Magnetic Resonance Imaging, Male.
Abstract
Pain is processed in multiple cortical and subcortical brain areas. Subcortical structures are substantially involved in different processes that are closely linked to pain processing, e.g. motor preparation, autonomic responses, affective components and learning. However, it is unclear to which extent nociceptive information is relayed to and processed in subcortical structures. We used single-trial functional magnetic resonance imaging (fMRI) to identify subcortical regions displaying hemodynamic responses to painful stimulation. Thulium-YAG (yttrium-aluminum-granate) laser evoked pain stimuli, which have no concomitant tactile component, were applied to either hand of healthy volunteers in a randomized order. This procedure allowed identification of areas displaying differential fMRI responses to right- and left-sided stimuli. Hippocampal complex, amygdala, red nucleus, brainstem and cerebellum were activated in response to painful stimuli. Structures related to the affective processing of pain showed bilateral activation, whereas structures involved in the generation of withdrawal behavior, namely red nucleus, putamen and cerebellum displayed differential (i.e. asymmetric) responses according to the side of stimulation. This suggests that spatial information about the nociceptive stimulus is made available in these structures for the guidance of defensive and withdrawal behavior.
PubMed: 12237210
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pubmed:12237210Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subcortical structures involved in pain processing: evidence from single-trial fMRI.</title><author><name sortKey="Bingel, U" sort="Bingel, U" uniqKey="Bingel U" first="U" last="Bingel">U. Bingel</name><affiliation><nlm:affiliation>Cognitive Neuroscience Laboratory, Department of Neurology, Hamburg University Medical School, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Quante, M" sort="Quante, M" uniqKey="Quante M" first="M" last="Quante">M. Quante</name></author><author><name sortKey="Knab, R" sort="Knab, R" uniqKey="Knab R" first="R" last="Knab">R. Knab</name></author><author><name sortKey="Bromm, B" sort="Bromm, B" uniqKey="Bromm B" first="B" last="Bromm">B. Bromm</name></author><author><name sortKey="Weiller, C" sort="Weiller, C" uniqKey="Weiller C" first="C" last="Weiller">C. Weiller</name></author><author><name sortKey="Buchel, C" sort="Buchel, C" uniqKey="Buchel C" first="C" last="Büchel">C. Büchel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12237210</idno><idno type="pmid">12237210</idno><idno type="wicri:Area/PubMed/Corpus">000712</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000712</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Subcortical structures involved in pain processing: evidence from single-trial fMRI.</title><author><name sortKey="Bingel, U" sort="Bingel, U" uniqKey="Bingel U" first="U" last="Bingel">U. Bingel</name><affiliation><nlm:affiliation>Cognitive Neuroscience Laboratory, Department of Neurology, Hamburg University Medical School, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Quante, M" sort="Quante, M" uniqKey="Quante M" first="M" last="Quante">M. Quante</name></author><author><name sortKey="Knab, R" sort="Knab, R" uniqKey="Knab R" first="R" last="Knab">R. Knab</name></author><author><name sortKey="Bromm, B" sort="Bromm, B" uniqKey="Bromm B" first="B" last="Bromm">B. Bromm</name></author><author><name sortKey="Weiller, C" sort="Weiller, C" uniqKey="Weiller C" first="C" last="Weiller">C. Weiller</name></author><author><name sortKey="Buchel, C" sort="Buchel, C" uniqKey="Buchel C" first="C" last="Büchel">C. Büchel</name></author></analytic><series><title level="j">Pain</title><idno type="ISSN">0304-3959</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Amygdala (physiology)</term><term>Brain (physiology)</term><term>Brain Stem (physiology)</term><term>Cerebellum (physiology)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Hippocampus (physiology)</term><term>Humans</term><term>Lasers</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Nociceptors (physiology)</term><term>Pain (physiopathology)</term><term>Putamen (physiology)</term><term>Red Nucleus (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Amygdala</term><term>Brain</term><term>Brain Stem</term><term>Cerebellum</term><term>Functional Laterality</term><term>Hippocampus</term><term>Nociceptors</term><term>Putamen</term><term>Red Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Pain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Lasers</term><term>Magnetic Resonance Imaging</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pain is processed in multiple cortical and subcortical brain areas. Subcortical structures are substantially involved in different processes that are closely linked to pain processing, e.g. motor preparation, autonomic responses, affective components and learning. However, it is unclear to which extent nociceptive information is relayed to and processed in subcortical structures. We used single-trial functional magnetic resonance imaging (fMRI) to identify subcortical regions displaying hemodynamic responses to painful stimulation. Thulium-YAG (yttrium-aluminum-granate) laser evoked pain stimuli, which have no concomitant tactile component, were applied to either hand of healthy volunteers in a randomized order. This procedure allowed identification of areas displaying differential fMRI responses to right- and left-sided stimuli. Hippocampal complex, amygdala, red nucleus, brainstem and cerebellum were activated in response to painful stimuli. Structures related to the affective processing of pain showed bilateral activation, whereas structures involved in the generation of withdrawal behavior, namely red nucleus, putamen and cerebellum displayed differential (i.e. asymmetric) responses according to the side of stimulation. This suggests that spatial information about the nociceptive stimulus is made available in these structures for the guidance of defensive and withdrawal behavior.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">12237210</PMID><DateCreated><Year>2002</Year><Month>09</Month><Day>18</Day></DateCreated><DateCompleted><Year>2002</Year><Month>12</Month><Day>06</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0304-3959</ISSN><JournalIssue CitedMedium="Print"><Volume>99</Volume><Issue>1-2</Issue><PubDate><Year>2002</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Pain</Title><ISOAbbreviation>Pain</ISOAbbreviation></Journal><ArticleTitle>Subcortical structures involved in pain processing: evidence from single-trial fMRI.</ArticleTitle><Pagination><MedlinePgn>313-21</MedlinePgn></Pagination><Abstract><AbstractText>Pain is processed in multiple cortical and subcortical brain areas. Subcortical structures are substantially involved in different processes that are closely linked to pain processing, e.g. motor preparation, autonomic responses, affective components and learning. However, it is unclear to which extent nociceptive information is relayed to and processed in subcortical structures. We used single-trial functional magnetic resonance imaging (fMRI) to identify subcortical regions displaying hemodynamic responses to painful stimulation. Thulium-YAG (yttrium-aluminum-granate) laser evoked pain stimuli, which have no concomitant tactile component, were applied to either hand of healthy volunteers in a randomized order. This procedure allowed identification of areas displaying differential fMRI responses to right- and left-sided stimuli. Hippocampal complex, amygdala, red nucleus, brainstem and cerebellum were activated in response to painful stimuli. Structures related to the affective processing of pain showed bilateral activation, whereas structures involved in the generation of withdrawal behavior, namely red nucleus, putamen and cerebellum displayed differential (i.e. asymmetric) responses according to the side of stimulation. This suggests that spatial information about the nociceptive stimulus is made available in these structures for the guidance of defensive and withdrawal behavior.</AbstractText><CopyrightInformation>Copyright 2002 International Association for the Study of Pain</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bingel</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Cognitive Neuroscience Laboratory, Department of Neurology, Hamburg University Medical School, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quante</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Knab</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Bromm</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Weiller</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Büchel</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Pain</MedlineTA><NlmUniqueID>7508686</NlmUniqueID><ISSNLinking>0304-3959</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000679">Amygdala</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001933">Brain Stem</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002531">Cerebellum</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006624">Hippocampus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007834">Lasers</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009619">Nociceptors</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010146">Pain</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011699">Putamen</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012012">Red Nucleus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>9</Month><Day>19</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>12</Month><Day>7</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>9</Month><Day>19</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12237210</ArticleId><ArticleId IdType="pii">S0304395902001574</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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