Differential nociceptive deficits in patients with borderline personality disorder and self-injurious behavior: laser-evoked potentials, spatial discrimination of noxious stimuli, and pain ratings.
Identifieur interne : 000677 ( PubMed/Corpus ); précédent : 000676; suivant : 000678Differential nociceptive deficits in patients with borderline personality disorder and self-injurious behavior: laser-evoked potentials, spatial discrimination of noxious stimuli, and pain ratings.
Auteurs : Christian Schmahl ; Wolfgang Greffrath ; Ulf Baumg Rtner ; Tanja Schlereth ; Walter Magerl ; Alexandra Philipsen ; Klaus Lieb ; Martin Bohus ; Rolf-Detlef TreedeSource :
- Pain [ 0304-3959 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Borderline Personality Disorder (physiopathology), Discrimination (Psychology) (physiology), Electroencephalography (methods), Evoked Potentials (physiology), Evoked Potentials (radiation effects), Female, Humans, Lasers, Neuropsychological Tests, Pain Measurement (methods), Pain Threshold (physiology), Reaction Time (physiology), Reaction Time (radiation effects), Self-Injurious Behavior (physiopathology), Space Perception (physiology), Statistics as Topic.
- MESH :
- methods : Electroencephalography, Pain Measurement.
- physiology : Discrimination (Psychology), Evoked Potentials, Pain Threshold, Reaction Time, Space Perception.
- physiopathology : Borderline Personality Disorder, Self-Injurious Behavior.
- radiation effects : Evoked Potentials, Reaction Time.
- Adult, Analysis of Variance, Female, Humans, Lasers, Neuropsychological Tests, Statistics as Topic.
Abstract
Approximately 70-80% of women meeting criteria for borderline personality disorder (BPD) report attenuated pain perception or analgesia during non-suicidal, intentional self-mutilation. The aim of this study was to use laser-evoked potentials (LEPs) and psychophysical methods to differentiate the factors that may underlie this analgesic state. Ten unmedicated female patients with BPD (according to DSM-IV) and 14 healthy female control subjects were investigated using brief radiant heat pulses generated by a thulium laser and five-channel LEP recording. Heat pulses were applied as part of a spatial discrimination task (two levels of difficulty) and during a mental arithmetic task. BPD patients had significantly higher heat pain thresholds (23%) and lower pain ratings (67%) than control subjects. Nevertheless, LEP amplitudes were either normal (N1, P2, P3) or moderately enhanced in BPD patients (N2). LEP latencies and task performance did not differ between patients and control subjects. The P3 amplitudes, the vertex potential (N2-P2), and the N1, which is generated near the secondary somatosensory cortex, were significantly reduced during distraction by mental arithmetic in both groups. In addition, P3 amplitudes reflected task difficulty. This study confirms previous findings of attenuated pain perception in BPD. Normal nociceptive discrimination task performance, normal LEPs, and normal P3 potentials indicate that this attenuation is neither related to a general impairment of the sensory-discriminative component of pain, nor to hyperactive descending inhibition, nor to attention deficits. These findings suggest that hypoalgesia in BPD may primarily be due to altered intracortical processing similar to certain meditative states.
DOI: 10.1016/j.pain.2004.04.035
PubMed: 15275800
Links to Exploration step
pubmed:15275800Le document en format XML
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T" first="Tanja" last="Schlereth">Tanja Schlereth</name></author><author><name sortKey="Magerl, Walter" sort="Magerl, Walter" uniqKey="Magerl W" first="Walter" last="Magerl">Walter Magerl</name></author><author><name sortKey="Philipsen, Alexandra" sort="Philipsen, Alexandra" uniqKey="Philipsen A" first="Alexandra" last="Philipsen">Alexandra Philipsen</name></author><author><name sortKey="Lieb, Klaus" sort="Lieb, Klaus" uniqKey="Lieb K" first="Klaus" last="Lieb">Klaus Lieb</name></author><author><name sortKey="Bohus, Martin" sort="Bohus, Martin" uniqKey="Bohus M" first="Martin" last="Bohus">Martin Bohus</name></author><author><name sortKey="Treede, Rolf Detlef" sort="Treede, Rolf Detlef" uniqKey="Treede R" first="Rolf-Detlef" last="Treede">Rolf-Detlef Treede</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15275800</idno><idno type="pmid">15275800</idno><idno 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sortKey="Baumg Rtner, Ulf" sort="Baumg Rtner, Ulf" uniqKey="Baumg Rtner U" first="Ulf" last="Baumg Rtner">Ulf Baumg Rtner</name></author><author><name sortKey="Schlereth, Tanja" sort="Schlereth, Tanja" uniqKey="Schlereth T" first="Tanja" last="Schlereth">Tanja Schlereth</name></author><author><name sortKey="Magerl, Walter" sort="Magerl, Walter" uniqKey="Magerl W" first="Walter" last="Magerl">Walter Magerl</name></author><author><name sortKey="Philipsen, Alexandra" sort="Philipsen, Alexandra" uniqKey="Philipsen A" first="Alexandra" last="Philipsen">Alexandra Philipsen</name></author><author><name sortKey="Lieb, Klaus" sort="Lieb, Klaus" uniqKey="Lieb K" first="Klaus" last="Lieb">Klaus Lieb</name></author><author><name sortKey="Bohus, Martin" sort="Bohus, Martin" uniqKey="Bohus M" first="Martin" last="Bohus">Martin Bohus</name></author><author><name sortKey="Treede, Rolf Detlef" sort="Treede, Rolf Detlef" uniqKey="Treede R" first="Rolf-Detlef" last="Treede">Rolf-Detlef Treede</name></author></analytic><series><title level="j">Pain</title><idno type="ISSN">0304-3959</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Borderline Personality Disorder (physiopathology)</term><term>Discrimination (Psychology) (physiology)</term><term>Electroencephalography (methods)</term><term>Evoked Potentials (physiology)</term><term>Evoked Potentials (radiation effects)</term><term>Female</term><term>Humans</term><term>Lasers</term><term>Neuropsychological Tests</term><term>Pain Measurement (methods)</term><term>Pain Threshold (physiology)</term><term>Reaction Time (physiology)</term><term>Reaction Time (radiation effects)</term><term>Self-Injurious Behavior (physiopathology)</term><term>Space Perception (physiology)</term><term>Statistics as Topic</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electroencephalography</term><term>Pain Measurement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Discrimination (Psychology)</term><term>Evoked Potentials</term><term>Pain Threshold</term><term>Reaction Time</term><term>Space Perception</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Borderline Personality Disorder</term><term>Self-Injurious Behavior</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Evoked Potentials</term><term>Reaction Time</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Lasers</term><term>Neuropsychological Tests</term><term>Statistics as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Approximately 70-80% of women meeting criteria for borderline personality disorder (BPD) report attenuated pain perception or analgesia during non-suicidal, intentional self-mutilation. The aim of this study was to use laser-evoked potentials (LEPs) and psychophysical methods to differentiate the factors that may underlie this analgesic state. Ten unmedicated female patients with BPD (according to DSM-IV) and 14 healthy female control subjects were investigated using brief radiant heat pulses generated by a thulium laser and five-channel LEP recording. Heat pulses were applied as part of a spatial discrimination task (two levels of difficulty) and during a mental arithmetic task. BPD patients had significantly higher heat pain thresholds (23%) and lower pain ratings (67%) than control subjects. Nevertheless, LEP amplitudes were either normal (N1, P2, P3) or moderately enhanced in BPD patients (N2). LEP latencies and task performance did not differ between patients and control subjects. The P3 amplitudes, the vertex potential (N2-P2), and the N1, which is generated near the secondary somatosensory cortex, were significantly reduced during distraction by mental arithmetic in both groups. In addition, P3 amplitudes reflected task difficulty. This study confirms previous findings of attenuated pain perception in BPD. Normal nociceptive discrimination task performance, normal LEPs, and normal P3 potentials indicate that this attenuation is neither related to a general impairment of the sensory-discriminative component of pain, nor to hyperactive descending inhibition, nor to attention deficits. These findings suggest that hypoalgesia in BPD may primarily be due to altered intracortical processing similar to certain meditative states.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15275800</PMID><DateCreated><Year>2004</Year><Month>07</Month><Day>27</Day></DateCreated><DateCompleted><Year>2004</Year><Month>10</Month><Day>25</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0304-3959</ISSN><JournalIssue CitedMedium="Print"><Volume>110</Volume><Issue>1-2</Issue><PubDate><Year>2004</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Pain</Title><ISOAbbreviation>Pain</ISOAbbreviation></Journal><ArticleTitle>Differential nociceptive deficits in patients with borderline personality disorder and self-injurious behavior: laser-evoked potentials, spatial discrimination of noxious stimuli, and pain ratings.</ArticleTitle><Pagination><MedlinePgn>470-9</MedlinePgn></Pagination><Abstract><AbstractText>Approximately 70-80% of women meeting criteria for borderline personality disorder (BPD) report attenuated pain perception or analgesia during non-suicidal, intentional self-mutilation. The aim of this study was to use laser-evoked potentials (LEPs) and psychophysical methods to differentiate the factors that may underlie this analgesic state. Ten unmedicated female patients with BPD (according to DSM-IV) and 14 healthy female control subjects were investigated using brief radiant heat pulses generated by a thulium laser and five-channel LEP recording. Heat pulses were applied as part of a spatial discrimination task (two levels of difficulty) and during a mental arithmetic task. BPD patients had significantly higher heat pain thresholds (23%) and lower pain ratings (67%) than control subjects. Nevertheless, LEP amplitudes were either normal (N1, P2, P3) or moderately enhanced in BPD patients (N2). LEP latencies and task performance did not differ between patients and control subjects. The P3 amplitudes, the vertex potential (N2-P2), and the N1, which is generated near the secondary somatosensory cortex, were significantly reduced during distraction by mental arithmetic in both groups. In addition, P3 amplitudes reflected task difficulty. This study confirms previous findings of attenuated pain perception in BPD. Normal nociceptive discrimination task performance, normal LEPs, and normal P3 potentials indicate that this attenuation is neither related to a general impairment of the sensory-discriminative component of pain, nor to hyperactive descending inhibition, nor to attention deficits. These findings suggest that hypoalgesia in BPD may primarily be due to altered intracortical processing similar to certain meditative states.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schmahl</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Physiology and Pathophysiology, Johannes Gutenberg-University, Mannheim, Germany. schmahl@zi-mannheim.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greffrath</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Baumgärtner</LastName><ForeName>Ulf</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Schlereth</LastName><ForeName>Tanja</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Magerl</LastName><ForeName>Walter</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Philipsen</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lieb</LastName><ForeName>Klaus</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Bohus</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Treede</LastName><ForeName>Rolf-Detlef</ForeName><Initials>RD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Pain</MedlineTA><NlmUniqueID>7508686</NlmUniqueID><ISSNLinking>0304-3959</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000704">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001883">Borderline Personality Disorder</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004192">Discrimination (Psychology)</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004569">Electroencephalography</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005071">Evoked Potentials</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000528">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007834">Lasers</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010147">Pain Measurement</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017288">Pain Threshold</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011930">Reaction Time</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000528">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016728">Self-Injurious Behavior</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013028">Space Perception</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013223">Statistics as Topic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>7</Month><Day>28</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>10</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="received"><Year>2003</Year><Month>Sep</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2004</Year><Month>Apr</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2004</Year><Month>Apr</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>7</Month><Day>28</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15275800</ArticleId><ArticleId IdType="doi">10.1016/j.pain.2004.04.035</ArticleId><ArticleId IdType="pii">S0304395904002386</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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