Common cortical network for first and second pain.
Identifieur interne : 000672 ( PubMed/Corpus ); précédent : 000671; suivant : 000673Common cortical network for first and second pain.
Auteurs : Nina Forss ; Tuukka T. Raij ; Mika Sepp ; Riitta HariSource :
- NeuroImage [ 1053-8119 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Brain Mapping, Cerebral Cortex (physiology), Dominance, Cerebral (physiology), Evoked Potentials, Somatosensory (physiology), Female, Gyrus Cinguli (physiology), Hand (innervation), Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Magnetoencephalography, Male, Nerve Fibers (physiology), Nerve Net (physiology), Nociceptors (physiology), Pain Threshold (physiology), Parietal Lobe (physiology), Reaction Time (physiology), Skin (innervation), Somatosensory Cortex (physiology), Synaptic Transmission (physiology).
- MESH :
- innervation : Hand, Skin.
- physiology : Cerebral Cortex, Dominance, Cerebral, Evoked Potentials, Somatosensory, Gyrus Cinguli, Nerve Fibers, Nerve Net, Nociceptors, Pain Threshold, Parietal Lobe, Reaction Time, Somatosensory Cortex, Synaptic Transmission.
- Adult, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Magnetoencephalography, Male.
Abstract
We measured, with whole-scalp magnetoencephalography, evoked fields from 10 healthy subjects to 1-ms thulium-laser stimuli that selectively activated nociceptive nerve fibers. The stimuli were delivered to the dorsum of the subject's left hand. The earliest cortical responses peaked at 165 +/- 7 ms, agreeing with the conduction velocity of Adelta-fibers. To stimulate unmyelinated C-fibers, we modified the method of Bragard et al. [Bragard, D., Chen, A.C., Plaghki, L., 1996. Direct isolation of ultra-late (C-fibre) evoked brain potentials by CO2 laser stimulation of tiny cutaneous surface areas in man. Neurosci. Lett. 209, 81-84], by decreasing the total energy of the laser beam and by restricting the size of the stimulated skin area to 0.2-0.3 mm2. The earliest cortical responses to these stimuli peaked at 811 +/- 14 ms. Bilateral activation of the SII cortices was detected in all 10 subjects to Adelta and in 8 subjects to C stimuli, emphasizing the importance of the SII cortex in processing of pain. Additional activation was observed in the posterior parietal cortex (PPC), probably related to sensorimotor coordination targeted to produce precise motor acts that reduce or prevent the pain; the PPC activation may have been accentuated by the required continuous evaluation of the perceived pain. In contrast to some earlier studies, we did not observe activation of the primary somatosensory cortex (SI). Additional activations to both types of stimuli were detected in the cingulate cortex (three subjects) and in the bilateral insular cortex (two subjects). These results implicate that the nociceptive inputs mediated by the Adelta- and C-fibers are processed in a common cortical network in different time windows. Reliable temporospatial characterization of cortical responses to first and second pain offers a unique tool for basic and clinical neuroscience to study the two distinctive pain fiber systems at cortical level.
DOI: 10.1016/j.neuroimage.2004.09.032
PubMed: 15588604
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pubmed:15588604Le document en format XML
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Raij</name></author><author><name sortKey="Sepp, Mika" sort="Sepp, Mika" uniqKey="Sepp M" first="Mika" last="Sepp">Mika Sepp</name></author><author><name sortKey="Hari, Riitta" sort="Hari, Riitta" uniqKey="Hari R" first="Riitta" last="Hari">Riitta Hari</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1016/j.neuroimage.2004.09.032</idno><idno type="RBID">pubmed:15588604</idno><idno type="pmid">15588604</idno><idno type="wicri:Area/PubMed/Corpus">000672</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000672</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Common cortical network for first and second pain.</title><author><name sortKey="Forss, Nina" sort="Forss, Nina" uniqKey="Forss N" first="Nina" last="Forss">Nina Forss</name><affiliation><nlm:affiliation>Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland. nina@neuro.hut.fi</nlm:affiliation></affiliation></author><author><name sortKey="Raij, Tuukka T" sort="Raij, Tuukka T" uniqKey="Raij T" first="Tuukka T" last="Raij">Tuukka T. Raij</name></author><author><name sortKey="Sepp, Mika" sort="Sepp, Mika" uniqKey="Sepp M" first="Mika" last="Sepp">Mika Sepp</name></author><author><name sortKey="Hari, Riitta" sort="Hari, Riitta" uniqKey="Hari R" first="Riitta" last="Hari">Riitta Hari</name></author></analytic><series><title level="j">NeuroImage</title><idno type="ISSN">1053-8119</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Cerebral Cortex (physiology)</term><term>Dominance, Cerebral (physiology)</term><term>Evoked Potentials, Somatosensory (physiology)</term><term>Female</term><term>Gyrus Cinguli (physiology)</term><term>Hand (innervation)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Magnetoencephalography</term><term>Male</term><term>Nerve Fibers (physiology)</term><term>Nerve Net (physiology)</term><term>Nociceptors (physiology)</term><term>Pain Threshold (physiology)</term><term>Parietal Lobe (physiology)</term><term>Reaction Time (physiology)</term><term>Skin (innervation)</term><term>Somatosensory Cortex (physiology)</term><term>Synaptic Transmission (physiology)</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Hand</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebral Cortex</term><term>Dominance, Cerebral</term><term>Evoked Potentials, Somatosensory</term><term>Gyrus Cinguli</term><term>Nerve Fibers</term><term>Nerve Net</term><term>Nociceptors</term><term>Pain Threshold</term><term>Parietal Lobe</term><term>Reaction Time</term><term>Somatosensory Cortex</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Magnetoencephalography</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We measured, with whole-scalp magnetoencephalography, evoked fields from 10 healthy subjects to 1-ms thulium-laser stimuli that selectively activated nociceptive nerve fibers. The stimuli were delivered to the dorsum of the subject's left hand. The earliest cortical responses peaked at 165 +/- 7 ms, agreeing with the conduction velocity of Adelta-fibers. To stimulate unmyelinated C-fibers, we modified the method of Bragard et al. [Bragard, D., Chen, A.C., Plaghki, L., 1996. Direct isolation of ultra-late (C-fibre) evoked brain potentials by CO2 laser stimulation of tiny cutaneous surface areas in man. Neurosci. Lett. 209, 81-84], by decreasing the total energy of the laser beam and by restricting the size of the stimulated skin area to 0.2-0.3 mm2. The earliest cortical responses to these stimuli peaked at 811 +/- 14 ms. Bilateral activation of the SII cortices was detected in all 10 subjects to Adelta and in 8 subjects to C stimuli, emphasizing the importance of the SII cortex in processing of pain. Additional activation was observed in the posterior parietal cortex (PPC), probably related to sensorimotor coordination targeted to produce precise motor acts that reduce or prevent the pain; the PPC activation may have been accentuated by the required continuous evaluation of the perceived pain. In contrast to some earlier studies, we did not observe activation of the primary somatosensory cortex (SI). Additional activations to both types of stimuli were detected in the cingulate cortex (three subjects) and in the bilateral insular cortex (two subjects). These results implicate that the nociceptive inputs mediated by the Adelta- and C-fibers are processed in a common cortical network in different time windows. Reliable temporospatial characterization of cortical responses to first and second pain offers a unique tool for basic and clinical neuroscience to study the two distinctive pain fiber systems at cortical level.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15588604</PMID><DateCreated><Year>2004</Year><Month>12</Month><Day>13</Day></DateCreated><DateCompleted><Year>2005</Year><Month>02</Month><Day>14</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1053-8119</ISSN><JournalIssue CitedMedium="Print"><Volume>24</Volume><Issue>1</Issue><PubDate><Year>2005</Year><Month>Jan</Month><Day>1</Day></PubDate></JournalIssue><Title>NeuroImage</Title><ISOAbbreviation>Neuroimage</ISOAbbreviation></Journal><ArticleTitle>Common cortical network for first and second pain.</ArticleTitle><Pagination><MedlinePgn>132-42</MedlinePgn></Pagination><Abstract><AbstractText>We measured, with whole-scalp magnetoencephalography, evoked fields from 10 healthy subjects to 1-ms thulium-laser stimuli that selectively activated nociceptive nerve fibers. The stimuli were delivered to the dorsum of the subject's left hand. The earliest cortical responses peaked at 165 +/- 7 ms, agreeing with the conduction velocity of Adelta-fibers. To stimulate unmyelinated C-fibers, we modified the method of Bragard et al. [Bragard, D., Chen, A.C., Plaghki, L., 1996. Direct isolation of ultra-late (C-fibre) evoked brain potentials by CO2 laser stimulation of tiny cutaneous surface areas in man. Neurosci. Lett. 209, 81-84], by decreasing the total energy of the laser beam and by restricting the size of the stimulated skin area to 0.2-0.3 mm2. The earliest cortical responses to these stimuli peaked at 811 +/- 14 ms. Bilateral activation of the SII cortices was detected in all 10 subjects to Adelta and in 8 subjects to C stimuli, emphasizing the importance of the SII cortex in processing of pain. Additional activation was observed in the posterior parietal cortex (PPC), probably related to sensorimotor coordination targeted to produce precise motor acts that reduce or prevent the pain; the PPC activation may have been accentuated by the required continuous evaluation of the perceived pain. In contrast to some earlier studies, we did not observe activation of the primary somatosensory cortex (SI). Additional activations to both types of stimuli were detected in the cingulate cortex (three subjects) and in the bilateral insular cortex (two subjects). These results implicate that the nociceptive inputs mediated by the Adelta- and C-fibers are processed in a common cortical network in different time windows. Reliable temporospatial characterization of cortical responses to first and second pain offers a unique tool for basic and clinical neuroscience to study the two distinctive pain fiber systems at cortical level.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Forss</LastName><ForeName>Nina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland. nina@neuro.hut.fi</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raij</LastName><ForeName>Tuukka T</ForeName><Initials>TT</Initials></Author><Author ValidYN="Y"><LastName>Seppä</LastName><ForeName>Mika</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hari</LastName><ForeName>Riitta</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neuroimage</MedlineTA><NlmUniqueID>9215515</NlmUniqueID><ISSNLinking>1053-8119</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001931">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004292">Dominance, Cerebral</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005073">Evoked Potentials, Somatosensory</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006179">Gyrus Cinguli</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006225">Hand</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D007091">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D008279">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" 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