Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10-tetraazacyclodoecane-alpha,alpha',alpha'',alpha'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA4-).
Identifieur interne : 000670 ( PubMed/Corpus ); précédent : 000669; suivant : 000671Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10-tetraazacyclodoecane-alpha,alpha',alpha'',alpha'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA4-).
Auteurs : S K Hekmatyar ; Paige Hopewell ; Sait Kubilay Pakin ; Andriy Babsky ; Navin BansalSource :
- Magnetic resonance in medicine [ 0740-3194 ] ; 2005.
English descriptors
- KwdEn :
- Algorithms, Animals, Cell Line, Tumor, Feasibility Studies, Fibrosarcoma (diagnosis), Image Interpretation, Computer-Assisted (methods), Lanthanoid Series Elements, Magnetic Resonance Imaging (methods), Magnetic Resonance Spectroscopy (methods), Magnetics, Mice, Mice, Inbred C3H, Phantoms, Imaging, Protons, Quaternary Ammonium Compounds, Rats, Rats, Inbred F344, Reproducibility of Results, Sensitivity and Specificity, Thermography (methods).
- MESH :
- chemical : Lanthanoid Series Elements, Protons, Quaternary Ammonium Compounds.
- diagnosis : Fibrosarcoma.
- methods : Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Thermography.
- Algorithms, Animals, Cell Line, Tumor, Feasibility Studies, Magnetics, Mice, Mice, Inbred C3H, Phantoms, Imaging, Rats, Rats, Inbred F344, Reproducibility of Results, Sensitivity and Specificity.
Abstract
Noninvasive techniques to monitor temperature have numerous useful biomedical applications. However, MR thermometry techniques based on the chemical shift, relaxation rates, and molecular diffusion rate of the water 1H signal suffer from poor thermal resolution. The feasibility of MR thermometry based on the strong temperature dependence of the hyperfine-shifted 1H signal from the paramagnetic lanthanide complex thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTA-) was recently demonstrated. The use of paramagnetic lanthanide complexes for MR thermometry can be further enhanced by improving the signal-to-noise ratio (SNR) of the observed signal. In this study, the use of lanthanide complexes of a methyl-substituted analog of DOTA4-, 1,4,7,10-tetramethyl 1,4,7,10-tetra azacyclodoecane-1,4,7,10-tetraacetic acetate (DOTMA4-) was evaluated. DOTMA4- complexes have 12 magnetically equivalent methyl protons, which provide an intense and sharper resonance compared to the corresponding DOTA- complexes. Experiments with paramagnetic Pr3+, Yb3+, Tb3+, Dy3+, and Tm3+ complexes of DOTMA4- showed that the Tm3+ complex is most favorable for MR thermometery because of the high temperature dependence of its chemical shift and its relatively narrow linewidth. The chemical shift of the methyl 1H signal from TmDOTMA- was approximately 60 times more sensitive to temperature than the water 1H shift and was insensitive to changes in concentration, pH, [Ca2+], or the presence of other ions and macromolecules. The application of TmDOTMA- for measuring temperature in a subcutaneously implanted tumor model was demonstrated. Lastly, the feasibility of obtaining 3D images from the methyl 1H resonance of TmDOTMA- was demonstrated in phantom and live animal experiments. Overall, TmDOTMA- appears to be a promising probe for MR thermometry in vivo.
DOI: 10.1002/mrm.20345
PubMed: 15678553
Links to Exploration step
pubmed:15678553Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10-tetraazacyclodoecane-alpha,alpha',alpha'',alpha'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA4-).</title><author><name sortKey="Hekmatyar, S K" sort="Hekmatyar, S K" uniqKey="Hekmatyar S" first="S K" last="Hekmatyar">S K Hekmatyar</name><affiliation><nlm:affiliation>Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5181, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hopewell, Paige" sort="Hopewell, Paige" uniqKey="Hopewell P" first="Paige" last="Hopewell">Paige Hopewell</name></author><author><name sortKey="Pakin, Sait Kubilay" sort="Pakin, Sait Kubilay" uniqKey="Pakin S" first="Sait Kubilay" last="Pakin">Sait Kubilay Pakin</name></author><author><name sortKey="Babsky, Andriy" sort="Babsky, Andriy" uniqKey="Babsky A" first="Andriy" last="Babsky">Andriy Babsky</name></author><author><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mrm.20345</idno><idno type="RBID">pubmed:15678553</idno><idno type="pmid">15678553</idno><idno type="wicri:Area/PubMed/Corpus">000670</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000670</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10-tetraazacyclodoecane-alpha,alpha',alpha'',alpha'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA4-).</title><author><name sortKey="Hekmatyar, S K" sort="Hekmatyar, S K" uniqKey="Hekmatyar S" first="S K" last="Hekmatyar">S K Hekmatyar</name><affiliation><nlm:affiliation>Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5181, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hopewell, Paige" sort="Hopewell, Paige" uniqKey="Hopewell P" first="Paige" last="Hopewell">Paige Hopewell</name></author><author><name sortKey="Pakin, Sait Kubilay" sort="Pakin, Sait Kubilay" uniqKey="Pakin S" first="Sait Kubilay" last="Pakin">Sait Kubilay Pakin</name></author><author><name sortKey="Babsky, Andriy" sort="Babsky, Andriy" uniqKey="Babsky A" first="Andriy" last="Babsky">Andriy Babsky</name></author><author><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name></author></analytic><series><title level="j">Magnetic resonance in medicine</title><idno type="ISSN">0740-3194</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Animals</term><term>Cell Line, Tumor</term><term>Feasibility Studies</term><term>Fibrosarcoma (diagnosis)</term><term>Image Interpretation, Computer-Assisted (methods)</term><term>Lanthanoid Series Elements</term><term>Magnetic Resonance Imaging (methods)</term><term>Magnetic Resonance Spectroscopy (methods)</term><term>Magnetics</term><term>Mice</term><term>Mice, Inbred C3H</term><term>Phantoms, Imaging</term><term>Protons</term><term>Quaternary Ammonium Compounds</term><term>Rats</term><term>Rats, Inbred F344</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Thermography (methods)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Lanthanoid Series Elements</term><term>Protons</term><term>Quaternary Ammonium Compounds</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Fibrosarcoma</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Interpretation, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Magnetic Resonance Spectroscopy</term><term>Thermography</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Animals</term><term>Cell Line, Tumor</term><term>Feasibility Studies</term><term>Magnetics</term><term>Mice</term><term>Mice, Inbred C3H</term><term>Phantoms, Imaging</term><term>Rats</term><term>Rats, Inbred F344</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Noninvasive techniques to monitor temperature have numerous useful biomedical applications. However, MR thermometry techniques based on the chemical shift, relaxation rates, and molecular diffusion rate of the water 1H signal suffer from poor thermal resolution. The feasibility of MR thermometry based on the strong temperature dependence of the hyperfine-shifted 1H signal from the paramagnetic lanthanide complex thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTA-) was recently demonstrated. The use of paramagnetic lanthanide complexes for MR thermometry can be further enhanced by improving the signal-to-noise ratio (SNR) of the observed signal. In this study, the use of lanthanide complexes of a methyl-substituted analog of DOTA4-, 1,4,7,10-tetramethyl 1,4,7,10-tetra azacyclodoecane-1,4,7,10-tetraacetic acetate (DOTMA4-) was evaluated. DOTMA4- complexes have 12 magnetically equivalent methyl protons, which provide an intense and sharper resonance compared to the corresponding DOTA- complexes. Experiments with paramagnetic Pr3+, Yb3+, Tb3+, Dy3+, and Tm3+ complexes of DOTMA4- showed that the Tm3+ complex is most favorable for MR thermometery because of the high temperature dependence of its chemical shift and its relatively narrow linewidth. The chemical shift of the methyl 1H signal from TmDOTMA- was approximately 60 times more sensitive to temperature than the water 1H shift and was insensitive to changes in concentration, pH, [Ca2+], or the presence of other ions and macromolecules. The application of TmDOTMA- for measuring temperature in a subcutaneously implanted tumor model was demonstrated. Lastly, the feasibility of obtaining 3D images from the methyl 1H resonance of TmDOTMA- was demonstrated in phantom and live animal experiments. Overall, TmDOTMA- appears to be a promising probe for MR thermometry in vivo.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15678553</PMID><DateCreated><Year>2005</Year><Month>02</Month><Day>02</Day></DateCreated><DateCompleted><Year>2005</Year><Month>05</Month><Day>05</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0740-3194</ISSN><JournalIssue CitedMedium="Print"><Volume>53</Volume><Issue>2</Issue><PubDate><Year>2005</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Magnetic resonance in medicine</Title><ISOAbbreviation>Magn Reson Med</ISOAbbreviation></Journal><ArticleTitle>Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10-tetraazacyclodoecane-alpha,alpha',alpha'',alpha'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA4-).</ArticleTitle><Pagination><MedlinePgn>294-303</MedlinePgn></Pagination><Abstract><AbstractText>Noninvasive techniques to monitor temperature have numerous useful biomedical applications. However, MR thermometry techniques based on the chemical shift, relaxation rates, and molecular diffusion rate of the water 1H signal suffer from poor thermal resolution. The feasibility of MR thermometry based on the strong temperature dependence of the hyperfine-shifted 1H signal from the paramagnetic lanthanide complex thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTA-) was recently demonstrated. The use of paramagnetic lanthanide complexes for MR thermometry can be further enhanced by improving the signal-to-noise ratio (SNR) of the observed signal. In this study, the use of lanthanide complexes of a methyl-substituted analog of DOTA4-, 1,4,7,10-tetramethyl 1,4,7,10-tetra azacyclodoecane-1,4,7,10-tetraacetic acetate (DOTMA4-) was evaluated. DOTMA4- complexes have 12 magnetically equivalent methyl protons, which provide an intense and sharper resonance compared to the corresponding DOTA- complexes. Experiments with paramagnetic Pr3+, Yb3+, Tb3+, Dy3+, and Tm3+ complexes of DOTMA4- showed that the Tm3+ complex is most favorable for MR thermometery because of the high temperature dependence of its chemical shift and its relatively narrow linewidth. The chemical shift of the methyl 1H signal from TmDOTMA- was approximately 60 times more sensitive to temperature than the water 1H shift and was insensitive to changes in concentration, pH, [Ca2+], or the presence of other ions and macromolecules. The application of TmDOTMA- for measuring temperature in a subcutaneously implanted tumor model was demonstrated. Lastly, the feasibility of obtaining 3D images from the methyl 1H resonance of TmDOTMA- was demonstrated in phantom and live animal experiments. Overall, TmDOTMA- appears to be a promising probe for MR thermometry in vivo.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hekmatyar</LastName><ForeName>S K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5181, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hopewell</LastName><ForeName>Paige</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Pakin</LastName><ForeName>Sait Kubilay</ForeName><Initials>SK</Initials></Author><Author ValidYN="Y"><LastName>Babsky</LastName><ForeName>Andriy</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Bansal</LastName><ForeName>Navin</ForeName><Initials>N</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>CA84434</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA94040</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL54574</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D023362">Evaluation Studies</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Magn Reson Med</MedlineTA><NlmUniqueID>8505245</NlmUniqueID><ISSNLinking>0740-3194</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D028581">Lanthanoid Series Elements</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011522">Protons</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000644">Quaternary Ammonium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>104162-48-3</RegistryNumber><NameOfSubstance UI="C054005">N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000465">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D045744">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005240">Feasibility Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005354">Fibrosarcoma</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007090">Image Interpretation, Computer-Assisted</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D028581">Lanthanoid Series Elements</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009682">Magnetic Resonance Spectroscopy</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008280">Magnetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008809">Mice, Inbred C3H</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019047">Phantoms, Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011522">Protons</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D000644">Quaternary Ammonium Compounds</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011916">Rats, Inbred F344</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015203">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012680">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013817">Thermography</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>1</Month><Day>29</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>5</Month><Day>6</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>1</Month><Day>29</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mrm.20345</ArticleId><ArticleId IdType="pubmed">15678553</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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