Histological and modeling study of skin thermal injury to 2.0 microm laser irradiation.
Identifieur interne : 000577 ( PubMed/Corpus ); précédent : 000576; suivant : 000578Histological and modeling study of skin thermal injury to 2.0 microm laser irradiation.
Auteurs : Bo Chen ; Sharon L. Thomsen ; Robert J. Thomas ; Jeffrey Oliver ; Ashley J. WelchSource :
- Lasers in surgery and medicine [ 0196-8092 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Laser Therapy.
- etiology : Burns.
- injuries : Skin.
- pathology : Burns.
- Animals, Disease Models, Animal, Female, Finite Element Analysis, Microscopy, Electron, Models, Cardiovascular, Predictive Value of Tests, Swine, Swine, Miniature.
Abstract
Qualitative and quantitative gross histopathologic studies of skin damage were performed at 48 hours after irradiation with a 2.0 microm thulium CW laser to determine the mechanisms of laser effects in the skin under various exposure conditions.
DOI: 10.1002/lsm.20630
PubMed: 18563778
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Histological and modeling study of skin thermal injury to 2.0 microm laser irradiation.</title><author><name sortKey="Chen, Bo" sort="Chen, Bo" uniqKey="Chen B" first="Bo" last="Chen">Bo Chen</name><affiliation><nlm:affiliation>Biomedical Engineering Laser Laboratory, University of Texas at Austin, Austin, Texas 78712, USA. chenbo@mail.utexas.edu</nlm:affiliation></affiliation></author><author><name sortKey="Thomsen, Sharon L" sort="Thomsen, Sharon L" uniqKey="Thomsen S" first="Sharon L" last="Thomsen">Sharon L. Thomsen</name></author><author><name sortKey="Thomas, Robert J" sort="Thomas, Robert J" uniqKey="Thomas R" first="Robert J" last="Thomas">Robert J. Thomas</name></author><author><name sortKey="Oliver, Jeffrey" sort="Oliver, Jeffrey" uniqKey="Oliver J" first="Jeffrey" last="Oliver">Jeffrey Oliver</name></author><author><name sortKey="Welch, Ashley J" sort="Welch, Ashley J" uniqKey="Welch A" first="Ashley J" last="Welch">Ashley J. Welch</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/lsm.20630</idno><idno type="RBID">pubmed:18563778</idno><idno type="pmid">18563778</idno><idno type="wicri:Area/PubMed/Corpus">000577</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000577</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Histological and modeling study of skin thermal injury to 2.0 microm laser irradiation.</title><author><name sortKey="Chen, Bo" sort="Chen, Bo" uniqKey="Chen B" first="Bo" last="Chen">Bo Chen</name><affiliation><nlm:affiliation>Biomedical Engineering Laser Laboratory, University of Texas at Austin, Austin, Texas 78712, USA. chenbo@mail.utexas.edu</nlm:affiliation></affiliation></author><author><name sortKey="Thomsen, Sharon L" sort="Thomsen, Sharon L" uniqKey="Thomsen S" first="Sharon L" last="Thomsen">Sharon L. Thomsen</name></author><author><name sortKey="Thomas, Robert J" sort="Thomas, Robert J" uniqKey="Thomas R" first="Robert J" last="Thomas">Robert J. Thomas</name></author><author><name sortKey="Oliver, Jeffrey" sort="Oliver, Jeffrey" uniqKey="Oliver J" first="Jeffrey" last="Oliver">Jeffrey Oliver</name></author><author><name sortKey="Welch, Ashley J" sort="Welch, Ashley J" uniqKey="Welch A" first="Ashley J" last="Welch">Ashley J. Welch</name></author></analytic><series><title level="j">Lasers in surgery and medicine</title><idno type="ISSN">0196-8092</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Burns (etiology)</term><term>Burns (pathology)</term><term>Disease Models, Animal</term><term>Female</term><term>Finite Element Analysis</term><term>Laser Therapy (adverse effects)</term><term>Microscopy, Electron</term><term>Models, Cardiovascular</term><term>Predictive Value of Tests</term><term>Skin (injuries)</term><term>Swine</term><term>Swine, Miniature</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Laser Therapy</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Burns</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Burns</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Finite Element Analysis</term><term>Microscopy, Electron</term><term>Models, Cardiovascular</term><term>Predictive Value of Tests</term><term>Swine</term><term>Swine, Miniature</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Qualitative and quantitative gross histopathologic studies of skin damage were performed at 48 hours after irradiation with a 2.0 microm thulium CW laser to determine the mechanisms of laser effects in the skin under various exposure conditions.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18563778</PMID><DateCreated><Year>2008</Year><Month>06</Month><Day>24</Day></DateCreated><DateCompleted><Year>2008</Year><Month>11</Month><Day>18</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0196-8092</ISSN><JournalIssue CitedMedium="Print"><Volume>40</Volume><Issue>5</Issue><PubDate><Year>2008</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Lasers in surgery and medicine</Title><ISOAbbreviation>Lasers Surg Med</ISOAbbreviation></Journal><ArticleTitle>Histological and modeling study of skin thermal injury to 2.0 microm laser irradiation.</ArticleTitle><Pagination><MedlinePgn>358-70</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/lsm.20630</ELocationID><Abstract><AbstractText Label="BACKGROUND AND OBJECTIVE" NlmCategory="OBJECTIVE">Qualitative and quantitative gross histopathologic studies of skin damage were performed at 48 hours after irradiation with a 2.0 microm thulium CW laser to determine the mechanisms of laser effects in the skin under various exposure conditions.</AbstractText><AbstractText Label="STUDY DESIGN/MATERIALS AND METHODS" NlmCategory="METHODS">Pig skin lesions were created at, below and beyond the threshold irradiation conditions for grossly apparent thermal lesions. Histological sections of these lesions were studied. For each threshold lesion, four quantitative histopathological parameters were measured: the widths of (1) epidermal necrosis at the surface, (2) the outer boundary of the thrombosis zone, (3) the depth of vascular thrombosis, and (4) the depth of perivascular inflammation (increased infiltrates of inflammatory cells) and edema. The quantitative histopathologic data were compared with predictions using an optical-thermal-damage model.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Histologically, the thermal damage mechanisms for grossly apparent threshold lesions of persistent redness at 48 hours included necrosis of the epidermal cells, intravascular thrombosis and perivascular inflammation and edema in dermal blood vessels. At irradiation levels just below 'gross threshold', non-lethal thermal effects, such as perivascular inflammation and edema were found in the histological sections. When the radiation reached about 1.5-2.5 times beyond the threshold, decrease of dermal collagen birefringence was observed.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A sequence of damage endpoints was defined in the skin as power increased. By choosing rate process coefficients to match specific mechanisms of lethal thermal damage, the optical-thermal-damage model is capable of predicting various types of thermal injury in the skin, such as epidermal necrosis, vascular thrombosis, and dermal collagen coagulation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Bo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Biomedical Engineering Laser Laboratory, University of Texas at Austin, Austin, Texas 78712, USA. chenbo@mail.utexas.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thomsen</LastName><ForeName>Sharon L</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Robert J</ForeName><Initials>RJ</Initials></Author><Author ValidYN="Y"><LastName>Oliver</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Welch</LastName><ForeName>Ashley J</ForeName><Initials>AJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Lasers Surg Med</MedlineTA><NlmUniqueID>8007168</NlmUniqueID><ISSNLinking>0196-8092</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002056">Burns</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004195">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020342">Finite Element Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D053685">Laser Therapy</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008854">Microscopy, Electron</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008955">Models, Cardiovascular</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011237">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012867">Skin</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000293">injuries</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013552">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013556">Swine, Miniature</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>6</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>11</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>6</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/lsm.20630</ArticleId><ArticleId IdType="pubmed">18563778</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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