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Upconversion nanophosphors Naluf₄:Yb,Tm for lymphatic imaging in vivo by real-time upconversion luminescence imaging under ambient light and high-resolution X-ray CT.

Identifieur interne : 000284 ( PubMed/Corpus ); précédent : 000283; suivant : 000285

Upconversion nanophosphors Naluf₄:Yb,Tm for lymphatic imaging in vivo by real-time upconversion luminescence imaging under ambient light and high-resolution X-ray CT.

Auteurs : Yun Sun ; Juanjuan Peng ; Wei Feng ; Fuyou Li

Source :

RBID : pubmed:23650481

English descriptors

Abstract

Lanthanide upconversion nanophosphor (UCNP) has attracted increasing attention for potential applications in bioimaging due to its excellence in deep and high contrast imaging. To date, most upconversion imaging applications were demonstrated in dark surroundings without ambient light for higher signal-to-noise ratio, which hindered the application of optical imaging guided surgery. Herein, the new established NaLuF₄-based UCNP (NaLuF₄:Yb,Tm, ~17 nm) with bright upconversion emission around 800 nm as imaging signal was used to realize imaging under ambient light to provide more convenient for clinician. Moreover, due to the existance of heavy element lutetium (Lu) in the host lattice, the NaLuF₄:Yb,Tm nanoparticles can also be used as an X-ray CT imaging agent to enhance the imaging depth and in vivo imaging resolution.

DOI: 10.7150/thno.5137
PubMed: 23650481

Links to Exploration step

pubmed:23650481

Le document en format XML

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<name sortKey="Sun, Yun" sort="Sun, Yun" uniqKey="Sun Y" first="Yun" last="Sun">Yun Sun</name>
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<div type="abstract" xml:lang="en">Lanthanide upconversion nanophosphor (UCNP) has attracted increasing attention for potential applications in bioimaging due to its excellence in deep and high contrast imaging. To date, most upconversion imaging applications were demonstrated in dark surroundings without ambient light for higher signal-to-noise ratio, which hindered the application of optical imaging guided surgery. Herein, the new established NaLuF₄-based UCNP (NaLuF₄:Yb,Tm, ~17 nm) with bright upconversion emission around 800 nm as imaging signal was used to realize imaging under ambient light to provide more convenient for clinician. Moreover, due to the existance of heavy element lutetium (Lu) in the host lattice, the NaLuF₄:Yb,Tm nanoparticles can also be used as an X-ray CT imaging agent to enhance the imaging depth and in vivo imaging resolution.</div>
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