Cholesterol-diethylenetriaminepentaacetate complexed with thulium ions integrated into bicelles to increase their magnetic alignability.
Identifieur interne : 000229 ( PubMed/Corpus ); précédent : 000228; suivant : 000230Cholesterol-diethylenetriaminepentaacetate complexed with thulium ions integrated into bicelles to increase their magnetic alignability.
Auteurs : Marianne Liebi ; Simon Kuster ; Joachim Kohlbrecher ; Takashi Ishikawa ; Peter Fischer ; Peter Walde ; Erich J. WindhabSource :
- The journal of physical chemistry. B [ 1520-5207 ] ; 2013.
English descriptors
- KwdEn :
- Birefringence, Chelating Agents (chemistry), Cholesterol (chemistry), Coordination Complexes (chemistry), Cryoelectron Microscopy, Dimyristoylphosphatidylcholine (chemistry), Lipid Bilayers (chemistry), Magnetic Phenomena, Magnetics, Neutron Diffraction, Pentetic Acid (chemistry), Scattering, Small Angle, Thulium (chemistry).
- MESH :
Abstract
Lanthanides have been used for several decades to increase the magnetic alignability of bicelles. DMPE-DTPA (1,2-dimyristoyl-sn-glycero-3-phospho-ethanolamine-diethylenetriaminepentaacetate) is commonly applied to anchor the lanthanides into the bicelles. However, because DMPE-DTPA has the tendency to accumulate at the highly curved edge region of the bicelles and if located there does not contribute to the magnetic orientation energy, we have tested cholesterol-DTPA complexed with thulium ions (Tm(3+)) as an alternative chelator to increase the magnetic alignability. Differential scanning calorimetric (DSC) measurements indicate the successful integration of cholesterol-DTPA into a DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) bilayer. Cryo transmission electron microscopy and small-angle neutron scattering (SANS) measurements show that the disklike structure, that is, bicelles, is maintained if cholesterol-DTPA·Tm(3+) is integrated into a mixture of DMPC, cholesterol, and DMPE-DTPA·Tm(3+). The size of the bicelles is increased compared to the size of the bicelles obtained from mixtures without cholesterol-DTPA·Tm(3+). Magnetic-field-induced birefringence and SANS measurements in a magnetic field show that with addition of cholesterol-DTPA·Tm(3+) the magnetic alignability of these bicelles is significantly increased compared to bicelles composed of DMPC, cholesterol, and DMPE-DTPA·Tm(3+) only.
DOI: 10.1021/jp406599c
PubMed: 24205912
Links to Exploration step
pubmed:24205912Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cholesterol-diethylenetriaminepentaacetate complexed with thulium ions integrated into bicelles to increase their magnetic alignability.</title><author><name sortKey="Liebi, Marianne" sort="Liebi, Marianne" uniqKey="Liebi M" first="Marianne" last="Liebi">Marianne Liebi</name><affiliation><nlm:affiliation>Laboratory of Food Process Engineering, ETH Zurich , Schmelzbergstrasse 9, 8092 Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Kuster, Simon" sort="Kuster, Simon" uniqKey="Kuster S" first="Simon" last="Kuster">Simon Kuster</name></author><author><name sortKey="Kohlbrecher, Joachim" sort="Kohlbrecher, Joachim" uniqKey="Kohlbrecher J" first="Joachim" last="Kohlbrecher">Joachim Kohlbrecher</name></author><author><name sortKey="Ishikawa, Takashi" sort="Ishikawa, Takashi" uniqKey="Ishikawa T" first="Takashi" last="Ishikawa">Takashi Ishikawa</name></author><author><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></author><author><name sortKey="Walde, Peter" sort="Walde, Peter" uniqKey="Walde P" first="Peter" last="Walde">Peter Walde</name></author><author><name sortKey="Windhab, Erich J" sort="Windhab, Erich J" uniqKey="Windhab E" first="Erich J" last="Windhab">Erich J. Windhab</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1021/jp406599c</idno><idno type="RBID">pubmed:24205912</idno><idno type="pmid">24205912</idno><idno type="wicri:Area/PubMed/Corpus">000229</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000229</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cholesterol-diethylenetriaminepentaacetate complexed with thulium ions integrated into bicelles to increase their magnetic alignability.</title><author><name sortKey="Liebi, Marianne" sort="Liebi, Marianne" uniqKey="Liebi M" first="Marianne" last="Liebi">Marianne Liebi</name><affiliation><nlm:affiliation>Laboratory of Food Process Engineering, ETH Zurich , Schmelzbergstrasse 9, 8092 Zurich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Kuster, Simon" sort="Kuster, Simon" uniqKey="Kuster S" first="Simon" last="Kuster">Simon Kuster</name></author><author><name sortKey="Kohlbrecher, Joachim" sort="Kohlbrecher, Joachim" uniqKey="Kohlbrecher J" first="Joachim" last="Kohlbrecher">Joachim Kohlbrecher</name></author><author><name sortKey="Ishikawa, Takashi" sort="Ishikawa, Takashi" uniqKey="Ishikawa T" first="Takashi" last="Ishikawa">Takashi Ishikawa</name></author><author><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></author><author><name sortKey="Walde, Peter" sort="Walde, Peter" uniqKey="Walde P" first="Peter" last="Walde">Peter Walde</name></author><author><name sortKey="Windhab, Erich J" sort="Windhab, Erich J" uniqKey="Windhab E" first="Erich J" last="Windhab">Erich J. Windhab</name></author></analytic><series><title level="j">The journal of physical chemistry. B</title><idno type="eISSN">1520-5207</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Birefringence</term><term>Chelating Agents (chemistry)</term><term>Cholesterol (chemistry)</term><term>Coordination Complexes (chemistry)</term><term>Cryoelectron Microscopy</term><term>Dimyristoylphosphatidylcholine (chemistry)</term><term>Lipid Bilayers (chemistry)</term><term>Magnetic Phenomena</term><term>Magnetics</term><term>Neutron Diffraction</term><term>Pentetic Acid (chemistry)</term><term>Scattering, Small Angle</term><term>Thulium (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Chelating Agents</term><term>Cholesterol</term><term>Coordination Complexes</term><term>Dimyristoylphosphatidylcholine</term><term>Lipid Bilayers</term><term>Pentetic Acid</term><term>Thulium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Birefringence</term><term>Cryoelectron Microscopy</term><term>Magnetic Phenomena</term><term>Magnetics</term><term>Neutron Diffraction</term><term>Scattering, Small Angle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lanthanides have been used for several decades to increase the magnetic alignability of bicelles. DMPE-DTPA (1,2-dimyristoyl-sn-glycero-3-phospho-ethanolamine-diethylenetriaminepentaacetate) is commonly applied to anchor the lanthanides into the bicelles. However, because DMPE-DTPA has the tendency to accumulate at the highly curved edge region of the bicelles and if located there does not contribute to the magnetic orientation energy, we have tested cholesterol-DTPA complexed with thulium ions (Tm(3+)) as an alternative chelator to increase the magnetic alignability. Differential scanning calorimetric (DSC) measurements indicate the successful integration of cholesterol-DTPA into a DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) bilayer. Cryo transmission electron microscopy and small-angle neutron scattering (SANS) measurements show that the disklike structure, that is, bicelles, is maintained if cholesterol-DTPA·Tm(3+) is integrated into a mixture of DMPC, cholesterol, and DMPE-DTPA·Tm(3+). The size of the bicelles is increased compared to the size of the bicelles obtained from mixtures without cholesterol-DTPA·Tm(3+). Magnetic-field-induced birefringence and SANS measurements in a magnetic field show that with addition of cholesterol-DTPA·Tm(3+) the magnetic alignability of these bicelles is significantly increased compared to bicelles composed of DMPC, cholesterol, and DMPE-DTPA·Tm(3+) only.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24205912</PMID><DateCreated><Year>2013</Year><Month>11</Month><Day>27</Day></DateCreated><DateCompleted><Year>2014</Year><Month>07</Month><Day>07</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5207</ISSN><JournalIssue CitedMedium="Internet"><Volume>117</Volume><Issue>47</Issue><PubDate><Year>2013</Year><Month>Nov</Month><Day>27</Day></PubDate></JournalIssue><Title>The journal of physical chemistry. B</Title><ISOAbbreviation>J Phys Chem B</ISOAbbreviation></Journal><ArticleTitle>Cholesterol-diethylenetriaminepentaacetate complexed with thulium ions integrated into bicelles to increase their magnetic alignability.</ArticleTitle><Pagination><MedlinePgn>14743-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/jp406599c</ELocationID><Abstract><AbstractText>Lanthanides have been used for several decades to increase the magnetic alignability of bicelles. DMPE-DTPA (1,2-dimyristoyl-sn-glycero-3-phospho-ethanolamine-diethylenetriaminepentaacetate) is commonly applied to anchor the lanthanides into the bicelles. However, because DMPE-DTPA has the tendency to accumulate at the highly curved edge region of the bicelles and if located there does not contribute to the magnetic orientation energy, we have tested cholesterol-DTPA complexed with thulium ions (Tm(3+)) as an alternative chelator to increase the magnetic alignability. Differential scanning calorimetric (DSC) measurements indicate the successful integration of cholesterol-DTPA into a DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) bilayer. Cryo transmission electron microscopy and small-angle neutron scattering (SANS) measurements show that the disklike structure, that is, bicelles, is maintained if cholesterol-DTPA·Tm(3+) is integrated into a mixture of DMPC, cholesterol, and DMPE-DTPA·Tm(3+). The size of the bicelles is increased compared to the size of the bicelles obtained from mixtures without cholesterol-DTPA·Tm(3+). Magnetic-field-induced birefringence and SANS measurements in a magnetic field show that with addition of cholesterol-DTPA·Tm(3+) the magnetic alignability of these bicelles is significantly increased compared to bicelles composed of DMPC, cholesterol, and DMPE-DTPA·Tm(3+) only.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liebi</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Food Process Engineering, ETH Zurich , Schmelzbergstrasse 9, 8092 Zurich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuster</LastName><ForeName>Simon</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Kohlbrecher</LastName><ForeName>Joachim</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ishikawa</LastName><ForeName>Takashi</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Walde</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Windhab</LastName><ForeName>Erich J</ForeName><Initials>EJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>11</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Phys Chem B</MedlineTA><NlmUniqueID>101157530</NlmUniqueID><ISSNLinking>1520-5207</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002614">Chelating 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