Comparative analysis of 11 different radioisotopes for palliative treatment of bone metastases by computational methods.
Identifieur interne : 000129 ( PubMed/Corpus ); précédent : 000128; suivant : 000130Comparative analysis of 11 different radioisotopes for palliative treatment of bone metastases by computational methods.
Auteurs : Francisco D C. Guerra Liberal ; Adriana Alexandre S. Tavares ; João Manuel R S. TavaresSource :
- Medical physics [ 0094-2405 ] ; 2014.
English descriptors
- KwdEn :
- Algorithms, Beta Particles (therapeutic use), Bone Neoplasms (pathology), Bone Neoplasms (radiotherapy), Computer Simulation, DNA (chemistry), DNA Damage, DNA Repair, Humans, Lutetium (therapeutic use), Monte Carlo Method, Neoplasm Metastasis, Palliative Care (methods), Radioisotopes (chemistry), Radioisotopes (therapeutic use), Radiopharmaceuticals (therapeutic use), Radium (therapeutic use), Rhenium (therapeutic use), Samarium (therapeutic use), Strontium Radioisotopes (therapeutic use).
- MESH :
- chemical , chemistry : DNA, Radioisotopes.
- methods : Palliative Care.
- pathology : Bone Neoplasms.
- radiotherapy : Bone Neoplasms.
- therapeutic use : Beta Particles, Lutetium, Radioisotopes, Radiopharmaceuticals, Radium, Rhenium, Samarium, Strontium Radioisotopes.
- Algorithms, Computer Simulation, DNA Damage, DNA Repair, Humans, Monte Carlo Method, Neoplasm Metastasis.
Abstract
Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology, but the choice of which bone seeking agent to use is not consensual across sites and limited data are available comparing the characteristics of each radioisotope. Computational simulation is a simple and practical method to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aims to evaluate and compare 11 different radioisotopes currently in use or under research for the palliative treatment of bone metastases using computational methods.
DOI: 10.1118/1.4897240
PubMed: 25370676
Links to Exploration step
pubmed:25370676Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative analysis of 11 different radioisotopes for palliative treatment of bone metastases by computational methods.</title><author><name sortKey="Guerra Liberal, Francisco D C" sort="Guerra Liberal, Francisco D C" uniqKey="Guerra Liberal F" first="Francisco D C" last="Guerra Liberal">Francisco D C. Guerra Liberal</name><affiliation><nlm:affiliation>Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Tavares, Adriana Alexandre S" sort="Tavares, Adriana Alexandre S" uniqKey="Tavares A" first="Adriana Alexandre S" last="Tavares">Adriana Alexandre S. Tavares</name><affiliation><nlm:affiliation>Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Tavares, Joao Manuel R S" sort="Tavares, Joao Manuel R S" uniqKey="Tavares J" first="João Manuel R S" last="Tavares">João Manuel R S. Tavares</name><affiliation><nlm:affiliation>Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465, Portugal.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="doi">10.1118/1.4897240</idno><idno type="RBID">pubmed:25370676</idno><idno type="pmid">25370676</idno><idno type="wicri:Area/PubMed/Corpus">000129</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000129</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparative analysis of 11 different radioisotopes for palliative treatment of bone metastases by computational methods.</title><author><name sortKey="Guerra Liberal, Francisco D C" sort="Guerra Liberal, Francisco D C" uniqKey="Guerra Liberal F" first="Francisco D C" last="Guerra Liberal">Francisco D C. Guerra Liberal</name><affiliation><nlm:affiliation>Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Tavares, Adriana Alexandre S" sort="Tavares, Adriana Alexandre S" uniqKey="Tavares A" first="Adriana Alexandre S" last="Tavares">Adriana Alexandre S. Tavares</name><affiliation><nlm:affiliation>Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Tavares, Joao Manuel R S" sort="Tavares, Joao Manuel R S" uniqKey="Tavares J" first="João Manuel R S" last="Tavares">João Manuel R S. Tavares</name><affiliation><nlm:affiliation>Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465, Portugal.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Medical physics</title><idno type="ISSN">0094-2405</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Beta Particles (therapeutic use)</term><term>Bone Neoplasms (pathology)</term><term>Bone Neoplasms (radiotherapy)</term><term>Computer Simulation</term><term>DNA (chemistry)</term><term>DNA Damage</term><term>DNA Repair</term><term>Humans</term><term>Lutetium (therapeutic use)</term><term>Monte Carlo Method</term><term>Neoplasm Metastasis</term><term>Palliative Care (methods)</term><term>Radioisotopes (chemistry)</term><term>Radioisotopes (therapeutic use)</term><term>Radiopharmaceuticals (therapeutic use)</term><term>Radium (therapeutic use)</term><term>Rhenium (therapeutic use)</term><term>Samarium (therapeutic use)</term><term>Strontium Radioisotopes (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA</term><term>Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Palliative Care</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Bone Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Beta Particles</term><term>Lutetium</term><term>Radioisotopes</term><term>Radiopharmaceuticals</term><term>Radium</term><term>Rhenium</term><term>Samarium</term><term>Strontium Radioisotopes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Computer Simulation</term><term>DNA Damage</term><term>DNA Repair</term><term>Humans</term><term>Monte Carlo Method</term><term>Neoplasm Metastasis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology, but the choice of which bone seeking agent to use is not consensual across sites and limited data are available comparing the characteristics of each radioisotope. Computational simulation is a simple and practical method to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aims to evaluate and compare 11 different radioisotopes currently in use or under research for the palliative treatment of bone metastases using computational methods.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25370676</PMID><DateCreated><Year>2014</Year><Month>11</Month><Day>05</Day></DateCreated><DateCompleted><Year>2015</Year><Month>07</Month><Day>16</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0094-2405</ISSN><JournalIssue CitedMedium="Internet"><Volume>41</Volume><Issue>11</Issue><PubDate><Year>2014</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Medical physics</Title><ISOAbbreviation>Med Phys</ISOAbbreviation></Journal><ArticleTitle>Comparative analysis of 11 different radioisotopes for palliative treatment of bone metastases by computational methods.</ArticleTitle><Pagination><MedlinePgn>114101</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1118/1.4897240</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology, but the choice of which bone seeking agent to use is not consensual across sites and limited data are available comparing the characteristics of each radioisotope. Computational simulation is a simple and practical method to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aims to evaluate and compare 11 different radioisotopes currently in use or under research for the palliative treatment of bone metastases using computational methods.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Computational models were used to estimate the percentage of deoxyribonucleic acid (DNA) damage (fast Monte Carlo damage algorithm), the probability of correct DNA repair (Monte Carlo excision repair algorithm), and the radiation-induced cellular effects (virtual cell radiobiology algorithm) post-irradiation with selected particles emitted by phosphorus-32 ((32)P), strontium-89 ((89)Sr), yttrium-90 ((90)Y ), tin-117 ((117m)Sn), samarium-153 ((153)Sm), holmium-166 ((166)Ho), thulium-170 ((170)Tm), lutetium-177 ((177)Lu), rhenium-186 ((186)Re), rhenium-188 ((188)Re), and radium-223 ((223)Ra).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">(223)Ra alpha particles, (177)Lu beta minus particles, and (170)Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by (89)Sr and (153)Sm, two of the most frequently used radionuclides in the palliative treatment of bone metastases in clinical routine practice, was higher than (177)Lu beta minus particles and (223)Ra alpha particles.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">(223)Ra and (177)Lu hold the highest potential for palliative treatment of bone metastases of all radioisotopes compared in this study. Data reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases, raise the need for the careful rethinking of the current widespread clinical use of (89)Sr and (153)Sm, and perhaps strengthen the use of (223)Ra and (177)Lu in the palliative treatment of bone metastases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Guerra Liberal</LastName><ForeName>Francisco D C</ForeName><Initials>FD</Initials><AffiliationInfo><Affiliation>Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavares</LastName><ForeName>Adriana Alexandre S</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavares</LastName><ForeName>João Manuel R S</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465, Portugal.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Med Phys</MedlineTA><NlmUniqueID>0425746</NlmUniqueID><ISSNLinking>0094-2405</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011868">Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013326">Strontium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>42OD65L39F</RegistryNumber><NameOfSubstance UI="D012493">Samarium</NameOfSubstance></Chemical><Chemical><RegistryNumber>5H0DOZ21UJ</RegistryNumber><NameOfSubstance UI="D008187">Lutetium</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-15-5</RegistryNumber><NameOfSubstance UI="D012211">Rhenium</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-49-2</RegistryNumber><NameOfSubstance UI="D004247">DNA</NameOfSubstance></Chemical><Chemical><RegistryNumber>W90AYD6R3Q</RegistryNumber><NameOfSubstance UI="D011883">Radium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000465">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001610">Beta Particles</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001859">Bone Neoplasms</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000532">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003198">Computer Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004247">DNA</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004249">DNA Damage</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004260">DNA Repair</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008187">Lutetium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009010">Monte Carlo Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009362">Neoplasm Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010166">Palliative Care</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011868">Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019275">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" 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