Assembly of near infra-red emitting upconverting nanoparticles and multiple Gd(III)-chelates as a potential bimodal contrast agent for MRI and optical imaging.
Identifieur interne : 000078 ( PubMed/Corpus ); précédent : 000077; suivant : 000079Assembly of near infra-red emitting upconverting nanoparticles and multiple Gd(III)-chelates as a potential bimodal contrast agent for MRI and optical imaging.
Auteurs : Sophie Carron ; Qiang Ying Li ; Luce Vander Elst ; Robert N. Muller ; Tatjana N. Parac-Vogt ; John A. CapobiancoSource :
- Dalton transactions (Cambridge, England : 2003) [ 1477-9234 ] ; 2015.
Abstract
Linking multiple paramagnetic gadolinium(III)-chelates based on the 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetate (DOTA) ligand to the surface of NaGdF4:Yb(3+),Tm(3+) upconverting nanoparticles with an average particle size of 20 nm resulted in an assembly that has favorable properties for bimodal Magnetic Resonance Imaging (MRI) and Optical Imaging (OI). An improved synthetic pathway was used to couple the paramagnetic precursor to the nanoparticles. The nanoparticles were rendered water dispersible via citrate capping, leaving one acid group free for amide coupling with the mono-amino precursor of the DOTA ligand. Luminescence spectroscopy measurements have shown that the excitation of the nanoconstruct at 980 nm resulted in intense upconverted emission of thulium(III) at 800 nm. The assembly of several paramagnetic centers on the nanoparticle scaffold reduces the overall tumbling rate, resulting in enhanced longitudinal relaxation times and improved relaxivity. The proton NMRD profiles show a characteristic hump at higher frequencies, which is caused by the slow rotation of the nanoconstruct, resulting in r1 values of 25 mM(-1) s(-1) per gadolinium(III)-ion at 60 MHz and 310 K. This is a significant improvement compared to the Gd-DO3A-ethylamine precursor (4) for which a value of r1 of 3.23 mM(-1) s(-1) was observed under the same conditions. Theoretical fitting by two different approaches showed an increase of τR from 57.3 ps for the Gd-DO3A-ethylamine precursor (4) to 392.0 ps for the nanoconstruct, which is responsible for the overall substantial increase in relaxivity.
DOI: 10.1039/c5dt00919g
PubMed: 26011519
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Muller</name></author><author><name sortKey="Parac Vogt, Tatjana N" sort="Parac Vogt, Tatjana N" uniqKey="Parac Vogt T" first="Tatjana N" last="Parac-Vogt">Tatjana N. Parac-Vogt</name></author><author><name sortKey="Capobianco, John A" sort="Capobianco, John A" uniqKey="Capobianco J" first="John A" last="Capobianco">John A. Capobianco</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.1039/c5dt00919g</idno><idno type="RBID">pubmed:26011519</idno><idno type="pmid">26011519</idno><idno type="wicri:Area/PubMed/Corpus">000078</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000078</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Assembly of near infra-red emitting upconverting nanoparticles and multiple Gd(III)-chelates as a potential bimodal contrast agent for MRI and optical imaging.</title><author><name sortKey="Carron, Sophie" sort="Carron, Sophie" uniqKey="Carron S" first="Sophie" last="Carron">Sophie Carron</name><affiliation><nlm:affiliation>Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. sophie.carron@chem.kuleuven.be.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Qiang Ying" sort="Li, Qiang Ying" uniqKey="Li Q" first="Qiang Ying" last="Li">Qiang Ying Li</name></author><author><name sortKey="Vander Elst, Luce" sort="Vander Elst, Luce" uniqKey="Vander Elst L" first="Luce" last="Vander Elst">Luce Vander Elst</name></author><author><name sortKey="Muller, Robert N" sort="Muller, Robert N" uniqKey="Muller R" first="Robert N" last="Muller">Robert N. Muller</name></author><author><name sortKey="Parac Vogt, Tatjana N" sort="Parac Vogt, Tatjana N" uniqKey="Parac Vogt T" first="Tatjana N" last="Parac-Vogt">Tatjana N. Parac-Vogt</name></author><author><name sortKey="Capobianco, John A" sort="Capobianco, John A" uniqKey="Capobianco J" first="John A" last="Capobianco">John A. Capobianco</name></author></analytic><series><title level="j">Dalton transactions (Cambridge, England : 2003)</title><idno type="eISSN">1477-9234</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Linking multiple paramagnetic gadolinium(III)-chelates based on the 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetate (DOTA) ligand to the surface of NaGdF4:Yb(3+),Tm(3+) upconverting nanoparticles with an average particle size of 20 nm resulted in an assembly that has favorable properties for bimodal Magnetic Resonance Imaging (MRI) and Optical Imaging (OI). An improved synthetic pathway was used to couple the paramagnetic precursor to the nanoparticles. The nanoparticles were rendered water dispersible via citrate capping, leaving one acid group free for amide coupling with the mono-amino precursor of the DOTA ligand. Luminescence spectroscopy measurements have shown that the excitation of the nanoconstruct at 980 nm resulted in intense upconverted emission of thulium(III) at 800 nm. The assembly of several paramagnetic centers on the nanoparticle scaffold reduces the overall tumbling rate, resulting in enhanced longitudinal relaxation times and improved relaxivity. The proton NMRD profiles show a characteristic hump at higher frequencies, which is caused by the slow rotation of the nanoconstruct, resulting in r1 values of 25 mM(-1) s(-1) per gadolinium(III)-ion at 60 MHz and 310 K. This is a significant improvement compared to the Gd-DO3A-ethylamine precursor (4) for which a value of r1 of 3.23 mM(-1) s(-1) was observed under the same conditions. Theoretical fitting by two different approaches showed an increase of τR from 57.3 ps for the Gd-DO3A-ethylamine precursor (4) to 392.0 ps for the nanoconstruct, which is responsible for the overall substantial increase in relaxivity.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="PubMed-not-MEDLINE"><PMID Version="1">26011519</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>18</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>18</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1477-9234</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>25</Issue><PubDate><Year>2015</Year><Month>Jul</Month><Day>7</Day></PubDate></JournalIssue><Title>Dalton transactions (Cambridge, England : 2003)</Title><ISOAbbreviation>Dalton Trans</ISOAbbreviation></Journal><ArticleTitle>Assembly of near infra-red emitting upconverting nanoparticles and multiple Gd(III)-chelates as a potential bimodal contrast agent for MRI and optical imaging.</ArticleTitle><Pagination><MedlinePgn>11331-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1039/c5dt00919g</ELocationID><Abstract><AbstractText>Linking multiple paramagnetic gadolinium(III)-chelates based on the 2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetate (DOTA) ligand to the surface of NaGdF4:Yb(3+),Tm(3+) upconverting nanoparticles with an average particle size of 20 nm resulted in an assembly that has favorable properties for bimodal Magnetic Resonance Imaging (MRI) and Optical Imaging (OI). An improved synthetic pathway was used to couple the paramagnetic precursor to the nanoparticles. The nanoparticles were rendered water dispersible via citrate capping, leaving one acid group free for amide coupling with the mono-amino precursor of the DOTA ligand. Luminescence spectroscopy measurements have shown that the excitation of the nanoconstruct at 980 nm resulted in intense upconverted emission of thulium(III) at 800 nm. The assembly of several paramagnetic centers on the nanoparticle scaffold reduces the overall tumbling rate, resulting in enhanced longitudinal relaxation times and improved relaxivity. The proton NMRD profiles show a characteristic hump at higher frequencies, which is caused by the slow rotation of the nanoconstruct, resulting in r1 values of 25 mM(-1) s(-1) per gadolinium(III)-ion at 60 MHz and 310 K. This is a significant improvement compared to the Gd-DO3A-ethylamine precursor (4) for which a value of r1 of 3.23 mM(-1) s(-1) was observed under the same conditions. Theoretical fitting by two different approaches showed an increase of τR from 57.3 ps for the Gd-DO3A-ethylamine precursor (4) to 392.0 ps for the nanoconstruct, which is responsible for the overall substantial increase in relaxivity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Carron</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. sophie.carron@chem.kuleuven.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Qiang Ying</ForeName><Initials>QY</Initials></Author><Author ValidYN="Y"><LastName>Vander Elst</LastName><ForeName>Luce</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Muller</LastName><ForeName>Robert N</ForeName><Initials>RN</Initials></Author><Author ValidYN="Y"><LastName>Parac-Vogt</LastName><ForeName>Tatjana N</ForeName><Initials>TN</Initials></Author><Author ValidYN="Y"><LastName>Capobianco</LastName><ForeName>John A</ForeName><Initials>JA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Dalton Trans</MedlineTA><NlmUniqueID>101176026</NlmUniqueID><ISSNLinking>1477-9226</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1039/c5dt00919g</ArticleId><ArticleId IdType="pubmed">26011519</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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