The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.
Identifieur interne : 000811 ( PubMed/Checkpoint ); précédent : 000810; suivant : 000812The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.
Auteurs : K. Schom Cker ; W G Franke ; E. Henke ; W D Fromm ; G. Maka ; G J BeyerSource :
- European journal of nuclear medicine [ 0340-6997 ] ; 1986.
Descripteurs français
- KwdFr :
- Acide citrique, Animaux, Cinétique, Citrates (métabolisme), Composés du fer II (métabolisme), Fer (pharmacologie), Gallium (pharmacologie), Lignées consanguines de souris, Radio-isotopes, Radio-isotopes du fer, Radio-isotopes du gallium, Répartition dans les tissus, Souris, Thulium (métabolisme), Thulium (pharmacologie), Tumeurs expérimentales de la mamelle (métabolisme).
- MESH :
- métabolisme : Citrates, Composés du fer II, Thulium, Tumeurs expérimentales de la mamelle.
- pharmacologie : Fer, Gallium, Thulium.
- Acide citrique, Animaux, Cinétique, Lignées consanguines de souris, Radio-isotopes, Radio-isotopes du fer, Radio-isotopes du gallium, Répartition dans les tissus, Souris.
English descriptors
- KwdEn :
- Animals, Citrates (metabolism), Citric Acid, Ferrous Compounds (metabolism), Gallium (pharmacology), Gallium Radioisotopes, Iron (pharmacology), Iron Radioisotopes, Kinetics, Mammary Neoplasms, Experimental (metabolism), Mice, Mice, Inbred Strains, Radioisotopes, Thulium (metabolism), Thulium (pharmacology), Tissue Distribution.
- MESH :
- chemical , metabolism : Citrates, Ferrous Compounds, Thulium.
- chemical , pharmacology : Gallium, Iron, Thulium.
- metabolism : Mammary Neoplasms, Experimental.
- Animals, Citric Acid, Gallium Radioisotopes, Iron Radioisotopes, Kinetics, Mice, Mice, Inbred Strains, Radioisotopes, Tissue Distribution.
Abstract
The influence of carrier amounts of Fe, Ga, and Tm on the biodistribution of 67Ga-, 59Fe-, and 167Tm-citrate in mice was investigated. Our results suggest that 167Tm, unlike 67Ga and 59Fe, is not transported by transferrin in the blood. Of the three radioisotopes tested, 167Tm had the highest tumor/background ratio (10 h after the injection). The application of Fe carrier led to an enhancement of the elimination of 67Ga from the blood and muscles, resulting in a better tumor/background ratio.
PubMed: 3456891
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Maka</name></author><author><name sortKey="Beyer, G J" sort="Beyer, G J" uniqKey="Beyer G" first="G J" last="Beyer">G J Beyer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1986">1986</date><idno type="RBID">pubmed:3456891</idno><idno type="pmid">3456891</idno><idno type="wicri:Area/PubMed/Corpus">000838</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000838</idno><idno type="wicri:Area/PubMed/Curation">000838</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000838</idno><idno type="wicri:Area/PubMed/Checkpoint">000838</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000838</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.</title><author><name sortKey="Schom Cker, K" sort="Schom Cker, K" uniqKey="Schom Cker K" first="K" last="Schom Cker">K. Schom Cker</name></author><author><name sortKey="Franke, W G" sort="Franke, W G" uniqKey="Franke W" first="W G" last="Franke">W G Franke</name></author><author><name sortKey="Henke, E" sort="Henke, E" uniqKey="Henke E" first="E" last="Henke">E. Henke</name></author><author><name sortKey="Fromm, W D" sort="Fromm, W D" uniqKey="Fromm W" first="W D" last="Fromm">W D Fromm</name></author><author><name sortKey="Maka, G" sort="Maka, G" uniqKey="Maka G" first="G" last="Maka">G. Maka</name></author><author><name sortKey="Beyer, G J" sort="Beyer, G J" uniqKey="Beyer G" first="G J" last="Beyer">G J Beyer</name></author></analytic><series><title level="j">European journal of nuclear medicine</title><idno type="ISSN">0340-6997</idno><imprint><date when="1986" type="published">1986</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Citrates (metabolism)</term><term>Citric Acid</term><term>Ferrous Compounds (metabolism)</term><term>Gallium (pharmacology)</term><term>Gallium Radioisotopes</term><term>Iron (pharmacology)</term><term>Iron Radioisotopes</term><term>Kinetics</term><term>Mammary Neoplasms, Experimental (metabolism)</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Radioisotopes</term><term>Thulium (metabolism)</term><term>Thulium (pharmacology)</term><term>Tissue Distribution</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide citrique</term><term>Animaux</term><term>Cinétique</term><term>Citrates (métabolisme)</term><term>Composés du fer II (métabolisme)</term><term>Fer (pharmacologie)</term><term>Gallium (pharmacologie)</term><term>Lignées consanguines de souris</term><term>Radio-isotopes</term><term>Radio-isotopes du fer</term><term>Radio-isotopes du gallium</term><term>Répartition dans les tissus</term><term>Souris</term><term>Thulium (métabolisme)</term><term>Thulium (pharmacologie)</term><term>Tumeurs expérimentales de la mamelle (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Citrates</term><term>Ferrous Compounds</term><term>Thulium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Gallium</term><term>Iron</term><term>Thulium</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mammary Neoplasms, Experimental</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Citrates</term><term>Composés du fer II</term><term>Thulium</term><term>Tumeurs expérimentales de la mamelle</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Fer</term><term>Gallium</term><term>Thulium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Citric Acid</term><term>Gallium Radioisotopes</term><term>Iron Radioisotopes</term><term>Kinetics</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Radioisotopes</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide citrique</term><term>Animaux</term><term>Cinétique</term><term>Lignées consanguines de souris</term><term>Radio-isotopes</term><term>Radio-isotopes du fer</term><term>Radio-isotopes du gallium</term><term>Répartition dans les tissus</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The influence of carrier amounts of Fe, Ga, and Tm on the biodistribution of 67Ga-, 59Fe-, and 167Tm-citrate in mice was investigated. Our results suggest that 167Tm, unlike 67Ga and 59Fe, is not transported by transferrin in the blood. Of the three radioisotopes tested, 167Tm had the highest tumor/background ratio (10 h after the injection). The application of Fe carrier led to an enhancement of the elimination of 67Ga from the blood and muscles, resulting in a better tumor/background ratio.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">3456891</PMID><DateCreated><Year>1986</Year><Month>04</Month><Day>25</Day></DateCreated><DateCompleted><Year>1986</Year><Month>04</Month><Day>25</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-6997</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><Issue>9</Issue><PubDate><Year>1986</Year></PubDate></JournalIssue><Title>European journal of nuclear medicine</Title><ISOAbbreviation>Eur J Nucl Med</ISOAbbreviation></Journal><ArticleTitle>The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.</ArticleTitle><Pagination><MedlinePgn>345-9</MedlinePgn></Pagination><Abstract><AbstractText>The influence of carrier amounts of Fe, Ga, and Tm on the biodistribution of 67Ga-, 59Fe-, and 167Tm-citrate in mice was investigated. Our results suggest that 167Tm, unlike 67Ga and 59Fe, is not transported by transferrin in the blood. Of the three radioisotopes tested, 167Tm had the highest tumor/background ratio (10 h after the injection). The application of Fe carrier led to an enhancement of the elimination of 67Ga from the blood and muscles, resulting in a better tumor/background ratio.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schomäcker</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Franke</LastName><ForeName>W G</ForeName><Initials>WG</Initials></Author><Author ValidYN="Y"><LastName>Henke</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Fromm</LastName><ForeName>W D</ForeName><Initials>WD</Initials></Author><Author ValidYN="Y"><LastName>Maka</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Beyer</LastName><ForeName>G J</ForeName><Initials>GJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>GERMANY, WEST</Country><MedlineTA>Eur J Nucl Med</MedlineTA><NlmUniqueID>7606882</NlmUniqueID><ISSNLinking>0340-6997</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002951">Citrates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005296">Ferrous Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005710">Gallium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007504">Iron Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011868">Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>2968PHW8QP</RegistryNumber><NameOfSubstance UI="D019343">Citric Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>33KM3X4QQW</RegistryNumber><NameOfSubstance UI="C016600">monoferrous acid citrate</NameOfSubstance></Chemical><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance UI="D013932">Thulium</NameOfSubstance></Chemical><Chemical><RegistryNumber>CH46OC8YV4</RegistryNumber><NameOfSubstance UI="D005708">Gallium</NameOfSubstance></Chemical><Chemical><RegistryNumber>E1UOL152H7</RegistryNumber><NameOfSubstance UI="D007501">Iron</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002951">Citrates</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019343">Citric Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005296">Ferrous Compounds</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005708">Gallium</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005710">Gallium Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007501">Iron</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007504">Iron Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007700">Kinetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008325">Mammary Neoplasms, Experimental</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008815">Mice, Inbred Strains</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011868">Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013932">Thulium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014018">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1986</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1986</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1986</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3456891</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Beyer, G J" sort="Beyer, G J" uniqKey="Beyer G" first="G J" last="Beyer">G J Beyer</name><name sortKey="Franke, W G" sort="Franke, W G" uniqKey="Franke W" first="W G" last="Franke">W G Franke</name><name sortKey="Fromm, W D" sort="Fromm, W D" uniqKey="Fromm W" first="W D" last="Fromm">W D Fromm</name><name sortKey="Henke, E" sort="Henke, E" uniqKey="Henke E" first="E" last="Henke">E. Henke</name><name sortKey="Maka, G" sort="Maka, G" uniqKey="Maka G" first="G" last="Maka">G. Maka</name><name sortKey="Schom Cker, K" sort="Schom Cker, K" uniqKey="Schom Cker K" first="K" last="Schom Cker">K. Schom Cker</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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