On-resonance low B1 pulses for imaging of the effects of PARACEST agents.
Identifieur interne : 000634 ( PubMed/Checkpoint ); précédent : 000633; suivant : 000635On-resonance low B1 pulses for imaging of the effects of PARACEST agents.
Auteurs : Elena Vinogradov [États-Unis] ; Shanrong Zhang ; Angelo Lubag ; James A. Balschi ; A Dean Sherry ; Robert E. LenkinskiSource :
- Journal of magnetic resonance (San Diego, Calif. : 1997) [ 1090-7807 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Contrast Media, Lanthanoid Series Elements, Organometallic Compounds.
- methods : Magnetic Resonance Imaging.
Abstract
Application of the exchange-sensitive, low-power RF pulses positioned on the bulk water resonance for imaging of the effects of PARACEST agents is proposed as an alternative to the standard CW off-resonance irradiation. Specifically, we applied a low-power WALTZ-16 RF train, with the 90 degrees pulse unit replaced by a pulse of the fixed length (WALTZ-16*). Using this sequence, the bulk water signal was found to be sensitive to exchange lifetimes with PARACEST complex bound protons, the transverse relaxation time of bulk water, and longitudinal relaxation time of bound protons. In this report, the concept of using WALTZ-16* to "activate" a PARACEST effect is introduced and some of the salient features of this technique with respect to experimental conditions and performance levels are discussed. Computational predictions are verified and explored by comparison with experimental spectroscopic and imaging data. It is shown that WALTZ-16* can be used to detect PARACEST agents with an RF intensity as low as 200 Hz for concentrations as low as a few tens of microM for lanthanide chelates having appropriate water-exchange rates (Tm,Dy).
DOI: 10.1016/j.jmr.2005.05.016
PubMed: 15979362
Affiliations:
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Balschi</name></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A Dean" last="Sherry">A Dean Sherry</name></author><author><name sortKey="Lenkinski, Robert E" sort="Lenkinski, Robert E" uniqKey="Lenkinski R" first="Robert E" last="Lenkinski">Robert E. Lenkinski</name></author></analytic><series><title level="j">Journal of magnetic resonance (San Diego, Calif. : 1997)</title><idno type="ISSN">1090-7807</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Contrast Media (chemistry)</term><term>Lanthanoid Series Elements (chemistry)</term><term>Magnetic Resonance Imaging (methods)</term><term>Organometallic Compounds (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Composés organométalliques ()</term><term>Imagerie par résonance magnétique ()</term><term>Lanthanides ()</term><term>Produits de contraste ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Contrast Media</term><term>Lanthanoid Series Elements</term><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Composés organométalliques</term><term>Imagerie par résonance magnétique</term><term>Lanthanides</term><term>Produits de contraste</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Application of the exchange-sensitive, low-power RF pulses positioned on the bulk water resonance for imaging of the effects of PARACEST agents is proposed as an alternative to the standard CW off-resonance irradiation. Specifically, we applied a low-power WALTZ-16 RF train, with the 90 degrees pulse unit replaced by a pulse of the fixed length (WALTZ-16*). Using this sequence, the bulk water signal was found to be sensitive to exchange lifetimes with PARACEST complex bound protons, the transverse relaxation time of bulk water, and longitudinal relaxation time of bound protons. In this report, the concept of using WALTZ-16* to "activate" a PARACEST effect is introduced and some of the salient features of this technique with respect to experimental conditions and performance levels are discussed. Computational predictions are verified and explored by comparison with experimental spectroscopic and imaging data. It is shown that WALTZ-16* can be used to detect PARACEST agents with an RF intensity as low as 200 Hz for concentrations as low as a few tens of microM for lanthanide chelates having appropriate water-exchange rates (Tm,Dy).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">15979362</PMID><DateCreated><Year>2005</Year><Month>08</Month><Day>16</Day></DateCreated><DateCompleted><Year>2005</Year><Month>11</Month><Day>10</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">1090-7807</ISSN><JournalIssue CitedMedium="Print"><Volume>176</Volume><Issue>1</Issue><PubDate><Year>2005</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of magnetic resonance (San Diego, Calif. : 1997)</Title><ISOAbbreviation>J. Magn. Reson.</ISOAbbreviation></Journal><ArticleTitle>On-resonance low B1 pulses for imaging of the effects of PARACEST agents.</ArticleTitle><Pagination><MedlinePgn>54-63</MedlinePgn></Pagination><Abstract><AbstractText>Application of the exchange-sensitive, low-power RF pulses positioned on the bulk water resonance for imaging of the effects of PARACEST agents is proposed as an alternative to the standard CW off-resonance irradiation. Specifically, we applied a low-power WALTZ-16 RF train, with the 90 degrees pulse unit replaced by a pulse of the fixed length (WALTZ-16*). Using this sequence, the bulk water signal was found to be sensitive to exchange lifetimes with PARACEST complex bound protons, the transverse relaxation time of bulk water, and longitudinal relaxation time of bound protons. In this report, the concept of using WALTZ-16* to "activate" a PARACEST effect is introduced and some of the salient features of this technique with respect to experimental conditions and performance levels are discussed. Computational predictions are verified and explored by comparison with experimental spectroscopic and imaging data. It is shown that WALTZ-16* can be used to detect PARACEST agents with an RF intensity as low as 200 Hz for concentrations as low as a few tens of microM for lanthanide chelates having appropriate water-exchange rates (Tm,Dy).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vinogradov</LastName><ForeName>Elena</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. evinogra@bidmc.harvard.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Shanrong</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lubag</LastName><ForeName>Angelo</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Balschi</LastName><ForeName>James A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Sherry</LastName><ForeName>A Dean</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Lenkinski</LastName><ForeName>Robert E</ForeName><Initials>RE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Magn Reson</MedlineTA><NlmUniqueID>9707935</NlmUniqueID><ISSNLinking>1090-7807</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003287">Contrast Media</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D028581">Lanthanoid Series Elements</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009942">Organometallic Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C463281">thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003287">Contrast Media</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D028581">Lanthanoid Series Elements</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009942">Organometallic Compounds</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2005</Year><Month>2</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2005</Year><Month>5</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2005</Year><Month>5</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>6</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>11</Month><Day>11</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>6</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S1090-7807(05)00169-2</ArticleId><ArticleId IdType="doi">10.1016/j.jmr.2005.05.016</ArticleId><ArticleId IdType="pubmed">15979362</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Balschi, James A" sort="Balschi, James A" uniqKey="Balschi J" first="James A" last="Balschi">James A. Balschi</name><name sortKey="Lenkinski, Robert E" sort="Lenkinski, Robert E" uniqKey="Lenkinski R" first="Robert E" last="Lenkinski">Robert E. Lenkinski</name><name sortKey="Lubag, Angelo" sort="Lubag, Angelo" uniqKey="Lubag A" first="Angelo" last="Lubag">Angelo Lubag</name><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A Dean" last="Sherry">A Dean Sherry</name><name sortKey="Zhang, Shanrong" sort="Zhang, Shanrong" uniqKey="Zhang S" first="Shanrong" last="Zhang">Shanrong Zhang</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Vinogradov, Elena" sort="Vinogradov, Elena" uniqKey="Vinogradov E" first="Elena" last="Vinogradov">Elena Vinogradov</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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