Development of a thulium (Tm:YAP) laser system for brain tissue ablation.
Identifieur interne : 000436 ( PubMed/Checkpoint ); précédent : 000435; suivant : 000437Development of a thulium (Tm:YAP) laser system for brain tissue ablation.
Auteurs : Temel Bilici [Turquie] ; Sevinc Mutlu ; Hamit Kalaycioglu ; Adnan Kurt ; Alphan Sennaroglu ; Murat GulsoySource :
- Lasers in medical science [ 1435-604X ] ; 2011.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Encéphale.
- Animaux, Encéphale, Rat Wistar, Rats, Techniques in vitro, Thulium, Thérapie laser.
English descriptors
- KwdEn :
- MESH :
- chemical : Thulium.
- instrumentation : Laser Therapy.
- methods : Laser Therapy.
- pathology : Brain.
- statistics & numerical data : Laser Therapy.
- surgery : Brain.
- Animals, In Vitro Techniques, Rats, Rats, Wistar.
Abstract
In this study, a thulium (Tm:YAP) laser system was developed for brain surgery applications. As the Tm:YAP laser is a continuous-wave laser delivered via silica fibers, it would have great potential for stereotaxic neurosurgery with highest local absorption in the IR region. The laser system developed in this study allowed the user to set the power level, exposure time, and modulation parameters (pulse width and on-off cycles). The Tm:YAP laser beam (200-600 mW, 69-208 W/cm(2)) was delivered from a distance of 2 mm to cortical and subcortical regions of ex-vivo Wistar rat brain tissue samples via a 200-μm-core optical fiber. The system performance, dosimetry study, and ablation characteristics of the Tm:YAP laser were tested at different power levels by maximizing the therapeutic effects and minimizing unwanted thermal side-effects. The coagulation and ablation diameters were measured under microscope. The maximum ablation efficiency (100 × ablation diameter/coagulation diameter) was obtained when the Tm:YAP laser system was operated at 200 mW for 10 s. At this laser dose, the ablation efficiency was found to be 71.4% and 58.7% for cortical and subcortical regions, respectively. The fiber-coupled Tm:YAP laser system in hence proposed for the delivery of photothermal therapies in medical applications.
DOI: 10.1007/s10103-011-0915-0
PubMed: 21484452
Affiliations:
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last="Kalaycioglu">Hamit Kalaycioglu</name></author><author><name sortKey="Kurt, Adnan" sort="Kurt, Adnan" uniqKey="Kurt A" first="Adnan" last="Kurt">Adnan Kurt</name></author><author><name sortKey="Sennaroglu, Alphan" sort="Sennaroglu, Alphan" uniqKey="Sennaroglu A" first="Alphan" last="Sennaroglu">Alphan Sennaroglu</name></author><author><name sortKey="Gulsoy, Murat" sort="Gulsoy, Murat" uniqKey="Gulsoy M" first="Murat" last="Gulsoy">Murat Gulsoy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="doi">10.1007/s10103-011-0915-0</idno><idno type="RBID">pubmed:21484452</idno><idno type="pmid">21484452</idno><idno type="wicri:Area/PubMed/Corpus">000440</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000440</idno><idno type="wicri:Area/PubMed/Curation">000440</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000440</idno><idno 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Mutlu</name></author><author><name sortKey="Kalaycioglu, Hamit" sort="Kalaycioglu, Hamit" uniqKey="Kalaycioglu H" first="Hamit" last="Kalaycioglu">Hamit Kalaycioglu</name></author><author><name sortKey="Kurt, Adnan" sort="Kurt, Adnan" uniqKey="Kurt A" first="Adnan" last="Kurt">Adnan Kurt</name></author><author><name sortKey="Sennaroglu, Alphan" sort="Sennaroglu, Alphan" uniqKey="Sennaroglu A" first="Alphan" last="Sennaroglu">Alphan Sennaroglu</name></author><author><name sortKey="Gulsoy, Murat" sort="Gulsoy, Murat" uniqKey="Gulsoy M" first="Murat" last="Gulsoy">Murat Gulsoy</name></author></analytic><series><title level="j">Lasers in medical science</title><idno type="eISSN">1435-604X</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (pathology)</term><term>Brain (surgery)</term><term>In Vitro Techniques</term><term>Laser 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qualifier="statistics & numerical data" xml:lang="en"><term>Laser Therapy</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>In Vitro Techniques</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Encéphale</term><term>Rat Wistar</term><term>Rats</term><term>Techniques in vitro</term><term>Thulium</term><term>Thérapie laser</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, a thulium (Tm:YAP) laser system was developed for brain surgery applications. As the Tm:YAP laser is a continuous-wave laser delivered via silica fibers, it would have great potential for stereotaxic neurosurgery with highest local absorption in the IR region. The laser system developed in this study allowed the user to set the power level, exposure time, and modulation parameters (pulse width and on-off cycles). The Tm:YAP laser beam (200-600 mW, 69-208 W/cm(2)) was delivered from a distance of 2 mm to cortical and subcortical regions of ex-vivo Wistar rat brain tissue samples via a 200-μm-core optical fiber. The system performance, dosimetry study, and ablation characteristics of the Tm:YAP laser were tested at different power levels by maximizing the therapeutic effects and minimizing unwanted thermal side-effects. The coagulation and ablation diameters were measured under microscope. The maximum ablation efficiency (100 × ablation diameter/coagulation diameter) was obtained when the Tm:YAP laser system was operated at 200 mW for 10 s. At this laser dose, the ablation efficiency was found to be 71.4% and 58.7% for cortical and subcortical regions, respectively. The fiber-coupled Tm:YAP laser system in hence proposed for the delivery of photothermal therapies in medical applications.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21484452</PMID><DateCreated><Year>2011</Year><Month>08</Month><Day>08</Day></DateCreated><DateCompleted><Year>2011</Year><Month>12</Month><Day>15</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1435-604X</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>5</Issue><PubDate><Year>2011</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Lasers in medical science</Title><ISOAbbreviation>Lasers Med Sci</ISOAbbreviation></Journal><ArticleTitle>Development of a thulium (Tm:YAP) laser system for brain tissue ablation.</ArticleTitle><Pagination><MedlinePgn>699-706</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10103-011-0915-0</ELocationID><Abstract><AbstractText>In this study, a thulium (Tm:YAP) laser system was developed for brain surgery applications. As the Tm:YAP laser is a continuous-wave laser delivered via silica fibers, it would have great potential for stereotaxic neurosurgery with highest local absorption in the IR region. The laser system developed in this study allowed the user to set the power level, exposure time, and modulation parameters (pulse width and on-off cycles). The Tm:YAP laser beam (200-600 mW, 69-208 W/cm(2)) was delivered from a distance of 2 mm to cortical and subcortical regions of ex-vivo Wistar rat brain tissue samples via a 200-μm-core optical fiber. The system performance, dosimetry study, and ablation characteristics of the Tm:YAP laser were tested at different power levels by maximizing the therapeutic effects and minimizing unwanted thermal side-effects. The coagulation and ablation diameters were measured under microscope. The maximum ablation efficiency (100 × ablation diameter/coagulation diameter) was obtained when the Tm:YAP laser system was operated at 200 mW for 10 s. At this laser dose, the ablation efficiency was found to be 71.4% and 58.7% for cortical and subcortical regions, respectively. The fiber-coupled Tm:YAP laser system in hence proposed for the delivery of photothermal therapies in medical applications.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bilici</LastName><ForeName>Temel</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Biophotonics Laboratory, Institute of Biomedical Engineering, Boğaziçi University, Kandilli Kampus, Cengelkoy, 34684, Istanbul, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mutlu</LastName><ForeName>Sevinc</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Kalaycioglu</LastName><ForeName>Hamit</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kurt</LastName><ForeName>Adnan</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Sennaroglu</LastName><ForeName>Alphan</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gulsoy</LastName><ForeName>Murat</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D023362">Evaluation Studies</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>04</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lasers Med Sci</MedlineTA><NlmUniqueID>8611515</NlmUniqueID><ISSNLinking>0268-8921</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance UI="D013932">Thulium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D066298">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D053685">Laser Therapy</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName><QualifierName MajorTopicYN="N" UI="Q000706">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017208">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013932">Thulium</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>11</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>3</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>4</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/s10103-011-0915-0</ArticleId><ArticleId IdType="pubmed">21484452</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Turquie</li></country></list><tree><noCountry><name sortKey="Gulsoy, Murat" sort="Gulsoy, Murat" uniqKey="Gulsoy M" first="Murat" last="Gulsoy">Murat Gulsoy</name><name sortKey="Kalaycioglu, Hamit" sort="Kalaycioglu, Hamit" uniqKey="Kalaycioglu H" first="Hamit" last="Kalaycioglu">Hamit Kalaycioglu</name><name sortKey="Kurt, Adnan" sort="Kurt, Adnan" uniqKey="Kurt A" first="Adnan" last="Kurt">Adnan Kurt</name><name sortKey="Mutlu, Sevinc" sort="Mutlu, Sevinc" uniqKey="Mutlu S" first="Sevinc" last="Mutlu">Sevinc Mutlu</name><name sortKey="Sennaroglu, Alphan" sort="Sennaroglu, Alphan" uniqKey="Sennaroglu A" first="Alphan" last="Sennaroglu">Alphan Sennaroglu</name></noCountry><country name="Turquie"><noRegion><name sortKey="Bilici, Temel" sort="Bilici, Temel" uniqKey="Bilici T" first="Temel" last="Bilici">Temel Bilici</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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