Thulium-170-labeled microparticles for local radiotherapy: preliminary studies.
Identifieur interne : 000139 ( PubMed/Checkpoint ); précédent : 000138; suivant : 000140Thulium-170-labeled microparticles for local radiotherapy: preliminary studies.
Auteurs : Andras Polyak [Hongrie] ; Tapas Das ; Sudipta Chakraborty ; Reka Kiraly ; Gabriella Dabasi ; Robert Peter Joba ; Csaba Jakab ; Julianna Thuroczy ; Zita Postenyi ; Veronika Haasz ; Gergely Janoki ; Gyozo A. Janoki ; Maroor R A. Pillai ; Lajos BaloghSource :
- Cancer biotherapy & radiopharmaceuticals [ 1557-8852 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Chiens, Membrane synoviale (effets des radiations), Mâle, Radio-isotopes (), Radio-isotopes (administration et posologie), Radiopharmaceutiques (), Radiopharmaceutiques (administration et posologie), Répartition dans les tissus, Synovite (radiothérapie), Taille de particule, Thulium (), Thulium (administration et posologie), Tomographie par émission monophotonique ().
- MESH :
- administration et posologie : Radio-isotopes, Radiopharmaceutiques, Thulium.
- effets des radiations : Membrane synoviale.
- radiothérapie : Synovite.
- Animaux, Chiens, Mâle, Radio-isotopes, Radiopharmaceutiques, Répartition dans les tissus, Taille de particule, Thulium, Tomographie par émission monophotonique.
English descriptors
- KwdEn :
- Animals, Dogs, Male, Particle Size, Radioisotopes (administration & dosage), Radioisotopes (chemistry), Radiopharmaceuticals (administration & dosage), Radiopharmaceuticals (chemistry), Synovial Membrane (radiation effects), Synovitis (radiotherapy), Thulium (administration & dosage), Thulium (chemistry), Tissue Distribution, Tomography, Emission-Computed, Single-Photon (methods).
- MESH :
- chemical , administration & dosage : Radioisotopes, Radiopharmaceuticals, Thulium.
- chemical , chemistry : Radioisotopes, Radiopharmaceuticals, Thulium.
- methods : Tomography, Emission-Computed, Single-Photon.
- radiation effects : Synovial Membrane.
- radiotherapy : Synovitis.
- Animals, Dogs, Male, Particle Size, Tissue Distribution.
Abstract
The present article describes the preparation, characterization, and biological evaluation of Thulium-170 ((170)Tm) [T1/2 = 128.4 days; Eβmax = 968 keV; Eγ = 84 keV (3.26%)] labeled tin oxide microparticles for its possible use in radiation synovectomy (RSV) of medium-sized joints. (170)Tm was produced by irradiation of natural thulium oxide target. 170Tm-labeled microparticles were synthesized with high yield and radionuclidic purity (> 99%) along with excellent in vitro stability by following a simple process. Particle sizes and morphology of the radiolabeled particles were examined by light microscope, dynamic light scattering, and transmission electron microscope and found to be of stable spherical morphology within the range of 1.4-3.2 μm. The preparation was injected into the knee joints of healthy Beagle dogs intraarticularly for biological studies. Serial whole-body and regional images were taken by single-photon-emission computed tomography (SPECT) and SPECT-CT cameras up to 9 months postadministration, which showed very low leakage (< 8% of I.D.) of the instilled particles. The majority of leaked radiocolloid particles were found in inguinal lymph nodes during the 9 months of follow-up. All the animals tolerated the treatment well; the compound did not show any possible radiotoxicological effect. These preliminary studies showed that 170Tm-labeled microparticles could be a promising nontoxic and effective radiopharmaceutical for RSV applications or later local antitumor therapy.
DOI: 10.1089/cbr.2014.1680
PubMed: 25226213
Affiliations:
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Research Institute for Radiobiology and Radiohygiene (NRIRR) , Budapest, Hungary .</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>1 National "F.J.C." Research Institute for Radiobiology and Radiohygiene (NRIRR) , Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Das, Tapas" sort="Das, Tapas" uniqKey="Das T" first="Tapas" last="Das">Tapas Das</name></author><author><name sortKey="Chakraborty, Sudipta" sort="Chakraborty, Sudipta" uniqKey="Chakraborty S" first="Sudipta" last="Chakraborty">Sudipta Chakraborty</name></author><author><name sortKey="Kiraly, Reka" sort="Kiraly, Reka" uniqKey="Kiraly R" first="Reka" last="Kiraly">Reka Kiraly</name></author><author><name sortKey="Dabasi, Gabriella" sort="Dabasi, Gabriella" uniqKey="Dabasi G" first="Gabriella" last="Dabasi">Gabriella Dabasi</name></author><author><name sortKey="Joba, Robert Peter" sort="Joba, Robert Peter" uniqKey="Joba R" first="Robert Peter" last="Joba">Robert Peter Joba</name></author><author><name sortKey="Jakab, Csaba" sort="Jakab, Csaba" uniqKey="Jakab C" first="Csaba" last="Jakab">Csaba Jakab</name></author><author><name sortKey="Thuroczy, Julianna" sort="Thuroczy, Julianna" uniqKey="Thuroczy J" first="Julianna" last="Thuroczy">Julianna Thuroczy</name></author><author><name sortKey="Postenyi, Zita" sort="Postenyi, Zita" uniqKey="Postenyi Z" first="Zita" last="Postenyi">Zita Postenyi</name></author><author><name sortKey="Haasz, Veronika" sort="Haasz, Veronika" uniqKey="Haasz V" first="Veronika" last="Haasz">Veronika Haasz</name></author><author><name sortKey="Janoki, Gergely" sort="Janoki, Gergely" uniqKey="Janoki G" first="Gergely" last="Janoki">Gergely Janoki</name></author><author><name sortKey="Janoki, Gyozo A" sort="Janoki, Gyozo A" uniqKey="Janoki G" first="Gyozo A" last="Janoki">Gyozo A. Janoki</name></author><author><name sortKey="Pillai, Maroor R A" sort="Pillai, Maroor R A" uniqKey="Pillai M" first="Maroor R A" last="Pillai">Maroor R A. Pillai</name></author><author><name sortKey="Balogh, Lajos" sort="Balogh, Lajos" uniqKey="Balogh L" first="Lajos" last="Balogh">Lajos Balogh</name></author></analytic><series><title level="j">Cancer biotherapy & radiopharmaceuticals</title><idno type="eISSN">1557-8852</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Male</term><term>Particle Size</term><term>Radioisotopes (administration & dosage)</term><term>Radioisotopes (chemistry)</term><term>Radiopharmaceuticals (administration & dosage)</term><term>Radiopharmaceuticals (chemistry)</term><term>Synovial Membrane (radiation effects)</term><term>Synovitis (radiotherapy)</term><term>Thulium (administration & dosage)</term><term>Thulium (chemistry)</term><term>Tissue Distribution</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Membrane synoviale (effets des radiations)</term><term>Mâle</term><term>Radio-isotopes ()</term><term>Radio-isotopes (administration et posologie)</term><term>Radiopharmaceutiques ()</term><term>Radiopharmaceutiques (administration et posologie)</term><term>Répartition dans les tissus</term><term>Synovite (radiothérapie)</term><term>Taille de particule</term><term>Thulium ()</term><term>Thulium (administration et posologie)</term><term>Tomographie par émission monophotonique ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Radioisotopes</term><term>Radiopharmaceuticals</term><term>Thulium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Radioisotopes</term><term>Radiopharmaceuticals</term><term>Thulium</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Radio-isotopes</term><term>Radiopharmaceutiques</term><term>Thulium</term></keywords><keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Membrane synoviale</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Synovial Membrane</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Synovitis</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Synovite</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dogs</term><term>Male</term><term>Particle Size</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chiens</term><term>Mâle</term><term>Radio-isotopes</term><term>Radiopharmaceutiques</term><term>Répartition dans les tissus</term><term>Taille de particule</term><term>Thulium</term><term>Tomographie par émission monophotonique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present article describes the preparation, characterization, and biological evaluation of Thulium-170 ((170)Tm) [T1/2 = 128.4 days; Eβmax = 968 keV; Eγ = 84 keV (3.26%)] labeled tin oxide microparticles for its possible use in radiation synovectomy (RSV) of medium-sized joints. (170)Tm was produced by irradiation of natural thulium oxide target. 170Tm-labeled microparticles were synthesized with high yield and radionuclidic purity (> 99%) along with excellent in vitro stability by following a simple process. Particle sizes and morphology of the radiolabeled particles were examined by light microscope, dynamic light scattering, and transmission electron microscope and found to be of stable spherical morphology within the range of 1.4-3.2 μm. The preparation was injected into the knee joints of healthy Beagle dogs intraarticularly for biological studies. Serial whole-body and regional images were taken by single-photon-emission computed tomography (SPECT) and SPECT-CT cameras up to 9 months postadministration, which showed very low leakage (< 8% of I.D.) of the instilled particles. The majority of leaked radiocolloid particles were found in inguinal lymph nodes during the 9 months of follow-up. All the animals tolerated the treatment well; the compound did not show any possible radiotoxicological effect. These preliminary studies showed that 170Tm-labeled microparticles could be a promising nontoxic and effective radiopharmaceutical for RSV applications or later local antitumor therapy.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25226213</PMID><DateCreated><Year>2014</Year><Month>10</Month><Day>04</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>07</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-8852</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Cancer biotherapy & radiopharmaceuticals</Title><ISOAbbreviation>Cancer Biother. Radiopharm.</ISOAbbreviation></Journal><ArticleTitle>Thulium-170-labeled microparticles for local radiotherapy: preliminary studies.</ArticleTitle><Pagination><MedlinePgn>330-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/cbr.2014.1680</ELocationID><Abstract><AbstractText>The present article describes the preparation, characterization, and biological evaluation of Thulium-170 ((170)Tm) [T1/2 = 128.4 days; Eβmax = 968 keV; Eγ = 84 keV (3.26%)] labeled tin oxide microparticles for its possible use in radiation synovectomy (RSV) of medium-sized joints. (170)Tm was produced by irradiation of natural thulium oxide target. 170Tm-labeled microparticles were synthesized with high yield and radionuclidic purity (> 99%) along with excellent in vitro stability by following a simple process. Particle sizes and morphology of the radiolabeled particles were examined by light microscope, dynamic light scattering, and transmission electron microscope and found to be of stable spherical morphology within the range of 1.4-3.2 μm. The preparation was injected into the knee joints of healthy Beagle dogs intraarticularly for biological studies. Serial whole-body and regional images were taken by single-photon-emission computed tomography (SPECT) and SPECT-CT cameras up to 9 months postadministration, which showed very low leakage (< 8% of I.D.) of the instilled particles. The majority of leaked radiocolloid particles were found in inguinal lymph nodes during the 9 months of follow-up. All the animals tolerated the treatment well; the compound did not show any possible radiotoxicological effect. These preliminary studies showed that 170Tm-labeled microparticles could be a promising nontoxic and effective radiopharmaceutical for RSV applications or later local antitumor therapy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Polyak</LastName><ForeName>Andras</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>1 National "F.J.C." Research Institute for Radiobiology and Radiohygiene (NRIRR) , Budapest, Hungary .</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Das</LastName><ForeName>Tapas</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Chakraborty</LastName><ForeName>Sudipta</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Kiraly</LastName><ForeName>Reka</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Dabasi</LastName><ForeName>Gabriella</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Joba</LastName><ForeName>Robert Peter</ForeName><Initials>RP</Initials></Author><Author ValidYN="Y"><LastName>Jakab</LastName><ForeName>Csaba</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Thuroczy</LastName><ForeName>Julianna</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Postenyi</LastName><ForeName>Zita</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Haasz</LastName><ForeName>Veronika</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Janoki</LastName><ForeName>Gergely</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Janoki</LastName><ForeName>Gyozo A</ForeName><Initials>GA</Initials></Author><Author ValidYN="Y"><LastName>Pillai</LastName><ForeName>Maroor R A</ForeName><Initials>MR</Initials></Author><Author ValidYN="Y"><LastName>Balogh</LastName><ForeName>Lajos</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>09</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Biother Radiopharm</MedlineTA><NlmUniqueID>9605408</NlmUniqueID><ISSNLinking>1084-9785</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011868">Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>12036-44-1</RegistryNumber><NameOfSubstance UI="C033160">thulium oxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance UI="D013932">Thulium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004285">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010316">Particle Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011868">Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000008">administration & dosage</QualifierName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019275">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000008">administration & dosage</QualifierName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013583">Synovial Membrane</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000528">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013585">Synovitis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000532">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013932">Thulium</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000008">administration & dosage</QualifierName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014018">Tissue Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015899">Tomography, Emission-Computed, Single-Photon</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000379">methods</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Beagle dogs</Keyword><Keyword MajorTopicYN="N">Thulium-170</Keyword><Keyword MajorTopicYN="N">labeled microparticles</Keyword><Keyword MajorTopicYN="N">radiation synovectomy</Keyword><Keyword MajorTopicYN="N">radionuclide therapy</Keyword><Keyword MajorTopicYN="N">radiotherapy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>9</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>9</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>9</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25226213</ArticleId><ArticleId IdType="doi">10.1089/cbr.2014.1680</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Hongrie</li></country><region><li>Hongrie centrale</li></region><settlement><li>Budapest</li></settlement></list><tree><noCountry><name sortKey="Balogh, Lajos" sort="Balogh, Lajos" uniqKey="Balogh L" first="Lajos" last="Balogh">Lajos Balogh</name><name sortKey="Chakraborty, Sudipta" sort="Chakraborty, Sudipta" uniqKey="Chakraborty S" first="Sudipta" last="Chakraborty">Sudipta Chakraborty</name><name sortKey="Dabasi, Gabriella" sort="Dabasi, Gabriella" uniqKey="Dabasi G" first="Gabriella" last="Dabasi">Gabriella Dabasi</name><name sortKey="Das, Tapas" sort="Das, Tapas" uniqKey="Das T" first="Tapas" last="Das">Tapas Das</name><name sortKey="Haasz, Veronika" sort="Haasz, Veronika" uniqKey="Haasz V" first="Veronika" last="Haasz">Veronika Haasz</name><name sortKey="Jakab, Csaba" sort="Jakab, Csaba" uniqKey="Jakab C" first="Csaba" last="Jakab">Csaba Jakab</name><name sortKey="Janoki, Gergely" sort="Janoki, Gergely" uniqKey="Janoki G" first="Gergely" last="Janoki">Gergely Janoki</name><name sortKey="Janoki, Gyozo A" sort="Janoki, Gyozo A" uniqKey="Janoki G" first="Gyozo A" last="Janoki">Gyozo A. Janoki</name><name sortKey="Joba, Robert Peter" sort="Joba, Robert Peter" uniqKey="Joba R" first="Robert Peter" last="Joba">Robert Peter Joba</name><name sortKey="Kiraly, Reka" sort="Kiraly, Reka" uniqKey="Kiraly R" first="Reka" last="Kiraly">Reka Kiraly</name><name sortKey="Pillai, Maroor R A" sort="Pillai, Maroor R A" uniqKey="Pillai M" first="Maroor R A" last="Pillai">Maroor R A. Pillai</name><name sortKey="Postenyi, Zita" sort="Postenyi, Zita" uniqKey="Postenyi Z" first="Zita" last="Postenyi">Zita Postenyi</name><name sortKey="Thuroczy, Julianna" sort="Thuroczy, Julianna" uniqKey="Thuroczy J" first="Julianna" last="Thuroczy">Julianna Thuroczy</name></noCountry><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Polyak, Andras" sort="Polyak, Andras" uniqKey="Polyak A" first="Andras" last="Polyak">Andras Polyak</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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