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Molecular Body Imaging: MR Imaging, CT, and US. Part I. Principles

Identifieur interne : 000402 ( Pmc/Curation ); précédent : 000401; suivant : 000403

Molecular Body Imaging: MR Imaging, CT, and US. Part I. Principles

Auteurs : Moritz F. Kircher ; Jürgen K. Willmann

Source :

RBID : PMC:3359513

Abstract

It will take a large multi- and interdisciplinary team consisting of experts with diverse training backgrounds, such as material scientists, chemists, biologists, pharmacologists, electrical engineers, mathematicians, and clinicians, working efficiently hand in hand with regulators to make the prospect of more widespread use of MR-, CT-, and US-based molecular imaging methods a reality in the clinical arena.


Url:
DOI: 10.1148/radiol.12102394
PubMed: 22623690
PubMed Central: 3359513

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PMC:3359513

Le document en format XML

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<name sortKey="Willmann, Jurgen K" sort="Willmann, Jurgen K" uniqKey="Willmann J" first="Jürgen K." last="Willmann">Jürgen K. Willmann</name>
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<title level="j">Radiology</title>
<idno type="ISSN">0033-8419</idno>
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<p>It will take a large multi- and interdisciplinary team consisting of experts with diverse training backgrounds, such as material scientists, chemists, biologists, pharmacologists, electrical engineers, mathematicians, and clinicians, working efficiently hand in hand with regulators to make the prospect of more widespread use of MR-, CT-, and US-based molecular imaging methods a reality in the clinical arena.</p>
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<journal-id journal-id-type="nlm-ta">Radiology</journal-id>
<journal-id journal-id-type="iso-abbrev">Radiology</journal-id>
<journal-id journal-id-type="hwp">radiology</journal-id>
<journal-id journal-id-type="pmc">radiology</journal-id>
<journal-id journal-id-type="publisher-id">Radiology</journal-id>
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<journal-title>Radiology</journal-title>
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<issn pub-type="ppub">0033-8419</issn>
<issn pub-type="epub">1527-1315</issn>
<publisher>
<publisher-name>Radiological Society of North America, Inc.</publisher-name>
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<article-id pub-id-type="doi">10.1148/radiol.12102394</article-id>
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<subject>26</subject>
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<subject>Reviews And Commentary</subject>
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<subject>State of the Art</subject>
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<title-group>
<article-title>Molecular Body Imaging: MR Imaging, CT, and US. Part I. Principles</article-title>
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<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Kircher</surname>
<given-names>Moritz F.</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Willmann</surname>
<given-names>Jürgen K.</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<aff id="aff1">From the Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY (M.F.K.); and Department of Radiology and Molecular Imaging Program at Stanford, Stanford University School of Medicine, 300 Pasteur Dr, Room H1307, Stanford, CA 94305-5621 (J.K.W.).</aff>
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<author-notes>
<corresp id="cor1">
<bold>Address correspondence to</bold>
J.K.W. (e-mail:
<italic>
<email>willmann@stanford.edu</email>
</italic>
).</corresp>
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<pub-date pub-type="ppub">
<month>6</month>
<year>2012</year>
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<month>6</month>
<year>2012</year>
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<month>6</month>
<year>2013</year>
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<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the . </pmc-comment>
<volume>263</volume>
<issue>3</issue>
<fpage>633</fpage>
<lpage>643</lpage>
<permissions>
<copyright-statement>© RSNA, 2012</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
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<abstract abstract-type="precis">
<p>It will take a large multi- and interdisciplinary team consisting of experts with diverse training backgrounds, such as material scientists, chemists, biologists, pharmacologists, electrical engineers, mathematicians, and clinicians, working efficiently hand in hand with regulators to make the prospect of more widespread use of MR-, CT-, and US-based molecular imaging methods a reality in the clinical arena.</p>
</abstract>
<abstract>
<p>Molecular imaging, generally defined as noninvasive imaging of cellular and subcellular events, has gained tremendous depth and breadth as a research and clinical discipline in recent years. The coalescence of major advances in engineering, molecular biology, chemistry, immunology, and genetics has fueled multi- and interdisciplinary innovations with the goal of driving clinical noninvasive imaging strategies that will ultimately allow disease identification, risk stratification, and monitoring of therapy effects with unparalleled sensitivity and specificity. Techniques that allow imaging of molecular and cellular events facilitate and go hand in hand with the development of molecular therapies, offering promise for successfully combining imaging with therapy. While traditionally nuclear medicine imaging techniques, in particular positron emission tomography (PET), PET combined with computed tomography (CT), and single photon emission computed tomography, have been the molecular imaging methods most familiar to clinicians, great advances have recently been made in developing imaging techniques that utilize magnetic resonance (MR), optical, CT, and ultrasonographic (US) imaging. In the first part of this review series, we present an overview of the principles of MR imaging-, CT-, and US-based molecular imaging strategies.</p>
<p>© RSNA, 2012</p>
</abstract>
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