Upconversion Nanophosphors Naluf4:Yb,Tm for Lymphatic Imaging In Vivo by Real-Time Upconversion Luminescence Imaging under Ambient Light and High-Resolution X-ray CT
Identifieur interne : 000397 ( Pmc/Curation ); précédent : 000396; suivant : 000398Upconversion Nanophosphors Naluf4:Yb,Tm for Lymphatic Imaging In Vivo by Real-Time Upconversion Luminescence Imaging under Ambient Light and High-Resolution X-ray CT
Auteurs : Yun Sun ; Juanjuan Peng ; Wei Feng ; Fuyou LiSource :
- Theranostics [ 1838-7640 ] ; 2013.
Abstract
Lanthanide upconversion nanophosphor (UCNP) has attracted increasing attention for potential applications in bioimaging due to its excellence in deep and high contrast imaging. To date, most upconversion imaging applications were demonstrated in dark surroundings without ambient light for higher signal-to-noise ratio, which hindered the application of optical imaging guided surgery. Herein, the new established NaLuF4-based UCNP (NaLuF4:Yb,Tm, ~17 nm) with bright upconversion emission around 800 nm as imaging signal was used to realize imaging under ambient light to provide more convenient for clinician. Moreover, due to the existance of heavy element lutetium (Lu) in the host lattice, the NaLuF4:Yb,Tm nanoparticles can also be used as an X-ray CT imaging agent to enhance the imaging depth and
Url:
DOI: 10.7150/thno.5137
PubMed: 23650481
PubMed Central: 3645060
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Upconversion Nanophosphors Naluf<sub>4</sub>:Yb,Tm for Lymphatic Imaging <italic>In Vivo</italic> by Real-Time Upconversion Luminescence Imaging under Ambient Light and High-Resolution X-ray CT</title><author><name sortKey="Sun, Yun" sort="Sun, Yun" uniqKey="Sun Y" first="Yun" last="Sun">Yun Sun</name></author><author><name sortKey="Peng, Juanjuan" sort="Peng, Juanjuan" uniqKey="Peng J" first="Juanjuan" last="Peng">Juanjuan Peng</name></author><author><name sortKey="Feng, Wei" sort="Feng, Wei" uniqKey="Feng W" first="Wei" last="Feng">Wei Feng</name></author><author><name sortKey="Li, Fuyou" sort="Li, Fuyou" uniqKey="Li F" first="Fuyou" last="Li">Fuyou Li</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23650481</idno><idno type="pmc">3645060</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645060</idno><idno type="RBID">PMC:3645060</idno><idno type="doi">10.7150/thno.5137</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000397</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000397</idno><idno type="wicri:Area/Pmc/Curation">000397</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000397</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Upconversion Nanophosphors Naluf<sub>4</sub>:Yb,Tm for Lymphatic Imaging <italic>In Vivo</italic> by Real-Time Upconversion Luminescence Imaging under Ambient Light and High-Resolution X-ray CT</title><author><name sortKey="Sun, Yun" sort="Sun, Yun" uniqKey="Sun Y" first="Yun" last="Sun">Yun Sun</name></author><author><name sortKey="Peng, Juanjuan" sort="Peng, Juanjuan" uniqKey="Peng J" first="Juanjuan" last="Peng">Juanjuan Peng</name></author><author><name sortKey="Feng, Wei" sort="Feng, Wei" uniqKey="Feng W" first="Wei" last="Feng">Wei Feng</name></author><author><name sortKey="Li, Fuyou" sort="Li, Fuyou" uniqKey="Li F" first="Fuyou" last="Li">Fuyou Li</name></author></analytic><series><title level="j">Theranostics</title><idno type="eISSN">1838-7640</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lanthanide upconversion nanophosphor (UCNP) has attracted increasing attention for potential applications in bioimaging due to its excellence in deep and high contrast imaging. To date, most upconversion imaging applications were demonstrated in dark surroundings without ambient light for higher signal-to-noise ratio, which hindered the application of optical imaging guided surgery. Herein, the new established NaLuF<sub>4</sub>-based UCNP (NaLuF<sub>4</sub>:Yb,Tm, ~17 nm) with bright upconversion emission around 800 nm as imaging signal was used to realize imaging under ambient light to provide more convenient for clinician. Moreover, due to the existance of heavy element lutetium (Lu) in the host lattice, the NaLuF<sub>4</sub>:Yb,Tm nanoparticles can also be used as an X-ray CT imaging agent to enhance the imaging depth and <italic>in vivo </italic>imaging resolution.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, Iy" uniqKey="Chen I">IY Chen</name></author><author><name sortKey="Wu, Jc" uniqKey="Wu J">JC Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, M" uniqKey="He M">M He</name></author><author><name sortKey="Huang, P" uniqKey="Huang P">P Huang</name></author><author><name sortKey="Zhang, Cl" uniqKey="Zhang C">CL Zhang</name></author><author><name sortKey="Hu, Hy" uniqKey="Hu H">HY Hu</name></author><author><name sortKey="Bao, Cc" uniqKey="Bao C">CC Bao</name></author><author><name sortKey="Gao, G" uniqKey="Gao G">G Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Theranostics</journal-id><journal-id journal-id-type="iso-abbrev">Theranostics</journal-id><journal-id journal-id-type="publisher-id">thno</journal-id><journal-title-group><journal-title>Theranostics</journal-title></journal-title-group><issn pub-type="epub">1838-7640</issn><publisher><publisher-name>Ivyspring International Publisher</publisher-name><publisher-loc>Sydney</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23650481</article-id><article-id pub-id-type="pmc">3645060</article-id><article-id pub-id-type="doi">10.7150/thno.5137</article-id><article-id pub-id-type="publisher-id">thnov03p0346</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group></article-categories><title-group><article-title>Upconversion Nanophosphors Naluf<sub>4</sub>:Yb,Tm for Lymphatic Imaging <italic>In Vivo</italic> by Real-Time Upconversion Luminescence Imaging under Ambient Light and High-Resolution X-ray CT</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sun</surname><given-names>Yun</given-names></name></contrib><contrib contrib-type="author"><name><surname>Peng</surname><given-names>Juanjuan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Feng</surname><given-names>Wei</given-names></name></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Fuyou</given-names></name><xref ref-type="corresp" rid="FNA_envelop">✉</xref></contrib></contrib-group><aff>Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P.R. China</aff><author-notes><corresp id="FNA_envelop">✉ Corresponding author: Fuyou Li, Email: <email>fyli@fudan.edu.cn</email></corresp><fn fn-type="conflict"><p>Competing Interests: The authors have declared that no competing interest exists.</p></fn></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>23</day><month>4</month><year>2013</year></pub-date><volume>3</volume><issue>5</issue><fpage>346</fpage><lpage>353</lpage><history><date date-type="received"><day>31</day><month>8</month><year>2012</year></date><date date-type="accepted"><day>9</day><month>10</month><year>2012</year></date></history><permissions><copyright-statement>© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p>Lanthanide upconversion nanophosphor (UCNP) has attracted increasing attention for potential applications in bioimaging due to its excellence in deep and high contrast imaging. To date, most upconversion imaging applications were demonstrated in dark surroundings without ambient light for higher signal-to-noise ratio, which hindered the application of optical imaging guided surgery. Herein, the new established NaLuF<sub>4</sub>-based UCNP (NaLuF<sub>4</sub>:Yb,Tm, ~17 nm) with bright upconversion emission around 800 nm as imaging signal was used to realize imaging under ambient light to provide more convenient for clinician. Moreover, due to the existance of heavy element lutetium (Lu) in the host lattice, the NaLuF<sub>4</sub>:Yb,Tm nanoparticles can also be used as an X-ray CT imaging agent to enhance the imaging depth and <italic>in vivo </italic>imaging resolution.</p></abstract><kwd-group><kwd>Lanthanide</kwd><kwd>upconversion luminescence</kwd><kwd>lutetium</kwd><kwd>computed tomography</kwd><kwd>bioimaging</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" position="float"><label>Figure 1</label><caption><p>(a) TEM image, (b) paticle size distribution, (c) XRD patterns, (d) EDXA of OA-NaLuF<sub>4</sub>:Yb,Tm nanoparticles.</p></caption><graphic xlink:href="thnov03p0346g01"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>The UCL emission spectrum and photo (inset) of the OA-NaLuF<sub>4</sub>:Yb,Tm in cyclohexane solution under excitation at CW 980 nm.</p></caption><graphic xlink:href="thnov03p0346g02"></graphic></fig><fig id="F3" position="float"><label>Figure 3</label><caption><p>(a) The scheme depicts <italic>in vivo</italic> UCL imaging under lamp light. Eight external 0-5 W adjustable CW 980 nm lasers were used as the ring shaped excitation sources, and a lamp as lighting system. An Andor DU897 EMCCD with an 800 nm bandpass filter was used as the signal collector. The UCL imaging of a whole-body animal could be achieved without cutting out ambient light due to the excellent UCL emission at 800 nm of NaLuF<sub>4</sub>:Yb,Tm. (b) The luminescence spectrum of a normal lamp and UCL spectrum of NaLuF<sub>4</sub>:Yb,Tm nanoparticles.</p></caption><graphic xlink:href="thnov03p0346g03"></graphic></fig><fig id="F4" position="float"><label>Figure 4</label><caption><p>(a) <italic>In vivo </italic>UCL imaging of the lymphatic vessel of the cit-NaLuF<sub>4</sub>:Yb,Tm-injected mouse upon irradiation at 980 nm laser in the presence of ambient lamp. (b) Quantitative analysis of UCL intensity in the identified area shown in (a).</p></caption><graphic xlink:href="thnov03p0346g04"></graphic></fig><fig id="F5" position="float"><label>Figure 5</label><caption><p>HU value to various concentration of iopromide (gray) and cit-NaLuF<sub>4</sub>:Yb,Tm (red) at room temperature detected by a Siemens CT.</p></caption><graphic xlink:href="thnov03p0346g05"></graphic></fig><fig id="F6" position="float"><label>Figure 6</label><caption><p>3D reconstruction (a) and raw data (b) of <italic>in vivo</italic> CT imaging of the lymphatic vessel of mouse injected with cit-NaLuF<sub>4</sub>:Yb,Tm. Red line in 6a is the simulated lymphatic vessel in 6b. (c) Some special cross sections shown in 6b.</p></caption><graphic xlink:href="thnov03p0346g06"></graphic></fig><fig id="F7" position="float"><label>Figure 7</label><caption><p><italic> In vitro </italic>toxicity assessment of cit-NaLuF<sub>4</sub>:Yb,Tm by MTT assay.</p></caption><graphic xlink:href="thnov03p0346g07"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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