Somatotopy of placebo analgesia is independent of spatial attention
Identifieur interne : 000375 ( Pmc/Curation ); précédent : 000374; suivant : 000376Somatotopy of placebo analgesia is independent of spatial attention
Auteurs : Claudia Domnick [Allemagne] ; Jürgen Lorenz [Allemagne] ; Michael Hauck [Allemagne]Source :
- Journal of Pain Research [ 1178-7090 ] ; 2011.
Abstract
Placebo analgesia is being increasingly appraised as an effective support of pharmacological and surgical treatments of pain. The understanding of its neurobiological and psychological basis is therefore of high clinical relevance. It has been shown that placebo analgesia is somatotopically organized and relies on endogenous opioids. However, it is not clear whether temporal fluctuations of cue-dependent spatial attention account for the site specificity of placebo analgesia or whether a somatotopic placebo effect is possible without an attentional focus on the respective location. To address this issue we induced placebo expectations for one specific foot in healthy subjects, the other foot serving as a control location. The feet were stimulated in random order by painful laser stimuli. Half of the pulses were cued for stimulus location, whereas in the other half of trials the subjects were naïve about the location. We found that about half of the subjects exhibited a somatotopic placebo effect that was statistically independent of the spatial cue. We suggest that, after the induction of an initial expectation, placebo analgesia is spatially specific but does not necessarily depend on momentary fluctuations of spatial attention. This result rather suggests that the somatotopy of placebo analgesia relies on the creation of spatially guided expectations or conditioning, but can be maintained without ongoing monitoring of the affected body part.
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DOI: 10.2147/JPR.S16610
PubMed: 21559353
PubMed Central: 3085266
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Somatotopy of placebo analgesia is independent of spatial attention</title><author><name sortKey="Domnick, Claudia" sort="Domnick, Claudia" uniqKey="Domnick C" first="Claudia" last="Domnick">Claudia Domnick</name><affiliation wicri:level="1"><nlm:aff id="af1-jpr-4-079">Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Lorenz, Jurgen" sort="Lorenz, Jurgen" uniqKey="Lorenz J" first="Jürgen" last="Lorenz">Jürgen Lorenz</name><affiliation wicri:level="1"><nlm:aff id="af2-jpr-4-079">Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Hauck, Michael" sort="Hauck, Michael" uniqKey="Hauck M" first="Michael" last="Hauck">Michael Hauck</name><affiliation wicri:level="1"><nlm:aff id="af1-jpr-4-079">Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-jpr-4-079">Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21559353</idno><idno type="pmc">3085266</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085266</idno><idno type="RBID">PMC:3085266</idno><idno type="doi">10.2147/JPR.S16610</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000375</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000375</idno><idno type="wicri:Area/Pmc/Curation">000375</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000375</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Somatotopy of placebo analgesia is independent of spatial attention</title><author><name sortKey="Domnick, Claudia" sort="Domnick, Claudia" uniqKey="Domnick C" first="Claudia" last="Domnick">Claudia Domnick</name><affiliation wicri:level="1"><nlm:aff id="af1-jpr-4-079">Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Lorenz, Jurgen" sort="Lorenz, Jurgen" uniqKey="Lorenz J" first="Jürgen" last="Lorenz">Jürgen Lorenz</name><affiliation wicri:level="1"><nlm:aff id="af2-jpr-4-079">Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Hauck, Michael" sort="Hauck, Michael" uniqKey="Hauck M" first="Michael" last="Hauck">Michael Hauck</name><affiliation wicri:level="1"><nlm:aff id="af1-jpr-4-079">Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-jpr-4-079">Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Pain Research</title><idno type="eISSN">1178-7090</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Placebo analgesia is being increasingly appraised as an effective support of pharmacological and surgical treatments of pain. The understanding of its neurobiological and psychological basis is therefore of high clinical relevance. It has been shown that placebo analgesia is somatotopically organized and relies on endogenous opioids. However, it is not clear whether temporal fluctuations of cue-dependent spatial attention account for the site specificity of placebo analgesia or whether a somatotopic placebo effect is possible without an attentional focus on the respective location. To address this issue we induced placebo expectations for one specific foot in healthy subjects, the other foot serving as a control location. The feet were stimulated in random order by painful laser stimuli. Half of the pulses were cued for stimulus location, whereas in the other half of trials the subjects were naïve about the location. We found that about half of the subjects exhibited a somatotopic placebo effect that was statistically independent of the spatial cue. We suggest that, after the induction of an initial expectation, placebo analgesia is spatially specific but does not necessarily depend on momentary fluctuations of spatial attention. This result rather suggests that the somatotopy of placebo analgesia relies on the creation of spatially guided expectations or conditioning, but can be maintained without ongoing monitoring of the affected body part.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fields, Hl" uniqKey="Fields H">HL Fields</name></author><author><name sortKey="Price, Dd" uniqKey="Price D">DD Price</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oeltjenbruns, J" uniqKey="Oeltjenbruns J">J Oeltjenbruns</name></author><author><name sortKey="Schafer, M" uniqKey="Schafer M">M Schafer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, Dd" uniqKey="Price D">DD Price</name></author><author><name sortKey="Milling, Ls" uniqKey="Milling L">LS Milling</name></author><author><name sortKey="Kirsch, I" uniqKey="Kirsch I">I Kirsch</name></author><author><name sortKey="Duff, A" uniqKey="Duff A">A Duff</name></author><author><name sortKey="Montgomery, Gh" uniqKey="Montgomery G">GH Montgomery</name></author><author><name sortKey="Nicholls, Ss" uniqKey="Nicholls S">SS Nicholls</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voudouris, Nj" uniqKey="Voudouris N">NJ Voudouris</name></author><author><name sortKey="Peck, Cl" uniqKey="Peck C">CL Peck</name></author><author><name sortKey="Coleman, G" uniqKey="Coleman G">G Coleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amanzio, M" uniqKey="Amanzio M">M Amanzio</name></author><author><name sortKey="Benedetti, F" uniqKey="Benedetti F">F Benedetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wager, Td" uniqKey="Wager T">TD Wager</name></author><author><name sortKey="Rilling, Jk" uniqKey="Rilling J">JK Rilling</name></author><author><name sortKey="Smith, Ee" uniqKey="Smith E">EE 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Pain Res</journal-id><journal-title-group><journal-title>Journal of Pain Research</journal-title></journal-title-group><issn pub-type="epub">1178-7090</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21559353</article-id><article-id pub-id-type="pmc">3085266</article-id><article-id pub-id-type="doi">10.2147/JPR.S16610</article-id><article-id pub-id-type="publisher-id">jpr-4-079</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Somatotopy of placebo analgesia is independent of spatial attention</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Domnick</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="af1-jpr-4-079"><sup>1</sup></xref><xref ref-type="corresp" rid="c1-jpr-4-079"></xref></contrib><contrib contrib-type="author"><name><surname>Lorenz</surname><given-names>Jürgen</given-names></name><xref ref-type="aff" rid="af2-jpr-4-079"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hauck</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="af1-jpr-4-079"><sup>1</sup></xref><xref ref-type="aff" rid="af3-jpr-4-079"><sup>3</sup></xref></contrib></contrib-group><aff id="af1-jpr-4-079"><label>1</label>Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;</aff><aff id="af2-jpr-4-079"><label>2</label>Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg, Germany;</aff><aff id="af3-jpr-4-079"><label>3</label>Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</aff><author-notes><corresp id="c1-jpr-4-079">Correspondence: Claudia Domnick, Martinistrasse 52, 20246 Hamburg, Germany, Tel +49 40 7410 56170, Fax +49 40 7410 57752, Email <email>c.domnick@uke.uni-hamburg.de</email></corresp></author-notes><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>24</day><month>3</month><year>2011</year></pub-date><volume>4</volume><fpage>79</fpage><lpage>83</lpage><history><date date-type="received"><day>23</day><month>3</month><year>2011</year></date></history><permissions><copyright-statement>© 2011 Domnick et al, publisher and licensee Dove Medical Press Ltd.</copyright-statement><license><license-p>This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Placebo analgesia is being increasingly appraised as an effective support of pharmacological and surgical treatments of pain. The understanding of its neurobiological and psychological basis is therefore of high clinical relevance. It has been shown that placebo analgesia is somatotopically organized and relies on endogenous opioids. However, it is not clear whether temporal fluctuations of cue-dependent spatial attention account for the site specificity of placebo analgesia or whether a somatotopic placebo effect is possible without an attentional focus on the respective location. To address this issue we induced placebo expectations for one specific foot in healthy subjects, the other foot serving as a control location. The feet were stimulated in random order by painful laser stimuli. Half of the pulses were cued for stimulus location, whereas in the other half of trials the subjects were naïve about the location. We found that about half of the subjects exhibited a somatotopic placebo effect that was statistically independent of the spatial cue. We suggest that, after the induction of an initial expectation, placebo analgesia is spatially specific but does not necessarily depend on momentary fluctuations of spatial attention. This result rather suggests that the somatotopy of placebo analgesia relies on the creation of spatially guided expectations or conditioning, but can be maintained without ongoing monitoring of the affected body part.</p></abstract><kwd-group><kwd>placebo analgesia</kwd><kwd>spatial attention</kwd><kwd>somatotopy</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-jpr-4-079" position="float"><label>Figure 1</label><caption><p>Experimental design. <bold>A</bold>) An inert cream was applied to both feet while subjects were told that one particular foot was treated by lidocaine. <bold>B</bold>) During the conditioning blocks, low intensity laser pulses were delivered to the placebo foot while the control foot was stimulated by high intensity pulses. All trials contained a cue about the stimulus location. During the experimental blocks, both feet were stimulated by high intensity laser pulses and only half of the trials contained information about the stimulus location. <bold>C</bold>) At the beginning of the trial, a visual cue (informative vs non-informative) preceded the laser stimulus that had to be rated on a visual analog scale 3 seconds later.</p></caption><graphic xlink:href="jpr-4-079f1"></graphic></fig><fig id="f2-jpr-4-079" position="float"><label>Figure 2</label><caption><p>Group statistic for the placebo responders. Pain ratings in the placebo condition are significantly lower than in the control condition. Note that the relief by the placebo treatment is independent of the type of cue.</p></caption><graphic xlink:href="jpr-4-079f2"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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