Attenuation of N2 amplitude of laser-evoked potentials by theta burst stimulation of primary somatosensory cortex
Identifieur interne : 000189 ( Pmc/Curation ); précédent : 000188; suivant : 000190Attenuation of N2 amplitude of laser-evoked potentials by theta burst stimulation of primary somatosensory cortex
Auteurs : Csaba Poreisz [Allemagne] ; Andrea Antal [Allemagne] ; Klára Boros [Allemagne] ; Nadine Brepohl [Allemagne] ; Gábor Csifcsák [Allemagne, Hongrie] ; Walter Paulus [Allemagne]Source :
- Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale [ 0014-4819 ] ; 2007.
Abstract
Theta burst stimulation (TBS) is a special repetitive transcranial magnetic stimulation (rTMS) paradigm, where bursts of low-intensity stimuli are applied in the theta frequency. The aim of this study was to investigate the effect of neuronavigated TBS over primary somatosensory cortex (SI) on laser-evoked potentials (LEPs) and acute pain perception induced with Tm : YAG laser stimulation. The amplitude changes of the N1, N2, and P2 components of LEPs and related subjective pain rating scores of 12 healthy subjects were analyzed prior to and following continuous TBS (cTBS), intermittent TBS (iTBS), intermediate TBS (imTBS), and sham stimulation. Our results demonstrate that all active TBS paradigms significantly diminished the amplitude of the N2 component, when the hand contralateral to the site of TBS was laser-stimulated. Sham stimulation condition had no significant effect. The subjective pain perception also decreased during the experimental sessions, but did not differ significantly from the sham stimulation condition. The main finding of our study is that TBS over SI diminished the amplitude of the N2 component evoked from the contralateral side without any significant analgesic effects. Furthermore, imTBS produced responses similar to those observed by other forms of TBS induced excitability changes in the SI.
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DOI: 10.1007/s00221-007-1188-5
PubMed: 18043910
PubMed Central: 2248215
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37075 Göttingen</wicri:regionArea></affiliation></author><author><name sortKey="Antal, Andrea" sort="Antal, Andrea" uniqKey="Antal A" first="Andrea" last="Antal">Andrea Antal</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Clinical Neurophysiology, Georg-August University of Göttingen, Robert Koch Strasse 40, 37075 Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Neurophysiology, Georg-August University of Göttingen, Robert Koch Strasse 40, 37075 Göttingen</wicri:regionArea></affiliation></author><author><name sortKey="Boros, Klara" sort="Boros, Klara" uniqKey="Boros K" first="Klára" last="Boros">Klára Boros</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Clinical Neurophysiology, Georg-August University of Göttingen, Robert Koch Strasse 40, 37075 Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Neurophysiology, Georg-August 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Göttingen</wicri:regionArea></affiliation></author></analytic><series><title level="j">Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale</title><idno type="ISSN">0014-4819</idno><idno type="eISSN">1432-1106</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Theta burst stimulation (TBS) is a special repetitive transcranial magnetic stimulation (rTMS) paradigm, where bursts of low-intensity stimuli are applied in the theta frequency. The aim of this study was to investigate the effect of neuronavigated TBS over primary somatosensory cortex (SI) on laser-evoked potentials (LEPs) and acute pain perception induced with Tm : YAG laser stimulation. The amplitude changes of the N1, N2, and P2 components of LEPs and related subjective pain rating scores of 12 healthy subjects were analyzed prior to and following continuous TBS (cTBS), intermittent TBS (iTBS), intermediate TBS (imTBS), and sham stimulation. Our results demonstrate that all active TBS paradigms significantly diminished the amplitude of the N2 component, when the hand contralateral to the site of TBS was laser-stimulated. Sham stimulation condition had no significant effect. The subjective pain perception also decreased during the experimental sessions, but did not differ significantly from the sham stimulation condition. The main finding of our study is that TBS over SI diminished the amplitude of the N2 component evoked from the contralateral side without any significant analgesic effects. Furthermore, imTBS produced responses similar to those observed by other forms of TBS induced excitability changes in the SI.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Exp Brain Res</journal-id><journal-title>Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale</journal-title><issn pub-type="ppub">0014-4819</issn><issn pub-type="epub">1432-1106</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18043910</article-id><article-id pub-id-type="pmc">2248215</article-id><article-id pub-id-type="publisher-id">1188</article-id><article-id pub-id-type="doi">10.1007/s00221-007-1188-5</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Attenuation of N2 amplitude of laser-evoked potentials by theta burst stimulation of primary somatosensory cortex</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Poreisz</surname><given-names>Csaba</given-names></name><address><phone>+49-551-3912310</phone><fax>+49-551-398126
</fax><email>csaba.poreisz@med.uni-goettingen.de</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Antal</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Boros</surname><given-names>Klára</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Brepohl</surname><given-names>Nadine</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Csifcsák</surname><given-names>Gábor</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Paulus</surname><given-names>Walter</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label>Department of Clinical Neurophysiology, Georg-August University of Göttingen, Robert Koch Strasse 40, 37075 Göttingen, Germany</aff><aff id="Aff2"><label>2</label>Department of Psychiatry, University of Szeged, Semmelweis u. 6, 6725 Szeged, Hungary</aff></contrib-group><pub-date pub-type="epub"><day>28</day><month>11</month><year>2007</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2008</year></pub-date><volume>185</volume><issue>4</issue><fpage>611</fpage><lpage>621</lpage><history><date date-type="received"><day>16</day><month>8</month><year>2007</year></date><date date-type="accepted"><day>17</day><month>10</month><year>2007</year></date></history><permissions><copyright-statement>© The Author(s) 2007</copyright-statement></permissions><abstract><p>Theta burst stimulation (TBS) is a special repetitive transcranial magnetic stimulation (rTMS) paradigm, where bursts of low-intensity stimuli are applied in the theta frequency. The aim of this study was to investigate the effect of neuronavigated TBS over primary somatosensory cortex (SI) on laser-evoked potentials (LEPs) and acute pain perception induced with Tm : YAG laser stimulation. The amplitude changes of the N1, N2, and P2 components of LEPs and related subjective pain rating scores of 12 healthy subjects were analyzed prior to and following continuous TBS (cTBS), intermittent TBS (iTBS), intermediate TBS (imTBS), and sham stimulation. Our results demonstrate that all active TBS paradigms significantly diminished the amplitude of the N2 component, when the hand contralateral to the site of TBS was laser-stimulated. Sham stimulation condition had no significant effect. The subjective pain perception also decreased during the experimental sessions, but did not differ significantly from the sham stimulation condition. The main finding of our study is that TBS over SI diminished the amplitude of the N2 component evoked from the contralateral side without any significant analgesic effects. Furthermore, imTBS produced responses similar to those observed by other forms of TBS induced excitability changes in the SI.</p></abstract><kwd-group><title>Keywords</title><kwd>Theta burst transcranial magnetic stimulation</kwd><kwd>Primary somatosensory cortex</kwd><kwd>Laser-evoked potentials</kwd><kwd>Pain</kwd><kwd>Neuronavigation</kwd></kwd-group><custom-meta-wrap><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag 2008</meta-value></custom-meta></custom-meta-wrap></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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