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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Studies of properties of “Pain Networks” as predictors of targets of stimulation for treatment of pain</title><author><name sortKey="Liu, C C" sort="Liu, C C" uniqKey="Liu C" first="C. C." last="Liu">C. C. Liu</name><affiliation><nlm:aff id="aff1"><institution>Department of Neurosurgery, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation></author><author><name sortKey="Franaszczuk, P" sort="Franaszczuk, P" uniqKey="Franaszczuk P" first="P." last="Franaszczuk">P. Franaszczuk</name><affiliation><nlm:aff id="aff2"><institution>Department of Neurology, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>US Army Research Laboratory, Human Research and Engineering Directorate</institution><country>Aberdeen Proving Ground, MD, USA</country></nlm:aff></affiliation></author><author><name sortKey="Crone, N E" sort="Crone, N E" uniqKey="Crone N" first="N. E." last="Crone">N. E. Crone</name><affiliation><nlm:aff id="aff2"><institution>Department of Neurology, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation></author><author><name sortKey="Jouny, C" sort="Jouny, C" uniqKey="Jouny C" first="C." last="Jouny">C. Jouny</name><affiliation><nlm:aff id="aff2"><institution>Department of Neurology, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation></author><author><name sortKey="Lenz, F A" sort="Lenz, F A" uniqKey="Lenz F" first="F. A." last="Lenz">F. A. Lenz</name><affiliation><nlm:aff id="aff1"><institution>Department of Neurosurgery, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22164137</idno><idno type="pmc">3230069</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230069</idno><idno type="RBID">PMC:3230069</idno><idno type="doi">10.3389/fnint.2011.00080</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000365</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000365</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Studies of properties of “Pain Networks” as predictors of targets of stimulation for treatment of pain</title><author><name sortKey="Liu, C C" sort="Liu, C C" uniqKey="Liu C" first="C. C." last="Liu">C. C. Liu</name><affiliation><nlm:aff id="aff1"><institution>Department of Neurosurgery, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation></author><author><name sortKey="Franaszczuk, P" sort="Franaszczuk, P" uniqKey="Franaszczuk P" first="P." last="Franaszczuk">P. Franaszczuk</name><affiliation><nlm:aff id="aff2"><institution>Department of Neurology, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>US Army Research Laboratory, Human Research and Engineering Directorate</institution><country>Aberdeen Proving Ground, MD, USA</country></nlm:aff></affiliation></author><author><name sortKey="Crone, N E" sort="Crone, N E" uniqKey="Crone N" first="N. E." last="Crone">N. E. Crone</name><affiliation><nlm:aff id="aff2"><institution>Department of Neurology, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation></author><author><name sortKey="Jouny, C" sort="Jouny, C" uniqKey="Jouny C" first="C." last="Jouny">C. Jouny</name><affiliation><nlm:aff id="aff2"><institution>Department of Neurology, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation></author><author><name sortKey="Lenz, F A" sort="Lenz, F A" uniqKey="Lenz F" first="F. A." last="Lenz">F. A. Lenz</name><affiliation><nlm:aff id="aff1"><institution>Department of Neurosurgery, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in Integrative Neuroscience</title><idno type="eISSN">1662-5145</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Two decades of functional imaging studies have demonstrated pain-related activations of primary somatic sensory cortex (S1), parasylvian cortical structures (PS), and medial frontal cortical structures (MF), which are often described as modules in a “pain network.” The directionality and temporal dynamics of interactions between and within the cortical and thalamic modules are uncertain. We now describe our studies of these interactions based upon recordings of local field potentials (LFPs) carried out in an epilepsy monitoring unit over the one week period between the implantation and removal of cortical electrodes during the surgical treatment of epilepsy. These recordings have unprecedented clarity and resolution for the study of LFPs related to the experimental pain induced by cutaneous application of a Thulium YAG laser. We also used attention and distraction as behavioral probes to study the psychophysics and neuroscience of the cortical “pain network.” In these studies, electrical activation of cortex was measured by event-related desynchronization (ERD), over SI, PS, and MF modules, and was more widespread and intense while attending to painful stimuli than while being distracted from them. This difference was particularly prominent over PS. In addition, greater perceived intensity of painful stimuli was associated with more widespread and intense ERD. Connectivity of these modules was then examined for dynamic causal interactions within and between modules by using the Granger causality (GRC). Prior to the laser stimuli, a task involving attention to the painful stimulus consistently increased the number of event-related causality (ERC) pairs both within the SI cortex, and from SI upon PS (SI > PS). After the laser stimulus, attention to a painful stimulus increased the number of ERC pairs from SI > PS, and SI > MF, and within the SI module. LFP at some electrode sites (critical sites) exerted ERC influences upon signals at multiple widespread electrodes, both in other cortical modules and within the module where the critical site was located. In summary, critical sites and SI modules may bind the cortical modules together into a “pain network,” and disruption of that network by stimulation might be used to treat pain. These results in humans may be uniquely useful to design and optimize anatomically based pain therapies, such as stimulation of the S1 or critical sites through transcutaneous magnetic fields or implanted electrodes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y. Agid</name></author><author><name sortKey="Buzsaki, G" uniqKey="Buzsaki G">G. Buzsaki</name></author><author><name sortKey="Diamond, D M" uniqKey="Diamond D">D. M. Diamond</name></author><author><name sortKey="Frackowiak, R" uniqKey="Frackowiak R">R. Frackowiak</name></author><author><name sortKey="Giedd, J" uniqKey="Giedd J">J. Giedd</name></author><author><name sortKey="Girault, J A" uniqKey="Girault J">J. A. Girault</name></author><author><name sortKey="Grace, A" uniqKey="Grace A">A. Grace</name></author><author><name sortKey="Lambert, J J" uniqKey="Lambert J">J. J. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Integr Neurosci</journal-id><journal-id journal-id-type="publisher-id">Front. Integr. Neurosci.</journal-id><journal-title-group><journal-title>Frontiers in Integrative Neuroscience</journal-title></journal-title-group><issn pub-type="epub">1662-5145</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22164137</article-id><article-id pub-id-type="pmc">3230069</article-id><article-id pub-id-type="doi">10.3389/fnint.2011.00080</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject><subj-group><subject>Original Research Article</subject></subj-group></subj-group></article-categories><title-group><article-title>Studies of properties of “Pain Networks” as predictors of targets of stimulation for treatment of pain</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Liu</surname><given-names>C. C.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Franaszczuk</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Crone</surname><given-names>N. E.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jouny</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lenz</surname><given-names>F. A.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn001">*</xref></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Department of Neurosurgery, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></aff><aff id="aff2"><sup>2</sup><institution>Department of Neurology, Johns Hopkins Hospital</institution><country>Baltimore, MD, USA</country></aff><aff id="aff3"><sup>3</sup><institution>US Army Research Laboratory, Human Research and Engineering Directorate</institution><country>Aberdeen Proving Ground, MD, USA</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Sridevi V. Sarma, Johns Hopkins University, USA</p></fn><fn fn-type="edited-by"><p>Reviewed by: Dante R. Chialvo, Northwestern University, USA; Guillermo A. Cecchi, IBM Watson Research Center, USA</p></fn><corresp id="fn001">*Correspondence: F. A. Lenz, Department of Neurosurgery, Johns Hopkins Hospital, Meyer Building 8-181, 600 North Wolfe Street, Baltimore, MD 21287-7713, USA. e-mail: <email>flenz1@jhmi.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>05</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="collection"><year>2011</year></pub-date><volume>5</volume><elocation-id>80</elocation-id><history><date date-type="received"><day>10</day><month>8</month><year>2011</year></date><date date-type="accepted"><day>19</day><month>11</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2011 Lenz, Liu, Franasczuk, Crone and Jouny.</copyright-statement><copyright-year>2011</copyright-year><license license-type="open-access" xlink:href="http://www.frontiersin.org/licenseagreement"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits use, distribution, and reproduction in other forums, provided the original authors and source are credited.</license-p></license></permissions><abstract><p>Two decades of functional imaging studies have demonstrated pain-related activations of primary somatic sensory cortex (S1), parasylvian cortical structures (PS), and medial frontal cortical structures (MF), which are often described as modules in a “pain network.” The directionality and temporal dynamics of interactions between and within the cortical and thalamic modules are uncertain. We now describe our studies of these interactions based upon recordings of local field potentials (LFPs) carried out in an epilepsy monitoring unit over the one week period between the implantation and removal of cortical electrodes during the surgical treatment of epilepsy. These recordings have unprecedented clarity and resolution for the study of LFPs related to the experimental pain induced by cutaneous application of a Thulium YAG laser. We also used attention and distraction as behavioral probes to study the psychophysics and neuroscience of the cortical “pain network.” In these studies, electrical activation of cortex was measured by event-related desynchronization (ERD), over SI, PS, and MF modules, and was more widespread and intense while attending to painful stimuli than while being distracted from them. This difference was particularly prominent over PS. In addition, greater perceived intensity of painful stimuli was associated with more widespread and intense ERD. Connectivity of these modules was then examined for dynamic causal interactions within and between modules by using the Granger causality (GRC). Prior to the laser stimuli, a task involving attention to the painful stimulus consistently increased the number of event-related causality (ERC) pairs both within the SI cortex, and from SI upon PS (SI > PS). After the laser stimulus, attention to a painful stimulus increased the number of ERC pairs from SI > PS, and SI > MF, and within the SI module. LFP at some electrode sites (critical sites) exerted ERC influences upon signals at multiple widespread electrodes, both in other cortical modules and within the module where the critical site was located. In summary, critical sites and SI modules may bind the cortical modules together into a “pain network,” and disruption of that network by stimulation might be used to treat pain. These results in humans may be uniquely useful to design and optimize anatomically based pain therapies, such as stimulation of the S1 or critical sites through transcutaneous magnetic fields or implanted electrodes.</p></abstract><kwd-group><kwd>pain networks</kwd><kwd>stimulation</kwd><kwd>treatment of pain</kwd><kwd>local field potentials</kwd></kwd-group><counts><fig-count count="0"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="112"></ref-count><page-count count="7"></page-count><word-count count="0"></word-count></counts></article-meta></front><body><sec id="s1"><title>Introduction</title><p>Over the past three decades, functional imaging studies have led to the model that pain is a complex experience that is associated with increased blood flow or BOLD signals in multiple structures in the brain (Davis, <xref ref-type="bibr" rid="B20">2000</xref>; Derbyshire, <xref ref-type="bibr" rid="B24">2000</xref>; Rainville et al., <xref ref-type="bibr" rid="B83">2000</xref>; Apkarian et al., <xref ref-type="bibr" rid="B3">2005</xref>; Lenz et al., <xref ref-type="bibr" rid="B54">2010</xref>). These structures have been characterized as a “pain network” or “neuro-matrix” (Melzack, <xref ref-type="bibr" rid="B63">1990</xref>; Gelnar et al., <xref ref-type="bibr" rid="B34">1999</xref>; Peyron et al., <xref ref-type="bibr" rid="B77">1999</xref>; Casey, <xref ref-type="bibr" rid="B15">2000</xref>; Strigo et al., <xref ref-type="bibr" rid="B97">2003</xref>), rather than as a collection of unrelated centers (Melzack and Casey, <xref ref-type="bibr" rid="B64">1968</xref>). A network consists of neural elements, their connections, and connectional weights, which are often equated respectively, with neurons/modules in the brain, axons, and synapses. Functional interactions within such a network may be conceived of as the network properties that enable its modules jointly to process inputs or outputs, or both.</p><p>The pain network includes cortical modules such as the medial frontal cortex (MF including anterior and middle cingulate cortex—ACC and MCC, and supplementary motor area—SMA), the primary sensory cortex (S1), and the parasylvian structures (PS including opercular and insular cortex) (Casey, <xref ref-type="bibr" rid="B15">2000</xref>; Davis, <xref ref-type="bibr" rid="B20">2000</xref>; Apkarian et al., <xref ref-type="bibr" rid="B3">2005</xref>; Lenz et al., <xref ref-type="bibr" rid="B54">2010</xref>). We now review our studies of the thalamic and cortical structures which mediate the effect of acute pain. We will review our evidence that these structures are characterized by the response to painful stimuli (Lee et al., <xref ref-type="bibr" rid="B51">1999</xref>; Ohara et al., <xref ref-type="bibr" rid="B71">2004b</xref>, <xref ref-type="bibr" rid="B72">2004c</xref>; Kobayashi et al., <xref ref-type="bibr" rid="B46">2009</xref>), by the analgesic effect of thalamic and cortical lesions (Greenspan et al., <xref ref-type="bibr" rid="B37">1999</xref>, <xref ref-type="bibr" rid="B36">2008</xref>; Kim et al., <xref ref-type="bibr" rid="B43">2007</xref>; Veldhuijzen et al., <xref ref-type="bibr" rid="B104">2009</xref>), and by the painful sensations evoked by thalamic stimulation (Lenz et al., <xref ref-type="bibr" rid="B57">1993</xref>, <xref ref-type="bibr" rid="B55">2004</xref>; Ohara and Lenz, <xref ref-type="bibr" rid="B74">2003</xref>; Patel et al., <xref ref-type="bibr" rid="B76">2006</xref>). Based upon this evidence cortical (S1, PS, and MF) and thalamic modules may subserve different components of the sensation of pain.</p><p>Pain is commonly viewed as a sensation composed of multiple components which are mediated through a network (Melzack, <xref ref-type="bibr" rid="B63">1990</xref>; Gelnar et al., <xref ref-type="bibr" rid="B34">1999</xref>; Peyron et al., <xref ref-type="bibr" rid="B77">1999</xref>; Casey, <xref ref-type="bibr" rid="B15">2000</xref>; Strigo et al., <xref ref-type="bibr" rid="B97">2003</xref>). However, there is evidence from functional imaging studies that cortical modules are local networks that are associated with different dimensions of pain. We now review psychophysical studies of patients with forebrain lesions, and our studies of interactions between signals recorded from different structures in the brain.</p><p>Studies of lesions by our group and others, demonstrate double dissociation of functions that are impaired following lesions of modules, or local networks. These modules with their corresponding dimension of pain include: (1) somatic sensory thalamus and parietal cortex with the sensory dimension (Ploner et al., <xref ref-type="bibr" rid="B79">1999</xref>; Rainville et al., <xref ref-type="bibr" rid="B84">1999</xref>; Hofbauer et al., <xref ref-type="bibr" rid="B40">2001</xref>; Greenspan et al., <xref ref-type="bibr" rid="B38">2004</xref>, <xref ref-type="bibr" rid="B36">2008</xref>; Montes et al., <xref ref-type="bibr" rid="B67">2005</xref>; Kim et al., <xref ref-type="bibr" rid="B43">2007</xref>), (2) the insula with decreased pain tolerance (Greenspan et al., <xref ref-type="bibr" rid="B37">1999</xref>; Starr et al., <xref ref-type="bibr" rid="B94">2009</xref>; Veldhuijzen et al., <xref ref-type="bibr" rid="B104">2009</xref>), and (3) the MCC with decreased gain of pain ratings (Davis et al., <xref ref-type="bibr" rid="B21">1994</xref>; Talbot et al., <xref ref-type="bibr" rid="B98">1995</xref>; Greenspan et al., <xref ref-type="bibr" rid="B36">2008</xref>).</p><p>These widespread, functional interactions between local networks or modules in the brain (Ohara et al., <xref ref-type="bibr" rid="B69">2004a</xref>, <xref ref-type="bibr" rid="B70">2006</xref>, <xref ref-type="bibr" rid="B68">2008</xref>; Greenspan et al., <xref ref-type="bibr" rid="B36">2008</xref>), may explain the binding of different dimensions of pain together to produce a unified pain sensation (Singer and Gray, <xref ref-type="bibr" rid="B92">1995</xref>). In particular, functional interactions of this type have been related to a number of cognitive tasks in humans (von der Malsburg, <xref ref-type="bibr" rid="B105">1995</xref>). Long range synchrony is often related to the lower frequency range, as in the case of the present study (Rodriguez et al., <xref ref-type="bibr" rid="B87">1999</xref>). This type of organization is well established in language networks in which normal language requires a network composed of modules subserving “speech production (frontal lobe),” and “speech reception” (temporal-parietal lobe), and their interconnections (Churchland and Sejnowski, <xref ref-type="bibr" rid="B17">1992</xref>; Arbib, <xref ref-type="bibr" rid="B6">2002</xref>; Korzeniewska et al., <xref ref-type="bibr" rid="B49">2008</xref>).</p></sec><sec id="s2"><title>The “Pain Network” and Stimulation Evoked Analgesia</title><p>Studies of the human “pain network” have fundamentally altered our concepts of both the “pain network,” and the treatment of pain by stimulation of that network (Coffey and Lozano, <xref ref-type="bibr" rid="B18">2006</xref>; Lenz, <xref ref-type="bibr" rid="B53">2006</xref>; Cruccu et al., <xref ref-type="bibr" rid="B19">2007</xref>; Dorsi and Lenz, <xref ref-type="bibr" rid="B29">in press</xref>). At present, these stimulation therapies include: (1) transcutaneous magnetic stimulation (TMS) of the motor cortex or dorsal lateral prefrontal cortex (Leo and Latif, <xref ref-type="bibr" rid="B58">2007</xref>; Wassermann et al., <xref ref-type="bibr" rid="B107">2010</xref>), or (2) electrical stimulation at sites including the thalamus (Schuurman et al., <xref ref-type="bibr" rid="B89">2000</xref>; Rasche et al., <xref ref-type="bibr" rid="B85">2006</xref>), or motor cortex (Fontaine et al., <xref ref-type="bibr" rid="B32">2008</xref>). Our more recent studies seek to predict effective stimulation sites based on their widespread causal influence upon other modules in the “pain network.” The present manuscript will examine the results of recent studies of functional connectivity within the thalamic and cortical modules in the “pain network.” If the location of cortical targets is consistent across patients using this approach, then new targets for stimulation could be rapidly applied to protocols of TMS. Our studies have been carried out with refinements of techniques employed during previous studies, as reviewed below.</p></sec><sec id="s3"><title>Technical Factors in the Analysis of the “Pain Network”</title><p>The “pain network” has previously been studied by fMRI signals analyzed by techniques focusing on the pre-stimulus interval or a fixed cognitive task/set (Kong et al., <xref ref-type="bibr" rid="B48">2006</xref>, <xref ref-type="bibr" rid="B47">2010</xref>; Boly et al., <xref ref-type="bibr" rid="B9">2007</xref>). These prior technical approaches to pain-related functional interactions are complicated by long sampling intervals and widespread modules. Perhaps because of these difficulties, the “pain network” is usually assumed to be static, or fixed across time and task (Melzack, <xref ref-type="bibr" rid="B63">1990</xref>; Peyron et al., <xref ref-type="bibr" rid="B77">1999</xref>; Price, <xref ref-type="bibr" rid="B82">2000</xref>; Apkarian et al., <xref ref-type="bibr" rid="B3">2005</xref>). Our recent studies have overcome these technical difficulties (Ohara et al., <xref ref-type="bibr" rid="B69">2004a</xref>, <xref ref-type="bibr" rid="B70">2006</xref>, <xref ref-type="bibr" rid="B68">2008</xref>; Zygierewicz et al., <xref ref-type="bibr" rid="B111">2005</xref>, <xref ref-type="bibr" rid="B112">2006</xref>; Korzeniewska et al., <xref ref-type="bibr" rid="B49">2008</xref>; Liu et al., <xref ref-type="bibr" rid="B62">2010</xref>), and have demonstrated that the pain networks composed of structures which are activated by painful stimuli are not static but dynamic and task specific (Ohara et al., <xref ref-type="bibr" rid="B69">2004a</xref>, <xref ref-type="bibr" rid="B70">2006</xref>, <xref ref-type="bibr" rid="B68">2008</xref>; Apkarian and Chialvo, <xref ref-type="bibr" rid="B4">2006</xref>; Liu et al., <xref ref-type="bibr" rid="B62">2010</xref>).</p><p>The techniques used in our recent studies represent technical and theoretical advances in the study of human forebrain pain-related networks. The resolution of our recordings made directly from the human brain have the unprecedented temporal and spatial resolution of thalamic neuronal spike trains (500 Hz, < 0.5 mm), and recordings of multiple neurons (local field potentials, LFPs) in the cortex (200 Hz, < 1 cm) and the thalamus (200 Hz, 2–3 mm, Figure 4). In comparison, current techniques for the study of human pain-related networks include Positron Emission Tomography (PET) (≪ 1 Hz, > 1 cm), fMRI (< 1 Hz, > 3 mm) (Kong et al., <xref ref-type="bibr" rid="B47">2010</xref>), and scalp EEG (scalp EEG 80 Hz, > 5 cm). Therefore, our recent studies have a broader bandwidth, a higher temporal resolution, and an increased spatial resolution than previous studies (Kong et al., <xref ref-type="bibr" rid="B48">2006</xref>, <xref ref-type="bibr" rid="B47">2010</xref>; Boly et al., <xref ref-type="bibr" rid="B9">2007</xref>; Ploner et al., <xref ref-type="bibr" rid="B80">2009</xref>).</p><p>These recording techniques yield high resolution signals which are analyzed by using the multivariate autoregressive models. Granger adopted the idea of causality introduced by Wiener and established the causality measure called Granger causality (GRC) (Weiner, <xref ref-type="bibr" rid="B109">1956</xref>; Granger, <xref ref-type="bibr" rid="B35">1969</xref>). The event-related causality (ERC) used in our studies for determining the significant interactions among different brain structures was based the same concept as GRC. ERC fulfills the following three conditions: (1) The changes in X predict Y, (2) The changes in X precede Y, and (3) when evaluating the causal influences between X and Y, ERC analysis take into account the changes in X and Y that are contributed by all other variables in the system. Therefore, under some suitable statistical sense, we conclude that X is granger causal Y. However, we have to keep in mind that the observed ERC might arise from the unobserved sources in the system.</p><p>Recent advances have enabled the evaluation of the short time ERC in a multivariate system. ERC is a multivariate approach and is based on the Short-time direct Directed Transfer Function (SdDTF) for estimating the changes the direct causal interactions within a multivariate system that are event-related in the frequency domain. The SdDTF is used for the signals that are short in duration and have a large number of repetitions. The essential part of the ERC method is the statistical testing procedure which will reveal the significant changes in inter-channel relationships that are event-related (Ding et al., <xref ref-type="bibr" rid="B28">2000</xref>; Korzeniewska et al., <xref ref-type="bibr" rid="B50">2003</xref>; Liu et al., <xref ref-type="bibr" rid="B60">2011a</xref>). We now review our studies of functional connectivity including those employing the ERC techniques described above.</p></sec><sec id="s4"><title>Cortical Modules in the “Pain Network”</title><p>Our studies have demonstrated that the functional connectivity between S1, PS, and MF changes dynamically with task, such as the anticipation of the laser stimulus, versus attention to the laser versus distraction from the laser (Ohara et al., <xref ref-type="bibr" rid="B69">2004a</xref>, <xref ref-type="bibr" rid="B73">2004d</xref>, <xref ref-type="bibr" rid="B70">2006</xref>, <xref ref-type="bibr" rid="B68">2008</xref>). We considered that the human “pain network” included cortical areas which are activated during the response to painful stimuli (termed category 1), or during psychological processes which modulate pain, such as distraction (termed category 2) (Liu et al., <xref ref-type="bibr" rid="B113">2011c</xref>). Among category 1 areas prior to the laser stimuli, directed attention to the painful stimulus (counting) consistently increased the number of ERC pairs both within the SI cortex, and from SI upon PS (SI > PS) (Liu et al., <xref ref-type="bibr" rid="B61">2011b</xref>, <xref ref-type="bibr" rid="B113">2011c</xref>). After the laser stimulus, attention to a painful stimulus increased the number of ERC pairs from SI > PS, and SI > MF, and within the SI area. LFP at some electrode sites (critical sites) exerted ERC influences upon signals at multiple widespread electrodes, both in other cortical areas and within the area where the critical site was located. Therefore, the number of electrodes involved in pairs with significant ERC in category 1 was greater for pre-stimulus versus post-stimulus period and for attention versus distraction, which is consistent with a network in which functional connections change rapidly with intervals and tasks.</p><p>In contrast, the interaction <italic>between</italic> categories 1 and 2 was often unchanged or stable across intervals and tasks, particularly in MF (Liu et al., 2011c). Functional interactions between categories were overwhelmingly in the direction from category 2 > 1, particularly for contacts in MF which often had a driver role. Therefore, some functional interactions within the pain network may be dynamic while others are apparently static. These temporal factors in the “pain network” and modules may clarify important parameters of the system such as the time course of pain stimuli, of attentive tasks, and of therapeutic stimulation. We next considered the MF module which has the largest number of causal interactions in the “pain network,” and so may play a pivotal role in the network.</p></sec><sec id="s5"><title>The MF Module is Pivotal in the “Pain Network”</title><p>Our most recent studies have identified MF as the most critical module in the “pain network.” The participation of MCC in pain processing is suggested by activation of this area in response to acute pain (Davis et al., <xref ref-type="bibr" rid="B22">1997</xref>; Derbyshire et al., <xref ref-type="bibr" rid="B25">1998</xref>). The extent of pain-related function along the caudal-rostral axis of MCC and ACC is suggested by functional imaging studies demonstrating widespread blood flow or BOLD activation between individuals (Davis et al., <xref ref-type="bibr" rid="B22">1997</xref>; Derbyshire et al., <xref ref-type="bibr" rid="B25">1998</xref>). Cingulate generators of laser evoked potentials (LEPs) are supported by source analysis of scalp EEG (Tarkka and Treede, <xref ref-type="bibr" rid="B99">1993</xref>; Chen and Bromm, <xref ref-type="bibr" rid="B16">1995</xref>; Kitamura et al., <xref ref-type="bibr" rid="B45">1995</xref>; Valeriani et al., <xref ref-type="bibr" rid="B103">1996</xref>); recordings directly from the surface of the cortex localize the generator in the MCC, just anterior to the M1 (Lenz et al., <xref ref-type="bibr" rid="B56">1998</xref>; Rios et al., <xref ref-type="bibr" rid="B86">1999</xref>; Ohara et al., <xref ref-type="bibr" rid="B72">2004c</xref>).</p><p>Attention-related tasks (e.g., verbal fluency or Stroop) will also activate widespread MF areas (Davis et al., <xref ref-type="bibr" rid="B22">1997</xref>; Derbyshire et al., <xref ref-type="bibr" rid="B25">1998</xref>). Direct comparisons identify interleaved subunits within the ACC and MCC which are activated by attention versus pain-related tasks (Ploghaus et al., <xref ref-type="bibr" rid="B78">1999</xref>). Therefore, the present results may be the result of widespread functionally discrete subunits or modules in MF which subserve pain and attention.</p><p>In comparison with other cortical areas, MF accounts for the largest number of contacts involved in consistent causal pairs, particularly in the case of attention and category 2 > category 1 interactions (Liu et al., 2011c). These consistent connections were often stable across time intervals and attentional tasks. Furthermore, functional interactions from category 2 > category 1 within the same cortical category were only found for MF (Davis et al., <xref ref-type="bibr" rid="B22">1997</xref>; Derbyshire et al., <xref ref-type="bibr" rid="B25">1998</xref>). These results strongly suggest that MF is the pivotal cortical module in the “pain network.” Interactions of cortical and thalamic modules are also likely to play a pivotal role as reviewed below.</p></sec><sec id="s6"><title>Cortico-thalamic Assemblies in the “Pain Network”</title><p>Thalamic structures are likely modules in the “pain network,” based on their involvement in densely inter-connected thalamo-cortical assemblies (Steriade et al., <xref ref-type="bibr" rid="B96">1997b</xref>; Destexhe and Sejnowski, <xref ref-type="bibr" rid="B27">2001</xref>) so that it is not possible to understand the function of one without the other (Steriade <xref ref-type="bibr" rid="B95">1997a</xref>; Destexhe and Sejnowski, <xref ref-type="bibr" rid="B27">2001</xref>; Sherman and Guillery, <xref ref-type="bibr" rid="B91">2001</xref>). Cortico-cortical synchrony may be related to interactions with thalamic modules by mechanisms including common input from thalamic to cortical modules, or thalamic oscillations which may be either intrinsic or related to afferent volleys (Burton, <xref ref-type="bibr" rid="B13">1975</xref>, <xref ref-type="bibr" rid="B14">1984</xref>; Apkarian and Shi, <xref ref-type="bibr" rid="B5">1994</xref>).</p><p>Thalamic neuronal I (intermediate, mixed single spikes, and bursts) category firing is more likely than other categories: (1) to show a response to laser stimuli (Kobayashi et al., <xref ref-type="bibr" rid="B46">2009</xref>), (2) to change category when the cognitive task changes (Kim et al., <xref ref-type="bibr" rid="B44">2009</xref>), and (3) to have synchrony with cortical modules. Therefore, I category firing may be a selective carrier of pain-related signals which is influenced by changes in cognitive tasks (Kim et al., <xref ref-type="bibr" rid="B44">2009</xref>), and which may enable both the thalamic response to the laser and the transmission of that response to the cortex. Furthermore, I category firing is associated with inhibitory events of GABAb duration leading to low threshold spike LTS bursts (Ohara et al., <xref ref-type="bibr" rid="B75">2007</xref>; Kim et al., <xref ref-type="bibr" rid="B44">2009</xref>), which might be exploited by pharmacological therapies targeting thalamic GABAergic transmission (Bal et al., <xref ref-type="bibr" rid="B7">1995</xref>; Rudolph and Mohler, <xref ref-type="bibr" rid="B88">2006</xref>; Agid et al., <xref ref-type="bibr" rid="B1">2007</xref>; Mohler et al., <xref ref-type="bibr" rid="B66">2008</xref>; Kim et al., <xref ref-type="bibr" rid="B44">2009</xref>), and possibly LTS channels (Huguenard and Prince, <xref ref-type="bibr" rid="B41">1994</xref>; Porcello et al., <xref ref-type="bibr" rid="B81">2003</xref>; Barton et al., <xref ref-type="bibr" rid="B8">2005</xref>; Fischer and Waxman, <xref ref-type="bibr" rid="B31">2010</xref>). Selective attention and learning may be increased by some of the newer GABAergic agonists; these agents might have analgesic properties, or might augment behavioral therapies (Mohler, <xref ref-type="bibr" rid="B65">2009</xref>) based upon their ability to influence I category firing. The connection of different modules in the “pain network” suggests strategies for analgesic stimulation of the brain, which are considered below.</p></sec><sec id="s7"><title>Strategies for Identifying Analgesic Stimulation Sites</title><p>The efficacy of stimulation therapies may result from activation and disruption of a single module (Desmurget et al., <xref ref-type="bibr" rid="B26">2009</xref>; Sirigu et al., <xref ref-type="bibr" rid="B93">2010</xref>), or from activation of a network by stimulation of either a single module (Desmurget et al., <xref ref-type="bibr" rid="B26">2009</xref>; Karnath et al., <xref ref-type="bibr" rid="B42">2010</xref>; Sirigu et al., <xref ref-type="bibr" rid="B93">2010</xref>) or a subcortical white matter pathway (De et al., <xref ref-type="bibr" rid="B23">2007</xref>; Herbsman et al., <xref ref-type="bibr" rid="B39">2009</xref>; Karnath et al., <xref ref-type="bibr" rid="B42">2010</xref>). In psychiatric disease, effective stimulation disrupts a widespread network as measured by the extent of stimulation-evoked change on cognitive testing (Levit-Binnun et al., <xref ref-type="bibr" rid="B59">2007</xref>), and of activation plus functional connectivity in functional imaging studies (Shajahan et al., <xref ref-type="bibr" rid="B90">2002</xref>).</p><p>At present, the motor cortex is the most common site for stimulation for pain based upon studies in animal models (Tsubokawa et al., <xref ref-type="bibr" rid="B101">1987</xref>). Its efficacy has been demonstrated in clinical studies of both electrical (Tsubokawa et al., <xref ref-type="bibr" rid="B102">1991</xref>; Brown and Barbaro, <xref ref-type="bibr" rid="B12">2003</xref>) and magnetic stimulation (Wassermann and Lisanby, <xref ref-type="bibr" rid="B108">2001</xref>; Lefaucher, <xref ref-type="bibr" rid="B52">2008</xref>), although other frontal (Borckardt et al., <xref ref-type="bibr" rid="B11">2006</xref>, <xref ref-type="bibr" rid="B10">2007</xref>; Fierro et al., <xref ref-type="bibr" rid="B30">2010</xref>) or parietal stimulation sites may have much greater therapeutic effects (Topper et al., <xref ref-type="bibr" rid="B100">2003</xref>; Fregni et al., <xref ref-type="bibr" rid="B33">2005</xref>).</p><p>Stimulation targeting modules in the “pain network” for the treatment of different types of pain, such as post-operative pain (Borckardt et al., <xref ref-type="bibr" rid="B11">2006</xref>) and chronic pain (Wassermann et al., <xref ref-type="bibr" rid="B107">2010</xref>). This organization of therapeutic effects could be as revolutionary as deep brain stimulation of the different modules in the basal ganglia network for the treatment of different movement disorders (Wichmann and DeLong, <xref ref-type="bibr" rid="B110">1996</xref>; Walter and Vitek, <xref ref-type="bibr" rid="B106">2004</xref>; Anderson and Lenz, <xref ref-type="bibr" rid="B2">2006</xref>). The basal ganglia model in patients with movement disorders differs from that in healthy individuals by the magnitude but not by the direction of causal influences, which suggests that the proposed studies of acute pain might describe functional interactions in a network which is relevant to chronic pain.</p><p>Studies of signals recorded simultaneously from the thalamus and cortex are important given the poorly understood interaction of these structures in pain networks. Our ongoing studies of activation and causality may also allow us to suggest synaptic mechanisms which mediate functional interactions in the “pain network.” If the GRC suggests that structure A exerts a causal influence upon structure B, then an increase in activation of both A and B suggests that this influence is excitatory.</p><p>If activation of A is increased as that of B is decreased, then the influence may be inhibitory. If activation of A is decreased while that of B is increased and the GRC influence from A to B diminishes, then the activation of B may be the result of disinhibition, i.e., decreased inhibition of B. For example, cortical output increases the activity of thalamic nucleus reticularis, which inhibits and so may decrease the activity of local circuit inhibitory interneurons, which leads to decreased inhibition of the activity of thalamocortical neurons, i.e., disinhibition (Steriade et al., <xref ref-type="bibr" rid="B95">1997a</xref>; Sherman and Guillery, <xref ref-type="bibr" rid="B91">2001</xref>).</p><p>Our electrophysiological studies have demonstrated that, PS showed decreased activation but increased functional interactions during distraction, while during attention increased activation was associated with decreased interactions. This suggests that an increased inhibitory process mediates the effect of distraction while disinhibition mediates the increased activation of attention.</p><p>Modulation of activity in PS by input from MF has been suggested by our prior psychophysical and PET study of the response to painful stimuli before and after a bilateral cingulotomy of the MCC. Following the cingulate lesion, there was an increase in pain ratings and increased activation of the parietal and insular cortex ipsilateral to a painful stimulus (Greenspan et al., <xref ref-type="bibr" rid="B36">2008</xref>). In view of the present results, cingulate lesions or stimulation may produce activation through disinhibition of PS, and the effect of attention may occur through a similar disinhibitory process, which is dependent upon MCC (Greenspan et al., <xref ref-type="bibr" rid="B36">2008</xref>). These studies point to the presence of functional interactions which may lead to complex patterns of response to stimulation delivered to produce an analgesic effect.</p></sec><sec><title>Conflict of interest statement</title><p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec></body><back><ack><p>This work was supported by the National Institutes of Health—National Institute of Neurological Disorders and Stroke RO1s NS38493 and NS40059 to F. A. Lenz, NS040596 to N. E. Crone, NS-xxxx, to C. Jouny. We thank C. Cordes and L. H. 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