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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prostatectomy using different lasers for the treatment of benign prostate hyperplasia in aging males</title><author><name sortKey="Lee, Wei Chang" sort="Lee, Wei Chang" uniqKey="Lee W" first="Wei-Chang" last="Lee">Wei-Chang Lee</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lin, Yu Hsiang" sort="Lin, Yu Hsiang" uniqKey="Lin Y" first="Yu-Hsiang" last="Lin">Yu-Hsiang Lin</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Chen Pang" sort="Hou, Chen Pang" uniqKey="Hou C" first="Chen-Pang" last="Hou">Chen-Pang Hou</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chang, Phei Lang" sort="Chang, Phei Lang" uniqKey="Chang P" first="Phei-Lang" last="Chang">Phei-Lang Chang</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chen, Chien Lun" sort="Chen, Chien Lun" uniqKey="Chen C" first="Chien-Lun" last="Chen">Chien-Lun Chen</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Juang, Horng Heng" sort="Juang, Horng Heng" uniqKey="Juang H" first="Horng-Heng" last="Juang">Horng-Heng Juang</name><affiliation><nlm:aff id="af2-cia-8-1483">Department of Anatomy, College of Medicine, Chang Gung University, Kweishan-Shan, Taoyuan, Taiwan, Republic of China</nlm:aff></affiliation></author><author><name sortKey="Tsui, Ke Hung" sort="Tsui, Ke Hung" uniqKey="Tsui K" first="Ke-Hung" last="Tsui">Ke-Hung Tsui</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24255595</idno><idno type="pmc">3832386</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832386</idno><idno type="RBID">PMC:3832386</idno><idno type="doi">10.2147/CIA.S52697</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000361</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000361</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prostatectomy using different lasers for the treatment of benign prostate hyperplasia in aging males</title><author><name sortKey="Lee, Wei Chang" sort="Lee, Wei Chang" uniqKey="Lee W" first="Wei-Chang" last="Lee">Wei-Chang Lee</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Lin, Yu Hsiang" sort="Lin, Yu Hsiang" uniqKey="Lin Y" first="Yu-Hsiang" last="Lin">Yu-Hsiang Lin</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Hou, Chen Pang" sort="Hou, Chen Pang" uniqKey="Hou C" first="Chen-Pang" last="Hou">Chen-Pang Hou</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chang, Phei Lang" sort="Chang, Phei Lang" uniqKey="Chang P" first="Phei-Lang" last="Chang">Phei-Lang Chang</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Chen, Chien Lun" sort="Chen, Chien Lun" uniqKey="Chen C" first="Chien-Lun" last="Chen">Chien-Lun Chen</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Juang, Horng Heng" sort="Juang, Horng Heng" uniqKey="Juang H" first="Horng-Heng" last="Juang">Horng-Heng Juang</name><affiliation><nlm:aff id="af2-cia-8-1483">Department of Anatomy, College of Medicine, Chang Gung University, Kweishan-Shan, Taoyuan, Taiwan, Republic of China</nlm:aff></affiliation></author><author><name sortKey="Tsui, Ke Hung" sort="Tsui, Ke Hung" uniqKey="Tsui K" first="Ke-Hung" last="Tsui">Ke-Hung Tsui</name><affiliation><nlm:aff id="af1-cia-8-1483">Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Interventions in Aging</title><idno type="ISSN">1176-9092</idno><idno type="eISSN">1178-1998</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Endoscopic lasers have become a treatment option for benign prostate hyperplasia (BPH). The study reported here sought to elucidate the benefits and drawbacks of different laser systems in the treatment of patients with BPH.</p></sec><sec><title>Methods</title><p>The study enrolled 741 patients diagnosed with lower urinary tract symptoms secondary to BPH during the period January 2005 to December 2011. The techniques used in the study were photoselective vaporization of the prostate, thulium laser prostatectomy, and diode laser prostatectomy. Patients were assigned to one of three groups according to the type of laser treatment they received. Outcomes were evaluated using the International Prostate Symptom Score (IPSS), quality of life, maximal urinary flow rate, post-voiding residual urine volume, and prostate-specific antigen (PSA) level.</p></sec><sec><title>Results</title><p>The baseline characteristics of patients who received diode laser prostatectomy show a significant elevated risk and high American Society of Anesthesiology score (<italic>P</italic>=0.001). Operative time and catheter removal time differed significantly between the three groups (<italic>P</italic>=0.001). No cases were converted to transurethral resection of the prostate intraoperatively due to bleeding (<italic>P</italic>=0.142). Among the three groups, there were no significant differences in maximal flow rate, lower post-void residual urine, and postoperative PSA level during the entire follow-up period (<italic>P</italic><0.05). Further, no significant differences in postoperative IPSS, quality of life, or bladder neck contracture (<italic>P</italic>=0.23) were observed. However, a significant difference was observed with regard to prolonged use of Foley catheters and prolonged hospital stay among patients in the diode laser group (<italic>P</italic>=0.001).</p></sec><sec><title>Conclusion</title><p>Laser prostatectomies are effective in dealing with lower urinary tract symptoms. Early subjective functional results (maximal flow rate, IPSS, and post-void residual urine) appeared the same as those obtained following laser prostatectomy. Thus, it appears that lasers are safe and effective as long as the patients are carefully selected for treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wasson, Jh" uniqKey="Wasson J">JH Wasson</name></author><author><name sortKey="Reda, Dj" uniqKey="Reda D">DJ Reda</name></author><author><name sortKey="Bruskewitz, Rc" uniqKey="Bruskewitz R">RC Bruskewitz</name></author><author><name sortKey="Elinson, J" uniqKey="Elinson J">J Elinson</name></author><author><name sortKey="Keller, Am" uniqKey="Keller A">AM Keller</name></author><author><name sortKey="Henderson, Wg" uniqKey="Henderson W">WG Henderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gravas, S" uniqKey="Gravas S">S Gravas</name></author><author><name sortKey="Bachmann, A" uniqKey="Bachmann A">A Bachmann</name></author><author><name sortKey="Reich, O" uniqKey="Reich O">O Reich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rieken, M" uniqKey="Rieken M">M Rieken</name></author><author><name sortKey="Ebinger Mundorff, N" uniqKey="Ebinger Mundorff N">N Ebinger Mundorff</name></author><author><name sortKey="Bonkat, G" uniqKey="Bonkat G">G Bonkat</name></author><author><name sortKey="Wyler, S" uniqKey="Wyler S">S Wyler</name></author><author><name sortKey="Bachmann, A" uniqKey="Bachmann A">A Bachmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reich, O" uniqKey="Reich O">O Reich</name></author><author><name sortKey="Bachmann, A" uniqKey="Bachmann A">A Bachmann</name></author><author><name sortKey="Siebels, M" uniqKey="Siebels M">M Siebels</name></author><author><name sortKey="Hofstetter, A" uniqKey="Hofstetter A">A Hofstetter</name></author><author><name sortKey="Stief, Cg" uniqKey="Stief C">CG Stief</name></author><author><name sortKey="Sulser, T" uniqKey="Sulser T">T Sulser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elzayat, E" uniqKey="Elzayat E">E Elzayat</name></author><author><name sortKey="Habib, E" uniqKey="Habib E">E Habib</name></author><author><name sortKey="Elhilali, M" uniqKey="Elhilali M">M Elhilali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shao, Ih" uniqKey="Shao I">IH Shao</name></author><author><name sortKey="Hou, Cp" uniqKey="Hou C">CP Hou</name></author><author><name sortKey="Chen, Sm" uniqKey="Chen S">SM Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elmansy, H" uniqKey="Elmansy H">H Elmansy</name></author><author><name sortKey="Baazeem, A" uniqKey="Baazeem A">A Baazeem</name></author><author><name sortKey="Kotb, A" uniqKey="Kotb A">A Kotb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madersbacher, S" uniqKey="Madersbacher S">S Madersbacher</name></author><author><name sortKey="Alivizatos, G" uniqKey="Alivizatos G">G Alivizatos</name></author><author><name sortKey="Nordling, J" uniqKey="Nordling J">J Nordling</name></author><author><name sortKey="Sanz, Cr" uniqKey="Sanz C">CR Sanz</name></author><author><name sortKey="Emberton, M" uniqKey="Emberton M">M Emberton</name></author><author><name sortKey="De La Rosette, Jj" uniqKey="De La Rosette J">JJ de la Rosette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rassweiler, J" uniqKey="Rassweiler J">J Rassweiler</name></author><author><name sortKey="Teber, D" uniqKey="Teber D">D Teber</name></author><author><name sortKey="Kuntz, R" uniqKey="Kuntz R">R Kuntz</name></author><author><name sortKey="Hofmann, R" uniqKey="Hofmann R">R Hofmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, K" uniqKey="Taylor K">K Taylor</name></author><author><name sortKey="Filgate, R" uniqKey="Filgate R">R Filgate</name></author><author><name sortKey="Guo, Dy" uniqKey="Guo D">DY Guo</name></author><author><name sortKey="Macneil, F" uniqKey="Macneil F">F Macneil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Descazeaud, A" uniqKey="Descazeaud A">A Descazeaud</name></author><author><name sortKey="Robert, G" uniqKey="Robert G">G Robert</name></author><author><name sortKey="Azzousi, Ar" uniqKey="Azzousi A">AR Azzousi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erol, A" uniqKey="Erol A">A Erol</name></author><author><name sortKey="Cam, K" uniqKey="Cam K">K Cam</name></author><author><name sortKey="Tekin, A" uniqKey="Tekin A">A Tekin</name></author><author><name sortKey="Memik, O" uniqKey="Memik O">O Memik</name></author><author><name sortKey="Coban, S" uniqKey="Coban S">S Coban</name></author><author><name sortKey="Ozer, Y" uniqKey="Ozer Y">Y Ozer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seitz, M" uniqKey="Seitz M">M Seitz</name></author><author><name sortKey="Sroka, R" uniqKey="Sroka R">R Sroka</name></author><author><name sortKey="Gratzke, C" uniqKey="Gratzke C">C Gratzke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rieken, M" uniqKey="Rieken M">M Rieken</name></author><author><name sortKey="Wyler, S" uniqKey="Wyler S">S Wyler</name></author><author><name sortKey="Muller, G" uniqKey="Muller G">G Müller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Capitan, C" uniqKey="Capitan C">C Capitán</name></author><author><name sortKey="Blazquez, C" uniqKey="Blazquez C">C Blázquez</name></author><author><name sortKey="Martin, Md" uniqKey="Martin M">MD Martin</name></author><author><name sortKey="Hernandez, V" uniqKey="Hernandez V">V Hernández</name></author><author><name sortKey="De La Pe A, E" uniqKey="De La Pe A E">E de la Peña</name></author><author><name sortKey="Llorente, C" uniqKey="Llorente C">C Llorente</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bach, T" uniqKey="Bach T">T Bach</name></author><author><name sortKey="Herrmann, Tr" uniqKey="Herrmann T">TR Herrmann</name></author><author><name sortKey="Haecker, A" uniqKey="Haecker A">A Haecker</name></author><author><name sortKey="Michel, Ms" uniqKey="Michel M">MS Michel</name></author><author><name sortKey="Gross, A" uniqKey="Gross A">A Gross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bach, T" uniqKey="Bach T">T Bach</name></author><author><name sortKey="Wendt Nordahl, G" uniqKey="Wendt Nordahl G">G Wendt-Nordahl</name></author><author><name sortKey="Michel, Ms" uniqKey="Michel M">MS Michel</name></author><author><name sortKey="Herrmann, Tr" uniqKey="Herrmann T">TR Herrmann</name></author><author><name sortKey="Gross, Aj" uniqKey="Gross A">AJ Gross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bach, T" uniqKey="Bach T">T Bach</name></author><author><name sortKey="Netsch, C" uniqKey="Netsch C">C Netsch</name></author><author><name sortKey="Haecker, A" uniqKey="Haecker A">A Haecker</name></author><author><name sortKey="Michel, Ms" uniqKey="Michel M">MS Michel</name></author><author><name sortKey="Herrmann, Tr" uniqKey="Herrmann T">TR Herrmann</name></author><author><name sortKey="Gross, Aj" uniqKey="Gross A">AJ Gross</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Interv Aging</journal-id><journal-id journal-id-type="iso-abbrev">Clin Interv Aging</journal-id><journal-title-group><journal-title>Clinical Interventions in Aging</journal-title></journal-title-group><issn pub-type="ppub">1176-9092</issn><issn pub-type="epub">1178-1998</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24255595</article-id><article-id pub-id-type="pmc">3832386</article-id><article-id pub-id-type="doi">10.2147/CIA.S52697</article-id><article-id pub-id-type="publisher-id">cia-8-1483</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Prostatectomy using different lasers for the treatment of benign prostate hyperplasia in aging males</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Wei-Chang</given-names></name><xref ref-type="aff" rid="af1-cia-8-1483">1</xref><xref ref-type="author-notes" rid="fn1-cia-8-1483">*</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Yu-Hsiang</given-names></name><xref ref-type="aff" rid="af1-cia-8-1483">1</xref><xref ref-type="author-notes" rid="fn1-cia-8-1483">*</xref></contrib><contrib contrib-type="author"><name><surname>Hou</surname><given-names>Chen-Pang</given-names></name><xref ref-type="aff" rid="af1-cia-8-1483">1</xref></contrib><contrib contrib-type="author"><name><surname>Chang</surname><given-names>Phei-Lang</given-names></name><xref ref-type="aff" rid="af1-cia-8-1483">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Chien-Lun</given-names></name><xref ref-type="aff" rid="af1-cia-8-1483">1</xref></contrib><contrib contrib-type="author"><name><surname>Juang</surname><given-names>Horng-Heng</given-names></name><xref ref-type="aff" rid="af2-cia-8-1483">2</xref></contrib><contrib contrib-type="author"><name><surname>Tsui</surname><given-names>Ke-Hung</given-names></name><xref ref-type="aff" rid="af1-cia-8-1483">1</xref><xref ref-type="corresp" rid="c1-cia-8-1483"></xref></contrib></contrib-group><aff id="af1-cia-8-1483"><label>1</label>Department of Urology, Chang Gung Memorial Hospital-Linko and Chang Gung University, College of Medicine, Taiwan</aff><aff id="af2-cia-8-1483"><label>2</label>Department of Anatomy, College of Medicine, Chang Gung University, Kweishan-Shan, Taoyuan, Taiwan, Republic of China</aff><author-notes><fn id="fn1-cia-8-1483"><p>*These authors contributed equally to this work</p></fn><corresp id="c1-cia-8-1483">Correspondence: Ke-Hung Tsui, Department of Urology, Chang Gung Memory Hospital-Linko, Chang Gung University, 5 Fu-Shing Street Kwei-Shan, Taoyuan 333, Taiwan, Republic of China, Tel +886 3 328 1200 ext 2137, Fax +886 3 211 8112, Email <email>khtsui@yahoo.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pmc-comment>Dove Press titles changed from ppub to collections in 2009.
Fake ppub written to satisfy Coll Date Type=ppub</pmc-comment>
<pub-date pub-type="ppub"><year>2013</year></pub-date><pub-date pub-type="epub"><day>04</day><month>11</month><year>2013</year></pub-date><volume>8</volume><fpage>1483</fpage><lpage>1488</lpage><permissions><copyright-statement>© 2013 Lee et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License</copyright-statement><copyright-year>2013</copyright-year><license><license-p>The full terms of the License are available at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><sec><title>Purpose</title><p>Endoscopic lasers have become a treatment option for benign prostate hyperplasia (BPH). The study reported here sought to elucidate the benefits and drawbacks of different laser systems in the treatment of patients with BPH.</p></sec><sec><title>Methods</title><p>The study enrolled 741 patients diagnosed with lower urinary tract symptoms secondary to BPH during the period January 2005 to December 2011. The techniques used in the study were photoselective vaporization of the prostate, thulium laser prostatectomy, and diode laser prostatectomy. Patients were assigned to one of three groups according to the type of laser treatment they received. Outcomes were evaluated using the International Prostate Symptom Score (IPSS), quality of life, maximal urinary flow rate, post-voiding residual urine volume, and prostate-specific antigen (PSA) level.</p></sec><sec><title>Results</title><p>The baseline characteristics of patients who received diode laser prostatectomy show a significant elevated risk and high American Society of Anesthesiology score (<italic>P</italic>=0.001). Operative time and catheter removal time differed significantly between the three groups (<italic>P</italic>=0.001). No cases were converted to transurethral resection of the prostate intraoperatively due to bleeding (<italic>P</italic>=0.142). Among the three groups, there were no significant differences in maximal flow rate, lower post-void residual urine, and postoperative PSA level during the entire follow-up period (<italic>P</italic><0.05). Further, no significant differences in postoperative IPSS, quality of life, or bladder neck contracture (<italic>P</italic>=0.23) were observed. However, a significant difference was observed with regard to prolonged use of Foley catheters and prolonged hospital stay among patients in the diode laser group (<italic>P</italic>=0.001).</p></sec><sec><title>Conclusion</title><p>Laser prostatectomies are effective in dealing with lower urinary tract symptoms. Early subjective functional results (maximal flow rate, IPSS, and post-void residual urine) appeared the same as those obtained following laser prostatectomy. Thus, it appears that lasers are safe and effective as long as the patients are carefully selected for treatment.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>prostate gland</kwd><kwd>laser prostatectomy</kwd><kwd>diode laser</kwd><kwd>thulium laser</kwd><kwd>photoselective vaporization of the prostate</kwd></kwd-group></article-meta></front><body><sec><title>Introduction</title><p>Transurethral resection of the prostate (TURP) is generally considered the gold standard for the surgical treatment of benign prostate hyperplasia (BPH).<xref ref-type="bibr" rid="b1-cia-8-1483">1</xref> However, laser technology has also been used to treat lower urinary tract symptoms (LUTS) secondary to BPH for more than 15 years.<xref ref-type="bibr" rid="b2-cia-8-1483">2</xref>,<xref ref-type="bibr" rid="b3-cia-8-1483">3</xref> Increasingly, laser therapy is being considered for the surgical management of BPH of any size, as an alternative to TURP.<xref ref-type="bibr" rid="b3-cia-8-1483">3</xref>,<xref ref-type="bibr" rid="b4-cia-8-1483">4</xref> Several different initial laser techniques have been introduced to make prostatectomy procedures safer and more effective. Such techniques include use of high-powered 120 W (GreenLight™ HPS®; American Medical Systems, Minnetonka, MN, USA), thulium (Tm), diode, holmium, and vela lasers. Techniques consist of coagulation (photoselective vaporization of the prostate [PVP]), vaporization (PVP and diode), resection, and enucleation (Tm), depending on the wavelength, power, and type of laser emission. These methods have proven safe among patients with a high risk of bleeding (anticoagulant users, those with a tendency for bleeding, or those with an American Society of Anesthesiology [ASA] score >3).<xref ref-type="bibr" rid="b5-cia-8-1483">5</xref>,<xref ref-type="bibr" rid="b6-cia-8-1483">6</xref></p><p>Laser prostatectomy is also superior to TURP with regard to reducing blood transfusions and the length of hospital stay; however, it results in a higher reoperation rate.<xref ref-type="bibr" rid="b5-cia-8-1483">5</xref>,<xref ref-type="bibr" rid="b7-cia-8-1483">7</xref> Advanced laser techniques have been proposed as an alternative to TURP; however, current lasers and laser techniques differ considerably in terms of handling and their interaction with tissue. The study reported here aimed to elucidate the differences between laser systems and help urologists critically evaluate the effectiveness of each system in the treatment of LUTS due to BPH. Our results provide a valuable guide to assist urologists in selecting the most suitable laser option for each patient.</p></sec><sec sec-type="materials|methods"><title>Materials and methods</title><p>The study enrolled 741 patients between January 2005 and December 2011 at Chang Gung Memorial Hospital-LinKo. Inclusion criterion was LUTS secondary to BPH. Patients with postoperative prostate pathology showing malignancies were excluded (24 patients, 3.2%). Surgical treatment was initiated according to BPH guidelines provided by the European Association of Urology.<xref ref-type="bibr" rid="b8-cia-8-1483">8</xref> Laser surgery in each group was performed or supervised by a single surgeon who possessed expertise in laser therapy.</p><p>Recorded parameters included age, history of antiplatelet or anticoagulant drugs, International Prostatic Symptom Score (IPSS), digital rectal exam, prostate-specific antigen (PSA) level, prostate volume, and transitional-zone volume determined by transrectal ultrasound. In addition, uroflow studies were conducted at 3, 6, 12, and 24 months before and after the operation. Postoperative evaluation focused on peak-flow rate (Qmax) and post-voiding residual urine, the occurrence of acute urine retention, and whether a Foley catheter was inserted prior to the operation.</p><p>We also recorded ASA score, duration of operation, length of catheterization, length of hospital stay, as well as intraoperative, early, and late complications. Intraoperative complications included blood loss requiring transfusion and TURP syndrome. Early operative complications (occurring within 30 days of surgery) included acute urine retention requiring re-catheterization, hematuria requiring surgical intervention, and urosepsis. Late complications included bladder neck contracture or a urethral stricture that required secondary surgical intervention. Follow-up evaluations were conducted in the outpatient department of the clinic.</p><sec sec-type="intro"><title>Characteristics of the lasers used</title><p>PVP is performed using a high-powered 120 W (GreenLight HPS) laser system and a side-firing AddStat™ Fiber (American Medical Systems) with a core diameter of 600 mm. Power settings were increased from 100 to 120 W after tissue was found to become resistant to vaporization.<xref ref-type="bibr" rid="b4-cia-8-1483">4</xref></p><p>Conversely, the Tm laser operates at a wavelength of 2,000 nm and is delivered as a continuous wave. Tm lasers enable the complete absorption of laser energy in water, and due to their slightly shorter wavelength, the depth of penetration is only 0.25 mm. This leads to rapid vaporization and resection of tissue. Nonetheless, Tm lasers are suitable for transurethral vaporization, resection, or enucleation of the prostate.</p><p>Diode lasers use a special diode to generate energy. The operating wavelength of 980 nm is near the infrared electromagnetic spectrum, and is therefore easily absorbed by water and hemoglobin. This results in good hemostatic properties and tissue vaporization performance.</p><p><xref ref-type="table" rid="t1-cia-8-1483">Table 1</xref> summarizes the main characteristics of the lasers discussed here.</p></sec><sec sec-type="methods"><title>Statistical analysis</title><p>The mean ± standard deviation of all continuous measures and scores was recorded at baseline and during all follow-up visits. Statistical analysis was performed using analysis of variance or Student’s <italic>t</italic>-test to produce continuous data approximating normal distribution. Continuous variables were compared between treatment groups using a second Student’s <italic>t</italic>-test, with <italic>P</italic>-values<0.05 considered significant. Multivariate logistic regression analysis was performed to assess the impact of selected factors on postoperative outcome parameters, with <italic>P</italic>-values<0.05 considered statistically significant. All analyses were performed using commercially available software.</p></sec></sec><sec sec-type="results"><title>Results</title><p>Baseline patient characteristics are listed in <xref ref-type="table" rid="t2-cia-8-1483">Table 2</xref>. The diode laser vaporization group included a greater number of anticoagulant users and patients with an ASA score >3, higher PSA level, prostate volume, and catheterization prior to the operation (<italic>P</italic>=0.01). Most patients taking warfarin and heparin who had a prostate weighing <60 g underwent PVP treatment and most patients taking these same anticoagulants with a prostate weighing >60 g underwent treatment with a diode laser. The remaining patients were assigned to Tm enucleation laser therapy. Additionally, the vast majority of patients who were given antiplatelet therapy (aspirin and/or clopidogrel) underwent diode laser therapy (<italic>P</italic>=0.001).</p><p>Urinary retention rates were as follows: GreenLight HPS group, 31.1%; Tm group, 38%; and diode group, 48.6%. The average length of hospital stay was 2.5 ± 1.4 days for the HPS group, 2.5 + 1.0 days for the Tm group, and 3.1 + 1.2 days for the diode group (<italic>P</italic><0.001).</p><p><xref ref-type="table" rid="t3-cia-8-1483">Table 3</xref> presents the intraoperative, early, and late postoperative complications and outcomes for patients in the three groups. With the exception of re-catheterization, no significant difference in the rate of complications was observed between the three groups. Despite the high re-catheterization rate in the diode laser group (<italic>P</italic>=0.001), all of these patients showed improvements after Foley training and medications. A total of 51 patients (7.1%) presented with urinary retention and were administered urethral catheters for a mean of 7.6 days. Patients in the diode laser group were at higher risk for bleeding; however, the blood transfusion rate and check bleeding rate were not significantly higher than those observed in the other groups (<italic>P</italic>>0.05). All groups (<xref ref-type="fig" rid="f1-cia-8-1483">Figure 1</xref>) showed significant improvements in terms of post-void residual urine volume, Qmax, and PSA level. The PSA levels are dramatically decreased after surgery, also indicated improvements for at least 1 year postoperatively.</p><p>Meta-analysis provided valuable information on the predictors of overall complications. Logistic regression results revealed that most cases of induced comorbidity presented significant differences in prostate volume (hazard ratio [HR] =1.03; 95% confidence interval [CI]: 1.01–1.05; <italic>P</italic>=0.003) and catheterization before the operation (HR =2.92, 95% CI: 1.16–7.36; <italic>P</italic>=0.023). Other factors, including age, incidence of diabetes mellitus, hypertension, and thrombocytopenia, as well as medical record post-TURP, IPSS score, PSA level, and operative time, were not associated with complications in any of the three laser groups. In the Tm group, catheterization before the operation presented a higher overall complication rate than that among patients who did not undergo catheterization (<italic>P</italic>=0.023). Additionally, in the Tm group, a 1 g increase in prostate volume did not present a significant increase in complication rates, but a prostate volume exceeding 100 g was associated with a significantly higher surgical morbidity rate (<xref ref-type="table" rid="t4-cia-8-1483">Table 4</xref>).</p></sec><sec sec-type="discussion"><title>Discussion</title><p>Laser prostatectomy for the treatment of LUTS provides outcomes and lower complication rates at least equal to those obtained with TURP.<xref ref-type="bibr" rid="b7-cia-8-1483">7</xref> However, the idea that TURP should be replaced by laser therapy as the gold standard is still not widely accepted due to the lack of studies on a large number of cases.</p><p>We found that laser prostatectomy resulted in relatively low rates of intraoperative and perioperative complications. We also observed that patients taking aspirin or warfarin had a higher rate of perioperative bleeding compared with those who did not take these drugs; however, withholding these medications resulted in increased rates of cardiovascular and cerebrovascular complications.<xref ref-type="bibr" rid="b6-cia-8-1483">6</xref>,<xref ref-type="bibr" rid="b8-cia-8-1483">8</xref> Nonetheless, laser prostatectomy was found to be a useful alternative to TURP in treating patients taking antiplatelet and anticoagulation drugs.<xref ref-type="bibr" rid="b9-cia-8-1483">9</xref>–<xref ref-type="bibr" rid="b11-cia-8-1483">11</xref></p><p>Patients undergoing diode laser therapy did not require postoperative blood transfusions. The re-catheterization rate was between 4.3% and 20.0%.<xref ref-type="bibr" rid="b12-cia-8-1483">12</xref>,<xref ref-type="bibr" rid="b13-cia-8-1483">13</xref> Patients in the diode laser group had a re-catheterization rate of approximately 17%. Diode lasers are recommended for patients at high risk of bleeding. Rieken et al reported that among patients who underwent diode laser treatment, 9.6% of those with bladder neck obstruction required reoperation, compared with 3.6% among those who underwent TURP.<xref ref-type="bibr" rid="b14-cia-8-1483">14</xref> In addition, a urethral stricture developed in 5.5% of those undergoing diode laser treatment versus 0.0% undergoing TURP.<xref ref-type="bibr" rid="b14-cia-8-1483">14</xref></p><p>The current study revealed higher complication rates in the diode laser group but no significant differences among the three groups (<italic>P</italic>=0.237). Additionally, there were no reports of TURP syndrome among patients in any group. The blood-loss-requiring-blood-transfusion rate has been reported as 0.0%–2.2%.<xref ref-type="bibr" rid="b14-cia-8-1483">14</xref> In our study, blood transfusion was required in one patient undergoing PVP treatment. In previous reviews of early complications, 1.1% of patients required re-catheterization.<xref ref-type="bibr" rid="b15-cia-8-1483">15</xref>,<xref ref-type="bibr" rid="b16-cia-8-1483">16</xref> Reported reoperation rates have been lower than 2.2%.<xref ref-type="bibr" rid="b17-cia-8-1483">17</xref>,<xref ref-type="bibr" rid="b18-cia-8-1483">18</xref> In the current study, no statistically significant differences were observed between these three groups.</p><p>As far as we are aware, this is the first study to outline the differences between laser prostatectomy techniques in terms of handling and operative outcome. This paper has provided necessary information to help urologists differentiate between laser systems and critically evaluate the role of these techniques in the treatment of LUTS due to BPH.</p></sec><sec><title>Conclusion</title><p>Laser prostatectomy is increasingly being considered as a valid clinical alternative to TURP. This study compared the efficacy of three laser techniques used to treat LUTS due to BPH. PVP, a coagulation-based technique, has durable efficacy for prostates weighing <60 g. Tm laser (an enucleation laser technique) has previously been criticized for having a steep learning curve due to the fact that this laser requires a certain volume of enucleated tissue. Nonetheless, our evidence supports the contention that Tm offers favorable and durable outcomes for prostates of any size and low morbidity rates, both early and late. GreenLight HPS laser prostatectomy has been more widely accepted and offers favorable outcomes for prostates weighing <60 g. Diode laser prostatectomy (a coagulation-based technique) is preferred for prostates weighing >60 g and among patients with thrombocytopenia or who have a tendency for bleeding.</p><p>In our study, these techniques were found to be equally safe and effective in the treatment of BPH without any severe drawbacks as long as patients were selected according to risk factors. However, future research should use higher quality data to further evaluate and compare types of laser treatment to confirm our results.</p></sec></body><back><fn-group><fn><p><bold>Disclosure</bold></p><p>The authors declare no conflicts of interest in this work.</p></fn></fn-group><ref-list><title>References</title><ref id="b1-cia-8-1483"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wasson</surname><given-names>JH</given-names></name><name><surname>Reda</surname><given-names>DJ</given-names></name><name><surname>Bruskewitz</surname><given-names>RC</given-names></name><name><surname>Elinson</surname><given-names>J</given-names></name><name><surname>Keller</surname><given-names>AM</given-names></name><name><surname>Henderson</surname><given-names>WG</given-names></name></person-group><article-title>A comparison of transurethral surgery with watchful waiting for moderate symptoms of benign prostatic hyperplasia. The Veterans Affairs Cooperative Study Group on Transurethral Resection of the Prostate</article-title><source>N Engl J Med</source><year>1995</year><volume>332</volume><issue>2</issue><fpage>75</fpage><lpage>79</lpage><pub-id pub-id-type="pmid">7527493</pub-id></element-citation></ref><ref id="b2-cia-8-1483"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gravas</surname><given-names>S</given-names></name><name><surname>Bachmann</surname><given-names>A</given-names></name><name><surname>Reich</surname><given-names>O</given-names></name><etal></etal></person-group><article-title>Critical review of lasers in benign prostatic hyperplasia (BPH)</article-title><source>BJU Int</source><year>2011</year><volume>107</volume><issue>7</issue><fpage>1030</fpage><lpage>1043</lpage><pub-id pub-id-type="pmid">21438974</pub-id></element-citation></ref><ref id="b3-cia-8-1483"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rieken</surname><given-names>M</given-names></name><name><surname>Ebinger Mundorff</surname><given-names>N</given-names></name><name><surname>Bonkat</surname><given-names>G</given-names></name><name><surname>Wyler</surname><given-names>S</given-names></name><name><surname>Bachmann</surname><given-names>A</given-names></name></person-group><article-title>Complications of laser prostatectomy: a review of recent data</article-title><source>World J Urol</source><year>2010</year><volume>28</volume><issue>1</issue><fpage>53</fpage><lpage>62</lpage><pub-id pub-id-type="pmid">20052586</pub-id></element-citation></ref><ref id="b4-cia-8-1483"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Reich</surname><given-names>O</given-names></name><name><surname>Bachmann</surname><given-names>A</given-names></name><name><surname>Siebels</surname><given-names>M</given-names></name><name><surname>Hofstetter</surname><given-names>A</given-names></name><name><surname>Stief</surname><given-names>CG</given-names></name><name><surname>Sulser</surname><given-names>T</given-names></name></person-group><article-title>High power (80 W) potassium-titanyl-phosphate laser vaporization of the prostate in 66 high risk patients</article-title><source>J Urol</source><year>2005</year><volume>173</volume><issue>1</issue><fpage>158</fpage><lpage>160</lpage><pub-id pub-id-type="pmid">15592063</pub-id></element-citation></ref><ref id="b5-cia-8-1483"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Elzayat</surname><given-names>E</given-names></name><name><surname>Habib</surname><given-names>E</given-names></name><name><surname>Elhilali</surname><given-names>M</given-names></name></person-group><article-title>Holmium laser enucleation of the prostate: a size-independent new “gold standard”</article-title><source>Urology</source><year>2005</year><volume>66</volume><issue>Suppl 5</issue><fpage>108</fpage><lpage>113</lpage><pub-id pub-id-type="pmid">16194716</pub-id></element-citation></ref><ref id="b6-cia-8-1483"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Shao</surname><given-names>IH</given-names></name><name><surname>Hou</surname><given-names>CP</given-names></name><name><surname>Chen</surname><given-names>SM</given-names></name><etal></etal></person-group><article-title>The safety and efficacy of aspirin intake in photoselective vaporization laser treatment of benign prostate hyperplasia</article-title><source>Clin Interv Aging</source><year>2013</year><volume>8</volume><fpage>265</fpage><lpage>269</lpage><pub-id pub-id-type="pmid">23662050</pub-id></element-citation></ref><ref id="b7-cia-8-1483"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Elmansy</surname><given-names>H</given-names></name><name><surname>Baazeem</surname><given-names>A</given-names></name><name><surname>Kotb</surname><given-names>A</given-names></name><etal></etal></person-group><article-title>Holmium laser enucleation versus photoselective vaporization for prostatic adenoma greater than 60 mL: preliminary results of a prospective, randomized clinical trial</article-title><source>J Urol</source><year>2012</year><volume>188</volume><issue>1</issue><fpage>216</fpage><lpage>221</lpage><pub-id pub-id-type="pmid">22591968</pub-id></element-citation></ref><ref id="b8-cia-8-1483"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Madersbacher</surname><given-names>S</given-names></name><name><surname>Alivizatos</surname><given-names>G</given-names></name><name><surname>Nordling</surname><given-names>J</given-names></name><name><surname>Sanz</surname><given-names>CR</given-names></name><name><surname>Emberton</surname><given-names>M</given-names></name><name><surname>de la Rosette</surname><given-names>JJ</given-names></name></person-group><article-title>EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines)</article-title><source>Eur Urol</source><year>2004</year><volume>46</volume><issue>5</issue><fpage>547</fpage><lpage>554</lpage><pub-id pub-id-type="pmid">15474261</pub-id></element-citation></ref><ref id="b9-cia-8-1483"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rassweiler</surname><given-names>J</given-names></name><name><surname>Teber</surname><given-names>D</given-names></name><name><surname>Kuntz</surname><given-names>R</given-names></name><name><surname>Hofmann</surname><given-names>R</given-names></name></person-group><article-title>Complications of transurethral resection of the prostate (TURP) – incidence, management, and prevention</article-title><source>Eur Urol</source><year>2006</year><volume>50</volume><issue>5</issue><fpage>969</fpage><lpage>979</lpage><comment>discussion 980</comment><pub-id pub-id-type="pmid">16469429</pub-id></element-citation></ref><ref id="b10-cia-8-1483"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Taylor</surname><given-names>K</given-names></name><name><surname>Filgate</surname><given-names>R</given-names></name><name><surname>Guo</surname><given-names>DY</given-names></name><name><surname>Macneil</surname><given-names>F</given-names></name></person-group><article-title>A retrospective study to assess the morbidity associated with transurethral prostatectomy in patients on antiplatelet or anticoagulant drugs</article-title><source>BJU Int</source><year>2011</year><volume>108</volume><issue>Suppl 2</issue><fpage>45</fpage><lpage>50</lpage><pub-id pub-id-type="pmid">22085127</pub-id></element-citation></ref><ref id="b11-cia-8-1483"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Descazeaud</surname><given-names>A</given-names></name><name><surname>Robert</surname><given-names>G</given-names></name><name><surname>Azzousi</surname><given-names>AR</given-names></name><etal></etal><collab>Committee for lower urinary tract symptoms of the French Association of Urology</collab></person-group><article-title>Laser treatment of benign prostatic hyperplasia in patients on oral anticoagulant therapy: a review</article-title><source>BJU Int</source><year>2009</year><volume>103</volume><issue>9</issue><fpage>1162</fpage><lpage>1165</lpage><pub-id pub-id-type="pmid">19154457</pub-id></element-citation></ref><ref id="b12-cia-8-1483"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Erol</surname><given-names>A</given-names></name><name><surname>Cam</surname><given-names>K</given-names></name><name><surname>Tekin</surname><given-names>A</given-names></name><name><surname>Memik</surname><given-names>O</given-names></name><name><surname>Coban</surname><given-names>S</given-names></name><name><surname>Ozer</surname><given-names>Y</given-names></name></person-group><article-title>High power diode laser vaporization of the prostate: preliminary results for benign prostatic hyperplasia</article-title><source>J Urol</source><year>2009</year><volume>182</volume><issue>3</issue><fpage>1078</fpage><lpage>1082</lpage><pub-id pub-id-type="pmid">19616811</pub-id></element-citation></ref><ref id="b13-cia-8-1483"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seitz</surname><given-names>M</given-names></name><name><surname>Sroka</surname><given-names>R</given-names></name><name><surname>Gratzke</surname><given-names>C</given-names></name><etal></etal></person-group><article-title>The diode laser: a novel side-firing approach for laser vaporisation of the human prostate – immediate efficacy and 1-year follow-up</article-title><source>Eur Urol</source><year>2007</year><volume>52</volume><issue>6</issue><fpage>1717</fpage><lpage>1722</lpage><pub-id pub-id-type="pmid">17628326</pub-id></element-citation></ref><ref id="b14-cia-8-1483"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rieken</surname><given-names>M</given-names></name><name><surname>Wyler</surname><given-names>S</given-names></name><name><surname>Müller</surname><given-names>G</given-names></name><etal></etal></person-group><article-title>589 laser vaporization of the prostate: intermediate-term follow-up with the 200 W high-intensity diode (HIDI) laser system</article-title><source>Eur Urol Suppl</source><year>2009</year><volume>8</volume><issue>4</issue><fpage>268</fpage></element-citation></ref><ref id="b15-cia-8-1483"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Capitán</surname><given-names>C</given-names></name><name><surname>Blázquez</surname><given-names>C</given-names></name><name><surname>Martin</surname><given-names>MD</given-names></name><name><surname>Hernández</surname><given-names>V</given-names></name><name><surname>de la Peña</surname><given-names>E</given-names></name><name><surname>Llorente</surname><given-names>C</given-names></name></person-group><article-title>GreenLight HPS 120-W laser vaporization versus transurethral resection of the prostate for the treatment of lower urinary tract symptoms due to benign prostatic hyperplasia: a randomized clinical trial with 2-year follow-up</article-title><source>Eur Urol</source><year>2011</year><volume>60</volume><issue>4</issue><fpage>734</fpage><lpage>739</lpage><pub-id pub-id-type="pmid">21658839</pub-id></element-citation></ref><ref id="b16-cia-8-1483"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bach</surname><given-names>T</given-names></name><name><surname>Herrmann</surname><given-names>TR</given-names></name><name><surname>Haecker</surname><given-names>A</given-names></name><name><surname>Michel</surname><given-names>MS</given-names></name><name><surname>Gross</surname><given-names>A</given-names></name></person-group><article-title>Thulium:yttrium-aluminium-garnet laser prostatectomy in men with refractory urinary retention</article-title><source>BJU Int</source><year>2009</year><volume>104</volume><issue>3</issue><fpage>361</fpage><lpage>364</lpage><pub-id pub-id-type="pmid">19220261</pub-id></element-citation></ref><ref id="b17-cia-8-1483"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bach</surname><given-names>T</given-names></name><name><surname>Wendt-Nordahl</surname><given-names>G</given-names></name><name><surname>Michel</surname><given-names>MS</given-names></name><name><surname>Herrmann</surname><given-names>TR</given-names></name><name><surname>Gross</surname><given-names>AJ</given-names></name></person-group><article-title>Feasibility and efficacy of Thulium:YAG laser enucleation (VapoEnucleation) of the prostate</article-title><source>World J Urol</source><year>2009</year><volume>27</volume><issue>4</issue><fpage>541</fpage><lpage>545</lpage><pub-id pub-id-type="pmid">19184038</pub-id></element-citation></ref><ref id="b18-cia-8-1483"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bach</surname><given-names>T</given-names></name><name><surname>Netsch</surname><given-names>C</given-names></name><name><surname>Haecker</surname><given-names>A</given-names></name><name><surname>Michel</surname><given-names>MS</given-names></name><name><surname>Herrmann</surname><given-names>TR</given-names></name><name><surname>Gross</surname><given-names>AJ</given-names></name></person-group><article-title>Thulium:YAG laser enucleation (VapoEnucleation) of the prostate: safety and durability during intermediate-term follow-up</article-title><source>World J Urol</source><year>2010</year><volume>28</volume><issue>1</issue><fpage>39</fpage><lpage>43</lpage><pub-id pub-id-type="pmid">19669645</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="f1-cia-8-1483" position="float"><label>Figure 1</label><caption><p>Logistic regression analysis for three types of laser prostatectomy: predicted (<bold>A</bold>) post-void residual urine volume, (<bold>B</bold>) peak-flow rate (PFR), and (<bold>C</bold>) prostate-specific antigen (PSA) level curves.</p><p><bold>Note:</bold> A significant improvement was observed in terms of post-voiding residual urine volume, peak-flow rate, and PSA level, compared with preoperative levels (<italic>P</italic><0.05).</p><p><bold>Abbreviations:</bold> M, months; OP, operation; PVP, photoselective vaporization of prostate; RU, residual urine; SE, standard error.</p></caption><graphic xlink:href="cia-8-1483Fig1"></graphic></fig><table-wrap id="t1-cia-8-1483" position="float"><label>Table 1</label><caption><p>Main characteristics of the different laser techniques</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">Laser technique</th><th align="left" valign="top" rowspan="1" colspan="1">WL, nm</th><th align="left" valign="top" rowspan="1" colspan="1">Chromophore(s)</th><th align="left" valign="top" rowspan="1" colspan="1">Depth, mm</th><th align="left" valign="top" rowspan="1" colspan="1">Application</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">PVP</td><td align="left" valign="top" rowspan="1" colspan="1">532</td><td align="left" valign="top" rowspan="1" colspan="1">Hemoglobin</td><td align="left" valign="top" rowspan="1" colspan="1">0.80</td><td align="left" valign="top" rowspan="1" colspan="1">Tissue vaporization</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Tm laser prostatectomy</td><td align="left" valign="top" rowspan="1" colspan="1">2,000</td><td align="left" valign="top" rowspan="1" colspan="1">Water</td><td align="left" valign="top" rowspan="1" colspan="1">0.25</td><td align="left" valign="top" rowspan="1" colspan="1">Tissue vaporization, resection, enucleation</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Diode laser prostatectomy</td><td align="left" valign="top" rowspan="1" colspan="1">980</td><td align="left" valign="top" rowspan="1" colspan="1">Water, hemoglobin</td><td align="left" valign="top" rowspan="1" colspan="1">>0.50</td><td align="left" valign="top" rowspan="1" colspan="1">Tissue vaporization</td></tr></tbody></table><table-wrap-foot><fn id="tfn1-cia-8-1483"><p><bold>Abbreviations</bold>: PVP, photoselective vaporization of prostate; Tm, thulium; WL, wavelength.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t2-cia-8-1483" position="float"><label>Table 2</label><caption><p>Baseline characteristics of patients in the three groups</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">Characteristics (mean ± standard deviation)</th><th align="left" valign="top" rowspan="1" colspan="1">PVP (n=402)</th><th align="left" valign="top" rowspan="1" colspan="1">Thulium (n=245)</th><th align="left" valign="top" rowspan="1" colspan="1">Diode (n=70)</th><th align="left" valign="top" rowspan="1" colspan="1"><italic>P</italic></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Age</td><td align="left" valign="top" rowspan="1" colspan="1">71.3 ± 9.6</td><td align="left" valign="top" rowspan="1" colspan="1">70.0 ± 8.1</td><td align="left" valign="top" rowspan="1" colspan="1">72.7 ± 9.4</td><td align="left" valign="top" rowspan="1" colspan="1">0.049</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Diabetes mellitus</td><td align="left" valign="top" rowspan="1" colspan="1">64 (15.9)</td><td align="left" valign="top" rowspan="1" colspan="1">38 (15.5)</td><td align="left" valign="top" rowspan="1" colspan="1">12 (17.1)</td><td align="left" valign="top" rowspan="1" colspan="1">0.947</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Hypertension</td><td align="left" valign="top" rowspan="1" colspan="1">202 (50.2)</td><td align="left" valign="top" rowspan="1" colspan="1">104 (42.4)</td><td align="left" valign="top" rowspan="1" colspan="1">37 (52.9)</td><td align="left" valign="top" rowspan="1" colspan="1">0.106</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">History of TURP</td><td align="left" valign="top" rowspan="1" colspan="1">18 (4.5)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (2.4)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (1.4)</td><td align="left" valign="top" rowspan="1" colspan="1">0.242</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Aspirin</td><td align="left" valign="top" rowspan="1" colspan="1">82 (20.4)</td><td align="left" valign="top" rowspan="1" colspan="1">30 (12.2)</td><td align="left" valign="top" rowspan="1" colspan="1">13 (18.6)</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>0.029</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Warfarin</td><td align="left" valign="top" rowspan="1" colspan="1">8 (2.0)</td><td align="left" valign="top" rowspan="1" colspan="1">4 (1.6)</td><td align="left" valign="top" rowspan="1" colspan="1">12 (17.1)</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Thrombocytopenia</td><td align="left" valign="top" rowspan="1" colspan="1">37 (9.2)</td><td align="left" valign="top" rowspan="1" colspan="1">13 (5.3)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (8.6)</td><td align="left" valign="top" rowspan="1" colspan="1">0.195</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">ASA score =3 or 4</td><td align="left" valign="top" rowspan="1" colspan="1">157 (39)</td><td align="left" valign="top" rowspan="1" colspan="1">91 (37.1)</td><td align="left" valign="top" rowspan="1" colspan="1">47 (67.1)</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">IPSS</td><td align="left" valign="top" rowspan="1" colspan="1">26.0 ± 3.8</td><td align="left" valign="top" rowspan="1" colspan="1">25.5 ± 4.1</td><td align="left" valign="top" rowspan="1" colspan="1">26.0 ± 3.6</td><td align="left" valign="top" rowspan="1" colspan="1">0.197</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">PSA</td><td align="left" valign="top" rowspan="1" colspan="1">6.1 ± 6.0</td><td align="left" valign="top" rowspan="1" colspan="1">8.0 ± 6.1</td><td align="left" valign="top" rowspan="1" colspan="1">8.5 ± 6.9</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Free PSA, %</td><td align="left" valign="top" rowspan="1" colspan="1">25.3 ± 11.2</td><td align="left" valign="top" rowspan="1" colspan="1">23.7 ± 8.3</td><td align="left" valign="top" rowspan="1" colspan="1">25.2 ± 9.7</td><td align="left" valign="top" rowspan="1" colspan="1">0.554</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Volume of prostate</td><td align="left" valign="top" rowspan="1" colspan="1">51.7 ± 20.9</td><td align="left" valign="top" rowspan="1" colspan="1">68.4 ± 26.3</td><td align="left" valign="top" rowspan="1" colspan="1">73.7 ± 37.8</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">T-volume</td><td align="left" valign="top" rowspan="1" colspan="1">25.7 ± 14.9</td><td align="left" valign="top" rowspan="1" colspan="1">33.6 ± 18.3</td><td align="left" valign="top" rowspan="1" colspan="1">37.6 ± 24.5</td><td align="left" valign="top" rowspan="1" colspan="1"><<bold>0.001</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Catheterization before op</td><td align="left" valign="top" rowspan="1" colspan="1">125 (31.1)</td><td align="left" valign="top" rowspan="1" colspan="1">93 (38.0)</td><td align="left" valign="top" rowspan="1" colspan="1">34 (48.6)</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>0.010</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Op with stone</td><td align="left" valign="top" rowspan="1" colspan="1">21 (6.8)</td><td align="left" valign="top" rowspan="1" colspan="1">29 (23.6)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (3.7)</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>0.010</bold></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Op time, minutes</td><td align="left" valign="top" rowspan="1" colspan="1">106.9 ± 39.9</td><td align="left" valign="top" rowspan="1" colspan="1">97.8 ± 39.0</td><td align="left" valign="top" rowspan="1" colspan="1">98.6 ± 31.4</td><td align="left" valign="top" rowspan="1" colspan="1"><bold>0.009</bold></td></tr></tbody></table><table-wrap-foot><fn id="tfn2-cia-8-1483"><p><bold>Note:</bold> Values in bold text, <italic>P</italic><0.05 is significant difference.</p></fn><fn id="tfn3-cia-8-1483"><p><bold>Abbreviations</bold>: ASA, American Society of Anesthesiology; IPSS, International Prostatic Symptom Score; PSA, prostate-specific antigen; PVP, photoselective vaporization of prostate; Op, operation; TURP, transurethral resection of prostate; T-volume, transitional zone of prostate volume.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t3-cia-8-1483" position="float"><label>Table 3</label><caption><p>Intraoperative, early, and late postoperative complications and outcomes in patients in the three groups</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">Mean ± SD (median) or n (%) variable</th><th align="left" valign="top" rowspan="1" colspan="1">PVP (n=402)</th><th align="left" valign="top" rowspan="1" colspan="1">Thulium (n=245)</th><th align="left" valign="top" rowspan="1" colspan="1">Diode (n=70)</th><th align="left" valign="top" rowspan="1" colspan="1"><italic>P</italic></th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Follow-up (months)</td><td align="left" valign="top" rowspan="1" colspan="1">38.7 (39)</td><td align="left" valign="top" rowspan="1" colspan="1">25.2 (23)</td><td align="left" valign="top" rowspan="1" colspan="1">24.4 (20)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">Intraoperative complications</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Blood transfusion</td><td align="left" valign="top" rowspan="1" colspan="1">1 (0.2)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0.0)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0.0)</td><td align="left" valign="top" rowspan="1" colspan="1">1.000</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> TURP syndrome</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0)</td><td align="left" valign="top" rowspan="1" colspan="1">0 (0)</td><td align="left" valign="top" rowspan="1" colspan="1">1.000</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">Early (<30 days) postoperative complications</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Check bleeding</td><td align="left" valign="top" rowspan="1" colspan="1">3 (0.7)</td><td align="left" valign="top" rowspan="1" colspan="1">5 (2.0)</td><td align="left" valign="top" rowspan="1" colspan="1">2 (2.9)</td><td align="left" valign="top" rowspan="1" colspan="1">0.142</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Re-catheterization</td><td align="left" valign="top" rowspan="1" colspan="1">30 (7.5)</td><td align="left" valign="top" rowspan="1" colspan="1">9 (3.7)</td><td align="left" valign="top" rowspan="1" colspan="1">12 (17.1)</td><td align="left" valign="top" rowspan="1" colspan="1">0.001</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Urosepsis</td><td align="left" valign="top" rowspan="1" colspan="1">8 (2.0)</td><td align="left" valign="top" rowspan="1" colspan="1">4 (1.6)</td><td align="left" valign="top" rowspan="1" colspan="1">1 (1.4)</td><td align="left" valign="top" rowspan="1" colspan="1">1.000</td></tr><tr><td colspan="5" align="left" valign="top" rowspan="1">Late (>30 days) postoperative complications</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Reop: TURP or TUR-BN</td><td align="left" valign="top" rowspan="1" colspan="1">20 (5.0)</td><td align="left" valign="top" rowspan="1" colspan="1">6 (2.4)</td><td align="left" valign="top" rowspan="1" colspan="1">4 (5.7)</td><td align="left" valign="top" rowspan="1" colspan="1">0.237</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Duration of hospitalization (days)</td><td align="left" valign="top" rowspan="1" colspan="1">3.5 ± 1.4</td><td align="left" valign="top" rowspan="1" colspan="1">3.5 ± 1.0</td><td align="left" valign="top" rowspan="1" colspan="1">4.1 ± 1.2</td><td align="left" valign="top" rowspan="1" colspan="1"><0.001</td></tr></tbody></table><table-wrap-foot><fn id="tfn4-cia-8-1483"><p><bold>Abbreviations</bold>: Reop, reoperation; PVP, photoselective vaporization of prostate; SD, standard deviation; TUR-BN, transurethral resection of bladder neck; TURP, transurethral resection of prostate.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t4-cia-8-1483" position="float"><label>Table 4</label><caption><p>Logistic regression analysis to predict overall morbidities of laser prostatectomy</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="2" colspan="1">Op method Characteristic</th><th colspan="2" align="left" valign="top" rowspan="1">PVP (n=402)
<hr></hr></th><th colspan="2" align="left" valign="top" rowspan="1">Thulium (n=245)
<hr></hr></th><th colspan="2" align="left" valign="top" rowspan="1">Diode (n=70)
<hr></hr></th></tr><tr><th align="left" valign="top" rowspan="1" colspan="1"><italic>P</italic></th><th align="left" valign="top" rowspan="1" colspan="1">OR</th><th align="left" valign="top" rowspan="1" colspan="1"><italic>P</italic></th><th align="left" valign="top" rowspan="1" colspan="1">OR</th><th align="left" valign="top" rowspan="1" colspan="1"><italic>P</italic></th><th align="left" valign="top" rowspan="1" colspan="1">OR</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Age</td><td align="left" valign="top" rowspan="1" colspan="1">0.713</td><td align="left" valign="top" rowspan="1" colspan="1">0.99</td><td align="left" valign="top" rowspan="1" colspan="1">0.654</td><td align="left" valign="top" rowspan="1" colspan="1">1.01</td><td align="left" valign="top" rowspan="1" colspan="1">0.659</td><td align="left" valign="top" rowspan="1" colspan="1">0.99</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Diabetes mellitus</td><td align="left" valign="top" rowspan="1" colspan="1">0.401</td><td align="left" valign="top" rowspan="1" colspan="1">1.38</td><td align="left" valign="top" rowspan="1" colspan="1">0.186</td><td align="left" valign="top" rowspan="1" colspan="1">0.25</td><td align="left" valign="top" rowspan="1" colspan="1">0.214</td><td align="left" valign="top" rowspan="1" colspan="1">2.40</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Hypertension</td><td align="left" valign="top" rowspan="1" colspan="1">0.734</td><td align="left" valign="top" rowspan="1" colspan="1">0.90</td><td align="left" valign="top" rowspan="1" colspan="1">0.968</td><td align="left" valign="top" rowspan="1" colspan="1">1.02</td><td align="left" valign="top" rowspan="1" colspan="1">0.405</td><td align="left" valign="top" rowspan="1" colspan="1">0.60</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">History of TURP</td><td align="left" valign="top" rowspan="1" colspan="1">0.207</td><td align="left" valign="top" rowspan="1" colspan="1">2.10</td><td align="left" valign="top" rowspan="1" colspan="1">1.000</td><td align="left" valign="top" rowspan="1" colspan="1">1.295<xref ref-type="table-fn" rid="tfn5-cia-8-1483">a</xref></td><td align="left" valign="top" rowspan="1" colspan="1">1.000</td><td align="left" valign="top" rowspan="1" colspan="1">4.00<xref ref-type="table-fn" rid="tfn5-cia-8-1483">a</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Thrombocytopenia</td><td align="left" valign="top" rowspan="1" colspan="1">0.407</td><td align="left" valign="top" rowspan="1" colspan="1">0.60</td><td align="left" valign="top" rowspan="1" colspan="1">0.605</td><td align="left" valign="top" rowspan="1" colspan="1">0.562<xref ref-type="table-fn" rid="tfn5-cia-8-1483">a</xref></td><td align="left" valign="top" rowspan="1" colspan="1">0.402</td><td align="left" valign="top" rowspan="1" colspan="1">2.17</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">IPSS</td><td align="left" valign="top" rowspan="1" colspan="1">0.545</td><td align="left" valign="top" rowspan="1" colspan="1">1.02</td><td align="left" valign="top" rowspan="1" colspan="1">0.982</td><td align="left" valign="top" rowspan="1" colspan="1">1.00</td><td align="left" valign="top" rowspan="1" colspan="1">0.855</td><td align="left" valign="top" rowspan="1" colspan="1">1.02</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Prostate-specific antigen</td><td align="left" valign="top" rowspan="1" colspan="1">0.740</td><td align="left" valign="top" rowspan="1" colspan="1">0.99</td><td align="left" valign="top" rowspan="1" colspan="1">0.083</td><td align="left" valign="top" rowspan="1" colspan="1">1.06</td><td align="left" valign="top" rowspan="1" colspan="1">0.297</td><td align="left" valign="top" rowspan="1" colspan="1">1.05</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Free prostate-specific antigen</td><td align="left" valign="top" rowspan="1" colspan="1">0.940</td><td align="left" valign="top" rowspan="1" colspan="1">1.00</td><td align="left" valign="top" rowspan="1" colspan="1">0.511</td><td align="left" valign="top" rowspan="1" colspan="1">1.03</td><td align="left" valign="top" rowspan="1" colspan="1">0.554</td><td align="left" valign="top" rowspan="1" colspan="1">1.04</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Volume</td><td align="left" valign="top" rowspan="1" colspan="1">0.131</td><td align="left" valign="top" rowspan="1" colspan="1">1.01</td><td align="left" valign="top" rowspan="1" colspan="1">0.003<xref ref-type="table-fn" rid="tfn6-cia-8-1483">b</xref></td><td align="left" valign="top" rowspan="1" colspan="1">1.03<xref ref-type="table-fn" rid="tfn6-cia-8-1483">b</xref></td><td align="left" valign="top" rowspan="1" colspan="1">0.089</td><td align="left" valign="top" rowspan="1" colspan="1">1.02</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">T-volume</td><td align="left" valign="top" rowspan="1" colspan="1">0.798</td><td align="left" valign="top" rowspan="1" colspan="1">1.00</td><td align="left" valign="top" rowspan="1" colspan="1">0.504</td><td align="left" valign="top" rowspan="1" colspan="1">1.01</td><td align="left" valign="top" rowspan="1" colspan="1">0.230</td><td align="left" valign="top" rowspan="1" colspan="1">1.02</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Catheterization before op</td><td align="left" valign="top" rowspan="1" colspan="1">0.078</td><td align="left" valign="top" rowspan="1" colspan="1">1.73</td><td align="left" valign="top" rowspan="1" colspan="1">0.023<xref ref-type="table-fn" rid="tfn6-cia-8-1483">b</xref></td><td align="left" valign="top" rowspan="1" colspan="1">2.92<xref ref-type="table-fn" rid="tfn6-cia-8-1483">b</xref></td><td align="left" valign="top" rowspan="1" colspan="1">0.064<xref ref-type="table-fn" rid="tfn7-cia-8-1483">c</xref></td><td align="left" valign="top" rowspan="1" colspan="1">3.33<xref ref-type="table-fn" rid="tfn7-cia-8-1483">c</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Surgical time</td><td align="left" valign="top" rowspan="1" colspan="1">0.257</td><td align="left" valign="top" rowspan="1" colspan="1">1.00</td><td align="left" valign="top" rowspan="1" colspan="1">0.738</td><td align="left" valign="top" rowspan="1" colspan="1">1.00</td><td align="left" valign="top" rowspan="1" colspan="1">0.480</td><td align="left" valign="top" rowspan="1" colspan="1">1.01</td></tr></tbody></table><table-wrap-foot><fn><p><bold>Note:</bold></p></fn><fn id="tfn5-cia-8-1483"><label>a</label><p>Kruskal–Wallis test</p></fn><fn id="tfn6-cia-8-1483"><label>b</label><p>Analysis of variance test</p></fn><fn id="tfn7-cia-8-1483"><label>c</label><p>chi-square test.</p></fn><fn id="tfn8-cia-8-1483"><p><bold>Abbreviations:</bold> IPSS, International Prostatic symptom score; PVP, photoselective vaporization of prostate; op, operation; OR, odds ratio; TURP, transurethral resection of prostate; T-volume, transitional zone of prostate volume.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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