Dendrimer-Based Responsive MRI Contrast Agents (G1-G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS)
Identifieur interne : 000336 ( Pmc/Corpus ); précédent : 000335; suivant : 000337Dendrimer-Based Responsive MRI Contrast Agents (G1-G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS)
Auteurs : Yuegao Huang ; Daniel Coman ; Fahmeed Hyder ; Meser M. AliSource :
- Bioconjugate chemistry [ 1043-1802 ] ; 2015.
Abstract
Biosensor imaging of redundant deviation in shifts (BIRDS) is a molecular imaging platform for magnetic resonance that utilizes unique properties of low molecular weight paramagnetic monomers by detecting hyperfine-shifted nonexchangeable protons and transforming the chemical shift information to reflect its microenvironment (e.g., via temperature, pH, etc.). To optimize translational biosensing potential of BIRDS we examined if this detection scheme observed with monomers can be extended onto dendrimers, which are versatile and biocompatible macromolecules with modifiable surface for molecular imaging and drug delivery. Here we report on feasibility of paramagnetic dendrimers for BIRDS. The results show that BIRDS is resilient with paramagnetic dendrimers up to the fourth generation (i.e., G1-G4), where the model dendrimer and chelate were based on poly(amido amine) (PAMAM) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA4−) complexed with thulium ion (Tm3+). Temperature sensitivities of two prominent signals of Gn-PAMAM-(TmDOTA−)x (where n = 1–4, x = 6–39) were comparable to that of prominent signals in TmDOTA−. Transverse relaxation times of the coalesced nonexchangeable protons on Gn-PAMAM-(TmDOTA−)x were relatively short to provide signal-to-noise ratio that was comparable to or better than that of TmDOTA−. A fluorescent dye, rhodamine, was conjugated to a G2-PAMAM-(TmDOTA)12 to create a dual-modality nanosized contrast agent. BIRDS properties of the dendrimer were unaltered with rhodamine conjugation. Purposely designed paramagnetic dendrimers for BIRDS in conjunction with novel macromolecular surface modification for functional ligands/drugs could potentially be used for biologically compatible theranostic sensors.
Url:
DOI: 10.1021/acs.bioconjchem.5b00568
PubMed: 26497087
PubMed Central: 4784965
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dendrimer-Based Responsive MRI Contrast Agents (G1-G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS)</title><author><name sortKey="Huang, Yuegao" sort="Huang, Yuegao" uniqKey="Huang Y" first="Yuegao" last="Huang">Yuegao Huang</name><affiliation><nlm:aff id="A1">Yale University, Department of Radiology and Biomedical Imaging, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Yale University, Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><affiliation><nlm:aff id="A1">Yale University, Department of Radiology and Biomedical Imaging, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Yale University, Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><affiliation><nlm:aff id="A1">Yale University, Department of Radiology and Biomedical Imaging, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Yale University, Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Yale University, Department of Biomedical Engineering, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Ali, Meser M" sort="Ali, Meser M" uniqKey="Ali M" first="Meser M." last="Ali">Meser M. Ali</name><affiliation><nlm:aff id="A4">Henry Ford Hospital, Department of Neurology, Detroit, MI 48202, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26497087</idno><idno type="pmc">4784965</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784965</idno><idno type="RBID">PMC:4784965</idno><idno type="doi">10.1021/acs.bioconjchem.5b00568</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000336</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000336</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dendrimer-Based Responsive MRI Contrast Agents (G1-G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS)</title><author><name sortKey="Huang, Yuegao" sort="Huang, Yuegao" uniqKey="Huang Y" first="Yuegao" last="Huang">Yuegao Huang</name><affiliation><nlm:aff id="A1">Yale University, Department of Radiology and Biomedical Imaging, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Yale University, Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><affiliation><nlm:aff id="A1">Yale University, Department of Radiology and Biomedical Imaging, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Yale University, Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><affiliation><nlm:aff id="A1">Yale University, Department of Radiology and Biomedical Imaging, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Yale University, Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Yale University, Department of Biomedical Engineering, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Ali, Meser M" sort="Ali, Meser M" uniqKey="Ali M" first="Meser M." last="Ali">Meser M. Ali</name><affiliation><nlm:aff id="A4">Henry Ford Hospital, Department of Neurology, Detroit, MI 48202, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Bioconjugate chemistry</title><idno type="ISSN">1043-1802</idno><idno type="eISSN">1520-4812</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Biosensor imaging of redundant deviation in shifts (BIRDS) is a molecular imaging platform for magnetic resonance that utilizes unique properties of low molecular weight paramagnetic monomers by detecting hyperfine-shifted nonexchangeable protons and transforming the chemical shift information to reflect its microenvironment (e.g., via temperature, pH, etc.). To optimize translational biosensing potential of BIRDS we examined if this detection scheme observed with monomers can be extended onto dendrimers, which are versatile and biocompatible macromolecules with modifiable surface for molecular imaging and drug delivery. Here we report on feasibility of paramagnetic dendrimers for BIRDS. The results show that BIRDS is resilient with paramagnetic dendrimers up to the fourth generation (i.e., G1-G4), where the model dendrimer and chelate were based on poly(amido amine) (PAMAM) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA<sup>4−</sup>) complexed with thulium ion (Tm<sup>3+</sup>). Temperature sensitivities of two prominent signals of Gn-PAMAM-(TmDOTA<sup>−</sup>)<sub>x</sub> (where n = 1–4, x = 6–39) were comparable to that of prominent signals in TmDOTA<sup>−</sup>. Transverse relaxation times of the coalesced nonexchangeable protons on Gn-PAMAM-(TmDOTA<sup>−</sup>)<sub>x</sub> were relatively short to provide signal-to-noise ratio that was comparable to or better than that of TmDOTA<sup>−</sup>. A fluorescent dye, rhodamine, was conjugated to a G2-PAMAM-(TmDOTA)<sub>12</sub> to create a dual-modality nanosized contrast agent. BIRDS properties of the dendrimer were unaltered with rhodamine conjugation. Purposely designed paramagnetic dendrimers for BIRDS in conjunction with novel macromolecular surface modification for functional ligands/drugs could potentially be used for biologically compatible theranostic sensors.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9010319</journal-id><journal-id journal-id-type="pubmed-jr-id">1061</journal-id><journal-id journal-id-type="nlm-ta">Bioconjug Chem</journal-id><journal-id journal-id-type="iso-abbrev">Bioconjug. Chem.</journal-id><journal-title-group><journal-title>Bioconjugate chemistry</journal-title></journal-title-group><issn pub-type="ppub">1043-1802</issn><issn pub-type="epub">1520-4812</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26497087</article-id><article-id pub-id-type="pmc">4784965</article-id><article-id pub-id-type="doi">10.1021/acs.bioconjchem.5b00568</article-id><article-id pub-id-type="manuscript">NIHMS763763</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Dendrimer-Based Responsive MRI Contrast Agents (G1-G4) for Biosensor Imaging of Redundant Deviation in Shifts (BIRDS)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Yuegao</given-names></name><xref ref-type="aff" rid="A1">†</xref><xref ref-type="aff" rid="A2">‡</xref><xref rid="FN1" ref-type="author-notes">*</xref><email>yuegao.huang@yale.edu</email></contrib><contrib contrib-type="author"><name><surname>Coman</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A1">†</xref><xref ref-type="aff" rid="A2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Hyder</surname><given-names>Fahmeed</given-names></name><xref ref-type="aff" rid="A1">†</xref><xref ref-type="aff" rid="A2">‡</xref><xref ref-type="aff" rid="A3">§</xref><xref rid="FN1" ref-type="author-notes">*</xref><email>fahmeed.hyder@yale.edu</email></contrib><contrib contrib-type="author"><name><surname>Ali</surname><given-names>Meser M.</given-names></name><xref ref-type="aff" rid="A4">||</xref><xref rid="FN1" ref-type="author-notes">*</xref><email>mali8@hfhs.org</email></contrib></contrib-group><aff id="A1"><label>†</label>Yale University, Department of Radiology and Biomedical Imaging, New Haven, CT 06520, USA</aff><aff id="A2"><label>‡</label>Yale University, Quantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, New Haven, CT 06520, USA</aff><aff id="A3"><label>§</label>Yale University, Department of Biomedical Engineering, New Haven, CT 06520, USA</aff><aff id="A4"><label>||</label>Henry Ford Hospital, Department of Neurology, Detroit, MI 48202, USA</aff><author-notes><corresp id="FN1">Correspondence: Y. Huang/F. Hyder, N143 TAC (MRRC), 300 Cedar Street, Yale University, New Haven, CT 06520, Tel: +1-203-785-6206; Fax: +1-203-785-6643. M. Ali, One Ford Place, 2F, Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, Tel: +1- 313-874-4479; Fax: +1-313-874-4494</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>05</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>16</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>09</day><month>3</month><year>2016</year></pub-date><volume>26</volume><issue>12</issue><fpage>2315</fpage><lpage>2323</lpage><pmc-comment>elocation-id from pubmed: 10.1021/acs.bioconjchem.5b00568</pmc-comment>
<abstract><p id="P1">Biosensor imaging of redundant deviation in shifts (BIRDS) is a molecular imaging platform for magnetic resonance that utilizes unique properties of low molecular weight paramagnetic monomers by detecting hyperfine-shifted nonexchangeable protons and transforming the chemical shift information to reflect its microenvironment (e.g., via temperature, pH, etc.). To optimize translational biosensing potential of BIRDS we examined if this detection scheme observed with monomers can be extended onto dendrimers, which are versatile and biocompatible macromolecules with modifiable surface for molecular imaging and drug delivery. Here we report on feasibility of paramagnetic dendrimers for BIRDS. The results show that BIRDS is resilient with paramagnetic dendrimers up to the fourth generation (i.e., G1-G4), where the model dendrimer and chelate were based on poly(amido amine) (PAMAM) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA<sup>4−</sup>) complexed with thulium ion (Tm<sup>3+</sup>). Temperature sensitivities of two prominent signals of Gn-PAMAM-(TmDOTA<sup>−</sup>)<sub>x</sub> (where n = 1–4, x = 6–39) were comparable to that of prominent signals in TmDOTA<sup>−</sup>. Transverse relaxation times of the coalesced nonexchangeable protons on Gn-PAMAM-(TmDOTA<sup>−</sup>)<sub>x</sub> were relatively short to provide signal-to-noise ratio that was comparable to or better than that of TmDOTA<sup>−</sup>. A fluorescent dye, rhodamine, was conjugated to a G2-PAMAM-(TmDOTA)<sub>12</sub> to create a dual-modality nanosized contrast agent. BIRDS properties of the dendrimer were unaltered with rhodamine conjugation. Purposely designed paramagnetic dendrimers for BIRDS in conjunction with novel macromolecular surface modification for functional ligands/drugs could potentially be used for biologically compatible theranostic sensors.</p></abstract><kwd-group><kwd>BIRDS</kwd><kwd>cancer</kwd><kwd>high-speed CSI</kwd><kwd>MRI</kwd><kwd>paramagnetic complex</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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