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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">FUNCTIONAL OUTCOMES AFTER TORS FOR OROPHARYNGEAL CANCER: A SYSTEMATIC REVIEW</title><author><name sortKey="Hutcheson, Katherine A" sort="Hutcheson, Katherine A" uniqKey="Hutcheson K" first="Katherine A." last="Hutcheson">Katherine A. Hutcheson</name></author><author><name sortKey="Holsinger, F Christopher" sort="Holsinger, F Christopher" uniqKey="Holsinger F" first="F. Christopher" last="Holsinger">F. Christopher Holsinger</name></author><author><name sortKey="Kupferman, Michael E" sort="Kupferman, Michael E" uniqKey="Kupferman M" first="Michael E." last="Kupferman">Michael E. Kupferman</name></author><author><name sortKey="Lewin, Jan S" sort="Lewin, Jan S" uniqKey="Lewin J" first="Jan S." last="Lewin">Jan S. Lewin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24643851</idno><idno type="pmc">4169348</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169348</idno><idno type="RBID">PMC:4169348</idno><idno type="doi">10.1007/s00405-014-2985-7</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000335</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000335</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">FUNCTIONAL OUTCOMES AFTER TORS FOR OROPHARYNGEAL CANCER: A SYSTEMATIC REVIEW</title><author><name sortKey="Hutcheson, Katherine A" sort="Hutcheson, Katherine A" uniqKey="Hutcheson K" first="Katherine A." last="Hutcheson">Katherine A. Hutcheson</name></author><author><name sortKey="Holsinger, F Christopher" sort="Holsinger, F Christopher" uniqKey="Holsinger F" first="F. Christopher" last="Holsinger">F. Christopher Holsinger</name></author><author><name sortKey="Kupferman, Michael E" sort="Kupferman, Michael E" uniqKey="Kupferman M" first="Michael E." last="Kupferman">Michael E. Kupferman</name></author><author><name sortKey="Lewin, Jan S" sort="Lewin, Jan S" uniqKey="Lewin J" first="Jan S." last="Lewin">Jan S. Lewin</name></author></analytic><series><title level="j">European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery</title><idno type="ISSN">0937-4477</idno><idno type="eISSN">1434-4726</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>OBJECTIVE</title><p id="P1">Summarize functional outcomes after transoral robotic surgery (TORS) ± adjuvant therapy for oropharyngeal cancer (OPC).</p></sec><sec id="S2"><title>STUDY DESIGN</title><p id="P2">A systematic review was conducted. The MEDLINE database was searched (MeSH terms: transoral robotic surgery, pharyngeal neoplasms, oropharyngeal neoplasms).</p></sec><sec id="S3"><title>METHODS</title><p id="P3">Peer-reviewed human subject papers published through December, 2013 were included. Exclusion criteria were: 1) case report design (n<10), 2) review article, or 3) technical, animal or cadaver studies. Functional outcomes extracted included feeding tube dependence, swallow examination findings, speech ratings, velopharyngeal insufficiency, pneumonia, and oral intake measures.</p></sec><sec id="S4"><title>RESULTS</title><p id="P4">Twelve papers comprising 441 patients with OPC treated with TORS ± adjuvant therapy were included. Feeding tube rates were the most commonly reported functional outcome. Excluding prophylactic placement, 18% to 39% of patients required gastrostomy placement, typically during adjuvant therapy. Chronic gastrostomy dependence ranged from 0% to 7% (mean follow-up: 11–26 months), regardless of disease stage. Composite MD Anderson Dysphagia Inventory (MDADI) scores ranged from 65.2 to 78 (89 patients, 3 series, mean follow-up: 12–13 months). Videofluoroscopic swallowing studies were not systematically reported. Incidence of postoperative pneumonia was 0% to 7%. Predictors of swallowing function included baseline function, T-stage, N-stage, tongue base primary tumors, and adjuvant chemoradiation. Rates of transient hypernasality were 4% to 9%. A single study suggested dose-dependent effects of adjuvant therapy (none, radiation alone, chemoradiation) on diet scores at 6- and 12-months.</p></sec><sec id="S5"><title>CONCLUSIONS</title><p id="P5">Crude endpoints of functional recovery after TORS ± adjuvant therapy suggest promising swallowing outcomes, depending on the functional measure reported.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9002937</journal-id><journal-id journal-id-type="pubmed-jr-id">1603</journal-id><journal-id journal-id-type="nlm-ta">Eur Arch Otorhinolaryngol</journal-id><journal-id journal-id-type="iso-abbrev">Eur Arch Otorhinolaryngol</journal-id><journal-title-group><journal-title>European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery</journal-title></journal-title-group><issn pub-type="ppub">0937-4477</issn><issn pub-type="epub">1434-4726</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24643851</article-id><article-id pub-id-type="pmc">4169348</article-id><article-id pub-id-type="doi">10.1007/s00405-014-2985-7</article-id><article-id pub-id-type="manuscript">NIHMS577364</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>FUNCTIONAL OUTCOMES AFTER TORS FOR OROPHARYNGEAL CANCER: A SYSTEMATIC REVIEW</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hutcheson</surname><given-names>Katherine A.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Holsinger</surname><given-names>F. Christopher</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Kupferman</surname><given-names>Michael E.</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Lewin</surname><given-names>Jan S.</given-names></name><degrees>PhD</degrees></contrib><aff id="A1">Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX (Drs. Hutcheson, Kupferman, and Lewin); Department of Otolaryngology-Head and Neck Surgery, Stanford School of Medicine, Stanford, CA (Dr. Holsinger)</aff></contrib-group><author-notes><corresp id="CR1">Corresponding author: Katherine A. Hutcheson, PhD, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1445, Houston, TX 77030, U.S.A. Telephone: 713-792-6513, Fax: 713-794-4662 <email>karnold@mdanderson.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>30</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>19</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2016</year></pub-date><volume>272</volume><issue>2</issue><fpage>463</fpage><lpage>471</lpage><pmc-comment>elocation-id from pubmed: 10.1007/s00405-014-2985-7</pmc-comment>
<abstract><sec id="S1"><title>OBJECTIVE</title><p id="P1">Summarize functional outcomes after transoral robotic surgery (TORS) ± adjuvant therapy for oropharyngeal cancer (OPC).</p></sec><sec id="S2"><title>STUDY DESIGN</title><p id="P2">A systematic review was conducted. The MEDLINE database was searched (MeSH terms: transoral robotic surgery, pharyngeal neoplasms, oropharyngeal neoplasms).</p></sec><sec id="S3"><title>METHODS</title><p id="P3">Peer-reviewed human subject papers published through December, 2013 were included. Exclusion criteria were: 1) case report design (n<10), 2) review article, or 3) technical, animal or cadaver studies. Functional outcomes extracted included feeding tube dependence, swallow examination findings, speech ratings, velopharyngeal insufficiency, pneumonia, and oral intake measures.</p></sec><sec id="S4"><title>RESULTS</title><p id="P4">Twelve papers comprising 441 patients with OPC treated with TORS ± adjuvant therapy were included. Feeding tube rates were the most commonly reported functional outcome. Excluding prophylactic placement, 18% to 39% of patients required gastrostomy placement, typically during adjuvant therapy. Chronic gastrostomy dependence ranged from 0% to 7% (mean follow-up: 11–26 months), regardless of disease stage. Composite MD Anderson Dysphagia Inventory (MDADI) scores ranged from 65.2 to 78 (89 patients, 3 series, mean follow-up: 12–13 months). Videofluoroscopic swallowing studies were not systematically reported. Incidence of postoperative pneumonia was 0% to 7%. Predictors of swallowing function included baseline function, T-stage, N-stage, tongue base primary tumors, and adjuvant chemoradiation. Rates of transient hypernasality were 4% to 9%. A single study suggested dose-dependent effects of adjuvant therapy (none, radiation alone, chemoradiation) on diet scores at 6- and 12-months.</p></sec><sec id="S5"><title>CONCLUSIONS</title><p id="P5">Crude endpoints of functional recovery after TORS ± adjuvant therapy suggest promising swallowing outcomes, depending on the functional measure reported.</p></sec></abstract><kwd-group><kwd>Transoral robotic surgery</kwd><kwd>Oropharyngeal cancer</kwd><kwd>Functional outcome</kwd><kwd>Swallowing</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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