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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Placebo effects in laser-evoked pain potentials</title>
<author><name sortKey="Wager, Tor D" sort="Wager, Tor D" uniqKey="Wager T" first="Tor D." last="Wager">Tor D. Wager</name>
<affiliation><nlm:aff id="A1">Department of Psychology, Columbia University, New York, NY 10027, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Matre, Dagfinn" sort="Matre, Dagfinn" uniqKey="Matre D" first="Dagfinn" last="Matre">Dagfinn Matre</name>
<affiliation><nlm:aff id="A2">Department of Physiology, National Institute of Occupational Health, 0033 Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Casey, Kenneth L" sort="Casey, Kenneth L" uniqKey="Casey K" first="Kenneth L." last="Casey">Kenneth L. Casey</name>
<affiliation><nlm:aff id="A3">Department of Neurology and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">16571371</idno>
<idno type="pmc">3735137</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735137</idno>
<idno type="RBID">PMC:3735137</idno>
<idno type="doi">10.1016/j.bbi.2006.01.007</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Pmc/Corpus">000332</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000332</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Placebo effects in laser-evoked pain potentials</title>
<author><name sortKey="Wager, Tor D" sort="Wager, Tor D" uniqKey="Wager T" first="Tor D." last="Wager">Tor D. Wager</name>
<affiliation><nlm:aff id="A1">Department of Psychology, Columbia University, New York, NY 10027, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Matre, Dagfinn" sort="Matre, Dagfinn" uniqKey="Matre D" first="Dagfinn" last="Matre">Dagfinn Matre</name>
<affiliation><nlm:aff id="A2">Department of Physiology, National Institute of Occupational Health, 0033 Oslo, Norway</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Casey, Kenneth L" sort="Casey, Kenneth L" uniqKey="Casey K" first="Kenneth L." last="Casey">Kenneth L. Casey</name>
<affiliation><nlm:aff id="A3">Department of Neurology and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Brain, behavior, and immunity</title>
<idno type="ISSN">0889-1591</idno>
<idno type="eISSN">1090-2139</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Placebo treatment may affect multiple components of pain, including inhibition of nociceptive input, automatic or deliberative appraisal of pain, or cognitive judgments involved in pain reporting. If placebo analgesia is due in part to an attenuation of early nociceptive processing, then pain-evoked event-related potentials (ERPs) should be reduced with placebo. In this study, we tested for placebo effects in P2 laser-evoked potentials at midline scalp electrodes. We found that placebo treatment produced significant decreases in P2 amplitude, and that P2 placebo responses were large enough to reflect a meaningful difference in nociceptive processing. However, we also found evidence that the very robust placebo-induced decreases in reported pain are not solely explained by early reductions in P2. N2 amplitude was affected by neither placebo nor reduction of laser intensity. These results suggest that placebo treatment affects early nociceptive processing, but that another component of placebo effects in reported pain occurs later, either in evaluation of pain or cognitive judgments about pain reports.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8800478</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1990</journal-id>
<journal-id journal-id-type="nlm-ta">Brain Behav Immun</journal-id>
<journal-id journal-id-type="iso-abbrev">Brain Behav. Immun.</journal-id>
<journal-title-group><journal-title>Brain, behavior, and immunity</journal-title>
</journal-title-group>
<issn pub-type="ppub">0889-1591</issn>
<issn pub-type="epub">1090-2139</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">16571371</article-id>
<article-id pub-id-type="pmc">3735137</article-id>
<article-id pub-id-type="doi">10.1016/j.bbi.2006.01.007</article-id>
<article-id pub-id-type="manuscript">NIHMS357019</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Placebo effects in laser-evoked pain potentials</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Wager</surname>
<given-names>Tor D.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Matre</surname>
<given-names>Dagfinn</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casey</surname>
<given-names>Kenneth L.</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Department of Psychology, Columbia University, New York, NY 10027, USA</aff>
<aff id="A2"><label>b</label>
Department of Physiology, National Institute of Occupational Health, 0033 Oslo, Norway</aff>
<aff id="A3"><label>c</label>
Department of Neurology and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author. Fax: +1 212 854 3609. <email>tor@psych.columbia.edu</email>
(T.D. Wager)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>2</day>
<month>4</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>3</month>
<year>2006</year>
</pub-date>
<pub-date pub-type="ppub"><month>5</month>
<year>2006</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>06</day>
<month>8</month>
<year>2013</year>
</pub-date>
<volume>20</volume>
<issue>3</issue>
<fpage>219</fpage>
<lpage>230</lpage>
<permissions><copyright-statement>© 2006 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2006</copyright-year>
</permissions>
<abstract><p id="P1">Placebo treatment may affect multiple components of pain, including inhibition of nociceptive input, automatic or deliberative appraisal of pain, or cognitive judgments involved in pain reporting. If placebo analgesia is due in part to an attenuation of early nociceptive processing, then pain-evoked event-related potentials (ERPs) should be reduced with placebo. In this study, we tested for placebo effects in P2 laser-evoked potentials at midline scalp electrodes. We found that placebo treatment produced significant decreases in P2 amplitude, and that P2 placebo responses were large enough to reflect a meaningful difference in nociceptive processing. However, we also found evidence that the very robust placebo-induced decreases in reported pain are not solely explained by early reductions in P2. N2 amplitude was affected by neither placebo nor reduction of laser intensity. These results suggest that placebo treatment affects early nociceptive processing, but that another component of placebo effects in reported pain occurs later, either in evaluation of pain or cognitive judgments about pain reports.</p>
</abstract>
<kwd-group><kwd>Placebo</kwd>
<kwd>Laser</kwd>
<kwd>Pain</kwd>
<kwd>EEG</kwd>
<kwd>ERP</kwd>
<kwd>LEP</kwd>
<kwd>P2</kwd>
<kwd>Evoked potentials</kwd>
<kwd>Placebo effect</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Mental Health : NIMH</funding-source>
<award-id>R01 MH076136-01A1 || MH</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
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