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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Method to Convert MRI Images of Temperature Change Into Images of Absolute Temperature in Solid Tumors</title><author><name sortKey="Davis, Ryan M" sort="Davis, Ryan M" uniqKey="Davis R" first="Ryan M." last="Davis">Ryan M. Davis</name><affiliation><nlm:aff id="A1">Graduate Program of Biomedical Engineering, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Viglianti, Benjamin L" sort="Viglianti, Benjamin L" uniqKey="Viglianti B" first="Benjamin L." last="Viglianti">Benjamin L. Viglianti</name><affiliation><nlm:aff id="A2">Department of Radiology, University of Michigan. Ann Arbor, Michigan 48197, USA</nlm:aff></affiliation></author><author><name sortKey="Yarmolenko, Pavel" sort="Yarmolenko, Pavel" uniqKey="Yarmolenko P" first="Pavel" last="Yarmolenko">Pavel Yarmolenko</name><affiliation><nlm:aff id="A3">Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Park, Ji Young" sort="Park, Ji Young" uniqKey="Park J" first="Ji-Young" last="Park">Ji-Young Park</name><affiliation><nlm:aff id="A4">Department of Radiation Oncology, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Stauffer, Paul" sort="Stauffer, Paul" uniqKey="Stauffer P" first="Paul" last="Stauffer">Paul Stauffer</name><affiliation><nlm:aff id="A4">Department of Radiation Oncology, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Needham, David" sort="Needham, David" uniqKey="Needham D" first="David" last="Needham">David Needham</name><affiliation><nlm:aff id="A5">Department of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Dewhirst, Mark W" sort="Dewhirst, Mark W" uniqKey="Dewhirst M" first="Mark W." last="Dewhirst">Mark W. Dewhirst</name><affiliation><nlm:aff id="A3">Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Radiation Oncology, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23957326</idno><idno type="pmc">3779909</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779909</idno><idno type="RBID">PMC:3779909</idno><idno type="doi">10.3109/02656736.2013.790091</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000330</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000330</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Method to Convert MRI Images of Temperature Change Into Images of Absolute Temperature in Solid Tumors</title><author><name sortKey="Davis, Ryan M" sort="Davis, Ryan M" uniqKey="Davis R" first="Ryan M." last="Davis">Ryan M. Davis</name><affiliation><nlm:aff id="A1">Graduate Program of Biomedical Engineering, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Viglianti, Benjamin L" sort="Viglianti, Benjamin L" uniqKey="Viglianti B" first="Benjamin L." last="Viglianti">Benjamin L. Viglianti</name><affiliation><nlm:aff id="A2">Department of Radiology, University of Michigan. Ann Arbor, Michigan 48197, USA</nlm:aff></affiliation></author><author><name sortKey="Yarmolenko, Pavel" sort="Yarmolenko, Pavel" uniqKey="Yarmolenko P" first="Pavel" last="Yarmolenko">Pavel Yarmolenko</name><affiliation><nlm:aff id="A3">Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Park, Ji Young" sort="Park, Ji Young" uniqKey="Park J" first="Ji-Young" last="Park">Ji-Young Park</name><affiliation><nlm:aff id="A4">Department of Radiation Oncology, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Stauffer, Paul" sort="Stauffer, Paul" uniqKey="Stauffer P" first="Paul" last="Stauffer">Paul Stauffer</name><affiliation><nlm:aff id="A4">Department of Radiation Oncology, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Needham, David" sort="Needham, David" uniqKey="Needham D" first="David" last="Needham">David Needham</name><affiliation><nlm:aff id="A5">Department of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author><author><name sortKey="Dewhirst, Mark W" sort="Dewhirst, Mark W" uniqKey="Dewhirst M" first="Mark W." last="Dewhirst">Mark W. Dewhirst</name><affiliation><nlm:aff id="A3">Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Radiation Oncology, Duke University, Durham, North Carolina 27708 USA</nlm:aff></affiliation></author></analytic><series><title level="j">International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group</title><idno type="ISSN">0265-6736</idno><idno type="eISSN">1464-5157</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">During hyperthermia (HT), the therapeutic response of tumors varies substantially within the target temperature range (39–43°C). Current thermometry methods are either invasive or measure only temperature change, which limits the ability to study tissue responses to HT. This study combines manganese-containing low-temperature sensitive liposomes (Mn-LTSL) with proton resonance frequency shift (PRFS) thermometry to measure absolute temperature in tumors with high spatial and temporal resolution using MRI.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Liposomes were loaded with 300mM MnSO<sub>4</sub>. The phase transition temperature (T<sub>m</sub>) of Mn-LTSL samples was measured by differential scanning calorimetry (DSC). The release of manganese from Mn-LTSL in saline was characterized with inductively-coupled plasma atomic emission spectroscopy. A 2T GE small animal scanner was used to acquire dynamic T<sub>1</sub>-weighted images and temperature change images of Mn-LTSL in saline phantoms and fibrosarcoma-bearing Fisher 344 rats receiving hyperthermia after Mn-LTSL injection.</p></sec><sec id="S3"><title>Results</title><p id="P3">The T<sub>m</sub> of Mn-LTSL in rat blood was 42.9 ± 0.2 °C (DSC). For Mn-LTSL samples (0.06mM – 0.5mM Mn<sup>2+</sup> in saline) heated monotonically from 30°C to 50°C, a peak in the <italic>rate</italic> of MRI signal enhancement occurred at 43.1 ± 0.3 °C. The same peak in signal enhancement rate was observed during heating of fibrosarcoma tumors (N=3) after injection of Mn-LTSL, and the peak was used to convert temperature change images into absolute temperature. Accuracies of calibrated temperature measurements were in the range 0.9 – 1.8°C.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">The release of Mn2<sup>+</sup> from Mn-LTSL affects the rate of MR signal enhancement which enables conversion of MRI-based temperature change images to absolute temperature.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8508395</journal-id><journal-id journal-id-type="pubmed-jr-id">4857</journal-id><journal-id journal-id-type="nlm-ta">Int J Hyperthermia</journal-id><journal-id journal-id-type="iso-abbrev">Int J Hyperthermia</journal-id><journal-title-group><journal-title>International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group</journal-title></journal-title-group><issn pub-type="ppub">0265-6736</issn><issn pub-type="epub">1464-5157</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23957326</article-id><article-id pub-id-type="pmc">3779909</article-id><article-id pub-id-type="doi">10.3109/02656736.2013.790091</article-id><article-id pub-id-type="manuscript">NIHMS513000</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A Method to Convert MRI Images of Temperature Change Into Images of Absolute Temperature in Solid Tumors</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Davis</surname><given-names>Ryan M.</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Viglianti</surname><given-names>Benjamin L.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Yarmolenko</surname><given-names>Pavel</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Ji-Young</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Stauffer</surname><given-names>Paul</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Needham</surname><given-names>David</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Dewhirst</surname><given-names>Mark W.</given-names></name><degrees>DVM, PhD</degrees><xref ref-type="aff" rid="A3">c</xref><xref ref-type="aff" rid="A4">d</xref></contrib></contrib-group><aff id="A1"><label>a</label>Graduate Program of Biomedical Engineering, Duke University, Durham, North Carolina 27708 USA</aff><aff id="A2"><label>b</label>Department of Radiology, University of Michigan. Ann Arbor, Michigan 48197, USA</aff><aff id="A3"><label>c</label>Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708 USA</aff><aff id="A4"><label>d</label>Department of Radiation Oncology, Duke University, Durham, North Carolina 27708 USA</aff><aff id="A5"><label>e</label>Department of Mechanical Engineering and Material Science, Duke University, Durham, North Carolina 27708 USA</aff><author-notes><corresp id="FN1">Corresponding Author: Mark W. Dewhirst, DVM, PhD, Box 3455 DUMC, Room 201 MSRB, Research Drive, Duke University, Durham, NC 27710</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>10</day><month>9</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>9</month><year>2014</year></pub-date><volume>29</volume><issue>6</issue><fpage>569</fpage><lpage>581</lpage><abstract><sec id="S1"><title>Purpose</title><p id="P1">During hyperthermia (HT), the therapeutic response of tumors varies substantially within the target temperature range (39–43°C). Current thermometry methods are either invasive or measure only temperature change, which limits the ability to study tissue responses to HT. This study combines manganese-containing low-temperature sensitive liposomes (Mn-LTSL) with proton resonance frequency shift (PRFS) thermometry to measure absolute temperature in tumors with high spatial and temporal resolution using MRI.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Liposomes were loaded with 300mM MnSO<sub>4</sub>. The phase transition temperature (T<sub>m</sub>) of Mn-LTSL samples was measured by differential scanning calorimetry (DSC). The release of manganese from Mn-LTSL in saline was characterized with inductively-coupled plasma atomic emission spectroscopy. A 2T GE small animal scanner was used to acquire dynamic T<sub>1</sub>-weighted images and temperature change images of Mn-LTSL in saline phantoms and fibrosarcoma-bearing Fisher 344 rats receiving hyperthermia after Mn-LTSL injection.</p></sec><sec id="S3"><title>Results</title><p id="P3">The T<sub>m</sub> of Mn-LTSL in rat blood was 42.9 ± 0.2 °C (DSC). For Mn-LTSL samples (0.06mM – 0.5mM Mn<sup>2+</sup> in saline) heated monotonically from 30°C to 50°C, a peak in the <italic>rate</italic> of MRI signal enhancement occurred at 43.1 ± 0.3 °C. The same peak in signal enhancement rate was observed during heating of fibrosarcoma tumors (N=3) after injection of Mn-LTSL, and the peak was used to convert temperature change images into absolute temperature. Accuracies of calibrated temperature measurements were in the range 0.9 – 1.8°C.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">The release of Mn2<sup>+</sup> from Mn-LTSL affects the rate of MR signal enhancement which enables conversion of MRI-based temperature change images to absolute temperature.</p></sec></abstract><kwd-group><kwd>magnetic resonance imaging</kwd><kwd>non-invasive thermometry</kwd><kwd>low temperature sensitive liposomes</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>U24 CA092656 || CA</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>P41 RR005959 || RR</award-id></award-group><award-group><funding-source country="United States">National Institute of Biomedical Imaging and Bioengineering : NIBIB</funding-source><award-id>P41 EB015897 || EB</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P01 CA042745 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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