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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multifunctional yolk-in-shell nanoparticles for pH-triggered drug release and imaging</title><author><name sortKey="Chen, Hongyu" sort="Chen, Hongyu" uniqKey="Chen H" first="Hongyu" last="Chen">Hongyu Chen</name><affiliation><nlm:aff id="A1">Department of Chemistry, Center for optical materials science and engineering (COMSET), and environmental toxicology program, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Qi, Bin" sort="Qi, Bin" uniqKey="Qi B" first="Bin" last="Qi">Bin Qi</name><affiliation><nlm:aff id="A3">Department of Materials Science Engineering, Center for optical materials science and engineering (COMSET), Clemson University, Clemson, SC 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Moore, Thomas" sort="Moore, Thomas" uniqKey="Moore T" first="Thomas" last="Moore">Thomas Moore</name><affiliation><nlm:aff id="A4">Department of Bioengineering, 301 Rhodes Research Center, Clemson, SC 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Fenglin" sort="Wang, Fenglin" uniqKey="Wang F" first="Fenglin" last="Wang">Fenglin Wang</name><affiliation><nlm:aff id="A1">Department of Chemistry, Center for optical materials science and engineering (COMSET), and environmental toxicology program, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Colvin, Daniel C" sort="Colvin, Daniel C" uniqKey="Colvin D" first="Daniel C." last="Colvin">Daniel C. Colvin</name><affiliation><nlm:aff id="A5">Vanderbilt University Medical Center, AAA 3107 MCN, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Sanjeewa, Liurukara D" sort="Sanjeewa, Liurukara D" uniqKey="Sanjeewa L" first="Liurukara D." last="Sanjeewa">Liurukara D. Sanjeewa</name><affiliation><nlm:aff id="A2">Department of Chemistry, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Gore, John C" sort="Gore, John C" uniqKey="Gore J" first="John C." last="Gore">John C. Gore</name><affiliation><nlm:aff id="A5">Vanderbilt University Medical Center, AAA 3107 MCN, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Hwu, Shiou Jyh" sort="Hwu, Shiou Jyh" uniqKey="Hwu S" first="Shiou-Jyh" last="Hwu">Shiou-Jyh Hwu</name><affiliation><nlm:aff id="A2">Department of Chemistry, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Mefford, O Thompson" sort="Mefford, O Thompson" uniqKey="Mefford O" first="O. Thompson" last="Mefford">O. Thompson Mefford</name><affiliation><nlm:aff id="A3">Department of Materials Science Engineering, Center for optical materials science and engineering (COMSET), Clemson University, Clemson, SC 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Alexis, Frank" sort="Alexis, Frank" uniqKey="Alexis F" first="Frank" last="Alexis">Frank Alexis</name><affiliation><nlm:aff id="A4">Department of Bioengineering, 301 Rhodes Research Center, Clemson, SC 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Anker, Jeffrey N" sort="Anker, Jeffrey N" uniqKey="Anker J" first="Jeffrey N." last="Anker">Jeffrey N. Anker</name><affiliation><nlm:aff id="A1">Department of Chemistry, Center for optical materials science and engineering (COMSET), and environmental toxicology program, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24753264</idno><idno type="pmc">4474407</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474407</idno><idno type="RBID">PMC:4474407</idno><idno type="doi">10.1002/smll.201303769</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000309</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000309</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Multifunctional yolk-in-shell nanoparticles for pH-triggered drug release and imaging</title><author><name sortKey="Chen, Hongyu" sort="Chen, Hongyu" uniqKey="Chen H" first="Hongyu" last="Chen">Hongyu Chen</name><affiliation><nlm:aff id="A1">Department of Chemistry, Center for optical materials science and engineering (COMSET), and environmental toxicology program, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Qi, Bin" sort="Qi, Bin" uniqKey="Qi B" first="Bin" last="Qi">Bin Qi</name><affiliation><nlm:aff id="A3">Department of Materials Science Engineering, Center for optical materials science and engineering (COMSET), Clemson University, Clemson, SC 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Moore, Thomas" sort="Moore, Thomas" uniqKey="Moore T" first="Thomas" last="Moore">Thomas Moore</name><affiliation><nlm:aff id="A4">Department of Bioengineering, 301 Rhodes Research Center, Clemson, SC 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Fenglin" sort="Wang, Fenglin" uniqKey="Wang F" first="Fenglin" last="Wang">Fenglin Wang</name><affiliation><nlm:aff id="A1">Department of Chemistry, Center for optical materials science and engineering (COMSET), and environmental toxicology program, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Colvin, Daniel C" sort="Colvin, Daniel C" uniqKey="Colvin D" first="Daniel C." last="Colvin">Daniel C. Colvin</name><affiliation><nlm:aff id="A5">Vanderbilt University Medical Center, AAA 3107 MCN, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Sanjeewa, Liurukara D" sort="Sanjeewa, Liurukara D" uniqKey="Sanjeewa L" first="Liurukara D." last="Sanjeewa">Liurukara D. Sanjeewa</name><affiliation><nlm:aff id="A2">Department of Chemistry, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Gore, John C" sort="Gore, John C" uniqKey="Gore J" first="John C." last="Gore">John C. Gore</name><affiliation><nlm:aff id="A5">Vanderbilt University Medical Center, AAA 3107 MCN, Nashville, TN 37232, USA</nlm:aff></affiliation></author><author><name sortKey="Hwu, Shiou Jyh" sort="Hwu, Shiou Jyh" uniqKey="Hwu S" first="Shiou-Jyh" last="Hwu">Shiou-Jyh Hwu</name><affiliation><nlm:aff id="A2">Department of Chemistry, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Mefford, O Thompson" sort="Mefford, O Thompson" uniqKey="Mefford O" first="O. Thompson" last="Mefford">O. Thompson Mefford</name><affiliation><nlm:aff id="A3">Department of Materials Science Engineering, Center for optical materials science and engineering (COMSET), Clemson University, Clemson, SC 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Alexis, Frank" sort="Alexis, Frank" uniqKey="Alexis F" first="Frank" last="Alexis">Frank Alexis</name><affiliation><nlm:aff id="A4">Department of Bioengineering, 301 Rhodes Research Center, Clemson, SC 29634, USA</nlm:aff></affiliation></author><author><name sortKey="Anker, Jeffrey N" sort="Anker, Jeffrey N" uniqKey="Anker J" first="Jeffrey N." last="Anker">Jeffrey N. Anker</name><affiliation><nlm:aff id="A1">Department of Chemistry, Center for optical materials science and engineering (COMSET), and environmental toxicology program, Clemson University, Clemson SC, 29634, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Small (Weinheim an der Bergstrasse, Germany)</title><idno type="ISSN">1613-6810</idno><idno type="eISSN">1613-6829</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Multifunctional nanoparticles are synthesized for both pH-triggered drug release and imaging with radioluminescence, upconversion luminescent, and magnetic resonance imaging (MRI). The particles have a yolk-in-shell morphology, with a radioluminescent core, an upconverting shell, and a hollow region between the core and shell for loading drugs. They are synthesized by controlled encapsulation of a radioluminescent nanophosphor yolk in a silica shell, partial etching of the yolk in acid, and encapsulation of the silica with an upconverting luminescent shell. Metroxantrone, a chemotherapy drug, was loaded into the hollow space between X-ray phosphor yolk and up-conversion phosphor shell through pores in the shell. To encapsulate the drug and control the release rate, the nanoparticles are coated with pH-responsive biocompatible polyelectrolyte layers of charged hyaluronic acid sodium salt and chitosan. The nanophosphors display bright luminescence under X-ray, blue light (480 nm), and infrared light (980 nm). They also served as T<sub>1</sub> and T<sub>2</sub> MRI contrast agents with relaxivities of 3.5 mM<sup>−1</sup> s<sup>−1</sup> (r<sub>1</sub>) and 64 mM<sup>−1</sup>s<sup>−1</sup> (r<sub>2</sub>). These multifunctional nanocapsules have applications in controlled drug delivery and multimodal imaging.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101235338</journal-id><journal-id journal-id-type="pubmed-jr-id">33154</journal-id><journal-id journal-id-type="nlm-ta">Small</journal-id><journal-id journal-id-type="iso-abbrev">Small</journal-id><journal-title-group><journal-title>Small (Weinheim an der Bergstrasse, Germany)</journal-title></journal-title-group><issn pub-type="ppub">1613-6810</issn><issn pub-type="epub">1613-6829</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24753264</article-id><article-id pub-id-type="pmc">4474407</article-id><article-id pub-id-type="doi">10.1002/smll.201303769</article-id><article-id pub-id-type="manuscript">NIHMS696198</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Multifunctional yolk-in-shell nanoparticles for pH-triggered drug release and imaging</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Hongyu</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Qi</surname><given-names>Bin</given-names></name><xref ref-type="aff" rid="A3">b</xref></contrib><contrib contrib-type="author"><name><surname>Moore</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A4">c</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Fenglin</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Colvin</surname><given-names>Daniel C.</given-names></name><xref ref-type="aff" rid="A5">d</xref></contrib><contrib contrib-type="author"><name><surname>Sanjeewa</surname><given-names>Liurukara D.</given-names></name><xref ref-type="aff" rid="A2">a</xref></contrib><contrib contrib-type="author"><name><surname>Gore</surname><given-names>John C.</given-names></name><xref ref-type="aff" rid="A5">d</xref></contrib><contrib contrib-type="author"><name><surname>Hwu</surname><given-names>Shiou-Jyh</given-names></name><xref ref-type="aff" rid="A2">a</xref></contrib><contrib contrib-type="author"><name><surname>Mefford</surname><given-names>O. Thompson</given-names></name><xref ref-type="aff" rid="A3">b</xref></contrib><contrib contrib-type="author"><name><surname>Alexis</surname><given-names>Frank</given-names></name><xref ref-type="aff" rid="A4">c</xref></contrib><contrib contrib-type="author"><name><surname>Anker</surname><given-names>Jeffrey N.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Chemistry, Center for optical materials science and engineering (COMSET), and environmental toxicology program, Clemson University, Clemson SC, 29634, USA</aff><aff id="A2"><label>a</label>Department of Chemistry, Clemson University, Clemson SC, 29634, USA</aff><aff id="A3"><label>b</label>Department of Materials Science Engineering, Center for optical materials science and engineering (COMSET), Clemson University, Clemson, SC 29634, USA</aff><aff id="A4"><label>c</label>Department of Bioengineering, 301 Rhodes Research Center, Clemson, SC 29634, USA</aff><aff id="A5"><label>d</label>Vanderbilt University Medical Center, AAA 3107 MCN, Nashville, TN 37232, USA</aff><author-notes><corresp id="cor1">Tel:+1-864-656-1726, <email>janker@clemson.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>19</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>27</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>19</day><month>6</month><year>2015</year></pub-date><volume>10</volume><issue>16</issue><fpage>3364</fpage><lpage>3370</lpage><pmc-comment>elocation-id from pubmed: 10.1002/smll.201303769</pmc-comment>
<abstract><p id="P1">Multifunctional nanoparticles are synthesized for both pH-triggered drug release and imaging with radioluminescence, upconversion luminescent, and magnetic resonance imaging (MRI). The particles have a yolk-in-shell morphology, with a radioluminescent core, an upconverting shell, and a hollow region between the core and shell for loading drugs. They are synthesized by controlled encapsulation of a radioluminescent nanophosphor yolk in a silica shell, partial etching of the yolk in acid, and encapsulation of the silica with an upconverting luminescent shell. Metroxantrone, a chemotherapy drug, was loaded into the hollow space between X-ray phosphor yolk and up-conversion phosphor shell through pores in the shell. To encapsulate the drug and control the release rate, the nanoparticles are coated with pH-responsive biocompatible polyelectrolyte layers of charged hyaluronic acid sodium salt and chitosan. The nanophosphors display bright luminescence under X-ray, blue light (480 nm), and infrared light (980 nm). They also served as T<sub>1</sub> and T<sub>2</sub> MRI contrast agents with relaxivities of 3.5 mM<sup>−1</sup> s<sup>−1</sup> (r<sub>1</sub>) and 64 mM<sup>−1</sup>s<sup>−1</sup> (r<sub>2</sub>). These multifunctional nanocapsules have applications in controlled drug delivery and multimodal imaging.</p></abstract><kwd-group><kwd>upconversion</kwd><kwd>radioluminescence</kwd><kwd>nanophosphors</kwd><kwd>controlled drug release</kwd><kwd>MRI contrast agent</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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