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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hybrid electro-optical stimulation of the rat sciatic nerve induces force generation in the plantarflexor muscles</title><author><name sortKey="Duke, Austin R" sort="Duke, Austin R" uniqKey="Duke A" first="Austin R" last="Duke">Austin R. Duke</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Peterson, Erik" sort="Peterson, Erik" uniqKey="Peterson E" first="Erik" last="Peterson">Erik Peterson</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Mackanos, Mark A" sort="Mackanos, Mark A" uniqKey="Mackanos M" first="Mark A" last="Mackanos">Mark A. Mackanos</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Atkinson, James" sort="Atkinson, James" uniqKey="Atkinson J" first="James" last="Atkinson">James Atkinson</name><affiliation><nlm:aff id="A3">Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Tyler, Dustin" sort="Tyler, Dustin" uniqKey="Tyler D" first="Dustin" last="Tyler">Dustin Tyler</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Jansen, E Duco" sort="Jansen, E Duco" uniqKey="Jansen E" first="E Duco" last="Jansen">E Duco Jansen</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Neurological Surgery, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23186608</idno><idno type="pmc">4533122</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533122</idno><idno type="RBID">PMC:4533122</idno><idno type="doi">10.1088/1741-2560/9/6/066006</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000306</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000306</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hybrid electro-optical stimulation of the rat sciatic nerve induces force generation in the plantarflexor muscles</title><author><name sortKey="Duke, Austin R" sort="Duke, Austin R" uniqKey="Duke A" first="Austin R" last="Duke">Austin R. Duke</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Peterson, Erik" sort="Peterson, Erik" uniqKey="Peterson E" first="Erik" last="Peterson">Erik Peterson</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Mackanos, Mark A" sort="Mackanos, Mark A" uniqKey="Mackanos M" first="Mark A" last="Mackanos">Mark A. Mackanos</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Atkinson, James" sort="Atkinson, James" uniqKey="Atkinson J" first="James" last="Atkinson">James Atkinson</name><affiliation><nlm:aff id="A3">Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author><author><name sortKey="Tyler, Dustin" sort="Tyler, Dustin" uniqKey="Tyler D" first="Dustin" last="Tyler">Dustin Tyler</name><affiliation><nlm:aff id="A2">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA</nlm:aff></affiliation></author><author><name sortKey="Jansen, E Duco" sort="Jansen, E Duco" uniqKey="Jansen E" first="E Duco" last="Jansen">E Duco Jansen</name><affiliation><nlm:aff id="A1">Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">Department of Neurological Surgery, Vanderbilt University, Nashville, TN, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of neural engineering</title><idno type="ISSN">1741-2560</idno><idno type="eISSN">1741-2552</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">Optical methods of neural activation are becoming important tools for the study and treatment of neurological disorders. Infrared nerve stimulation (INS) is an optical technique exhibiting spatially precise activation in the native neural system. While this technique shows great promise, the risk of thermal damage may limit some applications. Combining INS with traditional electrical stimulation, a method known as hybrid electro-optical stimulation, reduces the laser power requirements and mitigates the risk of thermal damage while maintaining spatial selectivity. Here we investigate the capability of inducing force generation in the rat hind-limb through hybrid stimulation of the sciatic nerve.</p></sec><sec id="S2"><title>Approach</title><p id="P2">Hybrid stimulation was achieved by combining an optically transparent nerve cuff for electrical stimulation and a diode laser coupled to an optical fiber for infrared stimulation. Force generation in the rat plantarflexor muscles was measured in response to hybrid stimulation with 1-second bursts of pulses at 15 and 20 Hz and with a burst frequency of 0.5 Hz.</p></sec><sec id="S3"><title>Main Results</title><p id="P3">Forces were found to increase with successive stimulus trains, ultimately reaching a plateau by the 20<sup>th</sup> train. Hybrid evoked forces decayed at a rate similar to the rate of thermal diffusion in tissue. Preconditioning the nerve with an optical stimulus resulted in an increase in the force response to both electrical and hybrid stimulation. Histological evaluation showed no signs of thermally induced morphological changes following hybrid stimulation. Our results indicate that an increase in baseline temperature is a likely contributor to hybrid force generation.</p></sec><sec id="S4"><title>Significance</title><p id="P4">Extraneural INS of peripheral nerves at physiologically relevant repetition rates is possible using hybrid electro-optical stimulation.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101217933</journal-id><journal-id journal-id-type="pubmed-jr-id">32339</journal-id><journal-id journal-id-type="nlm-ta">J Neural Eng</journal-id><journal-id journal-id-type="iso-abbrev">J Neural Eng</journal-id><journal-title-group><journal-title>Journal of neural engineering</journal-title></journal-title-group><issn pub-type="ppub">1741-2560</issn><issn pub-type="epub">1741-2552</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23186608</article-id><article-id pub-id-type="pmc">4533122</article-id><article-id pub-id-type="doi">10.1088/1741-2560/9/6/066006</article-id><article-id pub-id-type="manuscript">NIHMS426168</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Hybrid electro-optical stimulation of the rat sciatic nerve induces force generation in the plantarflexor muscles</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Duke</surname><given-names>Austin R</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Peterson</surname><given-names>Erik</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mackanos</surname><given-names>Mark A</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Atkinson</surname><given-names>James</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tyler</surname><given-names>Dustin</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Jansen</surname><given-names>E Duco</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA</aff><aff id="A2"><label>2</label>Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA</aff><aff id="A3"><label>3</label>Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA</aff><aff id="A4"><label>4</label>Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA</aff><aff id="A5"><label>5</label>Department of Neurological Surgery, Vanderbilt University, Nashville, TN, USA</aff><pub-date pub-type="nihms-submitted"><day>5</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>27</day><month>11</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>8</month><year>2015</year></pub-date><volume>9</volume><issue>6</issue><fpage>066006</fpage><lpage>066006</lpage><pmc-comment>elocation-id from pubmed: 10.1088/1741-2560/9/6/066006</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">Optical methods of neural activation are becoming important tools for the study and treatment of neurological disorders. Infrared nerve stimulation (INS) is an optical technique exhibiting spatially precise activation in the native neural system. While this technique shows great promise, the risk of thermal damage may limit some applications. Combining INS with traditional electrical stimulation, a method known as hybrid electro-optical stimulation, reduces the laser power requirements and mitigates the risk of thermal damage while maintaining spatial selectivity. Here we investigate the capability of inducing force generation in the rat hind-limb through hybrid stimulation of the sciatic nerve.</p></sec><sec id="S2"><title>Approach</title><p id="P2">Hybrid stimulation was achieved by combining an optically transparent nerve cuff for electrical stimulation and a diode laser coupled to an optical fiber for infrared stimulation. Force generation in the rat plantarflexor muscles was measured in response to hybrid stimulation with 1-second bursts of pulses at 15 and 20 Hz and with a burst frequency of 0.5 Hz.</p></sec><sec id="S3"><title>Main Results</title><p id="P3">Forces were found to increase with successive stimulus trains, ultimately reaching a plateau by the 20<sup>th</sup> train. Hybrid evoked forces decayed at a rate similar to the rate of thermal diffusion in tissue. Preconditioning the nerve with an optical stimulus resulted in an increase in the force response to both electrical and hybrid stimulation. Histological evaluation showed no signs of thermally induced morphological changes following hybrid stimulation. Our results indicate that an increase in baseline temperature is a likely contributor to hybrid force generation.</p></sec><sec id="S4"><title>Significance</title><p id="P4">Extraneural INS of peripheral nerves at physiologically relevant repetition rates is possible using hybrid electro-optical stimulation.</p></sec></abstract><kwd-group><kwd>hybrid</kwd><kwd>optical stimulation</kwd><kwd>infrared</kwd><kwd>force generation</kwd><kwd>sciatic nerve</kwd><kwd>temperature</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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