ThuliumV1, Pmc, Corpus, bibRecord, 000304

High Contrast In vitro and In vivo Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm3+ and Yb3+ Doped Fluoride Nanophosphors

Identifieur interne : 000304 ( Pmc/Corpus ); précédent : 000303; suivant : 000305

High Contrast In vitro and In vivo Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm3+ and Yb3+ Doped Fluoride Nanophosphors

Auteurs : Marcin Nyk ; Rajiv Kumar ; Tymish Y. Ohulchanskyy ; Earl J. Bergey ; Paras N. Prasad

Source :

Nano letters [ 1530-6984 ] ; 2008.

RBID : PMC:3523349

Abstract

A new approach for photoluminescence imaging in vitro and in vivo has been shown, utilizing near infrared to near infrared (NIR-to-NIR) up-conversion in nanophosphors. This NIR-to-NIR up-conversion process provides deeper light penetration into biological specimen and results in high contrast optical imaging due to absence of an autofluorescence background and decreased light scattering. Aqueous dispersible fluoride (NaYF₄) nanocrystals (20–30 nm size) co-doped with the rare earth ions, Tm³⁺ and Yb³⁺, were synthesized and characterized by TEM, XRD and photoluminescence (PL) spectroscopy. In vitro cellular uptake was shown by the PL microscopy visualizing the characteristic emission of Tm³⁺ at ~ 800 nm excited with 975 nm. No apparent cytotoxicity was observed. Subsequent animal imaging studies were performed using Balb-c mice injected intravenously with up-converting nanophosphors, demonstrating the high contrast PL imaging in vivo.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523349

DOI: 10.1021/nl802223f
PubMed: 18928324
PubMed Central: 3523349

Links to Exploration step

PMC:3523349

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High Contrast <italic>In vitro</italic>
 and <italic>In vivo</italic>
 Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm<sup>3+</sup>
 and Yb<sup>3+</sup>
 Doped Fluoride Nanophosphors</title>
<author><name sortKey="Nyk, Marcin" sort="Nyk, Marcin" uniqKey="Nyk M" first="Marcin" last="Nyk">Marcin Nyk</name>
</author>
<author><name sortKey="Kumar, Rajiv" sort="Kumar, Rajiv" uniqKey="Kumar R" first="Rajiv" last="Kumar">Rajiv Kumar</name>
</author>
<author><name sortKey="Ohulchanskyy, Tymish Y" sort="Ohulchanskyy, Tymish Y" uniqKey="Ohulchanskyy T" first="Tymish Y." last="Ohulchanskyy">Tymish Y. Ohulchanskyy</name>
</author>
<author><name sortKey="Bergey, Earl J" sort="Bergey, Earl J" uniqKey="Bergey E" first="Earl J." last="Bergey">Earl J. Bergey</name>
</author>
<author><name sortKey="Prasad, Paras N" sort="Prasad, Paras N" uniqKey="Prasad P" first="Paras N." last="Prasad">Paras N. Prasad</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18928324</idno>
<idno type="pmc">3523349</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523349</idno>
<idno type="RBID">PMC:3523349</idno>
<idno type="doi">10.1021/nl802223f</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">High Contrast <italic>In vitro</italic>
 and <italic>In vivo</italic>
 Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm<sup>3+</sup>
 and Yb<sup>3+</sup>
 Doped Fluoride Nanophosphors</title>
<author><name sortKey="Nyk, Marcin" sort="Nyk, Marcin" uniqKey="Nyk M" first="Marcin" last="Nyk">Marcin Nyk</name>
</author>
<author><name sortKey="Kumar, Rajiv" sort="Kumar, Rajiv" uniqKey="Kumar R" first="Rajiv" last="Kumar">Rajiv Kumar</name>
</author>
<author><name sortKey="Ohulchanskyy, Tymish Y" sort="Ohulchanskyy, Tymish Y" uniqKey="Ohulchanskyy T" first="Tymish Y." last="Ohulchanskyy">Tymish Y. Ohulchanskyy</name>
</author>
<author><name sortKey="Bergey, Earl J" sort="Bergey, Earl J" uniqKey="Bergey E" first="Earl J." last="Bergey">Earl J. Bergey</name>
</author>
<author><name sortKey="Prasad, Paras N" sort="Prasad, Paras N" uniqKey="Prasad P" first="Paras N." last="Prasad">Paras N. Prasad</name>
</author>
</analytic>
<series><title level="j">Nano letters</title>
<idno type="ISSN">1530-6984</idno>
<idno type="eISSN">1530-6992</idno>
<imprint><date when="2008">2008</date>
</imprint>
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</fileDesc>
<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p id="P1">A new approach for photoluminescence imaging <italic>in vitro</italic>
 and <italic>in vivo</italic>
 has been shown, utilizing near infrared to near infrared (NIR-to-NIR) up-conversion in nanophosphors. This NIR-to-NIR up-conversion process provides deeper light penetration into biological specimen and results in high contrast optical imaging due to absence of an autofluorescence background and decreased light scattering. Aqueous dispersible fluoride (NaYF<sub>4</sub>
) nanocrystals (20–30 nm size) co-doped with the rare earth ions, Tm<sup>3+</sup>
 and Yb<sup>3+</sup>
, were synthesized and characterized by TEM, XRD and photoluminescence (PL) spectroscopy. <italic>In vitro</italic>
 cellular uptake was shown by the PL microscopy visualizing the characteristic emission of Tm<sup>3+</sup>
 at ~ 800 nm excited with 975 nm. No apparent cytotoxicity was observed. Subsequent animal imaging studies were performed using Balb-c mice injected intravenously with up-converting nanophosphors, demonstrating the high contrast PL imaging <italic>in vivo</italic>
.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">101088070</journal-id>
<journal-id journal-id-type="pubmed-jr-id">22479</journal-id>
<journal-id journal-id-type="nlm-ta">Nano Lett</journal-id>
<journal-id journal-id-type="iso-abbrev">Nano Lett.</journal-id>
<journal-title-group><journal-title>Nano letters</journal-title>
</journal-title-group>
<issn pub-type="ppub">1530-6984</issn>
<issn pub-type="epub">1530-6992</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">18928324</article-id>
<article-id pub-id-type="pmc">3523349</article-id>
<article-id pub-id-type="doi">10.1021/nl802223f</article-id>
<article-id pub-id-type="manuscript">NIHMS91102</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>High Contrast <italic>In vitro</italic>
 and <italic>In vivo</italic>
 Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm<sup>3+</sup>
 and Yb<sup>3+</sup>
 Doped Fluoride Nanophosphors</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Nyk</surname>
<given-names>Marcin</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kumar</surname>
<given-names>Rajiv</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Ohulchanskyy</surname>
<given-names>Tymish Y.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Bergey</surname>
<given-names>Earl J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Prasad</surname>
<given-names>Paras N.</given-names>
</name>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<aff id="A1">Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260</aff>
</contrib-group>
<author-notes><corresp id="CR1"><label>*</label>
CORRESPONDING AUTHOR FOOTNOTE Dr. Paras N. Prasad Distinguished Professor Institute for Lasers, Photonics and Biophotonics 428 Natural Sciences Complex The State University of New York University at Buffalo Buffalo, NY 14260-3000 <email>pnprasad@buffalo.edu</email>
 Phone: 716-645-6800 ext.2099 Fax: 716-645-6945</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>7</day>
<month>9</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>18</day>
<month>10</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="ppub"><month>11</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>17</day>
<month>12</month>
<year>2012</year>
</pub-date>
<volume>8</volume>
<issue>11</issue>
<fpage>3834</fpage>
<lpage>3838</lpage>
<abstract><p id="P1">A new approach for photoluminescence imaging <italic>in vitro</italic>
 and <italic>in vivo</italic>
 has been shown, utilizing near infrared to near infrared (NIR-to-NIR) up-conversion in nanophosphors. This NIR-to-NIR up-conversion process provides deeper light penetration into biological specimen and results in high contrast optical imaging due to absence of an autofluorescence background and decreased light scattering. Aqueous dispersible fluoride (NaYF<sub>4</sub>
) nanocrystals (20–30 nm size) co-doped with the rare earth ions, Tm<sup>3+</sup>
 and Yb<sup>3+</sup>
, were synthesized and characterized by TEM, XRD and photoluminescence (PL) spectroscopy. <italic>In vitro</italic>
 cellular uptake was shown by the PL microscopy visualizing the characteristic emission of Tm<sup>3+</sup>
 at ~ 800 nm excited with 975 nm. No apparent cytotoxicity was observed. Subsequent animal imaging studies were performed using Balb-c mice injected intravenously with up-converting nanophosphors, demonstrating the high contrast PL imaging <italic>in vivo</italic>
.</p>
</abstract>
<kwd-group><kwd>Nanophosphors</kwd>
<kwd>Energy Up-conversion</kwd>
<kwd>Near Infrared <italic>In vitro</italic>
 and <italic>In vivo</italic>
 imaging</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R01 CA119358 || CA</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R01 CA104492 || CA</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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High Contrast In vitro and In vivo Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm3+ and Yb3+ Doped Fluoride Nanophosphors

High Contrast In vitro and In vivo Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm3+ and Yb3+ Doped Fluoride Nanophosphors

Source :

Abstract

Links to Exploration step

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