ThuliumV1, Pmc, Corpus, bibRecord, 000301

Functional Brain Basis of Hypnotizability

Identifieur interne : 000301 ( Pmc/Corpus ); précédent : 000300; suivant : 000302

Functional Brain Basis of Hypnotizability

Auteurs : Fumiko Hoeft ; John D. E. Gabrieli ; Susan Whitfield-Gabrieli ; Brian W. Haas ; Roland Bammer ; Vinod Menon ; David Spiegel

Source :

Archives of general psychiatry [ 0003-990X ] ; 2012.

RBID : PMC:4365296

Abstract

Context

Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known.

Objective

The main goal of the study was to investigate the brain basis of hypnotizability.

Design

Cross sectional, in-vivo neuroimaging study.

Setting

Academic medical center at Stanford University School of Medicine.

Patients

12 adults with high and 12 adults with low hypnotizability.

Main Outcome Measures

(1) functional MRI (fMRI) to measure functional connectivity networks at rest including default-mode, salience and executive-control networks, (2) structural T1 MRI to measure regional grey and white matter volumes, and (3) diffusion tensor imaging (DTI) to measure white matter microstructural integrity.

Results

High-compared to low-hypnotizable individuals showed greater functional connectivity between left dorsolateral prefrontal cortex (DLPFC), an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex (dACC), anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information, using independent component analysis (ICA). Seed based analysis confirmed elevated functional coupling between the dACC and the DLPFC in high, compared to low, hypnotizables. These functional differences were not due to variation in brain structure in these regions, including regional grey and white matter volumes and white matter microstructure.

Conclusions

Our results provide novel evidence that altered functional connectivity in DLPFC and dACC may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365296

DOI: 10.1001/archgenpsychiatry.2011.2190
PubMed: 23026956
PubMed Central: 4365296

Links to Exploration step

PMC:4365296

Le document en format XML

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<author><name sortKey="Hoeft, Fumiko" sort="Hoeft, Fumiko" uniqKey="Hoeft F" first="Fumiko" last="Hoeft">Fumiko Hoeft</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5795</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Center for Interdisciplinary Brain Sciences Research (CIBSR), Stanford University School of Medicine, Stanford CA 94305-5795</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of California San Francisco (UCSF), San Francisco, CA 94143</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gabrieli, John D E" sort="Gabrieli, John D E" uniqKey="Gabrieli J" first="John D. E." last="Gabrieli">John D. E. Gabrieli</name>
<affiliation><nlm:aff id="A4">Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Whitfield Gabrieli, Susan" sort="Whitfield Gabrieli, Susan" uniqKey="Whitfield Gabrieli S" first="Susan" last="Whitfield-Gabrieli">Susan Whitfield-Gabrieli</name>
<affiliation><nlm:aff id="A4">Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139</nlm:aff>
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<author><name sortKey="Haas, Brian W" sort="Haas, Brian W" uniqKey="Haas B" first="Brian W." last="Haas">Brian W. Haas</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5795</nlm:aff>
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<affiliation><nlm:aff id="A2">Center for Interdisciplinary Brain Sciences Research (CIBSR), Stanford University School of Medicine, Stanford CA 94305-5795</nlm:aff>
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<author><name sortKey="Bammer, Roland" sort="Bammer, Roland" uniqKey="Bammer R" first="Roland" last="Bammer">Roland Bammer</name>
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<author><name sortKey="Menon, Vinod" sort="Menon, Vinod" uniqKey="Menon V" first="Vinod" last="Menon">Vinod Menon</name>
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<author><name sortKey="Spiegel, David" sort="Spiegel, David" uniqKey="Spiegel D" first="David" last="Spiegel">David Spiegel</name>
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<affiliation><nlm:aff id="A2">Center for Interdisciplinary Brain Sciences Research (CIBSR), Stanford University School of Medicine, Stanford CA 94305-5795</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of California San Francisco (UCSF), San Francisco, CA 94143</nlm:aff>
</affiliation>
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<author><name sortKey="Gabrieli, John D E" sort="Gabrieli, John D E" uniqKey="Gabrieli J" first="John D. E." last="Gabrieli">John D. E. Gabrieli</name>
<affiliation><nlm:aff id="A4">Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139</nlm:aff>
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<author><name sortKey="Whitfield Gabrieli, Susan" sort="Whitfield Gabrieli, Susan" uniqKey="Whitfield Gabrieli S" first="Susan" last="Whitfield-Gabrieli">Susan Whitfield-Gabrieli</name>
<affiliation><nlm:aff id="A4">Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139</nlm:aff>
</affiliation>
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<author><name sortKey="Haas, Brian W" sort="Haas, Brian W" uniqKey="Haas B" first="Brian W." last="Haas">Brian W. Haas</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5795</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Center for Interdisciplinary Brain Sciences Research (CIBSR), Stanford University School of Medicine, Stanford CA 94305-5795</nlm:aff>
</affiliation>
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<author><name sortKey="Bammer, Roland" sort="Bammer, Roland" uniqKey="Bammer R" first="Roland" last="Bammer">Roland Bammer</name>
<affiliation><nlm:aff id="A5">Department of Radiology, Stanford University School of Medicine, Stanford CA 94305</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Menon, Vinod" sort="Menon, Vinod" uniqKey="Menon V" first="Vinod" last="Menon">Vinod Menon</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5795</nlm:aff>
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<author><name sortKey="Spiegel, David" sort="Spiegel, David" uniqKey="Spiegel D" first="David" last="Spiegel">David Spiegel</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5795</nlm:aff>
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<series><title level="j">Archives of general psychiatry</title>
<idno type="ISSN">0003-990X</idno>
<idno type="eISSN">1538-3636</idno>
<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Context</title>
<p id="P1">Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known.</p>
</sec>
<sec id="S2"><title>Objective</title>
<p id="P2">The main goal of the study was to investigate the brain basis of hypnotizability.</p>
</sec>
<sec id="S3"><title>Design</title>
<p id="P3">Cross sectional, in-vivo neuroimaging study.</p>
</sec>
<sec id="S4"><title>Setting</title>
<p id="P4">Academic medical center at Stanford University School of Medicine.</p>
</sec>
<sec id="S5"><title>Patients</title>
<p id="P5">12 adults with high and 12 adults with low hypnotizability.</p>
</sec>
<sec id="S6"><title>Main Outcome Measures</title>
<p id="P6">(1) functional MRI (fMRI) to measure functional connectivity networks at rest including default-mode, salience and executive-control networks, (2) structural T1 MRI to measure regional grey and white matter volumes, and (3) diffusion tensor imaging (DTI) to measure white matter microstructural integrity.</p>
</sec>
<sec id="S7"><title>Results</title>
<p id="P7">High-compared to low-hypnotizable individuals showed greater functional connectivity between left dorsolateral prefrontal cortex (DLPFC), an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex (dACC), anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information, using independent component analysis (ICA). Seed based analysis confirmed elevated functional coupling between the dACC and the DLPFC in high, compared to low, hypnotizables. These functional differences were not due to variation in brain structure in these regions, including regional grey and white matter volumes and white matter microstructure.</p>
</sec>
<sec id="S8"><title>Conclusions</title>
<p id="P8">Our results provide novel evidence that altered functional connectivity in DLPFC and dACC may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372435</journal-id>
<journal-id journal-id-type="pubmed-jr-id">744</journal-id>
<journal-id journal-id-type="nlm-ta">Arch Gen Psychiatry</journal-id>
<journal-id journal-id-type="iso-abbrev">Arch. Gen. Psychiatry</journal-id>
<journal-title-group><journal-title>Archives of general psychiatry</journal-title>
</journal-title-group>
<issn pub-type="ppub">0003-990X</issn>
<issn pub-type="epub">1538-3636</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23026956</article-id>
<article-id pub-id-type="pmc">4365296</article-id>
<article-id pub-id-type="doi">10.1001/archgenpsychiatry.2011.2190</article-id>
<article-id pub-id-type="manuscript">NIHMS463297</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Functional Brain Basis of Hypnotizability</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Hoeft</surname>
<given-names>Fumiko</given-names>
</name>
<degrees>MD PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gabrieli</surname>
<given-names>John D.E.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Whitfield-Gabrieli</surname>
<given-names>Susan</given-names>
</name>
<degrees>BSc</degrees>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haas</surname>
<given-names>Brian W.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bammer</surname>
<given-names>Roland</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Menon</surname>
<given-names>Vinod</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spiegel</surname>
<given-names>David</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5795</aff>
<aff id="A2"><label>2</label>
Center for Interdisciplinary Brain Sciences Research (CIBSR), Stanford University School of Medicine, Stanford CA 94305-5795</aff>
<aff id="A3"><label>3</label>
Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of California San Francisco (UCSF), San Francisco, CA 94143</aff>
<aff id="A4"><label>4</label>
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139</aff>
<aff id="A5"><label>5</label>
Department of Radiology, Stanford University School of Medicine, Stanford CA 94305</aff>
<author-notes><corresp id="cor1"><label>*</label>
<bold>CORRESPONDENCE</bold>
 ADDRESS: 401 Quarry Road, Office 2325, Stanford, CA, 94305-5718; <email>dspiegel@stanford.edu</email>
; TEL: 650 723-6421 FAX: 650 498-6678</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>12</day>
<month>3</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>19</day>
<month>3</month>
<year>2015</year>
</pub-date>
<volume>69</volume>
<issue>10</issue>
<fpage>1064</fpage>
<lpage>1072</lpage>
<pmc-comment>elocation-id from pubmed: 10.1001/archgenpsychiatry.2011.2190</pmc-comment>
      <abstract><sec id="S1"><title>Context</title>
<p id="P1">Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known.</p>
</sec>
<sec id="S2"><title>Objective</title>
<p id="P2">The main goal of the study was to investigate the brain basis of hypnotizability.</p>
</sec>
<sec id="S3"><title>Design</title>
<p id="P3">Cross sectional, in-vivo neuroimaging study.</p>
</sec>
<sec id="S4"><title>Setting</title>
<p id="P4">Academic medical center at Stanford University School of Medicine.</p>
</sec>
<sec id="S5"><title>Patients</title>
<p id="P5">12 adults with high and 12 adults with low hypnotizability.</p>
</sec>
<sec id="S6"><title>Main Outcome Measures</title>
<p id="P6">(1) functional MRI (fMRI) to measure functional connectivity networks at rest including default-mode, salience and executive-control networks, (2) structural T1 MRI to measure regional grey and white matter volumes, and (3) diffusion tensor imaging (DTI) to measure white matter microstructural integrity.</p>
</sec>
<sec id="S7"><title>Results</title>
<p id="P7">High-compared to low-hypnotizable individuals showed greater functional connectivity between left dorsolateral prefrontal cortex (DLPFC), an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex (dACC), anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information, using independent component analysis (ICA). Seed based analysis confirmed elevated functional coupling between the dACC and the DLPFC in high, compared to low, hypnotizables. These functional differences were not due to variation in brain structure in these regions, including regional grey and white matter volumes and white matter microstructure.</p>
</sec>
<sec id="S8"><title>Conclusions</title>
<p id="P8">Our results provide novel evidence that altered functional connectivity in DLPFC and dACC may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted.</p>
</sec>
</abstract>
<kwd-group><kwd>hypnosis</kwd>
<kwd>hypnotizability</kwd>
<kwd>fMRI</kwd>
<kwd>resting-state functional connectivity</kwd>
<kwd>dorsolateral prefrontal cortex (DLPFC)</kwd>
<kwd>dorsal anterior cingulate cortex (dACC)</kwd>
<kwd>salience network</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Functional Brain Basis of Hypnotizability

Functional Brain Basis of Hypnotizability

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki