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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Application of <sup>23</sup>Na MRI to Monitor Chemotherapeutic Response in RIF-1 Tumors<xref ref-type="fn" rid="FN1">1</xref></title><author><name sortKey="Babsky, Andriy M" sort="Babsky, Andriy M" uniqKey="Babsky A" first="Andriy M" last="Babsky">Andriy M. Babsky</name><affiliation><nlm:aff id="A1">Department of Radiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Hekmatyar, Shahryar K" sort="Hekmatyar, Shahryar K" uniqKey="Hekmatyar S" first="Shahryar K" last="Hekmatyar">Shahryar K. Hekmatyar</name><affiliation><nlm:aff id="A1">Department of Radiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation><nlm:aff id="A1">Department of Radiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Solomon, James L" sort="Solomon, James L" uniqKey="Solomon J" first="James L" last="Solomon">James L. Solomon</name><affiliation><nlm:aff id="A2">Department of Cardiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name><affiliation><nlm:aff id="A1">Department of Radiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16026645</idno><idno type="pmc">1501427</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501427</idno><idno type="RBID">PMC:1501427</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000286</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000286</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Application of <sup>23</sup>Na MRI to Monitor Chemotherapeutic Response in RIF-1 Tumors<xref ref-type="fn" rid="FN1">1</xref></title><author><name sortKey="Babsky, Andriy M" sort="Babsky, Andriy M" uniqKey="Babsky A" first="Andriy M" last="Babsky">Andriy M. Babsky</name><affiliation><nlm:aff id="A1">Department of Radiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Hekmatyar, Shahryar K" sort="Hekmatyar, Shahryar K" uniqKey="Hekmatyar S" first="Shahryar K" last="Hekmatyar">Shahryar K. Hekmatyar</name><affiliation><nlm:aff id="A1">Department of Radiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation><nlm:aff id="A1">Department of Radiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Solomon, James L" sort="Solomon, James L" uniqKey="Solomon J" first="James L" last="Solomon">James L. Solomon</name><affiliation><nlm:aff id="A2">Department of Cardiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author><author><name sortKey="Bansal, Navin" sort="Bansal, Navin" uniqKey="Bansal N" first="Navin" last="Bansal">Navin Bansal</name><affiliation><nlm:aff id="A1">Department of Radiology, Indiana University, Indianapolis, IN, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Neoplasia (New York, N.Y.)</title><idno type="ISSN">1522-8002</idno><idno type="eISSN">1476-5586</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Effects of an alkylating anticancer drug, cyclophosphamide (Cp), on <sup>23</sup>Na signal intensity (<sup>23</sup>Na SI) and water apparent diffusion coefficient (ADC) were examined in subcutaneously-implanted radiation-induced fibrosarcoma (RIF-1) tumors by <italic>in vivo</italic> <sup>23</sup>Na and <sup>1</sup>H magnetic resonance imaging (MRI). MRI experiments were performed on untreated control (<italic>n</italic> = 5) and Cp-treated (<italic>n</italic> = 6) C3H mice, once before Cp injection (300 mg/kg) then daily for 3 days after treatment. Tumor volumes were significantly lower in treated animals 2 and 3 days posttreatment. At the same time points, MRI experiments showed an increase in both <sup>23</sup>Na SI and water ADC in treated tumors, whereas control tumors did not show any significant changes. The correlation between <sup>23</sup>Na SI and water ADC changes was dramatically increased in the Cp-treated group, suggesting that the observed increases in <sup>23</sup>Na SI and water ADC were caused by the same mechanism. Histologic sections showed decreased cell density in the regions of increased <sup>23</sup>Na and water ADC SI. Destructive chemical analysis showed that Cp treatment increased the relative extracellular space and tumor [Na<sup>+</sup>]. We conclude that the changes in water ADC and <sup>23</sup>Na SI were largely due to an increase in extracellular space. <sup>23</sup>Na MRI and <sup>1</sup>H water ADC measurements may provide valuable noninvasive techniques for monitoring chemotherapeutic responses.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neoplasia</journal-id><journal-id journal-id-type="publisher-id">NEO</journal-id><journal-title>Neoplasia (New York, N.Y.)</journal-title><issn pub-type="ppub">1522-8002</issn><issn pub-type="epub">1476-5586</issn><publisher><publisher-name>Neoplasia Press Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16026645</article-id><article-id pub-id-type="pmc">1501427</article-id><article-id pub-id-type="publisher-id">05130</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Application of <sup>23</sup>Na MRI to Monitor Chemotherapeutic Response in RIF-1 Tumors<xref ref-type="fn" rid="FN1">1</xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Babsky</surname><given-names>Andriy M</given-names></name><xref rid="A1" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Hekmatyar</surname><given-names>Shahryar K</given-names></name><xref rid="A1" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Hong</given-names></name><xref rid="A1" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Solomon</surname><given-names>James L</given-names></name><xref rid="A2" ref-type="aff">†</xref></contrib><contrib contrib-type="author"><name><surname>Bansal</surname><given-names>Navin</given-names></name><xref rid="A1" ref-type="aff">*</xref></contrib></contrib-group><aff id="A1"><label>*</label>Department of Radiology, Indiana University, Indianapolis, IN, USA</aff><aff id="A2"><label>†</label>Department of Cardiology, Indiana University, Indianapolis, IN, USA</aff><author-notes><corresp>Address all correspondence to: Andriy Babsky, PhD or Navin Bansal, PhD, Department of Radiology, Indiana University School of Medicine, 950 West Walnut Street, R2 E124, Indianapolis, IN 46202-5181. E-mail: <email>ababsky@iupui.edu</email>, <email>nbansal@iupui.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2005</year></pub-date><volume>7</volume><issue>7</issue><fpage>658</fpage><lpage>666</lpage><history><date date-type="received"><day>13</day><month>1</month><year>2005</year></date><date date-type="rev-recd"><day>15</day><month>3</month><year>2005</year></date><date date-type="accepted"><day>16</day><month>3</month><year>2005</year></date></history><copyright-statement>Copyright © 2005 Neoplasia Press, Inc. All rights reserved</copyright-statement><copyright-year>2005</copyright-year><abstract><title>Abstract</title><p>Effects of an alkylating anticancer drug, cyclophosphamide (Cp), on <sup>23</sup>Na signal intensity (<sup>23</sup>Na SI) and water apparent diffusion coefficient (ADC) were examined in subcutaneously-implanted radiation-induced fibrosarcoma (RIF-1) tumors by <italic>in vivo</italic> <sup>23</sup>Na and <sup>1</sup>H magnetic resonance imaging (MRI). MRI experiments were performed on untreated control (<italic>n</italic> = 5) and Cp-treated (<italic>n</italic> = 6) C3H mice, once before Cp injection (300 mg/kg) then daily for 3 days after treatment. Tumor volumes were significantly lower in treated animals 2 and 3 days posttreatment. At the same time points, MRI experiments showed an increase in both <sup>23</sup>Na SI and water ADC in treated tumors, whereas control tumors did not show any significant changes. The correlation between <sup>23</sup>Na SI and water ADC changes was dramatically increased in the Cp-treated group, suggesting that the observed increases in <sup>23</sup>Na SI and water ADC were caused by the same mechanism. Histologic sections showed decreased cell density in the regions of increased <sup>23</sup>Na and water ADC SI. Destructive chemical analysis showed that Cp treatment increased the relative extracellular space and tumor [Na<sup>+</sup>]. We conclude that the changes in water ADC and <sup>23</sup>Na SI were largely due to an increase in extracellular space. <sup>23</sup>Na MRI and <sup>1</sup>H water ADC measurements may provide valuable noninvasive techniques for monitoring chemotherapeutic responses.</p></abstract><kwd-group><title>Keywords</title><kwd>RIF-1</kwd><kwd>chemotherapy</kwd><kwd>MRI</kwd><kwd>sodium</kwd><kwd>diffusion</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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