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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Painful Cutaneous Laser Stimulus Evokes Responses From Single Neurons in the Human Thalamic Principal Somatic Sensory Nucleus Ventral Caudal (Vc)</title><author><name sortKey="Kobayashi, K" sort="Kobayashi, K" uniqKey="Kobayashi K" first="K." last="Kobayashi">K. Kobayashi</name></author><author><name sortKey="Winberry, J" sort="Winberry, J" uniqKey="Winberry J" first="J." last="Winberry">J. Winberry</name></author><author><name sortKey="Liu, C C" sort="Liu, C C" uniqKey="Liu C" first="C. C." last="Liu">C. C. Liu</name></author><author><name sortKey="Treede, R D" sort="Treede, R D" uniqKey="Treede R" first="R. D." last="Treede">R. D. Treede</name></author><author><name sortKey="Lenz, F A" sort="Lenz, F A" uniqKey="Lenz F" first="F. A." last="Lenz">F. A. Lenz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19244350</idno><idno type="pmc">3815208</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815208</idno><idno type="RBID">PMC:3815208</idno><idno type="doi">10.1152/jn.91347.2008</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000283</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000283</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Painful Cutaneous Laser Stimulus Evokes Responses From Single Neurons in the Human Thalamic Principal Somatic Sensory Nucleus Ventral Caudal (Vc)</title><author><name sortKey="Kobayashi, K" sort="Kobayashi, K" uniqKey="Kobayashi K" first="K." last="Kobayashi">K. Kobayashi</name></author><author><name sortKey="Winberry, J" sort="Winberry, J" uniqKey="Winberry J" first="J." last="Winberry">J. Winberry</name></author><author><name sortKey="Liu, C C" sort="Liu, C C" uniqKey="Liu C" first="C. C." last="Liu">C. C. Liu</name></author><author><name sortKey="Treede, R D" sort="Treede, R D" uniqKey="Treede R" first="R. D." last="Treede">R. D. Treede</name></author><author><name sortKey="Lenz, F A" sort="Lenz, F A" uniqKey="Lenz F" first="F. A." last="Lenz">F. A. Lenz</name></author></analytic><series><title level="j">Journal of Neurophysiology</title><idno type="ISSN">0022-3077</idno><idno type="eISSN">1522-1598</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cutaneous application of painful radiant heat laser pulses evokes potentials (laser-evoked potentials) that can be recorded from scalp or intracranial electrodes. We have now tested the hypothesis that the response of thalamic neurons to a cutaneous laser stimulus occurs at latencies predicted by the conduction delay between the periphery and the thalamus. We have carried out recordings from human thalamic neurons in the principal sensory nucleus (ventral caudal) in patients undergoing awake surgery for the treatment of tremor. The results demonstrate that many neurons respond to the laser with early and/or late latency peaks of activity, consistent with conduction of the response to the laser stimulus through pathways from Aδ and C fibers to the thalamus. These peaks were of short duration, perhaps due to the somatotopic- and modality-specific arrangements of afferent pathways to the thalamus. The responses of these thalamic neurons to the laser stimulus sometimes included low-threshold spike (LTS) bursts of action potentials, consistent with previous studies of different painful stimuli. A prior study has demonstrated that spike trains characterized by common LTS bursts such as the intermediate (I) category spontaneously change their category more commonly than do those without LTS bursts (NG: nongrouped category) during changes in the cognitive task. Spike trains of laser-responsive neurons were more common in the I category, whereas those of laser nonresponsive neurons were more common in the NG category. Therefore neuronal spike trains in the I category may mediate shifts in endogenous or cognitive pain-related behavior.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurophysiol</journal-id><journal-id journal-id-type="iso-abbrev">J. Neurophysiol</journal-id><journal-id journal-id-type="hwp">jn</journal-id><journal-title-group><journal-title>Journal of Neurophysiology</journal-title></journal-title-group><issn pub-type="ppub">0022-3077</issn><issn pub-type="epub">1522-1598</issn><publisher><publisher-name>American Physiological Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19244350</article-id><article-id pub-id-type="pmc">3815208</article-id><article-id pub-id-type="other">J91347-8</article-id><article-id pub-id-type="doi">10.1152/jn.91347.2008</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>A Painful Cutaneous Laser Stimulus Evokes Responses From Single Neurons in the Human Thalamic Principal Somatic Sensory Nucleus Ventral Caudal (Vc)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kobayashi</surname><given-names>K.</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Winberry</surname><given-names>J.</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>C. C.</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author"><name><surname>Treede</surname><given-names>R. D.</given-names></name><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lenz</surname><given-names>F. A.</given-names></name><xref rid="AFF1">1</xref></contrib><aff id="AFF1"><label>1</label>Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland;</aff><aff id="AFF2"><label>2</label>Chair of Neurophysiology, University of Heidelberg at Mannheim, Mannheim, Germany</aff></contrib-group><author-notes><corresp>Address for reprint requests and other correspondence: F. A. Lenz, Department of Neurosurgery, Johns Hopkins Hospital, Meyer Building 8-181, 600 North Wolfe Street, Baltimore, MD 21287-7713 (E-mail: <email>flenz1@jhmi.edu</email>)</corresp></author-notes><pub-date pub-type="ppub"><month>5</month><year>2009</year></pub-date><volume>101</volume><issue>5</issue><fpage>2210</fpage><lpage>2217</lpage><history><date date-type="accepted"><day>20</day><month>2</month><year>2009</year></date><date date-type="received"><day>22</day><month>12</month><year>2008</year></date></history><permissions><copyright-statement>Copyright © 2009 the American Physiological Society</copyright-statement><copyright-year>2009</copyright-year></permissions><self-uri content-type="arthw-pdf" xlink:type="simple" xlink:href="z9k00509002210"></self-uri><abstract><p>Cutaneous application of painful radiant heat laser pulses evokes potentials (laser-evoked potentials) that can be recorded from scalp or intracranial electrodes. We have now tested the hypothesis that the response of thalamic neurons to a cutaneous laser stimulus occurs at latencies predicted by the conduction delay between the periphery and the thalamus. We have carried out recordings from human thalamic neurons in the principal sensory nucleus (ventral caudal) in patients undergoing awake surgery for the treatment of tremor. The results demonstrate that many neurons respond to the laser with early and/or late latency peaks of activity, consistent with conduction of the response to the laser stimulus through pathways from Aδ and C fibers to the thalamus. These peaks were of short duration, perhaps due to the somatotopic- and modality-specific arrangements of afferent pathways to the thalamus. The responses of these thalamic neurons to the laser stimulus sometimes included low-threshold spike (LTS) bursts of action potentials, consistent with previous studies of different painful stimuli. A prior study has demonstrated that spike trains characterized by common LTS bursts such as the intermediate (I) category spontaneously change their category more commonly than do those without LTS bursts (NG: nongrouped category) during changes in the cognitive task. Spike trains of laser-responsive neurons were more common in the I category, whereas those of laser nonresponsive neurons were more common in the NG category. Therefore neuronal spike trains in the I category may mediate shifts in endogenous or cognitive pain-related behavior.</p></abstract><custom-meta-group><custom-meta><meta-name>hwp-legacy-fpage</meta-name><meta-value>2210</meta-value></custom-meta><custom-meta><meta-name>cover-date</meta-name><meta-value>May 2009</meta-value></custom-meta><custom-meta><meta-name>hwp-legacy-dochead</meta-name><meta-value>Article</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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