The Effect of Multiple Sequential Light Sources to Activate Aminolevulinic Acid in the Treatment of Actinic Keratoses: A Retrospective Study
Identifieur interne : 000277 ( Pmc/Corpus ); précédent : 000276; suivant : 000278The Effect of Multiple Sequential Light Sources to Activate Aminolevulinic Acid in the Treatment of Actinic Keratoses: A Retrospective Study
Auteurs : Daniel P. Friedmann ; Mitchel P. Goldman ; Sabrina G. Fabi ; Isabella GuihaSource :
- The Journal of Clinical and Aesthetic Dermatology [ 1941-2789 ] ; 2014.
Abstract
There is a lack of research regarding the sequential use of multiple light sources for topical 5-aminolevulinic acid activation in photodynamic therapy for actinic keratosis. This study evaluated 5-aminolevulinic acid-photodynamic therapy for actinic keratosis using blue light combined with red light, pulsed dye laser, and/or intense pulsed light in a retrospective fashion. Field-directed 5-aminolevulinic acid-photodynamic therapy was performed with blue light only, blue light + pulsed dye laser, blue light + intense pulsed light, blue light + pulsed dye laser + intense pulsed light, or blue light + red light + pulsed dye laser + intense pulsed light for nonhyperkeratotic actinic keratoses of face, scalp, or upper trunk. Blue light + intense pulsed light + pulsed dye laser produced greater patient-reported improvement in actinic keratoses than blue light or blue light + intense pulsed light and greater subject-reported improvement in overall skin quality than blue light + intense pulsed light. The addition of red light led to no further benefit in either outcome measure. Photodynamic therapy with multiple, sequential laser and light sources led to greater patient-graded improvement in actinic keratoses than that with a single light source (blue light), without significant differences in post-treatment adverse events. However, the small, widely disparate number of patients between groups and follow-up times between patients, as well as retrospective assessments based on subjective patient recall, severely limit the significance of these findings. Nevertheless, the results raise interesting questions regarding the use of multiple light and laser sources for photodynamic therapy of actinic keratoses and warrant further research with a prospective, randomized, controlled study.
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PubMed: 25276272
PubMed Central: 4174915
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PMC:4174915Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Effect of Multiple Sequential Light Sources to Activate Aminolevulinic Acid in the Treatment of Actinic Keratoses: A Retrospective Study</title>
<author><name sortKey="Friedmann, Daniel P" sort="Friedmann, Daniel P" uniqKey="Friedmann D" first="Daniel P." last="Friedmann">Daniel P. Friedmann</name>
<affiliation><nlm:aff id="A1">Westlake Dermatology Clinical Research Center, Westlake Dermatology & Cosmetic Surgery, Austin, Texas;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goldman, Mitchel P" sort="Goldman, Mitchel P" uniqKey="Goldman M" first="Mitchel P." last="Goldman">Mitchel P. Goldman</name>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
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<author><name sortKey="Fabi, Sabrina G" sort="Fabi, Sabrina G" uniqKey="Fabi S" first="Sabrina G." last="Fabi">Sabrina G. Fabi</name>
<affiliation><nlm:aff>NONE</nlm:aff>
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<author><name sortKey="Guiha, Isabella" sort="Guiha, Isabella" uniqKey="Guiha I" first="Isabella" last="Guiha">Isabella Guiha</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Effect of Multiple Sequential Light Sources to Activate Aminolevulinic Acid in the Treatment of Actinic Keratoses: A Retrospective Study</title>
<author><name sortKey="Friedmann, Daniel P" sort="Friedmann, Daniel P" uniqKey="Friedmann D" first="Daniel P." last="Friedmann">Daniel P. Friedmann</name>
<affiliation><nlm:aff id="A1">Westlake Dermatology Clinical Research Center, Westlake Dermatology & Cosmetic Surgery, Austin, Texas;</nlm:aff>
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<author><name sortKey="Goldman, Mitchel P" sort="Goldman, Mitchel P" uniqKey="Goldman M" first="Mitchel P." last="Goldman">Mitchel P. Goldman</name>
<affiliation><nlm:aff>NONE</nlm:aff>
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<author><name sortKey="Fabi, Sabrina G" sort="Fabi, Sabrina G" uniqKey="Fabi S" first="Sabrina G." last="Fabi">Sabrina G. Fabi</name>
<affiliation><nlm:aff>NONE</nlm:aff>
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<author><name sortKey="Guiha, Isabella" sort="Guiha, Isabella" uniqKey="Guiha I" first="Isabella" last="Guiha">Isabella Guiha</name>
<affiliation><nlm:aff>NONE</nlm:aff>
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<series><title level="j">The Journal of Clinical and Aesthetic Dermatology</title>
<idno type="ISSN">1941-2789</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p>There is a lack of research regarding the sequential use of multiple light sources for topical 5-aminolevulinic acid activation in photodynamic therapy for actinic keratosis. This study evaluated 5-aminolevulinic acid-photodynamic therapy for actinic keratosis using blue light combined with red light, pulsed dye laser, and/or intense pulsed light in a retrospective fashion. Field-directed 5-aminolevulinic acid-photodynamic therapy was performed with blue light only, blue light + pulsed dye laser, blue light + intense pulsed light, blue light + pulsed dye laser + intense pulsed light, or blue light + red light + pulsed dye laser + intense pulsed light for nonhyperkeratotic actinic keratoses of face, scalp, or upper trunk. Blue light + intense pulsed light + pulsed dye laser produced greater patient-reported improvement in actinic keratoses than blue light or blue light + intense pulsed light and greater subject-reported improvement in overall skin quality than blue light + intense pulsed light. The addition of red light led to no further benefit in either outcome measure. Photodynamic therapy with multiple, sequential laser and light sources led to greater patient-graded improvement in actinic keratoses than that with a single light source (blue light), without significant differences in post-treatment adverse events. However, the small, widely disparate number of patients between groups and follow-up times between patients, as well as retrospective assessments based on subjective patient recall, severely limit the significance of these findings. Nevertheless, the results raise interesting questions regarding the use of multiple light and laser sources for photodynamic therapy of actinic keratoses and warrant further research with a prospective, randomized, controlled study.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Aesthet Dermatol</journal-id>
<journal-id journal-id-type="iso-abbrev">J Clin Aesthet Dermatol</journal-id>
<journal-id journal-id-type="publisher-id">JCAD</journal-id>
<journal-title-group><journal-title>The Journal of Clinical and Aesthetic Dermatology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1941-2789</issn>
<publisher><publisher-name>Matrix Medical Communications</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25276272</article-id>
<article-id pub-id-type="pmc">4174915</article-id>
<article-id pub-id-type="other">jcad_7_9_20</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>The Effect of Multiple Sequential Light Sources to Activate Aminolevulinic Acid in the Treatment of Actinic Keratoses: A Retrospective Study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Friedmann</surname>
<given-names>Daniel P.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goldman</surname>
<given-names>Mitchel P.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fabi</surname>
<given-names>Sabrina G.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guiha</surname>
<given-names>Isabella</given-names>
</name>
<degrees>BS</degrees>
<xref ref-type="aff" rid="A1">b</xref>
</contrib>
<aff id="A1"><label>a</label>
Westlake Dermatology Clinical Research Center, Westlake Dermatology & Cosmetic Surgery, Austin, Texas;</aff>
<aff id="A2"><label>b</label>
Goldman, Butterwick, Fitzpatrick, Groff, and Fabi: Cosmetic Laser Dermatology, San Diego, California</aff>
</contrib-group>
<author-notes><corresp><bold>ADDRESS CORRESPONDENCE TO:</bold>
Daniel P. Friedmann, MD, Westlake Dermatology Clinical Research Center, 8825 Bee Cave Rd, Ste 100, Austin, TX 78746; E-mail: <email xlink:type="simple">daniel@westlakedermatology.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>9</month>
<year>2014</year>
</pub-date>
<volume>7</volume>
<issue>9</issue>
<fpage>20</fpage>
<lpage>25</lpage>
<abstract><p>There is a lack of research regarding the sequential use of multiple light sources for topical 5-aminolevulinic acid activation in photodynamic therapy for actinic keratosis. This study evaluated 5-aminolevulinic acid-photodynamic therapy for actinic keratosis using blue light combined with red light, pulsed dye laser, and/or intense pulsed light in a retrospective fashion. Field-directed 5-aminolevulinic acid-photodynamic therapy was performed with blue light only, blue light + pulsed dye laser, blue light + intense pulsed light, blue light + pulsed dye laser + intense pulsed light, or blue light + red light + pulsed dye laser + intense pulsed light for nonhyperkeratotic actinic keratoses of face, scalp, or upper trunk. Blue light + intense pulsed light + pulsed dye laser produced greater patient-reported improvement in actinic keratoses than blue light or blue light + intense pulsed light and greater subject-reported improvement in overall skin quality than blue light + intense pulsed light. The addition of red light led to no further benefit in either outcome measure. Photodynamic therapy with multiple, sequential laser and light sources led to greater patient-graded improvement in actinic keratoses than that with a single light source (blue light), without significant differences in post-treatment adverse events. However, the small, widely disparate number of patients between groups and follow-up times between patients, as well as retrospective assessments based on subjective patient recall, severely limit the significance of these findings. Nevertheless, the results raise interesting questions regarding the use of multiple light and laser sources for photodynamic therapy of actinic keratoses and warrant further research with a prospective, randomized, controlled study.</p>
</abstract>
</article-meta>
</front>
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