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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Resting-State Networks and the Functional Connectome of the Human Brain in Agenesis of the Corpus Callosum</title><author><name sortKey="Owen, Julia P" sort="Owen, Julia P" uniqKey="Owen J" first="Julia P." last="Owen">Julia P. Owen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Yi Ou" sort="Li, Yi Ou" uniqKey="Li Y" first="Yi-Ou" last="Li">Yi-Ou Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yang, Fanpei G" sort="Yang, Fanpei G" uniqKey="Yang F" first="Fanpei G." last="Yang">Fanpei G. Yang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Shetty, Charvi" sort="Shetty, Charvi" uniqKey="Shetty C" first="Charvi" last="Shetty">Charvi Shetty</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bukshpun, Polina" sort="Bukshpun, Polina" uniqKey="Bukshpun P" first="Polina" last="Bukshpun">Polina Bukshpun</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Vora, Shivani" sort="Vora, Shivani" uniqKey="Vora S" first="Shivani" last="Vora">Shivani Vora</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Wakahiro, Mari" sort="Wakahiro, Mari" uniqKey="Wakahiro M" first="Mari" last="Wakahiro">Mari Wakahiro</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Hinkley, Leighton B N" sort="Hinkley, Leighton B N" uniqKey="Hinkley L" first="Leighton B. N." last="Hinkley">Leighton B. N. Hinkley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Nagarajan, Srikantan S" sort="Nagarajan, Srikantan S" uniqKey="Nagarajan S" first="Srikantan S." last="Nagarajan">Srikantan S. Nagarajan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Sherr, Elliott H" sort="Sherr, Elliott H" uniqKey="Sherr E" first="Elliott H." last="Sherr">Elliott H. Sherr</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Mukherjee, Pratik" sort="Mukherjee, Pratik" uniqKey="Mukherjee P" first="Pratik" last="Mukherjee">Pratik Mukherjee</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24063289</idno><idno type="pmc">3868398</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868398</idno><idno type="RBID">PMC:3868398</idno><idno type="doi">10.1089/brain.2013.0175</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000267</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000267</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Resting-State Networks and the Functional Connectome of the Human Brain in Agenesis of the Corpus Callosum</title><author><name sortKey="Owen, Julia P" sort="Owen, Julia P" uniqKey="Owen J" first="Julia P." last="Owen">Julia P. Owen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Yi Ou" sort="Li, Yi Ou" uniqKey="Li Y" first="Yi-Ou" last="Li">Yi-Ou Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yang, Fanpei G" sort="Yang, Fanpei G" uniqKey="Yang F" first="Fanpei G." last="Yang">Fanpei G. Yang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Shetty, Charvi" sort="Shetty, Charvi" uniqKey="Shetty C" first="Charvi" last="Shetty">Charvi Shetty</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bukshpun, Polina" sort="Bukshpun, Polina" uniqKey="Bukshpun P" first="Polina" last="Bukshpun">Polina Bukshpun</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Vora, Shivani" sort="Vora, Shivani" uniqKey="Vora S" first="Shivani" last="Vora">Shivani Vora</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Wakahiro, Mari" sort="Wakahiro, Mari" uniqKey="Wakahiro M" first="Mari" last="Wakahiro">Mari Wakahiro</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Hinkley, Leighton B N" sort="Hinkley, Leighton B N" uniqKey="Hinkley L" first="Leighton B. N." last="Hinkley">Leighton B. N. Hinkley</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Nagarajan, Srikantan S" sort="Nagarajan, Srikantan S" uniqKey="Nagarajan S" first="Srikantan S." last="Nagarajan">Srikantan S. Nagarajan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Sherr, Elliott H" sort="Sherr, Elliott H" uniqKey="Sherr E" first="Elliott H." last="Sherr">Elliott H. Sherr</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Mukherjee, Pratik" sort="Mukherjee, Pratik" uniqKey="Mukherjee P" first="Pratik" last="Mukherjee">Pratik Mukherjee</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author></analytic><series><title level="j">Brain Connectivity</title><idno type="ISSN">2158-0014</idno><idno type="eISSN">2158-0022</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The corpus callosum is the largest white matter fiber bundle connecting the two cerebral hemispheres. In this work, we investigate the effect of callosal dysgenesis on functional magnetic resonance imaging (fMRI) resting-state networks and the functional connectome. Since alternate commissural routes between the cerebral hemispheres exist, we hypothesize that bilateral cortical networks can still be maintained in partial or even complete agenesis of the corpus callosum (AgCC). However, since these commissural routes are frequently indirect, requiring polysynaptic pathways, we hypothesize that quantitative measurements of interhemispheric functional connectivity in bilateral networks will be reduced in AgCC compared with matched controls, especially in the most highly interconnected cortical regions that are the hubs of the connectome. Seventeen resting-state networks were extracted from fMRI of 11 subjects with partial or complete AgCC and 11 matched controls. The results show that the qualitative organization of resting-state networks is very similar between controls and AgCC. However, interhemispheric functional connectivity of precuneus, posterior cingulate cortex, and insular-opercular regions was significantly reduced in AgCC. The preserved network organization was confirmed with a connectomic analysis of the resting-state fMRI data, showing five functional modules that are largely consistent across the control and AgCC groups. Hence, the reduction or even complete absence of callosal connectivity does not affect the qualitative organization of bilateral resting-state networks or the modular organization of the functional connectome, although quantitatively reduced functional connectivity can be demonstrated by measurements within bilateral cortical hubs, supporting the hypothesis that indirect polysynaptic pathways are utilized to preserve interhemispheric temporal synchrony.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Brain Connect</journal-id><journal-id journal-id-type="iso-abbrev">Brain Connect</journal-id><journal-id journal-id-type="publisher-id">brain</journal-id><journal-title-group><journal-title>Brain Connectivity</journal-title></journal-title-group><issn pub-type="ppub">2158-0014</issn><issn pub-type="epub">2158-0022</issn><publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24063289</article-id><article-id pub-id-type="pmc">3868398</article-id><article-id pub-id-type="publisher-id">10.1089/brain.2013.0175</article-id><article-id pub-id-type="doi">10.1089/brain.2013.0175</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Resting-State Networks and the Functional Connectome of the Human Brain in Agenesis of the Corpus Callosum</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Owen</surname><given-names>Julia P.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1,</sup></xref><role><sup>*</sup></role><fn id="fn1" fn-type="equal"><label><sup>*</sup></label><p>These authors contributed equally to this work.</p></fn></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Yi-Ou</given-names></name><xref ref-type="aff" rid="aff1"><sup>1,</sup></xref><xref ref-type="fn" rid="fn1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Fanpei G.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1,</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shetty</surname><given-names>Charvi</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bukshpun</surname><given-names>Polina</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vora</surname><given-names>Shivani</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wakahiro</surname><given-names>Mari</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hinkley</surname><given-names>Leighton B.N.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nagarajan</surname><given-names>Srikantan S.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1,</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sherr</surname><given-names>Elliott H.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Mukherjee</surname><given-names>Pratik</given-names></name><xref ref-type="aff" rid="aff1"><sup>1,</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><aff id="aff1"><label><sup>1</sup></label>Department of Radiology and Biomedical Imaging,<institution>University of California</institution>, San Francisco, California.</aff><aff id="aff2"><label><sup>2</sup></label>Department of Foreign Languages and Literatures,<institution>National Tsinghua University</institution>, Hsinchu,<country>Taiwan</country>.</aff><aff id="aff3"><label><sup>3</sup></label>Department of Neurology,<institution>University of California</institution>, San Francisco, California.</aff><aff id="aff4"><label><sup>4</sup></label>Graduate Program in Bioengineering,<institution>University of California</institution>, San Francisco, California.</aff></contrib-group><author-notes><corresp><addr-line>Address correspondence to:</addr-line><addr-line><italic>Pratik Mukherjee</italic></addr-line><addr-line><italic>Department of Radiology & Biomedical Imaging</italic></addr-line><institution><italic>University of California</italic></institution><addr-line><italic>185 Berry Street, Box 0946</italic></addr-line><addr-line><italic>San Francisco, CA 94107-0946</italic></addr-line><italic>E-mail:</italic><email xlink:href="mailto:pratik.mukherjee@ucsf.edu">pratik.mukherjee@ucsf.edu</email></corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>12</month><year>2013</year></pub-date><volume>3</volume><issue>6</issue><fpage>547</fpage><lpage>562</lpage><permissions><copyright-statement>Copyright 2013, Mary Ann Liebert, Inc.</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="brain.2013.0175.pdf"></self-uri><abstract><title>Abstract</title><p>The corpus callosum is the largest white matter fiber bundle connecting the two cerebral hemispheres. In this work, we investigate the effect of callosal dysgenesis on functional magnetic resonance imaging (fMRI) resting-state networks and the functional connectome. Since alternate commissural routes between the cerebral hemispheres exist, we hypothesize that bilateral cortical networks can still be maintained in partial or even complete agenesis of the corpus callosum (AgCC). However, since these commissural routes are frequently indirect, requiring polysynaptic pathways, we hypothesize that quantitative measurements of interhemispheric functional connectivity in bilateral networks will be reduced in AgCC compared with matched controls, especially in the most highly interconnected cortical regions that are the hubs of the connectome. Seventeen resting-state networks were extracted from fMRI of 11 subjects with partial or complete AgCC and 11 matched controls. The results show that the qualitative organization of resting-state networks is very similar between controls and AgCC. However, interhemispheric functional connectivity of precuneus, posterior cingulate cortex, and insular-opercular regions was significantly reduced in AgCC. The preserved network organization was confirmed with a connectomic analysis of the resting-state fMRI data, showing five functional modules that are largely consistent across the control and AgCC groups. Hence, the reduction or even complete absence of callosal connectivity does not affect the qualitative organization of bilateral resting-state networks or the modular organization of the functional connectome, although quantitatively reduced functional connectivity can be demonstrated by measurements within bilateral cortical hubs, supporting the hypothesis that indirect polysynaptic pathways are utilized to preserve interhemispheric temporal synchrony.</p></abstract><kwd-group kwd-group-type="author"><title><bold>Key words:</bold> </title><kwd>brain development</kwd><kwd>connectivity</kwd><kwd>connectome</kwd><kwd>corpus callosum</kwd><kwd>fMRI</kwd><kwd>graph theory</kwd><kwd>malformations</kwd><kwd>white matter</kwd></kwd-group><counts><fig-count count="9"></fig-count><table-count count="3"></table-count><ref-count count="59"></ref-count><page-count count="16"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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