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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Optical stimulation enables paced electrophysiological studies in embryonic hearts</title><author><name sortKey="Wang, Yves T" sort="Wang, Yves T" uniqKey="Wang Y" first="Yves T." last="Wang">Yves T. Wang</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Pediatrics, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gu, Shi" sort="Gu, Shi" uniqKey="Gu S" first="Shi" last="Gu">Shi Gu</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Ma, Pei" sort="Ma, Pei" uniqKey="Ma P" first="Pei" last="Ma">Pei Ma</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Watanabe, Michiko" sort="Watanabe, Michiko" uniqKey="Watanabe M" first="Michiko" last="Watanabe">Michiko Watanabe</name><affiliation><nlm:aff id="aff2">Department of Pediatrics, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Rollins, Andrew M" sort="Rollins, Andrew M" uniqKey="Rollins A" first="Andrew M." last="Rollins">Andrew M. Rollins</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Jenkins, Michael W" sort="Jenkins, Michael W" uniqKey="Jenkins M" first="Michael W." last="Jenkins">Michael W. Jenkins</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Pediatrics, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24761284</idno><idno type="pmc">3985989</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985989</idno><idno type="RBID">PMC:3985989</idno><idno type="doi">10.1364/BOE.5.001000</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000262</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000262</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Optical stimulation enables paced electrophysiological studies in embryonic hearts</title><author><name sortKey="Wang, Yves T" sort="Wang, Yves T" uniqKey="Wang Y" first="Yves T." last="Wang">Yves T. Wang</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Pediatrics, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Gu, Shi" sort="Gu, Shi" uniqKey="Gu S" first="Shi" last="Gu">Shi Gu</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Ma, Pei" sort="Ma, Pei" uniqKey="Ma P" first="Pei" last="Ma">Pei Ma</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Watanabe, Michiko" sort="Watanabe, Michiko" uniqKey="Watanabe M" first="Michiko" last="Watanabe">Michiko Watanabe</name><affiliation><nlm:aff id="aff2">Department of Pediatrics, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Rollins, Andrew M" sort="Rollins, Andrew M" uniqKey="Rollins A" first="Andrew M." last="Rollins">Andrew M. Rollins</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Jenkins, Michael W" sort="Jenkins, Michael W" uniqKey="Jenkins M" first="Michael W." last="Jenkins">Michael W. Jenkins</name><affiliation><nlm:aff id="aff1">Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Pediatrics, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></nlm:aff></affiliation></author></analytic><series><title level="j">Biomedical Optics Express</title><idno type="eISSN">2156-7085</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cardiac electrophysiology plays a critical role in the development and function of the heart. Studies of early embryonic electrical activity have lacked a viable point stimulation technique to pace <italic>in vitro</italic> samples. Here, optical pacing by high-precision infrared stimulation is used to pace excised embryonic hearts, allowing electrophysiological parameters to be quantified during pacing at varying rates with optical mapping. Combined optical pacing and optical mapping enables electrophysiological studies in embryos under more physiological conditions and at varying heart rates, allowing detection of abnormal conduction and comparisons between normal and pathological electrical activity during development in various models.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Opt Express</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Opt Express</journal-id><journal-id journal-id-type="publisher-id">BOE</journal-id><journal-title-group><journal-title>Biomedical Optics Express</journal-title></journal-title-group><issn pub-type="epub">2156-7085</issn><publisher><publisher-name>Optical Society of America</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24761284</article-id><article-id pub-id-type="pmc">3985989</article-id><article-id pub-id-type="publisher-id">203122</article-id><article-id pub-id-type="doi">10.1364/BOE.5.001000</article-id><article-categories><subj-group subj-group-type="heading"><subject>Optogenetics and Optical Stimulation</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research-Article</subject></subj-group></article-categories><title-group><article-title>Optical stimulation enables paced electrophysiological studies in embryonic hearts</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yves T.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gu</surname><given-names>Shi</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Pei</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Watanabe</surname><given-names>Michiko</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rollins</surname><given-names>Andrew M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jenkins</surname><given-names>Michael W.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><aff id="aff1"><label>1</label>Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></aff><aff id="aff2"><label>2</label>Department of Pediatrics, Case Western Reserve University, Cleveland, OH, 44120,<country>USA</country></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label><email xlink:href="mwj5@case.edu">mwj5@case.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>28</day><month>2</month><year>2014</year></pub-date><pub-date pub-type="collection"><day>01</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>28</day><month>2</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>5</volume><issue>4</issue><fpage>1000</fpage><lpage>1013</lpage><history><date date-type="received"><day>17</day><month>12</month><year>2013</year></date><date date-type="rev-recd"><day>13</day><month>2</month><year>2014</year></date><date date-type="accepted"><day>21</day><month>2</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 Optical Society of America</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Optical Society of America</copyright-holder></permissions><abstract><p>Cardiac electrophysiology plays a critical role in the development and function of the heart. Studies of early embryonic electrical activity have lacked a viable point stimulation technique to pace <italic>in vitro</italic> samples. Here, optical pacing by high-precision infrared stimulation is used to pace excised embryonic hearts, allowing electrophysiological parameters to be quantified during pacing at varying rates with optical mapping. Combined optical pacing and optical mapping enables electrophysiological studies in embryos under more physiological conditions and at varying heart rates, allowing detection of abnormal conduction and comparisons between normal and pathological electrical activity during development in various models.</p></abstract><kwd-group kwd-group-type="OCIS"><title>OCIS codes: </title><kwd>(140.3460) Lasers</kwd><kwd>(140.6810) Thermal effects</kwd><kwd>(170.2520) Fluorescence microscopy</kwd><kwd>(120.3890) Medical optics instrumentation</kwd></kwd-group><funding-group><award-group><funding-source id="sp1">Coulter-Case Translational Research Partnership</funding-source></award-group></funding-group><funding-group><award-group><funding-source id="sp2">National Heart, Lung, and Blood Institute of the National Institutes of Health</funding-source><award-id rid="sp2">R21-HL115373</award-id><award-id rid="sp2">R01-HL083048</award-id><award-id rid="sp2">R01-HL095717</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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