Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A lanthanide complex with dual biosensing properties: CEST and BIRDS with EuDOTA-(gly)<sub>4</sub><sup>−</sup></title><author><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</nlm:aff></affiliation></author><author><name sortKey="Kiefer, Garry E" sort="Kiefer, Garry E" uniqKey="Kiefer G" first="Garry E." last="Kiefer">Garry E. Kiefer</name><affiliation><nlm:aff id="A5">Macrocyclics, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Rothman, Douglas L" sort="Rothman, Douglas L" uniqKey="Rothman D" first="Douglas L." last="Rothman">Douglas L. Rothman</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Yale University, New Haven, CT, USA</nlm:aff></affiliation></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name><affiliation><nlm:aff id="A6">Advanced Imaging Research Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Chemistry, University of Texas, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Yale University, New Haven, CT, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22020775</idno><idno type="pmc">3267016</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267016</idno><idno type="RBID">PMC:3267016</idno><idno type="doi">10.1002/nbm.1677</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000250</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000250</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A lanthanide complex with dual biosensing properties: CEST and BIRDS with EuDOTA-(gly)<sub>4</sub><sup>−</sup></title><author><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</nlm:aff></affiliation></author><author><name sortKey="Kiefer, Garry E" sort="Kiefer, Garry E" uniqKey="Kiefer G" first="Garry E." last="Kiefer">Garry E. Kiefer</name><affiliation><nlm:aff id="A5">Macrocyclics, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Rothman, Douglas L" sort="Rothman, Douglas L" uniqKey="Rothman D" first="Douglas L." last="Rothman">Douglas L. Rothman</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Yale University, New Haven, CT, USA</nlm:aff></affiliation></author><author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A. Dean" last="Sherry">A. Dean Sherry</name><affiliation><nlm:aff id="A6">Advanced Imaging Research Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Department of Chemistry, University of Texas, Dallas, TX, USA</nlm:aff></affiliation></author><author><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Department of Biomedical Engineering, Yale University, New Haven, CT, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Nmr in Biomedicine</title><idno type="ISSN">0952-3480</idno><idno type="eISSN">1099-1492</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Responsive contrast agents (RCAs) [R1.12] composed of lanthanide III ion (Ln<sup>3+</sup>) complexes with a variety of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA<sup>4−</sup>) derivatives have shown great potential as molecular imaging agents for magnetic resonance (MR). A variety of LnDOTA-tetraamide complexes have been demonstrated as RCAs for molecular imaging with <bold><italic>c</italic></bold>hemical <bold><italic>e</italic></bold>xchange <bold><italic>s</italic></bold>aturation <bold><italic>t</italic></bold>ransfer (CEST). The CEST method detects proton exchange between bulk water and any exchangeable sites on the ligand itself or an inner sphere of bound water that is shifted by a paramagnetic Ln<sup>3+</sup> bound in the core of the macrocycle. It has also been shown that molecular imaging is possible when the RCA itself is observed (i.e., not its affect on bulk water) using a method called <bold><italic>b</italic></bold>iosensor <bold><italic>i</italic></bold>maging of <bold><italic>r</italic></bold>edundant <bold><italic>d</italic></bold>eviation in <bold><italic>s</italic></bold>hifts (BIRDS). The BIRDS method utilizes redundant information stored in the non-exchangeable proton resonances emanating from the paramagnetic RCA for ambient factors like temperature and/or pH. Thus CEST and BIRDS rely on exchangeable and non-exchangeable protons, respectively, for biosensing. We posited that it is feasible to combine these two biosensing features into the same RCA (i.e., dual CEST and BIRDS properties). A complex between europium ion (Eu<sup>3+</sup>) and DOTA-tetra-glycinate (DOTA-(gly)<sub>4</sub><sup>4−</sup>) is used to demonstrate that its CEST characteristics are preserved while BIRDS properties are detected. In vitro temperature sensitivity of EuDOTA-(gly)<sub>4</sub><sup>−</sup> is used to show that qualitative MR contrast with CEST can be calibrated using quantitative MR mapping with BIRDS, thereby enabling quantitative molecular imaging at high spatial resolution.</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8915233</journal-id><journal-id journal-id-type="pubmed-jr-id">1782</journal-id><journal-id journal-id-type="nlm-ta">NMR Biomed</journal-id><journal-title-group><journal-title>Nmr in Biomedicine</journal-title></journal-title-group><issn pub-type="ppub">0952-3480</issn><issn pub-type="epub">1099-1492</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22020775</article-id><article-id pub-id-type="pmc">3267016</article-id><article-id pub-id-type="doi">10.1002/nbm.1677</article-id><article-id pub-id-type="manuscript">NIHMS317247</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A lanthanide complex with dual biosensing properties: CEST and BIRDS with EuDOTA-(gly)<sub>4</sub><sup>−</sup></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Coman</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A1">‖</xref><xref ref-type="aff" rid="A2">§</xref><xref ref-type="aff" rid="A3">*</xref></contrib><contrib contrib-type="author"><name><surname>Kiefer</surname><given-names>Garry E.</given-names></name><xref ref-type="aff" rid="A5">†</xref></contrib><contrib contrib-type="author"><name><surname>Rothman</surname><given-names>Douglas L.</given-names></name><xref ref-type="aff" rid="A1">‖</xref><xref ref-type="aff" rid="A2">§</xref><xref ref-type="aff" rid="A3">*</xref><xref ref-type="aff" rid="A4">‡</xref></contrib><contrib contrib-type="author"><name><surname>Sherry</surname><given-names>A. Dean</given-names></name><xref ref-type="aff" rid="A6">+</xref><xref ref-type="aff" rid="A7">$</xref></contrib><contrib contrib-type="author"><name><surname>Hyder</surname><given-names>Fahmeed</given-names></name><xref ref-type="aff" rid="A1">‖</xref><xref ref-type="aff" rid="A2">§</xref><xref ref-type="aff" rid="A3">*</xref><xref ref-type="aff" rid="A4">‡</xref></contrib></contrib-group><aff id="A1"><label>‖</label>Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</aff><aff id="A2"><label>§</label>Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA</aff><aff id="A3"><label>*</label>Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</aff><aff id="A4"><label>‡</label>Department of Biomedical Engineering, Yale University, New Haven, CT, USA</aff><aff id="A5"><label>†</label>Macrocyclics, Dallas, TX, USA</aff><aff id="A6"><label>+</label>Advanced Imaging Research Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA</aff><aff id="A7"><label>$</label>Department of Chemistry, University of Texas, Dallas, TX, USA</aff><author-notes><corresp id="cor1">Correspondence and reprint requests to: D.S. Fahmeed Hyder / Daniel Coman, N135 TAC (MRRC), 300 Cedar Street, Yale University, New Haven, CT 06520, USA, Tel: +1-203-785-6205, Fax: +1-203-785-6643, <email>fahmeed.hyder@yale.edu</email> / <email>daniel.coman@yale.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>8</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>12</month><year>2012</year></pub-date><volume>24</volume><issue>10</issue><fpage>1216</fpage><lpage>1225</lpage><abstract><p id="P1">Responsive contrast agents (RCAs) [R1.12] composed of lanthanide III ion (Ln<sup>3+</sup>) complexes with a variety of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA<sup>4−</sup>) derivatives have shown great potential as molecular imaging agents for magnetic resonance (MR). A variety of LnDOTA-tetraamide complexes have been demonstrated as RCAs for molecular imaging with <bold><italic>c</italic></bold>hemical <bold><italic>e</italic></bold>xchange <bold><italic>s</italic></bold>aturation <bold><italic>t</italic></bold>ransfer (CEST). The CEST method detects proton exchange between bulk water and any exchangeable sites on the ligand itself or an inner sphere of bound water that is shifted by a paramagnetic Ln<sup>3+</sup> bound in the core of the macrocycle. It has also been shown that molecular imaging is possible when the RCA itself is observed (i.e., not its affect on bulk water) using a method called <bold><italic>b</italic></bold>iosensor <bold><italic>i</italic></bold>maging of <bold><italic>r</italic></bold>edundant <bold><italic>d</italic></bold>eviation in <bold><italic>s</italic></bold>hifts (BIRDS). The BIRDS method utilizes redundant information stored in the non-exchangeable proton resonances emanating from the paramagnetic RCA for ambient factors like temperature and/or pH. Thus CEST and BIRDS rely on exchangeable and non-exchangeable protons, respectively, for biosensing. We posited that it is feasible to combine these two biosensing features into the same RCA (i.e., dual CEST and BIRDS properties). A complex between europium ion (Eu<sup>3+</sup>) and DOTA-tetra-glycinate (DOTA-(gly)<sub>4</sub><sup>4−</sup>) is used to demonstrate that its CEST characteristics are preserved while BIRDS properties are detected. In vitro temperature sensitivity of EuDOTA-(gly)<sub>4</sub><sup>−</sup> is used to show that qualitative MR contrast with CEST can be calibrated using quantitative MR mapping with BIRDS, thereby enabling quantitative molecular imaging at high spatial resolution.</p></abstract><kwd-group><kwd>amide protons</kwd><kwd>DIACEST</kwd><kwd>hydroxyl protons</kwd><kwd>methyl protons</kwd><kwd>PARACEST</kwd><kwd>pH</kwd><kwd>temperature</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Biomedical Imaging and Bioengineering : NIBIB</funding-source><award-id>R01 EB004582-06 || EB</award-id></award-group><award-group><funding-source country="United States">National Institute of Biomedical Imaging and Bioengineering : NIBIB</funding-source><award-id>R01 EB004582-05 || EB</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA115531-06A1 || CA</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG034953-02 || AG</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>P41 RR002584-22S1 || RR</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000250 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000250 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= ThuliumV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.21. |  |