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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Highly Sensitive and Selective Label-Free Optical Detection of Mercuric Ions Using Photon Upconverting Nanoparticles</title>
<author><name sortKey="Kumar, Manoj" sort="Kumar, Manoj" uniqKey="Kumar M" first="Manoj" last="Kumar">Manoj Kumar</name>
</author>
<author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20456935</idno>
<idno type="pmc">2880226</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880226</idno>
<idno type="RBID">PMC:2880226</idno>
<idno type="doi">10.1016/j.bios.2010.03.038</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000234</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000234</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Highly Sensitive and Selective Label-Free Optical Detection of Mercuric Ions Using Photon Upconverting Nanoparticles</title>
<author><name sortKey="Kumar, Manoj" sort="Kumar, Manoj" uniqKey="Kumar M" first="Manoj" last="Kumar">Manoj Kumar</name>
</author>
<author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name>
</author>
</analytic>
<series><title level="j">Biosensors & bioelectronics</title>
<idno type="ISSN">0956-5663</idno>
<idno type="eISSN">1873-4235</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">We demonstrate a fluorescence-based, label-free detection scheme that reports the presence of Hg(II) ion using photon upconverting nanoparticles. A single-stranded DNA containing a number of thymine bases to be used as the Hg<sup>2+</sup>
-capturing element is covalently attached to the photon upconverting NaYF<sub>4</sub>
:Yb<sup>3+</sup>
,Tm<sup>3+</sup>
nanoparticles. Under the illumination of 980 nm laser, energy transfer takes place between the NaYF<sub>4</sub>
:Yb<sup>3+</sup>
,Tm<sup>3+</sup>
nanoparticles as the donor and SYBR green I, a DNA intercalating dye, as the acceptor. By monitoring the ratio of the acceptor emission to the donor emission, we can quantitatively detect the presence of the mercuric ions with a directly observed detection limit of 0.06 nM. The remarkably high signal-to-noise ratio of photon upconverting particles leads to very high sensitivity and specificity without the need of fluorophore labeling. The sensor also does not suffer from photobleaching.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9001289</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1537</journal-id>
<journal-id journal-id-type="nlm-ta">Biosens Bioelectron</journal-id>
<journal-title>Biosensors & bioelectronics</journal-title>
<issn pub-type="ppub">0956-5663</issn>
<issn pub-type="epub">1873-4235</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20456935</article-id>
<article-id pub-id-type="pmc">2880226</article-id>
<article-id pub-id-type="doi">10.1016/j.bios.2010.03.038</article-id>
<article-id pub-id-type="manuscript">NIHMS194490</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Highly Sensitive and Selective Label-Free Optical Detection of Mercuric Ions Using Photon Upconverting Nanoparticles</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kumar</surname>
<given-names>Manoj</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Peng</given-names>
</name>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<aff id="A1">Laboratory of Nanomaterial Science, Department of Chemistry, New Mexico Tech, Socorro, NM 87801</aff>
</contrib-group>
<author-notes><corresp id="CR1"><label>*</label>
Corresponding author: Peng Zhang, Tel: 575-835-6192. Fax: 575-835-5364. <email>pzhang@nmt.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>22</day>
<month>4</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>7</day>
<month>4</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>7</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>7</month>
<year>2011</year>
</pub-date>
<volume>25</volume>
<issue>11</issue>
<fpage>2431</fpage>
<lpage>2435</lpage>
<permissions><copyright-statement>© 2010 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><p id="P1">We demonstrate a fluorescence-based, label-free detection scheme that reports the presence of Hg(II) ion using photon upconverting nanoparticles. A single-stranded DNA containing a number of thymine bases to be used as the Hg<sup>2+</sup>
-capturing element is covalently attached to the photon upconverting NaYF<sub>4</sub>
:Yb<sup>3+</sup>
,Tm<sup>3+</sup>
nanoparticles. Under the illumination of 980 nm laser, energy transfer takes place between the NaYF<sub>4</sub>
:Yb<sup>3+</sup>
,Tm<sup>3+</sup>
nanoparticles as the donor and SYBR green I, a DNA intercalating dye, as the acceptor. By monitoring the ratio of the acceptor emission to the donor emission, we can quantitatively detect the presence of the mercuric ions with a directly observed detection limit of 0.06 nM. The remarkably high signal-to-noise ratio of photon upconverting particles leads to very high sensitivity and specificity without the need of fluorophore labeling. The sensor also does not suffer from photobleaching.</p>
</abstract>
<kwd-group><kwd>Photon upconversion</kwd>
<kwd>label-free detection</kwd>
<kwd>mercury ion</kwd>
<kwd>oligonucleotide</kwd>
<kwd>energy transfer</kwd>
</kwd-group>
<contract-num rid="RR1">P20 RR016480-09
||RR</contract-num>
<contract-sponsor id="RR1">National Center for Research Resources : NCRR</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>
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