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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): Comparison between TmDOTP<sup>5−</sup> and TmDOTMA<sup>−</sup></title><author><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><affiliation><nlm:aff id="A1"> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Trubel, Hubert K" sort="Trubel, Hubert K" uniqKey="Trubel H" first="Hubert K." last="Trubel">Hubert K. Trubel</name><affiliation><nlm:aff id="A1"> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Department of Pediatrics at HELIOS-Klinikum Wuppertal and University of Witten/Herdecke, Germany</nlm:aff></affiliation></author><author><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><affiliation><nlm:aff id="A1"> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19957287</idno><idno type="pmc">2843767</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843767</idno><idno type="RBID">PMC:2843767</idno><idno type="doi">10.1002/nbm.1461</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000233</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000233</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): Comparison between TmDOTP<sup>5−</sup> and TmDOTMA<sup>−</sup></title><author><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><affiliation><nlm:aff id="A1"> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Trubel, Hubert K" sort="Trubel, Hubert K" uniqKey="Trubel H" first="Hubert K." last="Trubel">Hubert K. Trubel</name><affiliation><nlm:aff id="A1"> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5"> Department of Pediatrics at HELIOS-Klinikum Wuppertal and University of Witten/Herdecke, Germany</nlm:aff></affiliation></author><author><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><affiliation><nlm:aff id="A1"> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation></author></analytic><series><title level="j">NMR in biomedicine</title><idno type="ISSN">0952-3480</idno><idno type="eISSN">1099-1492</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Chemical shifts of complexes between paramagnetic lanthanide ions and macrocyclic chelates are sensitive to physiological variations (of temperature and/or pH). Here we demonstrate utility of a complex between thulium ion (Tm<sup>3+</sup>) and the macrocyclic chelate 1,4,7,10-tetramethyl 1,4,7,10-tetraazacyclodoecane-1,4,7,10-tetraacetate (or DOTMA<sup>4−</sup>) for absolute temperature mapping in rat brain. Feasibility of TmDOTMA<sup>−</sup> is compared with that of another Tm<sup>3+</sup>-containing biosensor which is based on the macrocyclic chelate 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) (or DOTP<sup>8−</sup>). In general, the in vitro and in vivo results suggest that Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) which originate from these agents (but exclude water) can provide temperature maps with good accuracy. While TmDOTP<sup>5−</sup> emanates three major distinct proton resonances which are differentially sensitive to temperature and pH, TmDOTMA<sup>−</sup> has a dominant pH-insensitive proton resonance from a −CH<sub>3</sub> group to allow higher signal-to-noise ratio (SNR) temperature assessment. Temperature (and pH) sensitivities of these resonances are practically identical at low (4.0T) and high (11.7T) magnetic fields and at nominal repetition times only marginal SNR loss is expected at the lower field. Since these resonances have extremely short relaxation times, high-speed chemical shift imaging (CSI) is needed to detect them. Repeated in vivo CSI scans with BIRDS demonstrate excellent measurement stability. Overall, results with TmDOTP<sup>5−</sup> and TmDOTMA<sup>−</sup> suggest that BIRDS can be reliably applied, either at low or high magnetic fields, for functional studies in rodents.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8915233</journal-id><journal-id journal-id-type="pubmed-jr-id">1782</journal-id><journal-id journal-id-type="nlm-ta">NMR Biomed</journal-id><journal-title>NMR in biomedicine</journal-title><issn pub-type="ppub">0952-3480</issn><issn pub-type="epub">1099-1492</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19957287</article-id><article-id pub-id-type="pmc">2843767</article-id><article-id pub-id-type="doi">10.1002/nbm.1461</article-id><article-id pub-id-type="manuscript">NIHMS158410</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): Comparison between TmDOTP<sup>5−</sup> and TmDOTMA<sup>−</sup></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Coman</surname><given-names>Daniel</given-names></name><xref rid="A1" ref-type="aff">||</xref><xref rid="A2" ref-type="aff">§</xref><xref rid="A3" ref-type="aff">*</xref></contrib><contrib contrib-type="author"><name><surname>Trubel</surname><given-names>Hubert K.</given-names></name><xref rid="A1" ref-type="aff">||</xref><xref rid="A3" ref-type="aff">*</xref><xref rid="A5" ref-type="aff">†</xref><xref rid="FN2" ref-type="author-notes">+</xref></contrib><contrib contrib-type="author"><name><surname>Hyder</surname><given-names>Fahmeed</given-names></name><xref rid="A1" ref-type="aff">||</xref><xref rid="A2" ref-type="aff">§</xref><xref rid="A3" ref-type="aff">*</xref><xref rid="A4" ref-type="aff">‡</xref></contrib></contrib-group><aff id="A1"><label>||</label> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</aff><aff id="A2"><label>§</label> Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</aff><aff id="A3"><label>*</label> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</aff><aff id="A4"><label>‡</label> Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA</aff><aff id="A5"><label>†</label> Department of Pediatrics at HELIOS-Klinikum Wuppertal and University of Witten/Herdecke, Germany</aff><author-notes><corresp id="FN1">Address correspondence and reprint requests to: Fahmeed Hyder/Daniel Coman, N135 TAC (MRRC), 300 Cedar Street, Yale University, New Haven, CT 06510, USA, Tel: +1-203-785-6205, Fax: +1-203-785-6643, <email>fahmeed.hyder@yale.edu</email>/ <email>daniel.coman@yale.edu</email></corresp><fn id="FN2" fn-type="current-aff"><label>+</label><p>currently at Bayer HealthCare AG, Wuppertal, Germany</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>11</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>10</month><year>2010</year></pub-date><volume>23</volume><issue>3</issue><fpage>277</fpage><lpage>285</lpage><abstract><p id="P1">Chemical shifts of complexes between paramagnetic lanthanide ions and macrocyclic chelates are sensitive to physiological variations (of temperature and/or pH). Here we demonstrate utility of a complex between thulium ion (Tm<sup>3+</sup>) and the macrocyclic chelate 1,4,7,10-tetramethyl 1,4,7,10-tetraazacyclodoecane-1,4,7,10-tetraacetate (or DOTMA<sup>4−</sup>) for absolute temperature mapping in rat brain. Feasibility of TmDOTMA<sup>−</sup> is compared with that of another Tm<sup>3+</sup>-containing biosensor which is based on the macrocyclic chelate 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) (or DOTP<sup>8−</sup>). In general, the in vitro and in vivo results suggest that Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) which originate from these agents (but exclude water) can provide temperature maps with good accuracy. While TmDOTP<sup>5−</sup> emanates three major distinct proton resonances which are differentially sensitive to temperature and pH, TmDOTMA<sup>−</sup> has a dominant pH-insensitive proton resonance from a −CH<sub>3</sub> group to allow higher signal-to-noise ratio (SNR) temperature assessment. Temperature (and pH) sensitivities of these resonances are practically identical at low (4.0T) and high (11.7T) magnetic fields and at nominal repetition times only marginal SNR loss is expected at the lower field. Since these resonances have extremely short relaxation times, high-speed chemical shift imaging (CSI) is needed to detect them. Repeated in vivo CSI scans with BIRDS demonstrate excellent measurement stability. Overall, results with TmDOTP<sup>5−</sup> and TmDOTMA<sup>−</sup> suggest that BIRDS can be reliably applied, either at low or high magnetic fields, for functional studies in rodents.</p></abstract><kwd-group><kwd>CEST</kwd><kwd>distribution</kwd><kwd>pH</kwd><kwd>paramagnetic</kwd><kwd>temperature</kwd><kwd>thulium</kwd></kwd-group><contract-num rid="MH1">R01 MH067528-05
||MH</contract-num><contract-num rid="NS1">P30 NS052519-03
||NS</contract-num><contract-sponsor id="MH1">National Institute of Mental Health : NIMH</contract-sponsor><contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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