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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Mineral-Rich Extract from the Red Marine Algae <italic>Lithothamnion calcareum</italic> Preserves Bone Structure and Function in Female Mice on a Western-Style Diet</title><author><name sortKey="Aslam, Muhammad Nadeem" sort="Aslam, Muhammad Nadeem" uniqKey="Aslam M" first="Muhammad Nadeem" last="Aslam">Muhammad Nadeem Aslam</name></author><author><name sortKey="Kreider, Jaclynn M" sort="Kreider, Jaclynn M" uniqKey="Kreider J" first="Jaclynn M." last="Kreider">Jaclynn M. Kreider</name></author><author><name sortKey="Paruchuri, Tejaswi" sort="Paruchuri, Tejaswi" uniqKey="Paruchuri T" first="Tejaswi" last="Paruchuri">Tejaswi Paruchuri</name></author><author><name sortKey="Bhagavathula, Narasimharao" sort="Bhagavathula, Narasimharao" uniqKey="Bhagavathula N" first="Narasimharao" last="Bhagavathula">Narasimharao Bhagavathula</name></author><author><name sortKey="Dasilva, Marissa" sort="Dasilva, Marissa" uniqKey="Dasilva M" first="Marissa" last="Dasilva">Marissa Dasilva</name></author><author><name sortKey="Zernicke, Ronald F" sort="Zernicke, Ronald F" uniqKey="Zernicke R" first="Ronald F." last="Zernicke">Ronald F. Zernicke</name></author><author><name sortKey="Goldstein, Steven A" sort="Goldstein, Steven A" uniqKey="Goldstein S" first="Steven A." last="Goldstein">Steven A. Goldstein</name></author><author><name sortKey="Varani, James" sort="Varani, James" uniqKey="Varani J" first="James" last="Varani">James Varani</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20180099</idno><idno type="pmc">2877502</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877502</idno><idno type="RBID">PMC:2877502</idno><idno type="doi">10.1007/s00223-010-9340-9</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000226</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000226</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Mineral-Rich Extract from the Red Marine Algae <italic>Lithothamnion calcareum</italic> Preserves Bone Structure and Function in Female Mice on a Western-Style Diet</title><author><name sortKey="Aslam, Muhammad Nadeem" sort="Aslam, Muhammad Nadeem" uniqKey="Aslam M" first="Muhammad Nadeem" last="Aslam">Muhammad Nadeem Aslam</name></author><author><name sortKey="Kreider, Jaclynn M" sort="Kreider, Jaclynn M" uniqKey="Kreider J" first="Jaclynn M." last="Kreider">Jaclynn M. Kreider</name></author><author><name sortKey="Paruchuri, Tejaswi" sort="Paruchuri, Tejaswi" uniqKey="Paruchuri T" first="Tejaswi" last="Paruchuri">Tejaswi Paruchuri</name></author><author><name sortKey="Bhagavathula, Narasimharao" sort="Bhagavathula, Narasimharao" uniqKey="Bhagavathula N" first="Narasimharao" last="Bhagavathula">Narasimharao Bhagavathula</name></author><author><name sortKey="Dasilva, Marissa" sort="Dasilva, Marissa" uniqKey="Dasilva M" first="Marissa" last="Dasilva">Marissa Dasilva</name></author><author><name sortKey="Zernicke, Ronald F" sort="Zernicke, Ronald F" uniqKey="Zernicke R" first="Ronald F." last="Zernicke">Ronald F. Zernicke</name></author><author><name sortKey="Goldstein, Steven A" sort="Goldstein, Steven A" uniqKey="Goldstein S" first="Steven A." last="Goldstein">Steven A. Goldstein</name></author><author><name sortKey="Varani, James" sort="Varani, James" uniqKey="Varani J" first="James" last="Varani">James Varani</name></author></analytic><series><title level="j">Calcified tissue international</title><idno type="ISSN">0171-967X</idno><idno type="eISSN">1432-0827</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The purpose of this study was to determine whether a mineral-rich extract derived from the red marine algae <italic>Lithothamnion calcareum</italic> could be used as a dietary supplement for prevention of bone mineral loss. Sixty C57BL/6 mice were divided into three groups based on diet: the first group received a high-fat Western-style diet (HFWD), the second group was fed the same HFWD along with the mineral-rich extract included as a dietary supplement, and the third group was used as a control and was fed a low-fat rodent chow diet (AIN76A). Mice were maintained on the respective diets for 15 months. Then, long bones (femora and tibiae) from both males and females were analyzed by three-dimensional micro-computed tomography (micro-CT) and (bones from female mice) concomitantly assessed in bone strength studies. Tartrate-resistant acid phosphatase (TRAP), osteocalcin, and N-terminal peptide of type I procollagen (PINP) were assessed in plasma samples obtained from female mice at the time of sacrifice. To summarize, female mice on the HFWD had reduced bone mineralization and reduced bone strength relative to female mice on the low-fat chow diet. The bone defects in female mice on the HFWD were overcome in the presence of the mineral-rich supplement. In fact, female mice receiving the mineral-rich supplement in the HFWD had better bone structure/function than did female mice on the low-fat chow diet. Female mice on the mineral-supplemented HFWD had higher plasma levels of TRAP than mice of the other groups. There were no differences in the other two markers. Male mice showed little diet-specific differences by micro-CT.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7905481</journal-id><journal-id journal-id-type="pubmed-jr-id">2713</journal-id><journal-id journal-id-type="nlm-ta">Calcif Tissue Int</journal-id><journal-title>Calcified tissue international</journal-title><issn pub-type="ppub">0171-967X</issn><issn pub-type="epub">1432-0827</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20180099</article-id><article-id pub-id-type="pmc">2877502</article-id><article-id pub-id-type="doi">10.1007/s00223-010-9340-9</article-id><article-id pub-id-type="manuscript">NIHMS197727</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A Mineral-Rich Extract from the Red Marine Algae <italic>Lithothamnion calcareum</italic> Preserves Bone Structure and Function in Female Mice on a Western-Style Diet</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Aslam</surname><given-names>Muhammad Nadeem</given-names></name><aff id="A1">Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, SPC 5602, Ann Arbor, MI 48109, USA</aff></contrib><contrib contrib-type="author"><name><surname>Kreider</surname><given-names>Jaclynn M.</given-names></name><aff id="A2">Department of Orthopedic Surgery, The University of Michigan, Ann Arbor, MI 48109, USA</aff></contrib><contrib contrib-type="author"><name><surname>Paruchuri</surname><given-names>Tejaswi</given-names></name><aff id="A3">Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, SPC 5602, Ann Arbor, MI 48109, USA</aff></contrib><contrib contrib-type="author"><name><surname>Bhagavathula</surname><given-names>Narasimharao</given-names></name><aff id="A4">Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, SPC 5602, Ann Arbor, MI 48109, USA</aff></contrib><contrib contrib-type="author"><name><surname>DaSilva</surname><given-names>Marissa</given-names></name><aff id="A5">Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, SPC 5602, Ann Arbor, MI 48109, USA</aff></contrib><contrib contrib-type="author"><name><surname>Zernicke</surname><given-names>Ronald F.</given-names></name><aff id="A6">Department of Orthopedic Surgery, The University of Michigan, Ann Arbor, MI 48109, USA</aff></contrib><contrib contrib-type="author"><name><surname>Goldstein</surname><given-names>Steven A.</given-names></name><aff id="A7">Department of Orthopedic Surgery, The University of Michigan, Ann Arbor, MI 48109, USA</aff></contrib><contrib contrib-type="author"><name><surname>Varani</surname><given-names>James</given-names></name><aff id="A8">Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, SPC 5602, Ann Arbor, MI 48109, USA</aff></contrib></contrib-group><author-notes><corresp id="CR1"><email>varani@umich.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>26</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>24</day><month>2</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2011</year></pub-date><volume>86</volume><issue>4</issue><fpage>313</fpage><lpage>324</lpage><permissions><copyright-statement>© Springer Science+Business Media, LLC 2010</copyright-statement><copyright-year>2010</copyright-year></permissions><abstract><p id="P1">The purpose of this study was to determine whether a mineral-rich extract derived from the red marine algae <italic>Lithothamnion calcareum</italic> could be used as a dietary supplement for prevention of bone mineral loss. Sixty C57BL/6 mice were divided into three groups based on diet: the first group received a high-fat Western-style diet (HFWD), the second group was fed the same HFWD along with the mineral-rich extract included as a dietary supplement, and the third group was used as a control and was fed a low-fat rodent chow diet (AIN76A). Mice were maintained on the respective diets for 15 months. Then, long bones (femora and tibiae) from both males and females were analyzed by three-dimensional micro-computed tomography (micro-CT) and (bones from female mice) concomitantly assessed in bone strength studies. Tartrate-resistant acid phosphatase (TRAP), osteocalcin, and N-terminal peptide of type I procollagen (PINP) were assessed in plasma samples obtained from female mice at the time of sacrifice. To summarize, female mice on the HFWD had reduced bone mineralization and reduced bone strength relative to female mice on the low-fat chow diet. The bone defects in female mice on the HFWD were overcome in the presence of the mineral-rich supplement. In fact, female mice receiving the mineral-rich supplement in the HFWD had better bone structure/function than did female mice on the low-fat chow diet. Female mice on the mineral-supplemented HFWD had higher plasma levels of TRAP than mice of the other groups. There were no differences in the other two markers. Male mice showed little diet-specific differences by micro-CT.</p></abstract><kwd-group><kwd>Bone mineralization</kwd><kwd>Bone strength</kwd><kwd>Mineral-rich red algae extract</kwd><kwd>Aquamin</kwd><kwd>High-fat Western-style diet</kwd><kwd>Osteoporosis</kwd></kwd-group><contract-num rid="CA1">R21 CA140760-01
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