Best of the 2007 AUA Annual Meeting
Identifieur interne : 000202 ( Pmc/Corpus ); précédent : 000201; suivant : 000203Best of the 2007 AUA Annual Meeting
Auteurs : Michael K. BrawerSource :
- Reviews in Urology [ 1523-6161 ] ; 2007.
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PubMed: 17934570
PubMed Central: 2002503
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</author>
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<series><title level="j">Reviews in Urology</title>
<idno type="ISSN">1523-6161</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
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<pmc article-type="meeting-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Rev Urol</journal-id>
<journal-id journal-id-type="publisher-id">RIU</journal-id>
<journal-title>Reviews in Urology</journal-title>
<issn pub-type="ppub">1523-6161</issn>
<publisher><publisher-name>MedReviews, LLC</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">17934570</article-id>
<article-id pub-id-type="pmc">2002503</article-id>
<article-id pub-id-type="other">1523-6161-9-3-133</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Meeting Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Best of the 2007 AUA Annual Meeting</article-title>
<subtitle>Highlights from the 2007 Annual Meeting of the American Urological Association, May 19–24, 2007, Anaheim, CA</subtitle>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Brawer</surname>
<given-names>Michael K</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<aff><institution>Threshold Pharmaceuticals</institution>
</aff>
</contrib-group>
<contrib-group><contrib contrib-type="author"><name><surname>Makarov</surname>
<given-names>Danil V</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<contrib contrib-type="author"><name><surname>Partin</surname>
<given-names>Alan W</given-names>
</name>
<degrees>MD, PhD</degrees>
</contrib>
<aff><institution>The Johns Hopkins Medical Institutions and Hospital</institution>
</aff>
</contrib-group>
<contrib-group><contrib contrib-type="author"><name><surname>Roehrborn</surname>
<given-names>Claus G</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<aff><institution>University of Texas Southwestern Medical Center</institution>
</aff>
</contrib-group>
<contrib-group><contrib contrib-type="author"><name><surname>Curtis Nickel</surname>
<given-names>J</given-names>
</name>
<degrees>MD, FRCSC</degrees>
</contrib>
<aff><institution>Queen’s University</institution>
</aff>
</contrib-group>
<contrib-group><contrib contrib-type="author"><name><surname>Chancellor</surname>
<given-names>Michael B</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<aff><institution>University of Pittsburgh School of Medicine</institution>
</aff>
</contrib-group>
<contrib-group><contrib contrib-type="author"><name><surname>Assimos</surname>
<given-names>Dean G</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<aff><institution>Wake Forest University School of Medicine</institution>
</aff>
</contrib-group>
<contrib-group><contrib contrib-type="author"><name><surname>Shapiro</surname>
<given-names>Ellen</given-names>
</name>
<degrees>MD, FACS, FAAP</degrees>
</contrib>
<aff><institution>New York University School of Medicine</institution>
</aff>
</contrib-group>
<contrib-group><contrib contrib-type="author"><name><surname>Rajfer</surname>
<given-names>Jacob</given-names>
</name>
<degrees>MD</degrees>
</contrib>
<aff><institution>University of California at Los Angeles</institution>
</aff>
</contrib-group>
<pub-date pub-type="ppub"><season>Summer</season>
<year>2007</year>
</pub-date>
<volume>9</volume>
<issue>3</issue>
<fpage>133</fpage>
<lpage>154</lpage>
<permissions><copyright-statement>© 2007 MedReviews, LLC</copyright-statement>
<copyright-year>2007</copyright-year>
<copyright-holder>MedReviews, LLC</copyright-holder>
</permissions>
<kwd-group><title>Key words</title>
<kwd>Prostate cancer</kwd>
<kwd>Prostate-specific antigen</kwd>
<kwd>Obesity</kwd>
<kwd>PSA velocity</kwd>
<kwd>Repeat biopsy</kwd>
<kwd>Human glandular kallikrein</kwd>
<kwd>Expectant management</kwd>
<kwd>Biomarkers</kwd>
<kwd>PCA3</kwd>
<kwd>EPCA-2</kwd>
<kwd>CRISP-3</kwd>
<kwd>MSP</kwd>
<kwd>Testosterone</kwd>
<kwd>Microvessel density</kwd>
<kwd>Endoglin</kwd>
<kwd>Survivin</kwd>
<kwd>Telomeres</kwd>
<kwd>Male voiding dysfunction</kwd>
<kwd>Lower urinary tract symptoms</kwd>
<kwd>Interleukin-8</kwd>
<kwd>Botulinum toxin</kwd>
<kwd>PDE-5 inhibitors</kwd>
<kwd>Antimuscarinic agents</kwd>
<kwd>Benign prostatic hyperplasia</kwd>
<kwd>Acute urinary retention</kwd>
<kwd>5Alpha-reductase inhibitors</kwd>
<kwd>Nocturia</kwd>
<kwd>Doxazosin</kwd>
<kwd>Finasteride</kwd>
<kwd>LHRH antagonists</kwd>
<kwd>Laser ablation</kwd>
<kwd>Transurethral microwave thermotherapy</kwd>
<kwd>TURP</kwd>
<kwd>Perioperative blood loss</kwd>
<kwd>Urinary tract infections</kwd>
<kwd>Microbial biofilms</kwd>
<kwd>Circumcision</kwd>
<kwd>HIV</kwd>
<kwd>Antibiotic prophylaxis</kwd>
<kwd>Stress urinary incontinence</kwd>
<kwd>Stem cell injection</kwd>
<kwd>Endourology</kwd>
<kwd>Urolithiasis</kwd>
<kwd>Ureteral stents</kwd>
<kwd>Medical expulsive therapy</kwd>
<kwd>Shock wave lithotripsy</kwd>
<kwd>Hyperoxaluria</kwd>
<kwd>Pregnancy</kwd>
<kwd>Erectile dysfunction</kwd>
<kwd>Prostatectomy</kwd>
<kwd>Peyronie’s disease</kwd>
<kwd>Ejaculatory dysfunction</kwd>
<kwd>Vesicoureteral reflux</kwd>
<kwd>Laparoscopic orchiopexy</kwd>
<kwd>Bladder exstrophy</kwd>
<kwd>Sexual function</kwd>
<kwd>Infertility</kwd>
</kwd-group>
</article-meta>
</front>
<floats-wrap><fig id="F1" position="float"><label>Figure 1</label>
<caption><p><italic>Predicted decrease in IPSS during placebo run-in. IPSS, International Prostate Symptom Score. Reprinted from Roehrborn et al<xref rid="B38" ref-type="bibr">38</xref>
with permission from the American Urological Association</italic>
.</p>
</caption>
<graphic xlink:href="RIU009003_0133_fig001"></graphic>
</fig>
<fig id="F2" position="float"><label>Figure 2</label>
<caption><p><italic>Dose-dependent improvement in IPSS with ozarelix. IPSS, International Prostate Symptom Score. Data from Debruyne<xref rid="B46" ref-type="bibr">46</xref>
</italic>
.</p>
</caption>
<graphic xlink:href="RIU009003_0133_fig002"></graphic>
</fig>
<fig id="F3" position="float"><label>Figure 3</label>
<caption><p><italic>Relationship between symptomatic improvement and prostate volume change with botulinum toxin treatment. IPSS, International Prostate Symptom Score; Qmax, maximum flow rate; QOL, quality of life. Reprinted from Chuang et al<xref rid="B51" ref-type="bibr">51</xref>
with permission from the American Urological Association</italic>
.</p>
</caption>
<graphic xlink:href="RIU009003_0133_fig003"></graphic>
</fig>
<table-wrap id="T1" position="float"><label>Table 1</label>
<caption><p>Association Between Waist Circumference and Parameters Associated With Voiding and Sexual Health</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="1" colspan="1"></th>
<th colspan="3" rowspan="1">Waist Circumference (inches)<hr></hr>
</th>
<th rowspan="1" colspan="1"></th>
</tr>
<tr><th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1">30–36 (n = 27)</th>
<th rowspan="1" colspan="1">36–40 (n = 36)</th>
<th rowspan="1" colspan="1">> 40 (n = 25)</th>
<th rowspan="1" colspan="1"><italic>P</italic>
Value</th>
</tr>
</thead>
<tbody valign="top"><tr><td rowspan="1" colspan="1">Age, years</td>
<td rowspan="1" colspan="1">61.39</td>
<td rowspan="1" colspan="1">62.36</td>
<td rowspan="1" colspan="1">63.89</td>
<td rowspan="1" colspan="1"><.08</td>
</tr>
<tr><td rowspan="1" colspan="1">PV, cc</td>
<td rowspan="1" colspan="1">28.53</td>
<td rowspan="1" colspan="1">31.67</td>
<td rowspan="1" colspan="1">36.78</td>
<td rowspan="1" colspan="1"><.001</td>
</tr>
<tr><td rowspan="1" colspan="1">PSA, ng/mL</td>
<td rowspan="1" colspan="1">2.32</td>
<td rowspan="1" colspan="1">2.92</td>
<td rowspan="1" colspan="1">3.54</td>
<td rowspan="1" colspan="1"><.003</td>
</tr>
<tr><td rowspan="1" colspan="1">IPSS at Screening</td>
<td rowspan="1" colspan="1">11.57</td>
<td rowspan="1" colspan="1">13.67</td>
<td rowspan="1" colspan="1">15.78</td>
<td rowspan="1" colspan="1"><.001</td>
</tr>
<tr><td rowspan="1" colspan="1">Diabetic, %</td>
<td rowspan="1" colspan="1">11.2</td>
<td rowspan="1" colspan="1">22.3</td>
<td rowspan="1" colspan="1">34.5</td>
<td rowspan="1" colspan="1">.001</td>
</tr>
<tr><td rowspan="1" colspan="1">Hypertension, %</td>
<td rowspan="1" colspan="1">12.6</td>
<td rowspan="1" colspan="1">24.7</td>
<td rowspan="1" colspan="1">37.8</td>
<td rowspan="1" colspan="1">.001</td>
</tr>
<tr><td rowspan="1" colspan="1">Qmax, mL/sec</td>
<td rowspan="1" colspan="1">10.6</td>
<td rowspan="1" colspan="1">9.45</td>
<td rowspan="1" colspan="1">8.65</td>
<td rowspan="1" colspan="1">.03</td>
</tr>
<tr><td rowspan="1" colspan="1">ED, %</td>
<td rowspan="1" colspan="1">34.6</td>
<td rowspan="1" colspan="1">49.5</td>
<td rowspan="1" colspan="1">78.6</td>
<td rowspan="1" colspan="1">.002</td>
</tr>
<tr><td rowspan="1" colspan="1">EjD, %</td>
<td rowspan="1" colspan="1">27.8</td>
<td rowspan="1" colspan="1">47.2</td>
<td rowspan="1" colspan="1">74.5</td>
<td rowspan="1" colspan="1">.002</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>PV, prostate volume; PSA, prostate-specific antigen; IPSS, International Prostate Symptom Score; Qmax, maximum flow rate; ED, erectile dysfunction; EjD, ejaculatory dysfunction. Reprinted from Kaplan et al<xref rid="B32" ref-type="bibr">32</xref>
with permission from the American Urological Association.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T2" position="float"><label>Table 2</label>
<caption><p>Age Specific Mortality Rates and Standardized Mortality Ratios (SMR) After AUR</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="1" colspan="1"></th>
<th colspan="3" rowspan="1">Mortality Rate % (95% CI)<hr></hr>
</th>
<th rowspan="1" colspan="1">SMR (95% CI)<hr></hr>
</th>
</tr>
<tr><th rowspan="1" colspan="1">Age Group</th>
<th rowspan="1" colspan="1">30 Days</th>
<th rowspan="1" colspan="1">90 Days</th>
<th rowspan="1" colspan="1">365 Days</th>
<th rowspan="1" colspan="1">365 Days</th>
</tr>
</thead>
<tbody valign="top"><tr><td rowspan="1" colspan="1">45–54</td>
<td rowspan="1" colspan="1">1.05 (0.82–1.34)</td>
<td rowspan="1" colspan="1">2.23 (1.88–2.64)</td>
<td rowspan="1" colspan="1">4.23 (3.74–4.79)</td>
<td rowspan="1" colspan="1">10.36 (9.14–11.75)</td>
</tr>
<tr><td rowspan="1" colspan="1">55–64</td>
<td rowspan="1" colspan="1">1.06 (0.91–1.24)</td>
<td rowspan="1" colspan="1">2.36 (2.13–2.61)</td>
<td rowspan="1" colspan="1">5.61 (5.25–6.00)</td>
<td rowspan="1" colspan="1">5.28 (4.93–5.65)</td>
</tr>
<tr><td rowspan="1" colspan="1">65–74</td>
<td rowspan="1" colspan="1">1.84 (1.71–1.99)</td>
<td rowspan="1" colspan="1">4.21 (4.01–4.43)</td>
<td rowspan="1" colspan="1">10.16 (9.84–10.49)</td>
<td rowspan="1" colspan="1">3.43 (3.32–3.55)</td>
</tr>
<tr><td rowspan="1" colspan="1">75–84</td>
<td rowspan="1" colspan="1">2.98 (2.82–3.14)</td>
<td rowspan="1" colspan="1">7.39 (7.15–7.64)</td>
<td rowspan="1" colspan="1">18.32 (17.95–18.69)</td>
<td rowspan="1" colspan="1">2.33 (2.28–2.39)</td>
</tr>
<tr><td rowspan="1" colspan="1">85–100</td>
<td rowspan="1" colspan="1">6.01 (5.66–6.38)</td>
<td rowspan="1" colspan="1">14.47 (13.95–15.01)</td>
<td rowspan="1" colspan="1">32.10 (31.38–32.83)</td>
<td rowspan="1" colspan="1">1.64 (1.59–1.68)</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>AUR, acute urinary retention. Reprinted from Armitage et al<xref rid="B36" ref-type="bibr">36</xref>
with permission from the American Urological Association.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T3" position="float"><label>Table 3</label>
<caption><p>Effect of Placebo vs Doxazosin vs Finasteride vs Combination Therapy on Nocturia Episodes at Year 1 and Year 4</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="1" colspan="1"></th>
<th colspan="2" rowspan="1">Placebo<hr></hr>
</th>
<th colspan="2" rowspan="1">Doxazosin<hr></hr>
</th>
<th colspan="2" rowspan="1">Finasteride<hr></hr>
</th>
<th colspan="2" rowspan="1">Combination<hr></hr>
</th>
</tr>
<tr><th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1">Mean</th>
<th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1">Mean</th>
<th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1">Mean</th>
<th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1">Mean</th>
</tr>
<tr><th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1">#</th>
<th rowspan="1" colspan="1">Change</th>
<th rowspan="1" colspan="1">#</th>
<th rowspan="1" colspan="1">Change</th>
<th rowspan="1" colspan="1">#</th>
<th rowspan="1" colspan="1">Change</th>
<th rowspan="1" colspan="1">#</th>
<th rowspan="1" colspan="1">Change</th>
</tr>
</thead>
<tbody valign="top"><tr><td colspan="9" rowspan="1">Participants completing at least 1 year of trial with ≥ 1 episode nocturia at baseline</td>
</tr>
<tr><td rowspan="1" colspan="1">Year 1</td>
<td rowspan="1" colspan="1">628</td>
<td rowspan="1" colspan="1">−0.35</td>
<td rowspan="1" colspan="1">649</td>
<td rowspan="1" colspan="1">−0.54<xref ref-type="table-fn" rid="TF1">*</xref>
<xref ref-type="table-fn" rid="TF2">†</xref>
</td>
<td rowspan="1" colspan="1">653</td>
<td rowspan="1" colspan="1">−0.40</td>
<td rowspan="1" colspan="1">653</td>
<td rowspan="1" colspan="1">−0.58<xref ref-type="table-fn" rid="TF1">*</xref>
<xref ref-type="table-fn" rid="TF2">†</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">Year 4</td>
<td rowspan="1" colspan="1">488</td>
<td rowspan="1" colspan="1">−0.38</td>
<td rowspan="1" colspan="1">533</td>
<td rowspan="1" colspan="1">−0.53<xref ref-type="table-fn" rid="TF1">*</xref>
</td>
<td rowspan="1" colspan="1">516</td>
<td rowspan="1" colspan="1">−0.42</td>
<td rowspan="1" colspan="1">528</td>
<td rowspan="1" colspan="1">−0.55<xref ref-type="table-fn" rid="TF1">*</xref>
</td>
</tr>
<tr><td colspan="9" rowspan="1">Subgroup analyses</td>
</tr>
<tr><td colspan="9" rowspan="1">Participants < 70 years of age<xref ref-type="table-fn" rid="TF3">‡</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">Year 1</td>
<td rowspan="1" colspan="1">501</td>
<td rowspan="1" colspan="1">−0.41</td>
<td rowspan="1" colspan="1">521</td>
<td rowspan="1" colspan="1">−0.56<xref ref-type="table-fn" rid="TF1">*</xref>
<xref ref-type="table-fn" rid="TF2">†</xref>
</td>
<td rowspan="1" colspan="1">527</td>
<td rowspan="1" colspan="1">−0.43</td>
<td rowspan="1" colspan="1">539</td>
<td rowspan="1" colspan="1">−0.61<xref ref-type="table-fn" rid="TF1">*</xref>
<xref ref-type="table-fn" rid="TF2">†</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">Year 4</td>
<td rowspan="1" colspan="1">389</td>
<td rowspan="1" colspan="1">−0.46</td>
<td rowspan="1" colspan="1">428</td>
<td rowspan="1" colspan="1">−0.52</td>
<td rowspan="1" colspan="1">417</td>
<td rowspan="1" colspan="1">−0.45</td>
<td rowspan="1" colspan="1">442</td>
<td rowspan="1" colspan="1">−0.58<xref ref-type="table-fn" rid="TF2">†</xref>
</td>
</tr>
<tr><td colspan="9" rowspan="1">Participants ≥ 70 years of age</td>
</tr>
<tr><td rowspan="1" colspan="1">Year 1</td>
<td rowspan="1" colspan="1">127</td>
<td rowspan="1" colspan="1">−0.11</td>
<td rowspan="1" colspan="1">128</td>
<td rowspan="1" colspan="1">−0.46<xref ref-type="table-fn" rid="TF1">*</xref>
</td>
<td rowspan="1" colspan="1">126</td>
<td rowspan="1" colspan="1">−0.29<xref ref-type="table-fn" rid="TF1">*</xref>
</td>
<td rowspan="1" colspan="1">114</td>
<td rowspan="1" colspan="1">−0.42<xref ref-type="table-fn" rid="TF1">*</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">Year 4</td>
<td rowspan="1" colspan="1">99</td>
<td rowspan="1" colspan="1">−0.08</td>
<td rowspan="1" colspan="1">105</td>
<td rowspan="1" colspan="1">−0.59<xref ref-type="table-fn" rid="TF1">*</xref>
</td>
<td rowspan="1" colspan="1">99</td>
<td rowspan="1" colspan="1">−0.29</td>
<td rowspan="1" colspan="1">89</td>
<td rowspan="1" colspan="1">−0.40<xref ref-type="table-fn" rid="TF1">*</xref>
</td>
</tr>
<tr><td colspan="9" rowspan="1">Participants, all ages, with 2 or more nocturia episodes at baseline</td>
</tr>
<tr><td rowspan="1" colspan="1">Year 1</td>
<td rowspan="1" colspan="1">459</td>
<td rowspan="1" colspan="1">−0.61</td>
<td rowspan="1" colspan="1">484</td>
<td rowspan="1" colspan="1">−0.77<xref ref-type="table-fn" rid="TF1">*</xref>
<xref ref-type="table-fn" rid="TF2">†</xref>
</td>
<td rowspan="1" colspan="1">496</td>
<td rowspan="1" colspan="1">−0.60</td>
<td rowspan="1" colspan="1">487</td>
<td rowspan="1" colspan="1">−0.80<xref ref-type="table-fn" rid="TF1">*</xref>
<xref ref-type="table-fn" rid="TF2">†</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">Year 4</td>
<td rowspan="1" colspan="1">354</td>
<td rowspan="1" colspan="1">−0.66</td>
<td rowspan="1" colspan="1">393</td>
<td rowspan="1" colspan="1">−0.77</td>
<td rowspan="1" colspan="1">385</td>
<td rowspan="1" colspan="1">−0.68</td>
<td rowspan="1" colspan="1">393</td>
<td rowspan="1" colspan="1">−0.79</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="TF1"><label>*</label>
<p><italic>P</italic>
< .05 versus placebo.</p>
</fn>
<fn id="TF2"><label>†</label>
<p><italic>P</italic>
< .05 versus finasteride.</p>
</fn>
<fn id="TF3"><label>‡</label>
<p>There is a treatment versus time interaction for men < 70 who were allocated to doxazosin when compared with those allocated to finasteride.</p>
</fn>
<fn><p>Data from Johnson et al.<xref rid="B41" ref-type="bibr">41</xref>
</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T4" position="float"><label>Table 4</label>
<caption><p>Long-Term Outcome of Laser Ablation vs Transurethral Resection of Prostate</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="1" colspan="1"></th>
<th colspan="3" rowspan="1">ILC (n = 100)<hr></hr>
</th>
<th colspan="3" rowspan="1">TURP (n = 50)<hr></hr>
</th>
</tr>
<tr><th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1">IPSS</th>
<th rowspan="1" colspan="1">QOL</th>
<th rowspan="1" colspan="1">Qmax</th>
<th rowspan="1" colspan="1">IPSS</th>
<th rowspan="1" colspan="1">QOL</th>
<th rowspan="1" colspan="1">Qmax</th>
</tr>
</thead>
<tbody valign="top"><tr><td rowspan="1" colspan="1">Pre-op</td>
<td rowspan="1" colspan="1">20.5 ± 5<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">4.2 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">8.4 ± 2<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">20.1 ± 5<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">3.8 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">8.4 ± 2<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">1 year</td>
<td rowspan="1" colspan="1">6.7 ± 6<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.6 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">17.2 ± 6<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">5.1 ± 4<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.0 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">21 ± 11<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">2 years</td>
<td rowspan="1" colspan="1">7.0 ± 6<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.7 ± 2<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">17.3 ± 7<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">5.8 ± 5<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.1 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">19 ± 10<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">3 years</td>
<td rowspan="1" colspan="1">7.0 ± 5<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.5 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">16.2 ± 7<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">4.9 ± 4<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.0 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">21.7 ± 11<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">4 years</td>
<td rowspan="1" colspan="1">7.3 ± 6<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.7 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">17.6 ± 8<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">5.6 ± 5<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.0 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">18.9 ± 11<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">5 years</td>
<td rowspan="1" colspan="1">6.7 ± 5<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.5 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">16.1 ± 6<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">5.8 ± 6<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.0 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">20.3 ± 11<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
</tr>
<tr><td rowspan="1" colspan="1">6 years</td>
<td rowspan="1" colspan="1">8.0 ± 6<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.6 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">14.6 ± 6<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">5.5 ± 4<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">1.0 ± 1<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
<td rowspan="1" colspan="1">20.8 ± 11<xref ref-type="table-fn" rid="TF4">*</xref>
</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="TF4"><label>*</label>
<p><italic>P</italic>
value < .001. ILC, Indigo laser; TURP, transurethral resection of prostate; IPSS, International Prostate Symptom Score; QOL, quality of life; Qmax, maximum flow rate. Reprinted from Chandrasekar et al<xref rid="B49" ref-type="bibr">49</xref>
with permission from the American Urological Association.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T5" position="float"><label>Table 5</label>
<caption><p>Effect of 5Alpha-Reductase Inhibition Therapy on Efficiency of KTP Laser PVP</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1">Without 5α-Reductase</th>
<th rowspan="1" colspan="1">With 5α-Reductase</th>
<th rowspan="1" colspan="1"></th>
</tr>
<tr><th rowspan="1" colspan="1">IPSS</th>
<th rowspan="1" colspan="1">Inhibition (n)</th>
<th rowspan="1" colspan="1">Inhibition (n)</th>
<th rowspan="1" colspan="1"><italic>P</italic>
Value</th>
</tr>
</thead>
<tbody valign="top"><tr><td rowspan="1" colspan="1">Baseline</td>
<td rowspan="1" colspan="1">26.9 ± 6.9 (117)</td>
<td rowspan="1" colspan="1">27.0 ± 7.8 (43)</td>
<td rowspan="1" colspan="1">.46</td>
</tr>
<tr><td rowspan="1" colspan="1">Follow-up Period</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1">(weeks)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1">1</td>
<td rowspan="1" colspan="1">14.7 ± 8.0 (104)</td>
<td rowspan="1" colspan="1">14.8 ± 7.5 (40)</td>
<td rowspan="1" colspan="1">.46</td>
</tr>
<tr><td rowspan="1" colspan="1">4</td>
<td rowspan="1" colspan="1">10.7 ± 7.2 (97)</td>
<td rowspan="1" colspan="1">10.4 ± 6.1 (40)</td>
<td rowspan="1" colspan="1">.40</td>
</tr>
<tr><td rowspan="1" colspan="1">12</td>
<td rowspan="1" colspan="1">9.6 ± 7.3 (81)</td>
<td rowspan="1" colspan="1">8.4 ± 5.2 (32)</td>
<td rowspan="1" colspan="1">.21</td>
</tr>
<tr><td rowspan="1" colspan="1">24</td>
<td rowspan="1" colspan="1">8.5 ± 6.0 (46)</td>
<td rowspan="1" colspan="1">6.4 ± 4.5 (21)</td>
<td rowspan="1" colspan="1">.10</td>
</tr>
<tr><td rowspan="1" colspan="1">52</td>
<td rowspan="1" colspan="1">5.6 ± 4.4 (21)</td>
<td rowspan="1" colspan="1">7.0 ± 7.1 (8)</td>
<td rowspan="1" colspan="1">.36</td>
</tr>
</tbody>
</table>
<table frame="hsides" rules="groups"><thead><tr><th rowspan="1" colspan="1"></th>
<th rowspan="1" colspan="1">Without 5α-Reductase</th>
<th rowspan="1" colspan="1">With 5α-Reductase</th>
<th rowspan="1" colspan="1"></th>
</tr>
<tr><th rowspan="1" colspan="1">Qmax (mL/sec)</th>
<th rowspan="1" colspan="1">Inhibition (n)</th>
<th rowspan="1" colspan="1">Inhibition (n)</th>
<th rowspan="1" colspan="1"><italic>P</italic>
Value</th>
</tr>
</thead>
<tbody valign="top"><tr><td rowspan="1" colspan="1">Baseline</td>
<td rowspan="1" colspan="1">10.7 ± 5.8 (117)</td>
<td rowspan="1" colspan="1">11.4 ± 6.1 (43)</td>
<td rowspan="1" colspan="1">.25</td>
</tr>
<tr><td rowspan="1" colspan="1">Follow-up Period</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1">(weeks)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1">1</td>
<td rowspan="1" colspan="1">17.1 ± 8.2 (104)</td>
<td rowspan="1" colspan="1">18.0 ± 7.0 (40)</td>
<td rowspan="1" colspan="1">.29</td>
</tr>
<tr><td rowspan="1" colspan="1">4</td>
<td rowspan="1" colspan="1">20.5 ± 9.0 (97)</td>
<td rowspan="1" colspan="1">21.7 ± 8.7 (40)</td>
<td rowspan="1" colspan="1">.24</td>
</tr>
<tr><td rowspan="1" colspan="1">12</td>
<td rowspan="1" colspan="1">21.9 ± 9.3 (81)</td>
<td rowspan="1" colspan="1">23.1 ± 8.0 (32)</td>
<td rowspan="1" colspan="1">.28</td>
</tr>
<tr><td rowspan="1" colspan="1">24</td>
<td rowspan="1" colspan="1">20.6 ± 8.2 (46)</td>
<td rowspan="1" colspan="1">23.9 ± 76 (21)</td>
<td rowspan="1" colspan="1">.08</td>
</tr>
<tr><td rowspan="1" colspan="1">52</td>
<td rowspan="1" colspan="1">18.2 ± 6.3 (21)</td>
<td rowspan="1" colspan="1">16.9 ± 1.1 (8)</td>
<td rowspan="1" colspan="1">.39</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>KTP, potassium-titanyl-phosphate; PVP, photoselective vaporization prostatectomy; Qmax, maximum flow rate. Reprinted from Araki et al<xref rid="B66" ref-type="bibr">66</xref>
with permission from the American Urological Association.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-wrap>
</pmc>
</record>
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