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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differences in vascular response between primary and transplanted tumours.</title><author><name sortKey="Field, S B" sort="Field, S B" uniqKey="Field S" first="S. B." last="Field">S. B. Field</name></author><author><name sortKey="Needham, S" sort="Needham, S" uniqKey="Needham S" first="S." last="Needham">S. Needham</name></author><author><name sortKey="Burney, I A" sort="Burney, I A" uniqKey="Burney I" first="I. A." last="Burney">I. A. Burney</name></author><author><name sortKey="Maxwell, R J" sort="Maxwell, R J" uniqKey="Maxwell R" first="R. J." last="Maxwell">R. J. Maxwell</name></author><author><name sortKey="Coggle, J E" sort="Coggle, J E" uniqKey="Coggle J" first="J. E." last="Coggle">J. E. Coggle</name></author><author><name sortKey="Griffiths, J R" sort="Griffiths, J R" uniqKey="Griffiths J" first="J. R." last="Griffiths">J. R. Griffiths</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">1645562</idno><idno type="pmc">1972409</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1972409</idno><idno type="RBID">PMC:1972409</idno><date when="1991">1991</date><idno type="wicri:Area/Pmc/Corpus">000188</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000188</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differences in vascular response between primary and transplanted tumours.</title><author><name sortKey="Field, S B" sort="Field, S B" uniqKey="Field S" first="S. B." last="Field">S. B. Field</name></author><author><name sortKey="Needham, S" sort="Needham, S" uniqKey="Needham S" first="S." last="Needham">S. Needham</name></author><author><name sortKey="Burney, I A" sort="Burney, I A" uniqKey="Burney I" first="I. A." last="Burney">I. A. Burney</name></author><author><name sortKey="Maxwell, R J" sort="Maxwell, R J" uniqKey="Maxwell R" first="R. J." last="Maxwell">R. J. Maxwell</name></author><author><name sortKey="Coggle, J E" sort="Coggle, J E" uniqKey="Coggle J" first="J. E." last="Coggle">J. E. Coggle</name></author><author><name sortKey="Griffiths, J R" sort="Griffiths, J R" uniqKey="Griffiths J" first="J. R." last="Griffiths">J. R. Griffiths</name></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="1991">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using 31P Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0.001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors' opinion, the most likely cause is that it results from an artefact of transplantation.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 3</label><graphic xlink:href="brjcancer00213-0077-a" xlink:role="725"></graphic></fig></sec></div></front></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-title>British Journal of Cancer</journal-title><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn></journal-meta><article-meta><article-id pub-id-type="pmid">1645562</article-id><article-id pub-id-type="pmc">1972409</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Differences in vascular response between primary and transplanted tumours.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Field</surname><given-names>S. B.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Needham</surname><given-names>S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Burney</surname><given-names>I. A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Maxwell</surname><given-names>R. J.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Coggle</surname><given-names>J. E.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Griffiths</surname><given-names>J. R.</given-names></name></contrib></contrib-group><aff>MRC Cyclotron Unit, Hammersmith Hospital, London, UK.</aff><pub-date pub-type="ppub"><month>5</month><year>1991</year></pub-date><volume>63</volume><issue>5</issue><fpage>723</fpage><lpage>726</lpage><abstract><p>The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using 31P Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0.001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors' opinion, the most likely cause is that it results from an artefact of transplantation.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 3</label><graphic xlink:href="brjcancer00213-0077-a" xlink:role="725"></graphic></fig></sec></abstract></article-meta></front><body><supplementary-material content-type="scanned-pages"><graphic xlink:href="brjcancer00213-0075.tif" xlink:title="scanned-page" xlink:role="723" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00213-0076.tif" xlink:title="scanned-page" xlink:role="724" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00213-0077.tif" xlink:title="scanned-page" xlink:role="725" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="brjcancer00213-0078.tif" xlink:title="scanned-page" xlink:role="726" mimetype="image" mime-subtype="tiff"></graphic></supplementary-material></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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