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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain correlates of subjective reality of physically and psychologically induced pain</title><author><name sortKey="Raij, Tuukka T" sort="Raij, Tuukka T" uniqKey="Raij T" first="Tuukka T." last="Raij">Tuukka T. Raij</name><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Brain Research Unit of Low Temperature Laboratory</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Advanced Magnetic Imaging Centre, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland;</nlm:aff></affiliation></author><author><name sortKey="Numminen, Jussi" sort="Numminen, Jussi" uniqKey="Numminen J" first="Jussi" last="Numminen">Jussi Numminen</name><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Brain Research Unit of Low Temperature Laboratory</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Helsinki Medical Imaging Center</nlm:aff></affiliation></author><author><name sortKey="N Rv Nen, Sakari" sort="N Rv Nen, Sakari" uniqKey="N Rv Nen S" first="Sakari" last="N Rv Nen">Sakari N Rv Nen</name><affiliation><nlm:aff wicri:cut="; and" id="N0x8ab77b8.0x9a40a48">Mannerheimintie 152 A 25, 00270, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hiltunen, Jaana" sort="Hiltunen, Jaana" uniqKey="Hiltunen J" first="Jaana" last="Hiltunen">Jaana Hiltunen</name><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Brain Research Unit of Low Temperature Laboratory</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Advanced Magnetic Imaging Centre, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland;</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Section of Clinical Neurosciences, Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hari, Riitta" sort="Hari, Riitta" uniqKey="Hari R" first="Riitta" last="Hari">Riitta Hari</name><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Brain Research Unit of Low Temperature Laboratory</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Advanced Magnetic Imaging Centre, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland;</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Department of Clinical Neurophysiology, University of Helsinki, 00290 Helsinki, Finland;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15684052</idno><idno type="pmc">548310</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548310</idno><idno type="RBID">PMC:548310</idno><idno type="doi">10.1073/pnas.0409542102</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000180</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000180</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brain correlates of subjective reality of physically and psychologically induced pain</title><author><name sortKey="Raij, Tuukka T" sort="Raij, Tuukka T" uniqKey="Raij T" first="Tuukka T." last="Raij">Tuukka T. Raij</name><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Brain Research Unit of Low Temperature Laboratory</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Advanced Magnetic Imaging Centre, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland;</nlm:aff></affiliation></author><author><name sortKey="Numminen, Jussi" sort="Numminen, Jussi" uniqKey="Numminen J" first="Jussi" last="Numminen">Jussi Numminen</name><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Brain Research Unit of Low Temperature Laboratory</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Helsinki Medical Imaging Center</nlm:aff></affiliation></author><author><name sortKey="N Rv Nen, Sakari" sort="N Rv Nen, Sakari" uniqKey="N Rv Nen S" first="Sakari" last="N Rv Nen">Sakari N Rv Nen</name><affiliation><nlm:aff wicri:cut="; and" id="N0x8ab77b8.0x9a40a48">Mannerheimintie 152 A 25, 00270, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hiltunen, Jaana" sort="Hiltunen, Jaana" uniqKey="Hiltunen J" first="Jaana" last="Hiltunen">Jaana Hiltunen</name><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Brain Research Unit of Low Temperature Laboratory</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Advanced Magnetic Imaging Centre, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland;</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Section of Clinical Neurosciences, Finnish Institute of Occupational Health, 00250 Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hari, Riitta" sort="Hari, Riitta" uniqKey="Hari R" first="Riitta" last="Hari">Riitta Hari</name><affiliation><nlm:aff wicri:cut=" and" id="N0x8ab77b8.0x9a40a48">Brain Research Unit of Low Temperature Laboratory</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Advanced Magnetic Imaging Centre, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland;</nlm:aff></affiliation><affiliation><nlm:aff id="N0x8ab77b8.0x9a40a48">Department of Clinical Neurophysiology, University of Helsinki, 00290 Helsinki, Finland;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Meaningful behavior requires successful differentiation of events surfacing from one's mind from those arising from the external world. Such judgements may be especially demanding during pain because of the strong contribution from psychological factors to this experience. It is unknown how the subjective reality of pain (SRP) is constructed in the human brain, and neuronal mechanisms of the subjective reality are poorly understood in general. To address these questions, 14 suggestion-prone healthy subjects rated reality of pain that was induced either by laser pulses to the skin or by hypnotic suggestion during functional MRI. Both pain states were associated with activation of the brain's pain circuitry. During laser stimulation, the sensory parts of this circuitry were activated more strongly, and their activation strengths correlated positively with the SRP. During suggestion-induced pain, the reality estimates were lower and correlated positively with activation strengths in the rostral and perigenual anterior cingulate cortex and in the pericingulate regions of the medial prefrontal cortex; a similar trend was evident during laser-induced pain. These findings support the view that information about sensory-discriminative characteristics of pain contributes to the SRP. Differences in such information between physically and psychologically induced pain, however, could be quantitative rather than qualitative and therefore insufficient for judging the reality of pain without knowledge about the source of this information. The medial prefrontal cortex is a likely area to contribute to such source monitoring.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Proc Natl Acad Sci U S A</journal-id><journal-id journal-id-type="publisher-id">pnas</journal-id><journal-title>Proceedings of the National Academy of Sciences of the United States of America</journal-title><issn pub-type="ppub">0027-8424</issn><issn pub-type="epub">1091-6490</issn><publisher><publisher-name>National Academy of Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15684052</article-id><article-id pub-id-type="pmc">548310</article-id><article-id pub-id-type="publisher-id">01022147</article-id><article-id pub-id-type="doi">10.1073/pnas.0409542102</article-id><article-categories><subj-group subj-group-type="heading"><subject>Biological Sciences</subject><subj-group><subject>Neuroscience</subject></subj-group></subj-group></article-categories><title-group><article-title>Brain correlates of subjective reality of physically and psychologically induced pain</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Raij</surname><given-names>Tuukka T.</given-names></name><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">*</xref><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">†</xref><xref ref-type="corresp" rid="cor1">‡</xref></contrib><contrib contrib-type="author"><name><surname>Numminen</surname><given-names>Jussi</given-names></name><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">*</xref><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">§</xref></contrib><contrib contrib-type="author"><name><surname>Närvänen</surname><given-names>Sakari</given-names></name><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">¶</xref></contrib><contrib contrib-type="author"><name><surname>Hiltunen</surname><given-names>Jaana</given-names></name><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">*</xref><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">†</xref><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">∥</xref></contrib><contrib contrib-type="author"><name><surname>Hari</surname><given-names>Riitta</given-names></name><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">*</xref><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">†</xref><xref ref-type="aff" rid="N0x8ab77b8.0x9a40a48">**</xref></contrib></contrib-group><aff id="N0x8ab77b8.0x9a40a48"><label>*</label>Brain Research Unit of Low Temperature Laboratory and<label>†</label>Advanced Magnetic Imaging Centre, Helsinki University of Technology, FIN-02015 HUT, Espoo, Finland;<label>§</label>Helsinki Medical Imaging Center and<label>**</label>Department of Clinical Neurophysiology, University of Helsinki, 00290 Helsinki, Finland;<label>¶</label>Mannerheimintie 152 A 25, 00270, Helsinki, Finland; and<label>∥</label>Section of Clinical Neurosciences, Finnish Institute of Occupational Health, 00250 Helsinki, Finland</aff><author-notes><fn id="cor1"><label>‡</label><p> To whom correspondence should be addressed. E-mail: <email>raijtu@neuro.hut.fi</email>. </p></fn><fn><p>Contributed by Riitta Hari, December 21, 2004</p></fn></author-notes><pub-date pub-type="ppub"><day>8</day><month>2</month><year>2005</year></pub-date><pub-date pub-type="epub"><day>31</day><month>1</month><year>2005</year></pub-date><volume>102</volume><issue>6</issue><fpage>2147</fpage><lpage>2151</lpage><copyright-statement>Copyright © 2005, The National Academy of Sciences</copyright-statement><copyright-year>2005</copyright-year><license><p>Freely available online through the PNAS open access option.</p></license><abstract><p>Meaningful behavior requires successful differentiation of events surfacing from one's mind from those arising from the external world. Such judgements may be especially demanding during pain because of the strong contribution from psychological factors to this experience. It is unknown how the subjective reality of pain (SRP) is constructed in the human brain, and neuronal mechanisms of the subjective reality are poorly understood in general. To address these questions, 14 suggestion-prone healthy subjects rated reality of pain that was induced either by laser pulses to the skin or by hypnotic suggestion during functional MRI. Both pain states were associated with activation of the brain's pain circuitry. During laser stimulation, the sensory parts of this circuitry were activated more strongly, and their activation strengths correlated positively with the SRP. During suggestion-induced pain, the reality estimates were lower and correlated positively with activation strengths in the rostral and perigenual anterior cingulate cortex and in the pericingulate regions of the medial prefrontal cortex; a similar trend was evident during laser-induced pain. These findings support the view that information about sensory-discriminative characteristics of pain contributes to the SRP. Differences in such information between physically and psychologically induced pain, however, could be quantitative rather than qualitative and therefore insufficient for judging the reality of pain without knowledge about the source of this information. The medial prefrontal cortex is a likely area to contribute to such source monitoring.</p></abstract><kwd-group><kwd>functional MRI</kwd><kwd>suggestion</kwd><kwd>hypnosis</kwd><kwd>human</kwd><kwd>cortex</kwd></kwd-group></article-meta><notes><fn-group><fn><p>Abbreviations: SII cortex, secondary somatosensory cortex; ACC, anterior cingulate cortex; pACC, perigenual ACC; rACC, rostral ACC; cACC, caudal ACC; mPFC, medial prefrontal cortex; SRP, subjective reality of pain; fMRI, functional MRI.</p></fn></fn-group></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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