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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.</title><author><name sortKey="Triggle, C R" sort="Triggle, C R" uniqKey="Triggle C" first="C R" last="Triggle">C R Triggle</name></author><author><name sortKey="Triggle, D J" sort="Triggle, D J" uniqKey="Triggle D" first="D J" last="Triggle">D J Triggle</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">1249741</idno><idno type="pmc">1309178</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1309178</idno><idno type="RBID">PMC:1309178</idno><date when="1976">1976</date><idno type="wicri:Area/Pmc/Corpus">000166</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000166</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.</title><author><name sortKey="Triggle, C R" sort="Triggle, C R" uniqKey="Triggle C" first="C R" last="Triggle">C R Triggle</name></author><author><name sortKey="Triggle, D J" sort="Triggle, D J" uniqKey="Triggle D" first="D J" last="Triggle">D J Triggle</name></author></analytic><series><title level="j">The Journal of Physiology</title><idno type="ISSN">0022-3751</idno><idno type="eISSN">1469-7793</idno><imprint><date when="1976">1976</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>1. The inhibitory effects of lanthanide cations (Ln3+) on mechanical responses and 45Ca uptake in guinea-pig ileal longitudinal smooth muscle were studied. 2. Ln3+ strongly inhibited the phasic and tonic component of the response to the muscarinic agonist cis-2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide (CD) the two components being affected to the same extent. Inhibition was also obtained for the responses evoked by high K+ but here the effect was mainly on the phasic response, the tonic component was merely delayed. 3. Other members of the Ln3+ series, with the exception of cerium, were found to be more effective than lanthanum in their ability to inhibit the CD response. Thulium, Tm3+, the thirteenth member of the series was the most effective cation. 4. Analysis of 170Tm uptake revealed at least two components. The concentration-dependence of one component, saturating at 2-5 x 10(-6) Tm, corresponded closely to that of the inhibitory effect of Tm3+ on contraction. 5. 170Tm uptake as a function of time showed a secondary rise after 30 min of exposure to the lanthanide. 6. Although 2-5 x 10(-6) M-Tm3+ produced 90% inhibition of the CD and the high K+ induced responses significant reduction of 45Ca uptake by the muscle was only detected when much higher Tm3+ concentrations (greater than or equal 10(-3) M-Tm3+) were used. 7. It is concluded that Ln3+ combine with membrane sites specifically involved in Ca2+ translocation during excitation-contraction coupling.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Physiol</journal-id><journal-title>The Journal of Physiology</journal-title><issn pub-type="ppub">0022-3751</issn><issn pub-type="epub">1469-7793</issn></journal-meta><article-meta><article-id pub-id-type="pmid">1249741</article-id><article-id pub-id-type="pmc">1309178</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Triggle</surname><given-names>C R</given-names></name></contrib><contrib contrib-type="author"><name><surname>Triggle</surname><given-names>D J</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>1</month><year>1976</year></pub-date><volume>254</volume><issue>1</issue><fpage>39</fpage><lpage>54</lpage><abstract><p>1. The inhibitory effects of lanthanide cations (Ln3+) on mechanical responses and 45Ca uptake in guinea-pig ileal longitudinal smooth muscle were studied. 2. Ln3+ strongly inhibited the phasic and tonic component of the response to the muscarinic agonist cis-2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide (CD) the two components being affected to the same extent. Inhibition was also obtained for the responses evoked by high K+ but here the effect was mainly on the phasic response, the tonic component was merely delayed. 3. Other members of the Ln3+ series, with the exception of cerium, were found to be more effective than lanthanum in their ability to inhibit the CD response. Thulium, Tm3+, the thirteenth member of the series was the most effective cation. 4. Analysis of 170Tm uptake revealed at least two components. The concentration-dependence of one component, saturating at 2-5 x 10(-6) Tm, corresponded closely to that of the inhibitory effect of Tm3+ on contraction. 5. 170Tm uptake as a function of time showed a secondary rise after 30 min of exposure to the lanthanide. 6. Although 2-5 x 10(-6) M-Tm3+ produced 90% inhibition of the CD and the high K+ induced responses significant reduction of 45Ca uptake by the muscle was only detected when much higher Tm3+ concentrations (greater than or equal 10(-3) M-Tm3+) were used. 7. It is concluded that Ln3+ combine with membrane sites specifically involved in Ca2+ translocation during excitation-contraction coupling.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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