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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.</title>
<author><name sortKey="Triggle, C R" sort="Triggle, C R" uniqKey="Triggle C" first="C R" last="Triggle">C R Triggle</name>
</author>
<author><name sortKey="Triggle, D J" sort="Triggle, D J" uniqKey="Triggle D" first="D J" last="Triggle">D J Triggle</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">1249741</idno>
<idno type="pmc">1309178</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1309178</idno>
<idno type="RBID">PMC:1309178</idno>
<date when="1976">1976</date>
<idno type="wicri:Area/Pmc/Corpus">000166</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000166</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.</title>
<author><name sortKey="Triggle, C R" sort="Triggle, C R" uniqKey="Triggle C" first="C R" last="Triggle">C R Triggle</name>
</author>
<author><name sortKey="Triggle, D J" sort="Triggle, D J" uniqKey="Triggle D" first="D J" last="Triggle">D J Triggle</name>
</author>
</analytic>
<series><title level="j">The Journal of Physiology</title>
<idno type="ISSN">0022-3751</idno>
<idno type="eISSN">1469-7793</idno>
<imprint><date when="1976">1976</date>
</imprint>
</series>
</biblStruct>
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</fileDesc>
<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p>1. The inhibitory effects of lanthanide cations (Ln3+) on mechanical responses and 45Ca uptake in guinea-pig ileal longitudinal smooth muscle were studied. 2. Ln3+ strongly inhibited the phasic and tonic component of the response to the muscarinic agonist cis-2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide (CD) the two components being affected to the same extent. Inhibition was also obtained for the responses evoked by high K+ but here the effect was mainly on the phasic response, the tonic component was merely delayed. 3. Other members of the Ln3+ series, with the exception of cerium, were found to be more effective than lanthanum in their ability to inhibit the CD response. Thulium, Tm3+, the thirteenth member of the series was the most effective cation. 4. Analysis of 170Tm uptake revealed at least two components. The concentration-dependence of one component, saturating at 2-5 x 10(-6) Tm, corresponded closely to that of the inhibitory effect of Tm3+ on contraction. 5. 170Tm uptake as a function of time showed a secondary rise after 30 min of exposure to the lanthanide. 6. Although 2-5 x 10(-6) M-Tm3+ produced 90% inhibition of the CD and the high K+ induced responses significant reduction of 45Ca uptake by the muscle was only detected when much higher Tm3+ concentrations (greater than or equal 10(-3) M-Tm3+) were used. 7. It is concluded that Ln3+ combine with membrane sites specifically involved in Ca2+ translocation during excitation-contraction coupling.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Physiol</journal-id>
<journal-title>The Journal of Physiology</journal-title>
<issn pub-type="ppub">0022-3751</issn>
<issn pub-type="epub">1469-7793</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">1249741</article-id>
<article-id pub-id-type="pmc">1309178</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Triggle</surname>
<given-names>C R</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Triggle</surname>
<given-names>D J</given-names>
</name>
</contrib>
</contrib-group>
<pub-date pub-type="ppub"><month>1</month>
<year>1976</year>
</pub-date>
<volume>254</volume>
<issue>1</issue>
<fpage>39</fpage>
<lpage>54</lpage>
<abstract><p>1. The inhibitory effects of lanthanide cations (Ln3+) on mechanical responses and 45Ca uptake in guinea-pig ileal longitudinal smooth muscle were studied. 2. Ln3+ strongly inhibited the phasic and tonic component of the response to the muscarinic agonist cis-2-methyl-4-dimethylaminomethyl-1,3-dioxolane methiodide (CD) the two components being affected to the same extent. Inhibition was also obtained for the responses evoked by high K+ but here the effect was mainly on the phasic response, the tonic component was merely delayed. 3. Other members of the Ln3+ series, with the exception of cerium, were found to be more effective than lanthanum in their ability to inhibit the CD response. Thulium, Tm3+, the thirteenth member of the series was the most effective cation. 4. Analysis of 170Tm uptake revealed at least two components. The concentration-dependence of one component, saturating at 2-5 x 10(-6) Tm, corresponded closely to that of the inhibitory effect of Tm3+ on contraction. 5. 170Tm uptake as a function of time showed a secondary rise after 30 min of exposure to the lanthanide. 6. Although 2-5 x 10(-6) M-Tm3+ produced 90% inhibition of the CD and the high K+ induced responses significant reduction of 45Ca uptake by the muscle was only detected when much higher Tm3+ concentrations (greater than or equal 10(-3) M-Tm3+) were used. 7. It is concluded that Ln3+ combine with membrane sites specifically involved in Ca2+ translocation during excitation-contraction coupling.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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