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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dermatomal laser-evoked potentials: a diagnostic approach to the dorsal root. Norm data in healthy volunteers and changes in patients with radiculopathy</title><author><name sortKey="Quante, Markus" sort="Quante, Markus" uniqKey="Quante M" first="Markus" last="Quante">Markus Quante</name><affiliation><nlm:aff id="Aff1">Department of Orthopaedics and Rheumatology, University Hospital Giessen and Marburg, Marburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3">Department of Orthopaedic Surgery, Eilbek General Hospital, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hauck, Michael" sort="Hauck, Michael" uniqKey="Hauck M" first="Michael" last="Hauck">Michael Hauck</name><affiliation><nlm:aff id="Aff2">Institute for Neurophysiology and Pathophysiology, University Hospital Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3">Department of Orthopaedic Surgery, Eilbek General Hospital, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gromoll, Melanie" sort="Gromoll, Melanie" uniqKey="Gromoll M" first="Melanie" last="Gromoll">Melanie Gromoll</name><affiliation><nlm:aff id="Aff2">Institute for Neurophysiology and Pathophysiology, University Hospital Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hille, Ekkehard" sort="Hille, Ekkehard" uniqKey="Hille E" first="Ekkehard" last="Hille">Ekkehard Hille</name><affiliation><nlm:aff id="Aff3">Department of Orthopaedic Surgery, Eilbek General Hospital, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lorenz, Jurgen" sort="Lorenz, Jurgen" uniqKey="Lorenz J" first="Jürgen" last="Lorenz">Jürgen Lorenz</name><affiliation><nlm:aff id="Aff2">Institute for Neurophysiology and Pathophysiology, University Hospital Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Biomedical Engineering, Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17103230</idno><idno type="pmc">2219653</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219653</idno><idno type="RBID">PMC:2219653</idno><idno type="doi">10.1007/s00586-006-0253-2</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000112</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000112</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dermatomal laser-evoked potentials: a diagnostic approach to the dorsal root. Norm data in healthy volunteers and changes in patients with radiculopathy</title><author><name sortKey="Quante, Markus" sort="Quante, Markus" uniqKey="Quante M" first="Markus" last="Quante">Markus Quante</name><affiliation><nlm:aff id="Aff1">Department of Orthopaedics and Rheumatology, University Hospital Giessen and Marburg, Marburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3">Department of Orthopaedic Surgery, Eilbek General Hospital, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hauck, Michael" sort="Hauck, Michael" uniqKey="Hauck M" first="Michael" last="Hauck">Michael Hauck</name><affiliation><nlm:aff id="Aff2">Institute for Neurophysiology and Pathophysiology, University Hospital Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3">Department of Orthopaedic Surgery, Eilbek General Hospital, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Gromoll, Melanie" sort="Gromoll, Melanie" uniqKey="Gromoll M" first="Melanie" last="Gromoll">Melanie Gromoll</name><affiliation><nlm:aff id="Aff2">Institute for Neurophysiology and Pathophysiology, University Hospital Eppendorf, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hille, Ekkehard" sort="Hille, Ekkehard" uniqKey="Hille E" first="Ekkehard" last="Hille">Ekkehard Hille</name><affiliation><nlm:aff id="Aff3">Department of Orthopaedic Surgery, Eilbek General Hospital, Hamburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Lorenz, Jurgen" sort="Lorenz, Jurgen" uniqKey="Lorenz J" first="Jürgen" last="Lorenz">Jürgen Lorenz</name><affiliation><nlm:aff id="Aff2">Institute for Neurophysiology and Pathophysiology, University Hospital Eppendorf, Hamburg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Biomedical Engineering, Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">European Spine Journal</title><idno type="ISSN">0940-6719</idno><idno type="eISSN">1432-0932</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We conducted a cross-sectional study of 40 radiculopathy patients in comparison with norm data from healthy subjects using a new electrophysiological method. Early manifestations of dorsal root impairment escape objective diagnosis by conventional somatosensory-evoked potentials due to the overlapping innervation of the affected dermatome by thickly myelinated mechanoreceptive afferents projecting to adjacent intact roots. Evidence suggested less intersegmental overlap for thermonociceptive afferents rendering laser-evoked potentials (LEP) sensitive to monosegmental dorsal root damage. Therefore we used this new method to study acute manifestations of monosegmental dorsal root pathology. Dorsal root function was tested in 12 healthy subjects and 40 sciatica patients by intraindividual interside comparison. Mechanosensibility and thermosensibility were clinically investigated. LEP were induced by moderately painful laser stimuli. The LEP were evaluated by amplitude and latency of the averaged electroencephalogram. Normal interside differences of LEP for amplitude were ±22% (lower limb) and ±35% (upper limb) and ±15 to ±16% for latency. Twenty-six patients (65%) showed significant LEP changes, mainly amplitude decreases. Six of these patients exhibited latency prolongations. Clinical testing yielded more frequent pathological results for pain compared to mechanosensibility. The study confirmed our preliminary evidence of LEP sensitivity to objectively document dorsal root impairment in patients suffering from acute monosegmental radiculopathy. This result opens the perspective of electrophysiologically differentiating the presence or absence of dorsal root pathology in patients with similar clinical symptoms but possibly different prognoses, which require different therapies.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur Spine J</journal-id><journal-title-group><journal-title>European Spine Journal</journal-title></journal-title-group><issn pub-type="ppub">0940-6719</issn><issn pub-type="epub">1432-0932</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17103230</article-id><article-id pub-id-type="pmc">2219653</article-id><article-id pub-id-type="publisher-id">253</article-id><article-id pub-id-type="doi">10.1007/s00586-006-0253-2</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Dermatomal laser-evoked potentials: a diagnostic approach to the dorsal root. Norm data in healthy volunteers and changes in patients with radiculopathy</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Quante</surname><given-names>Markus</given-names></name><address><phone>+49-6421-28649</phone><fax>+49-6421-28670</fax><email>quante@med.uni-marburg.de</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hauck</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Gromoll</surname><given-names>Melanie</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hille</surname><given-names>Ekkehard</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Lorenz</surname><given-names>Jürgen</given-names></name><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><aff id="Aff1"><label>1</label>Department of Orthopaedics and Rheumatology, University Hospital Giessen and Marburg, Marburg, Germany</aff><aff id="Aff2"><label>2</label>Institute for Neurophysiology and Pathophysiology, University Hospital Eppendorf, Hamburg, Germany</aff><aff id="Aff3"><label>3</label>Department of Orthopaedic Surgery, Eilbek General Hospital, Hamburg, Germany</aff><aff id="Aff4"><label>4</label>Department of Biomedical Engineering, Faculty of Life Sciences, Hamburg University of Applied Sciences, Hamburg, Germany</aff></contrib-group><pub-date pub-type="epub"><day>14</day><month>11</month><year>2006</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2007</year></pub-date><volume>16</volume><issue>7</issue><fpage>943</fpage><lpage>952</lpage><history><date date-type="received"><day>17</day><month>1</month><year>2006</year></date><date date-type="rev-recd"><day>6</day><month>9</month><year>2006</year></date><date date-type="accepted"><day>21</day><month>10</month><year>2006</year></date></history><permissions><copyright-statement>© Springer-Verlag 2006</copyright-statement></permissions><abstract><p>We conducted a cross-sectional study of 40 radiculopathy patients in comparison with norm data from healthy subjects using a new electrophysiological method. Early manifestations of dorsal root impairment escape objective diagnosis by conventional somatosensory-evoked potentials due to the overlapping innervation of the affected dermatome by thickly myelinated mechanoreceptive afferents projecting to adjacent intact roots. Evidence suggested less intersegmental overlap for thermonociceptive afferents rendering laser-evoked potentials (LEP) sensitive to monosegmental dorsal root damage. Therefore we used this new method to study acute manifestations of monosegmental dorsal root pathology. Dorsal root function was tested in 12 healthy subjects and 40 sciatica patients by intraindividual interside comparison. Mechanosensibility and thermosensibility were clinically investigated. LEP were induced by moderately painful laser stimuli. The LEP were evaluated by amplitude and latency of the averaged electroencephalogram. Normal interside differences of LEP for amplitude were ±22% (lower limb) and ±35% (upper limb) and ±15 to ±16% for latency. Twenty-six patients (65%) showed significant LEP changes, mainly amplitude decreases. Six of these patients exhibited latency prolongations. Clinical testing yielded more frequent pathological results for pain compared to mechanosensibility. The study confirmed our preliminary evidence of LEP sensitivity to objectively document dorsal root impairment in patients suffering from acute monosegmental radiculopathy. This result opens the perspective of electrophysiologically differentiating the presence or absence of dorsal root pathology in patients with similar clinical symptoms but possibly different prognoses, which require different therapies.</p></abstract><kwd-group><title>Keywords</title><kwd>Laser-evoked potential</kwd><kwd>Sciatica</kwd><kwd>Dorsal root impairment</kwd><kwd>Dermatomal-evoked potentials</kwd><kwd>Radiculopathy</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag 2007</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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